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The map label for this gene is sigD [H]

Identifier: 29142258

GI number: 29142258

Start: 1890441

End: 1892126

Strand: Direct

Name: sigD [H]

Synonym: t1828

Alternate gene names: 29142258

Gene position: 1890441-1892126 (Clockwise)

Preceding gene: 29142256

Following gene: 29142259

Centisome position: 39.45

GC content: 46.68

Gene sequence:

>1686_bases
ATGCAAATACAGAGCTTCTATCACTCAGCTTCACTAAAAACCCAGGAGGCTTTTAAAAGCCTACAAAAAACCTTATACAA
CGGAATGCAGATTCTCTCAGGCCAGGGCAAAGCGCCGGCTAAAGCGCCCGACGCTCGCCCGGAAATTATTGTCCTGCGAG
AACCTGGCGCGACATGGGGGAATTATCTACAGCATCAGAAGACGTCTAACCACTCGCTGCATAACCTCTATAACTTACAG
CGCGATCTTCTTACCGTCGCGGCAACCGTTCTGGGTAAACAAGACCCGGTTCTAACGTCAATGGCAAACCAAATGGAGTT
AGCCAAAGTTAAAGCGGACCGGCCAGCAACAAAACAAGAAGAAGCTGCGGCAAAAGCATTGAAGAAAAATCTTATCGAAC
TTATTGCAGCACGCACTCAGCAGCAAAATGGCTTACCTGCAAAAGAAGCTCATCGCTTTGCGGCAGTAGCGTTTAGAGAT
GCTCAGGTCAAGCAGCTCAATAACCAGCCCTGGCAAACCATAAAAAATACACTCACGCATAACGGGCATCACTATACCAA
CACGCAGCTCCCTGCCGCAGAGATGAAAATCGGCGCAAAAGATATCTTTCCCAGTGCTTATGAGGGAAAGGGCGTATGCA
GTTGGGATACCAAGAATATTCATCACGCCAATAATTTGTGGATGTCCACGGTGAGTGTGCATGAGGACGGTAAAGATAAA
ACGCTTTTTTGCGGGATACGTCATGGTGTGCTTTCCCCCTATCATGAAAAAGATCCGCTTCTGCGTCAGGCCGGCGCTGA
AAACAAAGCCAAAGAAGTATTAGCTGCGGCACTTTTTAGTAAACCTGAGTTGCTTAACAGAGCCTTAGAGGGCGAAGCGG
TAAGCCTGAAACTGGTATCCGTCGGGTTACTCACCGCGTCGAATATTTTCGGCAAAGAGGGAACTATGGTCGAGGATCAA
ATGCGCGCATGGCAATCGTTGACCCAGCCGGGAAAAATGATTCATTTAAAAATCCGCAATAAAGATGGCGATCTACAGAC
GGTAAAAATAAAACCGGACGTCGCCGCATTTAATGTGGGTGTTAATGAGCTGGCGCTCAAGCTCGGCTTTGGCCTTAAAG
CATCAGATAGCTATAATGCCGAAGCGCTACATCAGTTATTAGGCAATGATTTACGCCCTGAAGCCAGACCAGGTGGCTGG
GTTGGCGAATGGCTGGCGCAATACCCGGATAATTATGAGGTCGTCAATACATTAGCGCGCCAGATTAAGGATATCTGGAA
AAATAACCAACATCATAAAGATGGCGGCGAACCCTATAAACTCGCACAACGCCTTGCCATGTTAGCCCATGAAATTGACG
CGGTGCCCGCCTGGAATTGTAAAAGCGGCAAAGATCGTACAGGGATGATGGATTCAGAAATCAAGCGAGAGCTCATTTCT
TTCCATCAGACCCATATGTTAAGTGCGCCTGGTAGTCTTCCGGATAGCGGTGGACAGAAAATTTTCCAAAAAGTATTACT
GAATAGCGGTAACCTGGAGATTCAGAAACAAAATACGGGCGGGGCGGGAAACAAAGTAATGAAAAATTTATCGCCAGAGG
TGCTCAATCTTTCCTATCAAAAACGAGTTGGGGATGAAAATATTTGGCAGTCAGTAAAAGGTATTTCTTCATTAATCACA
TCTTGA

