| Definition | Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome. |
|---|---|
| Accession | NC_004631 |
| Length | 4,791,961 |
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The map label for this gene is entA [H]
Identifier: 29142670
GI number: 29142670
Start: 2336307
End: 2337062
Strand: Reverse
Name: entA [H]
Synonym: t2270
Alternate gene names: 29142670
Gene position: 2337062-2336307 (Counterclockwise)
Preceding gene: 29142671
Following gene: 29142669
Centisome position: 48.77
GC content: 58.99
Gene sequence:
>756_bases ATGGCCAGCTTTGATTTTTCAGACAAAACGGTATGGGTGACCGGGGCGGGGAAAGGGATCGGTTACGCGACGGCGCTGGC GTTTGTCGACGCCGGGGCGCGGGTGATCGGCTTCGATCGCGAATTTACGCAAGAGAATTATCCCTTTGCTACCGAAGTTA TGGATGTGGCGGATGCCGCACAGGTTGCGCAGGTGTGCCAGCGTGTGTTGCAAAAAACGCCGCGGCTGGATGTGCTGGTC AACGCCGCCGGTATTTTGCGTATGGGAGCGACCGACGCGCTTAACGTCGACGACTGGCAGCAGACATTTGCGGTCAATGT GGGCGGGGCATTTAACCTGTTTTCCCAGACGATGGCGCAGTTTCGCCGTCAGCAGGGAGGGGCGATTGTCACCGTAGCCT CAGATGCGGCGCATACGCCGCGTATCGGTATGGGCGCTTACGGCGCCTCTAAAGCGGCGCTGAAAAGCCTGGCGCTAACC GTAGGGCTGGAGCTGGCGGGCTGCGGGGTACGCTGTAATGTGGTGTCGCCGGGCTCGACCGACACCGATATGCAGCGCAC GTTATGGGTGAGTGAAGATGCCGAACAGCAGCGCATTCGCGGTTTCGGCGAACAGTTTAAGCTCGGCATACCGCTCGGTA AAATCGCCCGTCCGCAGGAGATAGCCAATACCATTTTGTTTCTTGCCTCCGATCTGGCCAGCCACATTACCTTGCAGGAT ATCGTGGTGGACGGCGGTTCAACATTGGGAGCCTGA
Upstream 100 bases:
>100_bases CGCGCTGGCGTAAAGTACACGGCGATATCGACTTCGTGATGCTGGCGAAAAATCCGACCATTGACGCCTGGTGGGCGCTG CTTTCTCGCGGGGTAGAGTA
Downstream 100 bases:
>100_bases CGATGATCTGGAAACGGCATTTAACGCTGGATGAATTGAATGCTACCAGTCAGAACACGCTGGTGGCGCATCTGGGCATT GTTTACACCCGTCTGGGCGA
Product: 2,3-dihydroxybenzoate-2,3-dehydrogenase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 251; Mature: 250
Protein sequence:
>251_residues MASFDFSDKTVWVTGAGKGIGYATALAFVDAGARVIGFDREFTQENYPFATEVMDVADAAQVAQVCQRVLQKTPRLDVLV NAAGILRMGATDALNVDDWQQTFAVNVGGAFNLFSQTMAQFRRQQGGAIVTVASDAAHTPRIGMGAYGASKAALKSLALT VGLELAGCGVRCNVVSPGSTDTDMQRTLWVSEDAEQQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQD IVVDGGSTLGA
Sequences:
>Translated_251_residues MASFDFSDKTVWVTGAGKGIGYATALAFVDAGARVIGFDREFTQENYPFATEVMDVADAAQVAQVCQRVLQKTPRLDVLV NAAGILRMGATDALNVDDWQQTFAVNVGGAFNLFSQTMAQFRRQQGGAIVTVASDAAHTPRIGMGAYGASKAALKSLALT VGLELAGCGVRCNVVSPGSTDTDMQRTLWVSEDAEQQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQD IVVDGGSTLGA >Mature_250_residues ASFDFSDKTVWVTGAGKGIGYATALAFVDAGARVIGFDREFTQENYPFATEVMDVADAAQVAQVCQRVLQKTPRLDVLVN AAGILRMGATDALNVDDWQQTFAVNVGGAFNLFSQTMAQFRRQQGGAIVTVASDAAHTPRIGMGAYGASKAALKSLALTV GLELAGCGVRCNVVSPGSTDTDMQRTLWVSEDAEQQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDI VVDGGSTLGA
Specific function: Siderophore biosynthesis; enterobactin biosynthesis. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=255, Percent_Identity=28.6274509803922, Blast_Score=99, Evalue=4e-21, Organism=Homo sapiens, GI66933014, Length=248, Percent_Identity=31.0483870967742, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI5031737, Length=254, Percent_Identity=29.9212598425197, Blast_Score=96, Evalue=4e-20, Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=29.9610894941634, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI40254992, Length=252, Percent_Identity=30.5555555555556, Blast_Score=89, Evalue=5e-18, Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=28.9156626506024, Blast_Score=85, Evalue=7e-17, Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=30.6122448979592, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI10190704, Length=257, Percent_Identity=24.9027237354086, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=23.828125, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI126723750, Length=261, Percent_Identity=24.904214559387, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI59889578, Length=231, Percent_Identity=26.8398268398268, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI4504505, Length=188, Percent_Identity=29.7872340425532, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI31542939, Length=258, Percent_Identity=27.5193798449612, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI4758504, Length=199, Percent_Identity=31.6582914572864, Blast_Score=66, Evalue=2e-11, Organism=Homo