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The map label for this gene is acrR [H]

Identifier: 29142771

GI number: 29142771

Start: 2453832

End: 2454485

Strand: Reverse

Name: acrR [H]

Synonym: t2383

Alternate gene names: 29142771

Gene position: 2454485-2453832 (Counterclockwise)

Preceding gene: 29142778

Following gene: 29142770

Centisome position: 51.22

GC content: 46.79

Gene sequence:

>654_bases
ATGGCACGAAAAACCAAACAACAAGCGCTGGAGACACGACAACACATCCTGGATGTGGCCCTGCGTTTGTTCTCGCAGCA
AGGCGTATCGGCAACCTCGCTGGCGGAGATTGCGAACGCTGCTGGCGTGACGCGCGGCGCAATCTATTGGCATTTCAAAA
ATAAGTCGGATTTATTCAGTGAGATCTGGGAGCTATCAGAATCCAATATTGGTGAGCTTGAGATTGAGTATCAGGCAAAA
TTCCCCGACGATCCACTATCTGTATTAAGAGAAATTTTAGTTCATATTCTTGAAGCTACTGTAACAGAAGAACGACGCCG
CTTATTGATGGAGATTATATTCCATAAATGTGAGTTTGTCGGAGAAATGGTTGTGGTTCAACAGGCGCAACGTAGCCTTT
GTCTGGAAAGTTACGATCGGATTGAACAAACGTTAAAACATTGTATTAATGCTAAAATGCTGCCTGAAAATCTGCTGACC
CGTCGTGCGGCGATACTGATGCGCAGCTTTATTTCAGGGCTCATGGAAAACTGGTTATTTGCTCCGCAATCGTTTGATTT
AAAAAAAGAAGCTCGCGCCTACGTCACGATCCTGCTGGAGATGTATCAATTGTGTCCGACGCTGCGCGCGTCGACGGTCA
ACGGCTCCCCCTGA

Upstream 100 bases:

>100_bases
AAAGGTCCTTAAACCCATTGCTGCGTTTATATTATCGTCATGCTATGGTACATACATCCATAAATGTATGTAAATCTAAC
GCCTGTAAATTCACCGACAT

Downstream 100 bases:

>100_bases
TAATATTCCAGGAAAACTCCTGGACATTTTCTGTGTCGCTATTCTGTTTGTTACAGGCGTGATATTCTTGCGACTCAATT
ATTTCCGGTCTGCTTGCCGG

Product: DNA-binding transcriptional repressor AcrR

Products: NA

Alternate protein names: Potential acrAB operon repressor [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MARKTKQQALETRQHILDVALRLFSQQGVSATSLAEIANAAGVTRGAIYWHFKNKSDLFSEIWELSESNIGELEIEYQAK
FPDDPLSVLREILVHILEATVTEERRRLLMEIIFHKCEFVGEMVVVQQAQRSLCLESYDRIEQTLKHCINAKMLPENLLT
RRAAILMRSFISGLMENWLFAPQSFDLKKEARAYVTILLEMYQLCPTLRASTVNGSP

Sequences:

>Translated_217_residues
MARKTKQQALETRQHILDVALRLFSQQGVSATSLAEIANAAGVTRGAIYWHFKNKSDLFSEIWELSESNIGELEIEYQAK
FPDDPLSVLREILVHILEATVTEERRRLLMEIIFHKCEFVGEMVVVQQAQRSLCLESYDRIEQTLKHCINAKMLPENLLT
RRAAILMRSFISGLMENWLFAPQSFDLKKEARAYVTILLEMYQLCPTLRASTVNGSP
>Mature_216_residues
ARKTKQQALETRQHILDVALRLFSQQGVSATSLAEIANAAGVTRGAIYWHFKNKSDLFSEIWELSESNIGELEIEYQAKF
PDDPLSVLREILVHILEATVTEERRRLLMEIIFHKCEFVGEMVVVQQAQRSLCLESYDRIEQTLKHCINAKMLPENLLTR
RAAILMRSFISGLMENWLFAPQSFDLKKEARAYVTILLEMYQLCPTLRASTVNGSP

Specific function: Potential regulator protein for the acrAB genes [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=214, Percent_Identity=87.3831775700935, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1789664, Length=203, Percent_Identity=37.9310344827586, Blast_Score=137, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24903; Mature: 24772

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTKQQALETRQHILDVALRLFSQQGVSATSLAEIANAAGVTRGAIYWHFKNKSDLFS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
EIWELSESNIGELEIEYQAKFPDDPLSVLREILVHILEATVTEERRRLLMEIIFHKCEFV
HHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEMVVVQQAQRSLCLESYDRIEQTLKHCINAKMLPENLLTRRAAILMRSFISGLMENWLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
APQSFDLKKEARAYVTILLEMYQLCPTLRASTVNGSP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ARKTKQQALETRQHILDVALRLFSQQGVSATSLAEIANAAGVTRGAIYWHFKNKSDLFS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
EIWELSESNIGELEIEYQAKFPDDPLSVLREILVHILEATVTEERRRLLMEIIFHKCEFV
HHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEMVVVQQAQRSLCLESYDRIEQTLKHCINAKMLPENLLTRRAAILMRSFISGLMENWLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
APQSFDLKKEARAYVTILLEMYQLCPTLRASTVNGSP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]