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The map label for this gene is dmsA [H]

Identifier: 29142392

GI number: 29142392

Start: 2022796

End: 2025240

Strand: Reverse

Name: dmsA [H]

Synonym: t1970

Alternate gene names: 29142392

Gene position: 2025240-2022796 (Counterclockwise)

Preceding gene: 29142393

Following gene: 29142391

Centisome position: 42.26

GC content: 53.33

Gene sequence:

>2445_bases
ATGAAAACTAAGATCCCTGATGCCGTGCTGGCAGCCGAGGTGAGCCGTCGTGGTTTAGTCAAAACCACCGCGATAGGCGG
CCTGGCGATGGCCAGTAGCGCATTTACCCTGCCATTTACCCGCATCGCTAACGCCGCAGAGGCGATAAGCCCGACGAAAA
CCGACGAGAAAGTCGTCTGGAGCGCCTGTACGGTAAACTGTGGCAGCCGTTGTCCGCTACGTATGCATGTTGTGGATGGC
GAAATCAAATATGTAGAAACGGATAATACCGGAAACGATGATTACGATGGCCTGCACCAGGTTCGCGCCTGCCTGCGCGG
TCGTTCTATGCGTCGTCGCGTCTATAACCCGGATCGTCTCAAGTATCCGATGAAGCGCGTCGGCGCGCGCGGCGAAGGTA
AATTTGAGCGTATTAGCTGGGACGAAGCCTACGATATCATTGCCACCAATATGCAGCGTCTTATCAAAGAGTATGGCAAC
GAGTCCATTTATCTGAACTATGGCACGGGAACGCTGGGCGGCACTTTGACACGTTCATGGCCGCCGGGAAAAACGCTGGT
CGCTCGTCTGATGAACTGCTGCGGCGGTTATCTTAATCACTACGGTGATTACTCTTCCGCGCAAATCGCAGCGGGTCTGA
ATTACACCTATGGCGGCTGGGCGGATGGCAATAGTCCATCCGACATTGAAAACAGTAAGCTGGTGGTGTTGTTTGGTAAT
AACCCTGGCGAAACCCGCATGAGCGGGGGCGGTGGAACGTATTATCTTGAACAGGCGCGGCAGAAATCAAACGCGCGGAT
GATCATTATCGATCCTCGTTACACCGACACCGGCGCCGGTCGCGAAGATGAGTGGATTCCGATTCGTCCAGGTACCGATG
CGGCGCTGGTCAATGGTCTGGCATATGTCTTAATCACCGAGAACATGGTCGATCAGCCGTTCCTGGATAAATATTGCGTC
GGTTATGACGAAAAAACCTTGCCTGCCAGCGCGCCGAAAAACGGTCACTACAAAGCCTATATTCTGGGCTTGGGTAAAGA
CGGTATCGCAAAGACGCCGGAGTGGGCGGCGCAAATTACCGGTATTCCGGCAGATCGCATTATTAAACTGGCGCGAGAAA
TCGGCAGCGCTAAACCCGCCTATATTTGCCAGGGGTGGGGGCCACAACGTCATGCTAATGGAGAAATCGCCACGCGCGCC
ATCTCGATGCTGGCGATCCTGACGGGTAATGTTGGGATTAACGGCGGTAACAGCGGCGCGCGCGAAGGGTCTTATGCCCT
GCCATTTGAACGTATGCCCACGTTGGAAAATCCGGTTGAAACCAGCATCTCCATGTTTATGTGGACCGATGCCATTGAAC
GCGGCCCGGAAATGACAGCGCTGCGTGATGGCGTGCGGGGGAAAGATAAGCTGGACGTGCCGATCAAAATGATCTGGAAC
TATGCTGGCAACTGTTTGATTAACCAGCACTCTGAGATTAACCGCACCCACGAAATCCTGCAGGATGACAGTAAATGTGA
AATGATCGTCGTTATCGACTGTCATATGACCTCGTCGGCAAAATACGCCGATATTCTGTTGCCTGATTGCACTGCTTCTG
AGCAGATGGACTTTGCGCTGGATGCCTCCTGCGGGAACATGTCTTACGTTATCTTCACTGACCAGGCGATTAAACCGCGC
TTCGAGTGTAAGACGATTTATGAGATGACCAGCGAACTGGCGAAACGTCTTGGCGTGGAACAACAGTTTACCGAAGGCCG
GACGCAAGAAGAGTGGATGCGTCATCTGTACGAACAGTCGCGTAAATCCATTCCGAATCTGCCCACCTTTGAGGAGTTCC
GTAAGCAAGGCATCTTCAAACAGCGCGACCCCGAAGGCCACCATGTCGCCTATAAAGACTTCCGCGAAGATCCGCAAGCG
AATCCACTTACAACGCCATCGGGCAAGATTGAAATCTATTCACAGGCGTTGGCGGATATCGCCGCCACCTGGGAGCTGCC
GGAAGGCGACGTGATCGATCCATTACCGATCTACACGCTAGGTTTTGAAAACTATAACGATCCGCTAACGGATAAATTCC
CGCTGCAGTTGACGGGTTTCCACTATAAAGCGCGTGTGCATTCCACTTATGGCAACGTAGACGTACTGAAAGCCGCCTGT
CGCCAGGAAATGTGGATTAACCCAATGGATGCGCAGAAACGCGGTATCAACAATGGCGATAAAGTCCGCATCTTCAACGA
TCGCGGCGAAGTTCATATCGAGGCTAAAGTGACGCCGCGCATGATGCCGGGCGTGGTCGCTCTGGGAGAAGGCGCATGGT
ATGACCCGGATGCAAAACGCGTGGATCAGGGCGGATGTATTAACGTACTGACCAGTCAACGTCCTTCTCCGCTGGCGAAG
GGGAACCCGTCACATACGAACCTCGTTCAGGTTGAAAAGGCGTAA