Upstream 100 bases:

>100_bases
TTTTTTTAAAGTTCCTGGTGCATAAAAGTCACATCCTTTTAAAAGATTGTTAACCCTGTTGAATGTTCCCACTCCCCTAT
TCAGGAATATTAAAAACGCT

Downstream 100 bases:

>100_bases
GTCTTGAGGTAACTATATGGAAAGTCTATTAAATCGTTTATATGACGCGTTAGGCCTGGATGCGCCAGAAGATGAGCCAC
TGCTTATCATTGATGATGGG

Product: cell invasion protein

Products: NA

Alternate protein names: Effector protein sopB [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MQIQSFYHSASLKTQEAFKSLQKTLYNGMQILSGQGKAPAKAPDARPEIIVLREPGATWGNYLQHQKTSNHSLHNLYNLQ
RDLLTVAATVLGKQDPVLTSMANQMELAKVKADRPATKQEEAAAKALKKNLIELIAARTQQQNGLPAKEAHRFAAVAFRD
AQVKQLNNQPWQTIKNTLTHNGHHYTNTQLPAAEMKIGAKDIFPSAYEGKGVCSWDTKNIHHANNLWMSTVSVHEDGKDK
TLFCGIRHGVLSPYHEKDPLLRQAGAENKAKEVLAAALFSKPELLNRALEGEAVSLKLVSVGLLTASNIFGKEGTMVEDQ
MRAWQSLTQPGKMIHLKIRNKDGDLQTVKIKPDVAAFNVGVNELALKLGFGLKASDSYNAEALHQLLGNDLRPEARPGGW
VGEWLAQYPDNYEVVNTLARQIKDIWKNNQHHKDGGEPYKLAQRLAMLAHEIDAVPAWNCKSGKDRTGMMDSEIKRELIS
FHQTHMLSAPGSLPDSGGQKIFQKVLLNSGNLEIQKQNTGGAGNKVMKNLSPEVLNLSYQKRVGDENIWQSVKGISSLIT
S

Sequences:

>Translated_561_residues
MQIQSFYHSASLKTQEAFKSLQKTLYNGMQILSGQGKAPAKAPDARPEIIVLREPGATWGNYLQHQKTSNHSLHNLYNLQ
RDLLTVAATVLGKQDPVLTSMANQMELAKVKADRPATKQEEAAAKALKKNLIELIAARTQQQNGLPAKEAHRFAAVAFRD
AQVKQLNNQPWQTIKNTLTHNGHHYTNTQLPAAEMKIGAKDIFPSAYEGKGVCSWDTKNIHHANNLWMSTVSVHEDGKDK
TLFCGIRHGVLSPYHEKDPLLRQAGAENKAKEVLAAALFSKPELLNRALEGEAVSLKLVSVGLLTASNIFGKEGTMVEDQ
MRAWQSLTQPGKMIHLKIRNKDGDLQTVKIKPDVAAFNVGVNELALKLGFGLKASDSYNAEALHQLLGNDLRPEARPGGW
VGEWLAQYPDNYEVVNTLARQIKDIWKNNQHHKDGGEPYKLAQRLAMLAHEIDAVPAWNCKSGKDRTGMMDSEIKRELIS
FHQTHMLSAPGSLPDSGGQKIFQKVLLNSGNLEIQKQNTGGAGNKVMKNLSPEVLNLSYQKRVGDENIWQSVKGISSLIT
S
>Mature_561_residues
MQIQSFYHSASLKTQEAFKSLQKTLYNGMQILSGQGKAPAKAPDARPEIIVLREPGATWGNYLQHQKTSNHSLHNLYNLQ
RDLLTVAATVLGKQDPVLTSMANQMELAKVKADRPATKQEEAAAKALKKNLIELIAARTQQQNGLPAKEAHRFAAVAFRD
AQVKQLNNQPWQTIKNTLTHNGHHYTNTQLPAAEMKIGAKDIFPSAYEGKGVCSWDTKNIHHANNLWMSTVSVHEDGKDK
TLFCGIRHGVLSPYHEKDPLLRQAGAENKAKEVLAAALFSKPELLNRALEGEAVSLKLVSVGLLTASNIFGKEGTMVEDQ
MRAWQSLTQPGKMIHLKIRNKDGDLQTVKIKPDVAAFNVGVNELALKLGFGLKASDSYNAEALHQLLGNDLRPEARPGGW
VGEWLAQYPDNYEVVNTLARQIKDIWKNNQHHKDGGEPYKLAQRLAMLAHEIDAVPAWNCKSGKDRTGMMDSEIKRELIS
FHQTHMLSAPGSLPDSGGQKIFQKVLLNSGNLEIQKQNTGGAGNKVMKNLSPEVLNLSYQKRVGDENIWQSVKGISSLIT
S

