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The map label for this gene is ybgR

Identifier: 29142535

GI number: 29142535

Start: 2184098

End: 2185036

Strand: Direct

Name: ybgR

Synonym: t2120

Alternate gene names: 29142535

Gene position: 2184098-2185036 (Clockwise)

Preceding gene: 29142534

Following gene: 29142558

Centisome position: 45.58

GC content: 54.85

Gene sequence:

>939_bases
ATGGCGCACTCACACTCTCATGCCGATTCACACCTGCCGAAAGATAATAATGCTCGTCGCCTGCTTTTCGCCTTTATCGT
CACTGCCGGATTTATGCTCCTTGAGGTGGTGGGCGGGATACTCTCCGGCTCTCTGGCGTTGTTGGCGGATGCGGGACATA
TGCTCACCGACGCGGCGGCTCTTCTCTTTGCGCTGCTGGTGGTTCAATTTTCCCGTCGCCCCCCGACTGTTCGCCACACT
TTTGGCTGGCTAAGACTCACCACACTGGCGGCCTTTGTGAATGCCATTGCGTTGGTGGTCATTACCCTTCTCATTGTCTG
GGAAGCGATAGAGCGCTTTTACACGCCACGTCCGGTGGCGGGCAATCTGATGATGGTGATTGCGGTCGCGGGTCTGCTGG
CGAACCTGTTTGCGTTCTGGATACTCCATCGGGGAAGCGATGAAAAAAACCTGAACGTGCGCGCTGCCGCGCTACATGTG
ATGGGCGATTTGCTGGGTTCCGTCGGCGCAATAGTCGCCGCGTTGATCATTATCTGGACGGGCTGGACGCCAGCGGACCC
GATTCTCTCTATTCTGGTTTCGGTACTGGTACTACGCAGCGCCTGGCGTTTGTTAAAAGATAGCGTCAACGAATTGCTGG
AAGGCGCGCCGGTTTCACTGGATATTAATGCCTTACAGCGCCATTTAAGCCGGGAAATCCCCGAAGTCCGCAACGTACAC
CATGTGCATGTCTGGATGGTCGGCGAAAAACCAGTCATGACATTGCACGCTCAGGTCATTCCGCCACACGACCATGATGC
GCTGCTGGAACGTATCCAGGATTTCCTGATGCACGAATACCATATTGCGCACGCTACGATTCAAATGGAGTATCAAATGT
GTCACGGCCCGGACTGTCACCTGAATCAGACGCCATCCGGGCATGTTCATCACCATTAA

Upstream 100 bases:

>100_bases
AGTCTGATAACGGGAGAGCTTTCGCTCTCCTTTTTATTTTGTCAGCGAAAAATCAGTATGATATCTACAGTATTGATGAG
AATAACAAAGGAATGACGTT

Downstream 100 bases:

>100_bases
CGGGAAAGCGCGCGCGATCCTCGCTCCCGCGCGCTGTTTATCCACAGGCGACTACCGTTCACGGCGATAAATGTCAGGAT
CAGATATTCCAGCGACATCG

Product: zinc transporter ZitB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MAHSHSHADSHLPKDNNARRLLFAFIVTAGFMLLEVVGGILSGSLALLADAGHMLTDAAALLFALLVVQFSRRPPTVRHT
FGWLRLTTLAAFVNAIALVVITLLIVWEAIERFYTPRPVAGNLMMVIAVAGLLANLFAFWILHRGSDEKNLNVRAAALHV
MGDLLGSVGAIVAALIIIWTGWTPADPILSILVSVLVLRSAWRLLKDSVNELLEGAPVSLDINALQRHLSREIPEVRNVH
HVHVWMVGEKPVMTLHAQVIPPHDHDALLERIQDFLMHEYHIAHATIQMEYQMCHGPDCHLNQTPSGHVHHH

Sequences:

>Translated_312_residues
MAHSHSHADSHLPKDNNARRLLFAFIVTAGFMLLEVVGGILSGSLALLADAGHMLTDAAALLFALLVVQFSRRPPTVRHT
FGWLRLTTLAAFVNAIALVVITLLIVWEAIERFYTPRPVAGNLMMVIAVAGLLANLFAFWILHRGSDEKNLNVRAAALHV
MGDLLGSVGAIVAALIIIWTGWTPADPILSILVSVLVLRSAWRLLKDSVNELLEGAPVSLDINALQRHLSREIPEVRNVH
HVHVWMVGEKPVMTLHAQVIPPHDHDALLERIQDFLMHEYHIAHATIQMEYQMCHGPDCHLNQTPSGHVHHH
>Mature_311_residues
AHSHSHADSHLPKDNNARRLLFAFIVTAGFMLLEVVGGILSGSLALLADAGHMLTDAAALLFALLVVQFSRRPPTVRHTF
GWLRLTTLAAFVNAIALVVITLLIVWEAIERFYTPRPVAGNLMMVIAVAGLLANLFAFWILHRGSDEKNLNVRAAALHVM
GDLLGSVGAIVAALIIIWTGWTPADPILSILVSVLVLRSAWRLLKDSVNELLEGAPVSLDINALQRHLSREIPEVRNVHH
VHVWMVGEKPVMTLHAQVIPPHDHDALLERIQDFLMHEYHIAHATIQMEYQMCHGPDCHLNQTPSGHVHHH

