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The map label for this gene is nagC [H]

Identifier: 29142601

GI number: 29142601

Start: 2262179

End: 2263399

Strand: Direct

Name: nagC [H]

Synonym: t2193

Alternate gene names: 29142601

Gene position: 2262179-2263399 (Clockwise)

Preceding gene: 29142600

Following gene: 29142602

Centisome position: 47.21

GC content: 53.56

Gene sequence:

>1221_bases
ATGACACCAGGCGGACAAGCTCAGATAGGTAACGTTGATCTCGTAAAACAGCTTAACAGCGCGGCCGTTTACCGCCTGAT
TGACCAGCATGGTCCTATCTCGCGCATACAAATTGCCGAGCAAAGCCAGCTTGCTCCCGCCAGCGTAACGAAAATTACGC
GTCAACTCATTGAACGCGGGCTGATCAAAGAAGTCGATCAGCAGGCCTCTACCGGAGGCCGCCGCGCTATCTCTATCGTC
ACGGAAACCCGTAACTTCCACGCCATTGGCGTTCGCCTGGGGCGTCATGACACCACTTTAACGCTCTACGATCTGAGCAG
TAAAGTGGTCGCTGAGGAGCATTATCCGCTGCCGGAGCGCACCCAGGAGACGCTGGAACATGCGCTGCTCAACACTATCG
CCGTCTTTATTGATAGTTGTCAGCGTAAAATTCGTGAATTGATCGCTATCTCGGTGATCCTGCCAGGGCTTGTCGATCCG
GAAAGCGGCGTGATTCGTTACATGCCGCACATTCAGGTTGAAAACTGGGGACTGGTCGAAGCGCTGGAAAAACGGTTTCA
CGTTACCTGTTTCGTGGGTCACGATATTCGTAGCCTGGCACTGGCGGAACACTACTTCGGCGCCAGTCAGGATTGCGAGG
ACTCGATTCTGGTGCGCGTCCATCGTGGTACAGGTGCCGGGATTATCTCCAACGGACGCATCTTCATTGGCCGTAACGGC
AACGTCGGCGAAATTGGGCATATTCAGGTGGAGCCGTTGGGCGAGCGCTGCCACTGCGGTAATTTCGGCTGTCTGGAAAC
CATTGCCGCCAATGCGGCGATTGAACAACGGGTGCTGAATTTGCTTAAACAAGGGTATCAAAGCCGTGTTCCGCTTGACG
ACTGCACGATTAAAACCATCTGTAAGGCGGCAAACCGGGGCGACAGCCTGGCCTCGGAAGTCATTGAGCATGTTGGCCGC
CATTTGGGCAAAACGATCGCCATTGCTATCAACCTGTTTAATCCGCAAAAAATCGTCATTGCCGGCGAGATCATTGAAGC
CGATAAAGTCCTGTTGCCCGCTATCGAAAGCTGTATCAATACGCAGGCGTTAAAGGCCTTTCGCAAAAATTTGCCGGTGG
TACGCTCCACGCTGGATCACCGTTCTGCTATCGGCGCATTTGCCTTAGTTAAACGCGCCATGCTCAACGGAACATTGCTG
CAACGTTTGCTGGAAAGCTGA

Upstream 100 bases:

>100_bases
CCGAGTAAAGTCGCCAACCTGACCGCGTTCACCCACGATTTTAAAATTATCAAGACCATCGTTAATGGTGACGAGGTCGT
TGACTTGAGTAAGTGAGAAT

Downstream 100 bases:

>100_bases
TGCGCTCTTATAGTATCGGATTATTCACAAATTCCCTGGGTAGTTCATGACCATCAAGAATGTAATCTGCGATATCGACG
GCGTGCTGATGCACGACAAC

Product: N-acetylglucosamine repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MTPGGQAQIGNVDLVKQLNSAAVYRLIDQHGPISRIQIAEQSQLAPASVTKITRQLIERGLIKEVDQQASTGGRRAISIV
TETRNFHAIGVRLGRHDTTLTLYDLSSKVVAEEHYPLPERTQETLEHALLNTIAVFIDSCQRKIRELIAISVILPGLVDP
ESGVIRYMPHIQVENWGLVEALEKRFHVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG
NVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANRGDSLASEVIEHVGR
HLGKTIAIAINLFNPQKIVIAGEIIEADKVLLPAIESCINTQALKAFRKNLPVVRSTLDHRSAIGAFALVKRAMLNGTLL
QRLLES