Upstream 100 bases:

>100_bases
TTTTTCGATATATATCAGACTTTATAGCGACGTTATCGCTATATAAAATTCTATACATCGTTTTATTGCTTTTTTATTGT
GAGCAGCAGAGTGAGCCCTT

Downstream 100 bases:

>100_bases
GGAGTAACCGATGACAACCCAGTATGGATTTTTTATTGATTCCAGCCGTTGCACCGGTTGCAAAACCTGCGAACTGGCCT
GCAAGGACTACAAAGATTTG

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 814; Mature: 814

Protein sequence:

>814_residues
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSAFTLPFTRIANAAEAISPTKTDEKVVWSACTVNCGSRCPLRMHVVDG
EIKYVETDNTGNDDYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWDEAYDIIATNMQRLIKEYGN
ESIYLNYGTGTLGGTLTRSWPPGKTLVARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSKLVVLFGN
NPGETRMSGGGGTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVLITENMVDQPFLDKYCV
GYDEKTLPASAPKNGHYKAYILGLGKDGIAKTPEWAAQITGIPADRIIKLAREIGSAKPAYICQGWGPQRHANGEIATRA
ISMLAILTGNVGINGGNSGAREGSYALPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
YAGNCLINQHSEINRTHEILQDDSKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFTDQAIKPR
FECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYEQSRKSIPNLPTFEEFRKQGIFKQRDPEGHHVAYKDFREDPQA
NPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTLGFENYNDPLTDKFPLQLTGFHYKARVHSTYGNVDVLKAAC
RQEMWINPMDAQKRGINNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDAKRVDQGGCINVLTSQRPSPLAK
GNPSHTNLVQVEKA

Sequences:

>Translated_814_residues
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSAFTLPFTRIANAAEAISPTKTDEKVVWSACTVNCGSRCPLRMHVVDG
EIKYVETDNTGNDDYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWDEAYDIIATNMQRLIKEYGN
ESIYLNYGTGTLGGTLTRSWPPGKTLVARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSKLVVLFGN
NPGETRMSGGGGTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVLITENMVDQPFLDKYCV
GYDEKTLPASAPKNGHYKAYILGLGKDGIAKTPEWAAQITGIPADRIIKLAREIGSAKPAYICQGWGPQRHANGEIATRA
ISMLAILTGNVGINGGNSGAREGSYALPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
YAGNCLINQHSEINRTHEILQDDSKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFTDQAIKPR
FECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYEQSRKSIPNLPTFEEFRKQGIFKQRDPEGHHVAYKDFREDPQA
NPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTLGFENYNDPLTDKFPLQLTGFHYKARVHSTYGNVDVLKAAC
RQEMWINPMDAQKRGINNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDAKRVDQGGCINVLTSQRPSPLAK
GNPSHTNLVQVEKA
>Mature_814_residues
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSAFTLPFTRIANAAEAISPTKTDEKVVWSACTVNCGSRCPLRMHVVDG
EIKYVETDNTGNDDYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWDEAYDIIATNMQRLIKEYGN
ESIYLNYGTGTLGGTLTRSWPPGKTLVARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSKLVVLFGN
NPGETRMSGGGGTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVLITENMVDQPFLDKYCV
GYDEKTLPASAPKNGHYKAYILGLGKDGIAKTPEWAAQITGIPADRIIKLAREIGSAKPAYICQGWGPQRHANGEIATRA
ISMLAILTGNVGINGGNSGAREGSYALPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
YAGNCLINQHSEINRTHEILQDDSKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFTDQAIKPR
FECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYEQSRKSIPNLPTFEEFRKQGIFKQRDPEGHHVAYKDFREDPQA
NPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTLGFENYNDPLTDKFPLQLTGFHYKARVHSTYGNVDVLKAAC
RQEMWINPMDAQKRGINNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDAKRVDQGGCINVLTSQRPSPLAK
GNPSHTNLVQVEKA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=814, Percent_Identity=92.997542997543, Blast_Score=1582, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=804, Percent_Identity=68.5323383084577, Blast_Score=1165, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=817, Percent_Identity=66.7074663402693, Blast_Score=1140, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=751, Percent_Identity=32.2237017310253, Blast_Score=303, Evalue=3e-83,
Organism=Escherichia coli, GI1787231, Length=761, Percent_Identity=31.6688567674113, Blast_Score=295, Evalue=7e-81,
Organism=Escherichia coli, GI87081994, Length=752, Percent_Identity=31.6489361702128, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI3868721, Length=782, Percent_Identity=24.8081841432225, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI3868720, Length=468, Percent_Identity=26.2820512820513, Blast_Score=109, Evalue=7e-25,
Organism=Escherichia coli, GI3868719, Length=462, Percent_Identity=25.5411255411255, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788534, Length=842, Percent_Identity=22.9216152019002, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1787477, Length=348, Percent_Identity=25.2873563218391, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1787741, Length=309, Percent_Identity=25.2427184466019, Blast_Score=83, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 90339; Mature: 90339