Specific function: Converts phosphatidylinositol-3,4,5-triphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Secreted via the type III secretion system 1 (SPI-1 TTSS) (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphatase ipgD/sopB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008108 [H]

Pfam domain/function: PF05925 IpgD [H]

EC number: NA

Molecular weight: Translated: 62018; Mature: 62018

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIQSFYHSASLKTQEAFKSLQKTLYNGMQILSGQGKAPAKAPDARPEIIVLREPGATWG
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCHH
NYLQHQKTSNHSLHNLYNLQRDLLTVAATVLGKQDPVLTSMANQMELAKVKADRPATKQE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
EAAAKALKKNLIELIAARTQQQNGLPAKEAHRFAAVAFRDAQVKQLNNQPWQTIKNTLTH
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
NGHHYTNTQLPAAEMKIGAKDIFPSAYEGKGVCSWDTKNIHHANNLWMSTVSVHEDGKDK
CCCEECCCCCCHHHHHCCHHHCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCC
TLFCGIRHGVLSPYHEKDPLLRQAGAENKAKEVLAAALFSKPELLNRALEGEAVSLKLVS
EEEEEEHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEE
VGLLTASNIFGKEGTMVEDQMRAWQSLTQPGKMIHLKIRNKDGDLQTVKIKPDVAAFNVG
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCEEEECC
VNELALKLGFGLKASDSYNAEALHQLLGNDLRPEARPGGWVGEWLAQYPDNYEVVNTLAR
HHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
QIKDIWKNNQHHKDGGEPYKLAQRLAMLAHEIDAVPAWNCKSGKDRTGMMDSEIKRELIS
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
FHQTHMLSAPGSLPDSGGQKIFQKVLLNSGNLEIQKQNTGGAGNKVMKNLSPEVLNLSYQ
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCHHHHCCHHH
KRVGDENIWQSVKGISSLITS
HHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQIQSFYHSASLKTQEAFKSLQKTLYNGMQILSGQGKAPAKAPDARPEIIVLREPGATWG
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCHH
NYLQHQKTSNHSLHNLYNLQRDLLTVAATVLGKQDPVLTSMANQMELAKVKADRPATKQE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
EAAAKALKKNLIELIAARTQQQNGLPAKEAHRFAAVAFRDAQVKQLNNQPWQTIKNTLTH
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
NGHHYTNTQLPAAEMKIGAKDIFPSAYEGKGVCSWDTKNIHHANNLWMSTVSVHEDGKDK
CCCEECCCCCCHHHHHCCHHHCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCC
TLFCGIRHGVLSPYHEKDPLLRQAGAENKAKEVLAAALFSKPELLNRALEGEAVSLKLVS
EEEEEEHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEE
VGLLTASNIFGKEGTMVEDQMRAWQSLTQPGKMIHLKIRNKDGDLQTVKIKPDVAAFNVG
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCEEEECC
VNELALKLGFGLKASDSYNAEALHQLLGNDLRPEARPGGWVGEWLAQYPDNYEVVNTLAR
HHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
QIKDIWKNNQHHKDGGEPYKLAQRLAMLAHEIDAVPAWNCKSGKDRTGMMDSEIKRELIS
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
FHQTHMLSAPGSLPDSGGQKIFQKVLLNSGNLEIQKQNTGGAGNKVMKNLSPEVLNLSYQ
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCHHHHCCHHH
KRVGDENIWQSVKGISSLITS
HHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9364916; 9723926; 11200542; 9826652 [H]