Click here to switch to the map view.

The map label for this gene is cobC [H]

Identifier: 29142625

GI number: 29142625

Start: 2290642

End: 2291250

Strand: Direct

Name: cobC [H]

Synonym: t2224

Alternate gene names: 29142625

Gene position: 2290642-2291250 (Clockwise)

Preceding gene: 29142623

Following gene: 29142626

Centisome position: 47.8

GC content: 58.29

Gene sequence:

>609_bases
ATGCGATTGTGGCTGGTGCGTCATGGCGAAACCGAGGCCAATGTCGCCGGGTTGTATAGCGGACATGCTCCCACGCCGTT
AACGGAAAAAGGGATTGGCCAGGCGAAAACGCTACATACTTTATTGCGCCACGCGCCATTTGACAGGGTGTTATGCAGCG
AGCTGGAGCGCGCGCGCCATACCGCCCGGCTCGTACTGGAGGGCCGGGATACGCCGCAACACATCTTACCTGAGCTTAAT
GAGATGTACTTCGGCGACTGGGAAATGCGCCATCACCGCGACCTCACCCATGAAGATGCCGAAAGCTATGCCGCCTGGTG
TACGGACTGGCAGAATGCGGTTCCGACCAATGGCGAGGGTTTTCAGGCTTTTACCCGGCGCGTAGAGCGCTTTATCTCGC
GACTCGGCGCGTTCAGCGATTGCCAGAACCTGCTGATCGTCAGCCATCAGGGCGTACTCAGCCTGTTGATTGCCCGCCTG
CTCGCAATGCCCGCCGCCTCGCTATGGCATTTCCGGGTAGAACAGGGATGCTGGAGCACAATCGACATATGCGAAGGGTT
CGCCACCCTGAAAGTATTAAATAGTCGTGCCGTCTGGCGGCCTGAGTGA

Upstream 100 bases:

>100_bases
CCATTATGCCTCCGGCCAAAAAACGCTATTTTAGTGAAAAAAACGTTGCGCAATCAGGGGCATTATCATGTTTTGCGCAT
TTAACCTCATGAGGAATACC

Downstream 100 bases:

>100_bases
TGAATTTTCCGTTTTTTCTCGCCGCAGCGGTTTCGCCCATTGACAGCCCCCGACAGGCTGTTATTCTCCGCAGCCAGGCT
TTTTTCACCTTGCAGAGCTT

Product: alpha-ribazole-5'-phosphate phosphatase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MRLWLVRHGETEANVAGLYSGHAPTPLTEKGIGQAKTLHTLLRHAPFDRVLCSELERARHTARLVLEGRDTPQHILPELN
EMYFGDWEMRHHRDLTHEDAESYAAWCTDWQNAVPTNGEGFQAFTRRVERFISRLGAFSDCQNLLIVSHQGVLSLLIARL
LAMPAASLWHFRVEQGCWSTIDICEGFATLKVLNSRAVWRPE

Sequences:

>Translated_202_residues
MRLWLVRHGETEANVAGLYSGHAPTPLTEKGIGQAKTLHTLLRHAPFDRVLCSELERARHTARLVLEGRDTPQHILPELN
EMYFGDWEMRHHRDLTHEDAESYAAWCTDWQNAVPTNGEGFQAFTRRVERFISRLGAFSDCQNLLIVSHQGVLSLLIARL
LAMPAASLWHFRVEQGCWSTIDICEGFATLKVLNSRAVWRPE
>Mature_202_residues
MRLWLVRHGETEANVAGLYSGHAPTPLTEKGIGQAKTLHTLLRHAPFDRVLCSELERARHTARLVLEGRDTPQHILPELN
EMYFGDWEMRHHRDLTHEDAESYAAWCTDWQNAVPTNGEGFQAFTRRVERFISRLGAFSDCQNLLIVSHQGVLSLLIARL
LAMPAASLWHFRVEQGCWSTIDICEGFATLKVLNSRAVWRPE

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=198, Percent_Identity=73.7373737373737, Blast_Score=319, Evalue=7e-89,
Organism=Escherichia coli, GI1790856, Length=193, Percent_Identity=27.4611398963731, Blast_Score=70, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324857, Length=173, Percent_Identity=30.635838150289, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 23068; Mature: 23068

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLWLVRHGETEANVAGLYSGHAPTPLTEKGIGQAKTLHTLLRHAPFDRVLCSELERARH
CEEEEEECCCCCCCHHHEECCCCCCCCCHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
TARLVLEGRDTPQHILPELNEMYFGDWEMRHHRDLTHEDAESYAAWCTDWQNAVPTNGEG
HHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCH
FQAFTRRVERFISRLGAFSDCQNLLIVSHQGVLSLLIARLLAMPAASLWHFRVEQGCWST
HHHHHHHHHHHHHHHCCHHHHCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHH
IDICEGFATLKVLNSRAVWRPE
HHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRLWLVRHGETEANVAGLYSGHAPTPLTEKGIGQAKTLHTLLRHAPFDRVLCSELERARH
CEEEEEECCCCCCCHHHEECCCCCCCCCHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
TARLVLEGRDTPQHILPELNEMYFGDWEMRHHRDLTHEDAESYAAWCTDWQNAVPTNGEG
HHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCH
FQAFTRRVERFISRLGAFSDCQNLLIVSHQGVLSLLIARLLAMPAASLWHFRVEQGCWST
HHHHHHHHHHHHHHHCCHHHHCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHH
IDICEGFATLKVLNSRAVWRPE
HHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]