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily

Homologues:

Organism=Homo sapiens, GI52352805, Length=320, Percent_Identity=33.125, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI289803013, Length=323, Percent_Identity=31.5789473684211, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI289803009, Length=323, Percent_Identity=31.5789473684211, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI289803007, Length=323, Percent_Identity=31.5789473684211, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI289803003, Length=323, Percent_Identity=31.5789473684211, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI64762489, Length=323, Percent_Identity=31.5789473684211, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI21359890, Length=317, Percent_Identity=30.2839116719243, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI21361112, Length=320, Percent_Identity=30.625, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI20070323, Length=345, Percent_Identity=24.3478260869565, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI14210520, Length=231, Percent_Identity=29.4372294372294, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI52352803, Length=129, Percent_Identity=42.6356589147287, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI52351208, Length=162, Percent_Identity=30.2469135802469, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI222080086, Length=129, Percent_Identity=27.906976744186, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI40255009, Length=129, Percent_Identity=27.906976744186, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786966, Length=296, Percent_Identity=85.8108108108108, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1790349, Length=191, Percent_Identity=27.7486910994764, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193210990, Length=328, Percent_Identity=32.9268292682927, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17555794, Length=309, Percent_Identity=33.6569579288026, Blast_Score=153, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17555796, Length=307, Percent_Identity=32.5732899022801, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI32564488, Length=305, Percent_Identity=29.8360655737705, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17550440, Length=126, Percent_Identity=34.9206349206349, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17550442, Length=126, Percent_Identity=34.9206349206349, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320411, Length=181, Percent_Identity=35.9116022099448, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323899, Length=132, Percent_Identity=36.3636363636364, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=121, Percent_Identity=37.1900826446281, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24656728, Length=346, Percent_Identity=30.0578034682081, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24656724, Length=346, Percent_Identity=30.0578034682081, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24656720, Length=346, Percent_Identity=30.0578034682081, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24656715, Length=346, Percent_Identity=30.0578034682081, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21357035, Length=346, Percent_Identity=30.0578034682081, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24583858, Length=333, Percent_Identity=28.5285285285285, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24584409, Length=136, Percent_Identity=36.0294117647059, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585900, Length=147, Percent_Identity=32.6530612244898, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585898, Length=147, Percent_Identity=32.6530612244898, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585896, Length=147, Percent_Identity=32.6530612244898, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921672, Length=147, Percent_Identity=32.6530612244898, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574430, Length=136, Percent_Identity=36.0294117647059, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24645863, Length=127, Percent_Identity=31.496062992126, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ZITB_SALTI (Q8Z8B6)

Other databases:

- EMBL:   AL627268
- EMBL:   AE014613
- RefSeq:   NP_455309.1
- RefSeq:   NP_805877.1
- ProteinModelPortal:   Q8Z8B6
- GeneID:   1069246
- GeneID:   1247247
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t2120
- KEGG:   sty:STY0799
- HOGENOM:   HBG317426
- OMA:   KEKFHVE
- ProtClustDB:   PRK03557
- BioCyc:   SENT209261:T2120-MONOMER
- BioCyc:   SENT220341:STY0799-MONOMER
- HAMAP:   MF_00552
- InterPro:   IPR002524
- PANTHER:   PTHR11562
- TIGRFAMs:   TIGR01297

Pfam domain/function: PF01545 Cation_efflux

EC number: NA

Molecular weight: Translated: 34532; Mature: 34401

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00511 CRF

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xdf11ea0)-; HASH(0xfae2b64)-; HASH(0xfc684f8)-; HASH(0xfcb7de0)-; HASH(0xfc156cc)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHSHSHADSHLPKDNNARRLLFAFIVTAGFMLLEVVGGILSGSLALLADAGHMLTDAAA
CCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHH
LLFALLVVQFSRRPPTVRHTFGWLRLTTLAAFVNAIALVVITLLIVWEAIERFYTPRPVA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GNLMMVIAVAGLLANLFAFWILHRGSDEKNLNVRAAALHVMGDLLGSVGAIVAALIIIWT
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GWTPADPILSILVSVLVLRSAWRLLKDSVNELLEGAPVSLDINALQRHLSREIPEVRNVH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCHHHHCCE
HVHVWMVGEKPVMTLHAQVIPPHDHDALLERIQDFLMHEYHIAHATIQMEYQMCHGPDCH
EEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEHCCCCCCCC
LNQTPSGHVHHH
CCCCCCCCCCCH
>Mature Secondary Structure 
AHSHSHADSHLPKDNNARRLLFAFIVTAGFMLLEVVGGILSGSLALLADAGHMLTDAAA
CCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHH
LLFALLVVQFSRRPPTVRHTFGWLRLTTLAAFVNAIALVVITLLIVWEAIERFYTPRPVA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GNLMMVIAVAGLLANLFAFWILHRGSDEKNLNVRAAALHVMGDLLGSVGAIVAALIIIWT
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GWTPADPILSILVSVLVLRSAWRLLKDSVNELLEGAPVSLDINALQRHLSREIPEVRNVH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCHHHHCCE
HVHVWMVGEKPVMTLHAQVIPPHDHDALLERIQDFLMHEYHIAHATIQMEYQMCHGPDCH
EEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEHCCCCCCCC
LNQTPSGHVHHH
CCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504