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The map label for this gene is fimB [H]

Identifier: 29142569

GI number: 29142569

Start: 2223360

End: 2223926

Strand: Reverse

Name: fimB [H]

Synonym: t2160

Alternate gene names: 29142569

Gene position: 2223926-2223360 (Counterclockwise)

Preceding gene: 29142570

Following gene: 29142568

Centisome position: 46.41

GC content: 50.62

Gene sequence:

>567_bases
GTGAAAAGAAAATATCTTACGCAAGAAGAGATTGAAAAACTGCTGTCAGCGACCGACAGAATGCCCTTCCCGGAAAGAAA
CCGCTGCTTAATCCTGATGGCGTTTATTCACGGCTTCCGGGCCAGTGAGCTGCTGGGGCTGCGCTTGTCGGATATTGATC
TTGCAGGAAGACAGCTTTATATCCGGCGCCTCAAAAATGGCTTTTCAACGTGTCACCCCCTCCTTCCCGATGAGTATAAC
GTACTGAAAAGCTGGCTCAGGGCCAGGAAGTATCTTGAGAAAGGGGCTGACGGAGACTGGCTGTTCCTGTCGCTACGACG
GCATCCGCTCAGCAGGCAACAATTTTTTTACATACTTCGTGAGGCAGGGCGGTTGGCCGAATTAACGATAGCGCCACATC
CTCATATGCTGCGACATGCCTGCGGCTACGCCCTTGCTGATAAAGGGATTGATACACGACTCATACAGGACTATCTGGGG
CACAGGAATATCCAGCACACCGTAAGATACACCGCAAGTAACGCCGGGCGTTTTCATGGAATATGGCGAAAAAAACGTCG
AGTATAA

Upstream 100 bases:

>100_bases
TTAAGCTGTTTACGCATAGCAACTTTTTTAGCGAAAATTAAACTCATCTGATCAGTGATTTTTTAGTATATTACTCATTT
TGTTATGATGGATTTGTTTT

Downstream 100 bases:

>100_bases
CCGTACGTTCTGATTCATATTGTTAAATCACAGAGAAGTCTGTTCAGGGAAAGCTGATTTACATAATCAACATATAAATC
AATAGATTACTGTATTTTCT

Product: DNA recombinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MKRKYLTQEEIEKLLSATDRMPFPERNRCLILMAFIHGFRASELLGLRLSDIDLAGRQLYIRRLKNGFSTCHPLLPDEYN
VLKSWLRARKYLEKGADGDWLFLSLRRHPLSRQQFFYILREAGRLAELTIAPHPHMLRHACGYALADKGIDTRLIQDYLG
HRNIQHTVRYTASNAGRFHGIWRKKRRV

Sequences:

>Translated_188_residues
MKRKYLTQEEIEKLLSATDRMPFPERNRCLILMAFIHGFRASELLGLRLSDIDLAGRQLYIRRLKNGFSTCHPLLPDEYN
VLKSWLRARKYLEKGADGDWLFLSLRRHPLSRQQFFYILREAGRLAELTIAPHPHMLRHACGYALADKGIDTRLIQDYLG
HRNIQHTVRYTASNAGRFHGIWRKKRRV
>Mature_188_residues
MKRKYLTQEEIEKLLSATDRMPFPERNRCLILMAFIHGFRASELLGLRLSDIDLAGRQLYIRRLKNGFSTCHPLLPDEYN
VLKSWLRARKYLEKGADGDWLFLSLRRHPLSRQQFFYILREAGRLAELTIAPHPHMLRHACGYALADKGIDTRLIQDYLG
HRNIQHTVRYTASNAGRFHGIWRKKRRV

Specific function: FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches f

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790767, Length=185, Percent_Identity=60, Blast_Score=228, Evalue=2e-61,
Organism=Escherichia coli, GI1790768, Length=185, Percent_Identity=54.5945945945946, Blast_Score=194, Evalue=4e-51,
Organism=Escherichia coli, GI1789261, Length=173, Percent_Identity=33.5260115606936, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1790244, Length=171, Percent_Identity=28.0701754385965, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 22170; Mature: 22170

Theoretical pI: Translated: 10.79; Mature: 10.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKYLTQEEIEKLLSATDRMPFPERNRCLILMAFIHGFRASELLGLRLSDIDLAGRQLY
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCHHHHHCCEECCCHHHHHHHH
IRRLKNGFSTCHPLLPDEYNVLKSWLRARKYLEKGADGDWLFLSLRRHPLSRQQFFYILR
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHH
EAGRLAELTIAPHPHMLRHACGYALADKGIDTRLIQDYLGHRNIQHTVRYTASNAGRFHG
HCCCEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHECCCCCCHHHH
IWRKKRRV
HHHHHCCC
>Mature Secondary Structure
MKRKYLTQEEIEKLLSATDRMPFPERNRCLILMAFIHGFRASELLGLRLSDIDLAGRQLY
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCHHHHHCCEECCCHHHHHHHH
IRRLKNGFSTCHPLLPDEYNVLKSWLRARKYLEKGADGDWLFLSLRRHPLSRQQFFYILR
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHH
EAGRLAELTIAPHPHMLRHACGYALADKGIDTRLIQDYLGHRNIQHTVRYTASNAGRFHG
HCCCEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHECCCCCCHHHH
IWRKKRRV
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]