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The map label for this gene is bioA [H]

Identifier: 29142509

GI number: 29142509

Start: 2156398

End: 2157687

Strand: Direct

Name: bioA [H]

Synonym: t2094

Alternate gene names: 29142509

Gene position: 2156398-2157687 (Clockwise)

Preceding gene: 29142502

Following gene: 29142510

Centisome position: 45.0

GC content: 58.14

Gene sequence:

>1290_bases
ATGACAACGGACGATCTGGCCTTCGATAAACGCCATATTTGGCATCCTTACACTTCCATGACCTCGCCGCTGCCGGTATA
TCCCGTTGAGCGGGCCGAAGGCTGCGAGCTGGTTCTCGCCTCGGGCGAACGCCTGATTGAGGGGATGTCCTCCTGGTGGG
CGGCCATTCATGGTTATAACCACCCGCAATTGAACGCGGCGATGAAAGCGCAAATTGACGCCATGTCGCATGTCATGTTC
GGCGGCATAACCCATCAACCTGCGGTGAATCTGTGCCGTAAGCTGGTCGCGATAACGCCTGAGCCGCTGGAGTGTGTCTT
TCTGGCCGACTCTGGTTCGGTGTCGGTAGAAGTGGCCATGAAGATGGCGCTGCAATACTGGCAGGCTCGTGGCGAATCGC
GTCAGCGTTTTCTGACGTTTCGCCACGGTTATCATGGCGACACGTTCGGCGCGATGTCGGTGTGCGATCCGGATAACTCC
ATGCACAGCTTGTGGAAAGGCTATCTGCCTGAAAATCTGTTCGCGCCGGCGCCGCAAAGCCGGATGGATGGCGAATGGGA
TGAAAGCGACATCGCGCCATTTGCCCGCCTGATGGCCGCGCATCGCCATGAAATAGCCGCCGTGATTCTGGAACCTATCG
TTCAGGGCGCGGGCGGGATGCGCATATATCATCCACAATGGCTCAGGCGTATTCGTAACATGTGCGATCGCGAAGGCATT
CTGCTGATTGCCGATGAAATAGCCACCGGGTTTGGCCGTACCGGCAAACTGTTCGCCTGTGAGCACGCCGGGATCGCGCC
GGATATTCTGTGTCTCGGCAAAGCCTTAACCGGCGGTACCATGACCCTCTCGGCAACGCTCACGACACGCCAGGTTGCAG
AGACTATTAGCAACGGCGAGGCGGGGTGTTTTATGCATGGCCCGACGTTTATGGGGAATCCGCTGGCCTGCGCCGTCGCT
TGCGCCAGCCTGACGCTGCTGGAAAGCGGCGAATGGCGTCAGCAGGTGGCGTCTATCGAGTCTCAGTTACGCGCTGAGTT
AGCCCCCGCGCAAAGTTCGCCCTGGGTGGCGGATGTGCGGGTGTTGGGCGCGATTGGGGTGGTTGAAACTACGCATCCGG
TCAATATGGCGGCGCTTCAACGCTTCTTCGTCGGGCAAGGCGTCTGGATCAGGCCGTTCGGCAAGCTAATCTACCTGATG
CCGCCCTACATTATTCGTCCGGATCAACTGCGCCGTTTGACCCAGGCGGTCAATGACGCGGTACACAATGAAACATTTTT
TAGCCATTAA

Upstream 100 bases:

>100_bases
GGGTGGCGAGCCATCGGGCCTCTCCAAAATATGTTGTTTGTTTTTGATATGGTGTAGACTCGTAAACCTAAATCTTTTTA
ATTTGGTTTACAAGTCGATT

Downstream 100 bases:

>100_bases
TCAGCGGTAAGCGATGCTGCTTCTGGCTACACTTCTGGTGAGTCAAAAGGAGAGCGCATGAAACTTATCAGCAACGATTT
GCGCGATGGAGATAAACTTC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTTDDLAFDKRHIWHPYTSMTSPLPVYPVERAEGCELVLASGERLIEGMSSWWAAIHGYNHPQLNAAMKAQIDAMSHVMF
GGITHQPAVNLCRKLVAITPEPLECVFLADSGSVSVEVAMKMALQYWQARGESRQRFLTFRHGYHGDTFGAMSVCDPDNS
MHSLWKGYLPENLFAPAPQSRMDGEWDESDIAPFARLMAAHRHEIAAVILEPIVQGAGGMRIYHPQWLRRIRNMCDREGI
LLIADEIATGFGRTGKLFACEHAGIAPDILCLGKALTGGTMTLSATLTTRQVAETISNGEAGCFMHGPTFMGNPLACAVA
CASLTLLESGEWRQQVASIESQLRAELAPAQSSPWVADVRVLGAIGVVETTHPVNMAALQRFFVGQGVWIRPFGKLIYLM
PPYIIRPDQLRRLTQAVNDAVHNETFFSH

Sequences:

