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The map label for this gene is grxA

Identifier: 29142445

GI number: 29142445

Start: 2081327

End: 2081590

Strand: Direct

Name: grxA

Synonym: t2024

Alternate gene names: 29142445

Gene position: 2081327-2081590 (Clockwise)

Preceding gene: 29142430

Following gene: 29142447

Centisome position: 43.43

GC content: 43.94

Gene sequence:

>264_bases
ATGTTTACTGTTATTTTTGGCCGCCCAGGGTGCCCTTATTGCGTGCGTGCAAAAGAGTTGGCGGAAAAACTGAGCAAAGA
ACGCGACGATTTCAACTACCGCTATATTGATATCCATGCCGAAGGCATTACTAAAGCGGATTTGGAAAAAACCGTAGGTA
AACCTGTAGAAACCGTACCGCAGATTTTTGTCGATCAAAAACATATCGGCGGCTGTACGGATTTTGAAGCATGGGCAAAA
GAAAATCTGAATCTTTTCGCCTGA

Upstream 100 bases:

>100_bases
CTGAGTTATCAAAGGAACAGGCGTAACCTGCTTTTCATCTGCCGTAAATCGCGGCATGATAACACCTGTTCGCCGTCTGG
CTTTATGTTCGAGGAGAGAT

Downstream 100 bases:

>100_bases
TTGCTCTGGCGACGCCCTCTGCCGGAGGGCGCTATCGGCGTTTTTTTCGCCGGTGGCTAAACAGGCTGCTAATAAACAAA
TAGCAGAGCGCGCCTAACGC

Product: glutaredoxin 1

Products: deoxyribonucleotides [C]

Alternate protein names: Grx1

Number of amino acids: Translated: 87; Mature: 87

Protein sequence:

>87_residues
MFTVIFGRPGCPYCVRAKELAEKLSKERDDFNYRYIDIHAEGITKADLEKTVGKPVETVPQIFVDQKHIGGCTDFEAWAK
ENLNLFA

Sequences:

>Translated_87_residues
MFTVIFGRPGCPYCVRAKELAEKLSKERDDFNYRYIDIHAEGITKADLEKTVGKPVETVPQIFVDQKHIGGCTDFEAWAK
ENLNLFA
>Mature_87_residues
MFTVIFGRPGCPYCVRAKELAEKLSKERDDFNYRYIDIHAEGITKADLEKTVGKPVETVPQIFVDQKHIGGCTDFEAWAK
ENLNLFA

Specific function: The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione re

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain

Homologues:

Organism=Escherichia coli, GI1787073, Length=84, Percent_Identity=78.5714285714286, Blast_Score=144, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLRX1_SALTI (P0A1P9)

Other databases:

- EMBL:   AL627268
- EMBL:   AE014613
- RefSeq:   NP_455399.1
- RefSeq:   NP_805787.1
- ProteinModelPortal:   P0A1P9
- SMR:   P0A1P9
- PRIDE:   P0A1P9
- GeneID:   1069091
- GeneID:   1247343
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t2024
- KEGG:   sty:STY0905
- HOGENOM:   HBG728471
- OMA:   VGGCTEF
- ProtClustDB:   PRK11200
- BioCyc:   SENT209261:T2024-MONOMER
- BioCyc:   SENT220341:STY0905-MONOMER
- GO:   GO:0006810
- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011902
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PRINTS:   PR00160
- TIGRFAMs:   TIGR02183

Pfam domain/function: PF00462 Glutaredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 9924; Mature: 9924

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00195 GLUTAREDOXIN_1; PS51354 GLUTAREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTVIFGRPGCPYCVRAKELAEKLSKERDDFNYRYIDIHAEGITKADLEKTVGKPVETVP
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHHH
QIFVDQKHIGGCTDFEAWAKENLNLFA
HHHCCCCCCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MFTVIFGRPGCPYCVRAKELAEKLSKERDDFNYRYIDIHAEGITKADLEKTVGKPVETVP
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHHH
QIFVDQKHIGGCTDFEAWAKENLNLFA
HHHCCCCCCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ribonucleotides [C]

Specific reaction: ribonucleotides = deoxyribonucleotides [C]

General reaction: deoxyribonucleotide biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504