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSAFTLPFTRIANAAEAISPTKTDEKVVW
CCCCCCHHHHHHHHHHCCCEEEHHHCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEE
SACTVNCGSRCPLRMHVVDGEIKYVETDNTGNDDYDGLHQVRACLRGRSMRRRVYNPDRL
EEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHH
KYPMKRVGARGEGKFERISWDEAYDIIATNMQRLIKEYGNESIYLNYGTGTLGGTLTRSW
CCCHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCC
PPGKTLVARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSKLVVLFGN
CCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
NPGETRMSGGGGTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGL
CCCCCEECCCCCEEHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHCCE
AYVLITENMVDQPFLDKYCVGYDEKTLPASAPKNGHYKAYILGLGKDGIAKTPEWAAQIT
EEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHCC
GIPADRIIKLAREIGSAKPAYICQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGA
CCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
REGSYALPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
CCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHC
YAGNCLINQHSEINRTHEILQDDSKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFAL
CCCCEEEECCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCEEE
DASCGNMSYVIFTDQAIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYEQS
ECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHH
RKSIPNLPTFEEFRKQGIFKQRDPEGHHVAYKDFREDPQANPLTTPSGKIEIYSQALADI
HHCCCCCCCHHHHHHCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCCCCCEEEHHHHHHHH
AATWELPEGDVIDPLPIYTLGFENYNDPLTDKFPLQLTGFHYKARVHSTYGNVDVLKAAC
HHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECEEEEEEEECCCCCHHHHHHHH
RQEMWINPMDAQKRGINNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDAKR
HHHHCCCCCCHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCHHH
VDQGGCINVLTSQRPSPLAKGNPSHTNLVQVEKA
CCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSAFTLPFTRIANAAEAISPTKTDEKVVW
CCCCCCHHHHHHHHHHCCCEEEHHHCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEE
SACTVNCGSRCPLRMHVVDGEIKYVETDNTGNDDYDGLHQVRACLRGRSMRRRVYNPDRL
EEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHH
KYPMKRVGARGEGKFERISWDEAYDIIATNMQRLIKEYGNESIYLNYGTGTLGGTLTRSW
CCCHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCC
PPGKTLVARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSKLVVLFGN
CCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
NPGETRMSGGGGTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGL
CCCCCEECCCCCEEHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHCCE
AYVLITENMVDQPFLDKYCVGYDEKTLPASAPKNGHYKAYILGLGKDGIAKTPEWAAQIT
EEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHCC
GIPADRIIKLAREIGSAKPAYICQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGA
CCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
REGSYALPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
CCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHC
YAGNCLINQHSEINRTHEILQDDSKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFAL
CCCCEEEECCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCEEE
DASCGNMSYVIFTDQAIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYEQS
ECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHH
RKSIPNLPTFEEFRKQGIFKQRDPEGHHVAYKDFREDPQANPLTTPSGKIEIYSQALADI
HHCCCCCCCHHHHHHCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCCCCCEEEHHHHHHHH
AATWELPEGDVIDPLPIYTLGFENYNDPLTDKFPLQLTGFHYKARVHSTYGNVDVLKAAC
HHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECEEEEEEEECCCCCHHHHHHHH
RQEMWINPMDAQKRGINNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDAKR
HHHHCCCCCCHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCHHH
VDQGGCINVLTSQRPSPLAKGNPSHTNLVQVEKA
CCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]