sapiens, GI22507405, Length=221, Percent_Identity=27.1493212669683, Blast_Score=66, Evalue=3e-11, Organism=Escherichia coli, GI1786812, Length=248, Percent_Identity=89.5161290322581, Blast_Score=452, Evalue=1e-128, Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=32.4110671936759, Blast_Score=115, Evalue=3e-27, Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=31.25, Blast_Score=114, Evalue=5e-27, Organism=Escherichia coli, GI1788459, Length=200, Percent_Identity=33.5, Blast_Score=94, Evalue=6e-21, Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=28.9156626506024, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI2367175, Length=255, Percent_Identity=31.3725490196078, Blast_Score=82, Evalue=3e-17, Organism=Escherichia coli, GI1789378, Length=269, Percent_Identity=28.6245353159851, Blast_Score=82, Evalue=4e-17, Organism=Escherichia coli, GI1789208, Length=255, Percent_Identity=24.7058823529412, Blast_Score=80, Evalue=9e-17, Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=24.5059288537549, Blast_Score=80, Evalue=1e-16, Organism=Escherichia coli, GI2367365, Length=249, Percent_Identity=30.1204819277108, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI87082160, Length=262, Percent_Identity=27.4809160305344, Blast_Score=75, Evalue=3e-15, Organism=Escherichia coli, GI1787526, Length=205, Percent_Identity=27.3170731707317, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1787820, Length=178, Percent_Identity=28.6516853932584, Blast_Score=66, Evalue=3e-12, Organism=Caenorhabditis elegans, GI115534694, Length=257, Percent_Identity=34.6303501945525, Blast_Score=113, Evalue=9e-26, Organism=Caenorhabditis elegans, GI17561402, Length=257, Percent_Identity=32.6848249027237, Blast_Score=107, Evalue=6e-24, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=32.5757575757576, Blast_Score=104, Evalue=4e-23, Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=31.4176245210728, Blast_Score=103, Evalue=6e-23, Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=33.0827067669173, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI17562908, Length=267, Percent_Identity=34.4569288389513, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=31.4393939393939, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=33.0798479087452, Blast_Score=97, Evalue=7e-21, Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=31.5789473684211, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=31.2977099236641, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=28.6245353159851, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=31.0606060606061, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=29.5275590551181, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=30.6772908366534, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=30.4832713754647, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=29.7397769516729, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=29.6442687747036, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17538480, Length=266, Percent_Identity=28.1954887218045, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=29.718875502008, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=29.0322580645161, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17508651, Length=194, Percent_Identity=29.8969072164948, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=29.9242424242424, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17551412, Length=268, Percent_Identity=28.3582089552239, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=28.030303