>Translated_429_residues
MTTDDLAFDKRHIWHPYTSMTSPLPVYPVERAEGCELVLASGERLIEGMSSWWAAIHGYNHPQLNAAMKAQIDAMSHVMF
GGITHQPAVNLCRKLVAITPEPLECVFLADSGSVSVEVAMKMALQYWQARGESRQRFLTFRHGYHGDTFGAMSVCDPDNS
MHSLWKGYLPENLFAPAPQSRMDGEWDESDIAPFARLMAAHRHEIAAVILEPIVQGAGGMRIYHPQWLRRIRNMCDREGI
LLIADEIATGFGRTGKLFACEHAGIAPDILCLGKALTGGTMTLSATLTTRQVAETISNGEAGCFMHGPTFMGNPLACAVA
CASLTLLESGEWRQQVASIESQLRAELAPAQSSPWVADVRVLGAIGVVETTHPVNMAALQRFFVGQGVWIRPFGKLIYLM
PPYIIRPDQLRRLTQAVNDAVHNETFFSH
>Mature_428_residues
TTDDLAFDKRHIWHPYTSMTSPLPVYPVERAEGCELVLASGERLIEGMSSWWAAIHGYNHPQLNAAMKAQIDAMSHVMFG
GITHQPAVNLCRKLVAITPEPLECVFLADSGSVSVEVAMKMALQYWQARGESRQRFLTFRHGYHGDTFGAMSVCDPDNSM
HSLWKGYLPENLFAPAPQSRMDGEWDESDIAPFARLMAAHRHEIAAVILEPIVQGAGGMRIYHPQWLRRIRNMCDREGIL
LIADEIATGFGRTGKLFACEHAGIAPDILCLGKALTGGTMTLSATLTTRQVAETISNGEAGCFMHGPTFMGNPLACAVAC
ASLTLLESGEWRQQVASIESQLRAELAPAQSSPWVADVRVLGAIGVVETTHPVNMAALQRFFVGQGVWIRPFGKLIYLMP
PYIIRPDQLRRLTQAVNDAVHNETFFSH

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=437, Percent_Identity=29.9771167048055, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI284507298, Length=239, Percent_Identity=35.1464435146443, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI13994255, Length=382, Percent_Identity=28.0104712041885, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI37574042, Length=377, Percent_Identity=26.790450928382, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI226442705, Length=377, Percent_Identity=26.525198938992, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI226442709, Length=323, Percent_Identity=27.5541795665635, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI24119277, Length=376, Percent_Identity=25, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=87.1194379391101, Blast_Score=775, Evalue=0.0,
Organism=Escherichia coli, GI1789016, Length=350, Percent_Identity=30.5714285714286, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI145693181, Length=300, Percent_Identity=34.6666666666667, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=29.2978208232446, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788044, Length=317, Percent_Identity=33.1230283911672, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787560, Length=410, Percent_Identity=27.8048780487805, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786349, Length=387, Percent_Identity=26.0981912144703, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=414, Percent_Identity=25.8454106280193, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=215, Percent_Identity=32.093023255814, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=420, Percent_Identity=25, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=327, Percent_Identity=23.5474006116208, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324386, Length=459, Percent_Identity=47.9302832244009, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=27.2289156626506, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=322, Percent_Identity=27.0186335403727, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI21357415, Length=405, Percent_Identity=28.3950617283951, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28574759, Length=363, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI161085790, Length=363, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21356575, Length=379, Percent_Identity=25.065963060686, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281366494, Length=286, Percent_Identity=24.4755244755245, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667139, Length=286, Percent_Identity=24.4755244755245, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667143, Length=286, Percent_Identity=24.4755244755245, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47327; Mature: 47196

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDDLAFDKRHIWHPYTSMTSPLPVYPVERAEGCELVLASGERLIEGMSSWWAAIHGYN
CCCCCCCCCCHHCCCCHHHCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCC
HPQLNAAMKAQIDAMSHVMFGGITHQPAVNLCRKLVAITPEPLECVFLADSGSVSVEVAM
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHH
KMALQYWQARGESRQRFLTFRHGYHGDTFGAMSVCDPDNSMHSLWKGYLPENLFAPAPQS
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCCCCCCCC
RMDGEWDESDIAPFARLMAAHRHEIAAVILEPIVQGAGGMRIYHPQWLRRIRNMCDREGI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCE
LLIADEIATGFGRTGKLFACEHAGIAPDILCLGKALTGGTMTLSATLTTRQVAETISNGE
EEEEHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCC
AGCFMHGPTFMGNPLACAVACASLTLLESGEWRQQVASIESQLRAELAPAQSSPWVADVR
CCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
VLGAIGVVETTHPVNMAALQRFFVGQGVWIRPFGKLIYLMPPYIIRPDQLRRLTQAVNDA
HHHHHCEEECCCCCCHHHHHHHHHCCCCEECCCCCEEEECCCCEECHHHHHHHHHHHHHH
VHNETFFSH
HHCCHHCCC
>Mature Secondary Structure 
TTDDLAFDKRHIWHPYTSMTSPLPVYPVERAEGCELVLASGERLIEGMSSWWAAIHGYN
CCCCCCCCCHHCCCCHHHCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCC
HPQLNAAMKAQIDAMSHVMFGGITHQPAVNLCRKLVAITPEPLECVFLADSGSVSVEVAM
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHH
KMALQYWQARGESRQRFLTFRHGYHGDTFGAMSVCDPDNSMHSLWKGYLPENLFAPAPQS
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCCCCCCCC
RMDGEWDESDIAPFARLMAAHRHEIAAVILEPIVQGAGGMRIYHPQWLRRIRNMCDREGI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCE
LLIADEIATGFGRTGKLFACEHAGIAPDILCLGKALTGGTMTLSATLTTRQVAETISNGE
EEEEHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCC
AGCFMHGPTFMGNPLACAVACASLTLLESGEWRQQVASIESQLRAELAPAQSSPWVADVR
CCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
VLGAIGVVETTHPVNMAALQRFFVGQGVWIRPFGKLIYLMPPYIIRPDQLRRLTQAVNDA
HHHHHCEEECCCCCCHHHHHHHHHCCCCEECCCCCEEEECCCCEECHHHHHHHHHHHHHH
VHNETFFSH
HHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 2971595 [H]