Sequences:

>Translated_406_residues
MTPGGQAQIGNVDLVKQLNSAAVYRLIDQHGPISRIQIAEQSQLAPASVTKITRQLIERGLIKEVDQQASTGGRRAISIV
TETRNFHAIGVRLGRHDTTLTLYDLSSKVVAEEHYPLPERTQETLEHALLNTIAVFIDSCQRKIRELIAISVILPGLVDP
ESGVIRYMPHIQVENWGLVEALEKRFHVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG
NVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANRGDSLASEVIEHVGR
HLGKTIAIAINLFNPQKIVIAGEIIEADKVLLPAIESCINTQALKAFRKNLPVVRSTLDHRSAIGAFALVKRAMLNGTLL
QRLLES
>Mature_405_residues
TPGGQAQIGNVDLVKQLNSAAVYRLIDQHGPISRIQIAEQSQLAPASVTKITRQLIERGLIKEVDQQASTGGRRAISIVT
ETRNFHAIGVRLGRHDTTLTLYDLSSKVVAEEHYPLPERTQETLEHALLNTIAVFIDSCQRKIRELIAISVILPGLVDPE
SGVIRYMPHIQVENWGLVEALEKRFHVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGN
VGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANRGDSLASEVIEHVGRH
LGKTIAIAINLFNPQKIVIAGEIIEADKVLLPAIESCINTQALKAFRKNLPVVRSTLDHRSAIGAFALVKRAMLNGTLLQ
RLLES

Specific function: Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Escherichia coli, GI1786891, Length=406, Percent_Identity=94.3349753694581, Blast_Score=781, Evalue=0.0,
Organism=Escherichia coli, GI1787878, Length=400, Percent_Identity=41, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI87082127, Length=347, Percent_Identity=23.6311239193084, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081733, Length=272, Percent_Identity=23.1617647058824, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790522, Length=293, Percent_Identity=24.5733788395904, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000835
- InterPro:   IPR000600
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR; PF00480 ROK [H]

EC number: NA

Molecular weight: Translated: 44495; Mature: 44364

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPGGQAQIGNVDLVKQLNSAAVYRLIDQHGPISRIQIAEQSQLAPASVTKITRQLIERG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHEEECHHCCCCHHHHHHHHHHHHHHH
LIKEVDQQASTGGRRAISIVTETRNFHAIGVRLGRHDTTLTLYDLSSKVVAEEHYPLPER
HHHHHHHHHCCCCCEEEEEEEECCCEEEEEEEECCCCCEEEEEECCCHHHHHCCCCCCHH
TQETLEHALLNTIAVFIDSCQRKIRELIAISVILPGLVDPESGVIRYMPHIQVENWGLVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEECCCCHHH
ALEKRFHVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG
HHHHCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEECCEEEEECCC
NVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTI
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
CKAANRGDSLASEVIEHVGRHLGKTIAIAINLFNPQKIVIAGEIIEADKVLLPAIESCIN
HHHCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHC
TQALKAFRKNLPVVRSTLDHRSAIGAFALVKRAMLNGTLLQRLLES
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPGGQAQIGNVDLVKQLNSAAVYRLIDQHGPISRIQIAEQSQLAPASVTKITRQLIERG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHEEECHHCCCCHHHHHHHHHHHHHHH
LIKEVDQQASTGGRRAISIVTETRNFHAIGVRLGRHDTTLTLYDLSSKVVAEEHYPLPER
HHHHHHHHHCCCCCEEEEEEEECCCEEEEEEEECCCCCEEEEEECCCHHHHHCCCCCCHH
TQETLEHALLNTIAVFIDSCQRKIRELIAISVILPGLVDPESGVIRYMPHIQVENWGLVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEECCCCHHH
ALEKRFHVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG
HHHHCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEECCEEEEECCC
NVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTI
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
CKAANRGDSLASEVIEHVGRHLGKTIAIAINLFNPQKIVIAGEIIEADKVLLPAIESCIN
HHHCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHC
TQALKAFRKNLPVVRSTLDHRSAIGAFALVKRAMLNGTLLQRLLES
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]