030303, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=25.2918287937743, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17568967, Length=206, Percent_Identity=30.0970873786408, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17538182, Length=228, Percent_Identity=28.0701754385965, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17508895, Length=195, Percent_Identity=28.7179487179487, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI193210355, Length=219, Percent_Identity=26.027397260274, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17561272, Length=201, Percent_Identity=24.3781094527363, Blast_Score=65, Evalue=3e-11, Organism=Saccharomyces cerevisiae, GI6322227, Length=198, Percent_Identity=26.7676767676768, Blast_Score=74, Evalue=2e-14, Organism=Saccharomyces cerevisiae, GI6324126, Length=256, Percent_Identity=24.21875, Blast_Score=71, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=28.4974093264249, Blast_Score=71, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6322226, Length=216, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=3e-13, Organism=Saccharomyces cerevisiae, GI6323882, Length=220, Percent_Identity=26.8181818181818, Blast_Score=64, Evalue=3e-11, Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=32.8063241106719, Blast_Score=107, Evalue=5e-24, Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=33.6, Blast_Score=105, Evalue=3e-23, Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=32.1428571428571, Blast_Score=104, Evalue=6e-23, Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=32.156862745098, Blast_Score=100, Evalue=6e-22, Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=32.6771653543307, Blast_Score=98, Evalue=5e-21, Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=31.3253012048193, Blast_Score=94, Evalue=9e-20, Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=28.6852589641434, Blast_Score=93, Evalue=1e-19, Organism=Drosophila melanogaster, GI24644337, Length=259, Percent_Identity=32.046332046332, Blast_Score=89, Evalue=2e-18, Organism=Drosophila melanogaster, GI18859837, Length=188, Percent_Identity=30.3191489361702, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI17737361, Length=235, Percent_Identity=30.2127659574468, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI21356301, Length=210, Percent_Identity=27.6190476190476, Blast_Score=67, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR003560 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.3.1.28 [H]
Molecular weight: Translated: 26564; Mature: 26433
Theoretical pI: Translated: 4.84; Mature: 4.84
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MASFDFSDKTVWVTGAGKGIGYATALAFVDAGARVIGFDREFTQENYPFATEVMDVADAA CCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCHHHCCCCCCHHHHHHHHHHHH QVAQVCQRVLQKTPRLDVLVNAAGILRMGATDALNVDDWQQTFAVNVGGAFNLFSQTMAQ HHHHHHHHHHHHCCCEEEEECCCHHEEECCCCCCCCCCHHHEEEEECCCHHHHHHHHHHH FRRQQGGAIVTVASDAAHTPRIGMGAYGASKAALKSLALTVGLELAGCGVRCNVVSPGST HHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCEEEEEECCCCC DTDMQRTLWVSEDAEQQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQD CCCHHHEEEECCCHHHHHHHCCCCCEEECCCHHCCCCHHHHHHHHHHHHHHHHHHCEEEH IVVDGGSTLGA EEEECCCCCCC >Mature Secondary Structure ASFDFSDKTVWVTGAGKGIGYATALAFVDAGARVIGFDREFTQENYPFATEVMDVADAA CCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCHHHCCCCCCHHHHHHHHHHHH QVAQVCQRVLQKTPRLDVLVNAAGILRMGATDALNVDDWQQTFAVNVGGAFNLFSQTMAQ HHHHHHHHHHHHCCCEEEEECCCHHEEECCCCCCCCCCHHHEEEEECCCHHHHHHHHHHH FRRQQGGAIVTVASDAAHTPRIGMGAYGASKAALKSLALTVGLELAGCGVRCNVVSPGST HHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCEEEEEECCCCC DTDMQRTLWVSEDAEQQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQD CCCHHHEEEECCCHHHHHHHCCCCCEEECCCHHCCCCHHHHHHHHHHHHHHHHHHCEEEH IVVDGGSTLGA EEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 2521622; 2521621; 9278503 [H]