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The map label for this gene is apt [H]

Identifier: 29142766

GI number: 29142766

Start: 2447458

End: 2448009

Strand: Reverse

Name: apt [H]

Synonym: t2377

Alternate gene names: 29142766

Gene position: 2448009-2447458 (Counterclockwise)

Preceding gene: 29142767

Following gene: 29142765

Centisome position: 51.09

GC content: 53.8

Gene sequence:

>552_bases
ATGACCGCGACTGCACAGCAGCTTGAGTTTCTCAAAAACAGCATCAAAAGCATTCAGGATTACCCGAAACCGGGCATTCT
TTTCCGTGATGTCACCAGCTTACTGGAAGACCCGAAAGCCTACGCGCTCAGTATTGAACTGTTAGTTGAGCGTTATAAAA
ATGCGGGTATCACCAAAGTGGTCGGCACCGAAGCGCGTGGCTTCCTGTTTGGCGCGCCGGTTGCGCTTGGGCTGGGCGTT
GGTTTTGTTCCGGTACGTAAACCGCGCAAATTACCGCGTGAAACTATTGCCGAGACCTATGAATTAGAGTACGGCACCGA
TCAGCTGGAAATCCATGTCGACGCGATTAAACCTGGCGACAACGTGCTGGTCGTGGACGATCTGCTGGCGACTGGCGGCA
CCATTGAGGCGACCGTGAAGCTGATCCGTCGTCTGGGCGGGAAAGTCACCGATGCGGCGTTCATCATCAATTTGTTCGAT
CTGGGCGGCGAGCAGCGTCTGGAAAAGCAGGGGATTACCTGTTATAGCCTGATGCCGTTTCCAGGGCATTGA

Upstream 100 bases:

>100_bases
TTTCGAGCACAGGCGCAGGCGGTCAAAGAGTAACCGAGCGTTACCCCTGACTGAAAAGTATTGCGCCGTGAGTAACACCG
TACTTAGCAGGCATATATCC

Downstream 100 bases:

>100_bases
TTCAGGCTATTCGCACTGCTATTTTAGCCAGAGAGACAACCTCGCTGTATCGGCGAGGTTGTGTTAGCATTACCCTTCTA
TGAATCCACCTTCCAGCGTT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MTATAQQLEFLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIELLVERYKNAGITKVVGTEARGFLFGAPVALGLGV
GFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGDNVLVVDDLLATGGTIEATVKLIRRLGGKVTDAAFIINLFD
LGGEQRLEKQGITCYSLMPFPGH

Sequences:

>Translated_183_residues
MTATAQQLEFLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIELLVERYKNAGITKVVGTEARGFLFGAPVALGLGV
GFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGDNVLVVDDLLATGGTIEATVKLIRRLGGKVTDAAFIINLFD
LGGEQRLEKQGITCYSLMPFPGH
>Mature_182_residues
TATAQQLEFLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIELLVERYKNAGITKVVGTEARGFLFGAPVALGLGVG
FVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGDNVLVVDDLLATGGTIEATVKLIRRLGGKVTDAAFIINLFDL
GGEQRLEKQGITCYSLMPFPGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=165, Percent_Identity=41.8181818181818, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI71773201, Length=130, Percent_Identity=44.6153846153846, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI1786675, Length=183, Percent_Identity=94.5355191256831, Blast_Score=348, Evalue=8e-98,
Organism=Caenorhabditis elegans, GI17509087, Length=168, Percent_Identity=45.2380952380952, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=164, Percent_Identity=41.4634146341463, Blast_Score=111, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=35.672514619883, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136334, Length=180, Percent_Identity=40, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20017; Mature: 19886

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATAQQLEFLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIELLVERYKNAGITKV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEE
VGTEARGFLFGAPVALGLGVGFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGD
ECCCCCCEEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEECCCC
NVLVVDDLLATGGTIEATVKLIRRLGGKVTDAAFIINLFDLGGEQRLEKQGITCYSLMPF
CEEEEEHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHCCCEEEEECCC
PGH
CCC
>Mature Secondary Structure 
TATAQQLEFLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIELLVERYKNAGITKV
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEE
VGTEARGFLFGAPVALGLGVGFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGD
ECCCCCCEEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEECCCC
NVLVVDDLLATGGTIEATVKLIRRLGGKVTDAAFIINLFDLGGEQRLEKQGITCYSLMPF
CEEEEEHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHCCCEEEEECCC
PGH
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA