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The map label for this gene is phoP [H]

Identifier: 29142123

GI number: 29142123

Start: 1752335

End: 1753009

Strand: Direct

Name: phoP [H]

Synonym: t1689

Alternate gene names: 29142123

Gene position: 1752335-1753009 (Clockwise)

Preceding gene: 29142122

Following gene: 29142124

Centisome position: 36.57

GC content: 51.26

Gene sequence:

>675_bases
ATGATGCGCGTACTGGTTGTAGAGGATAATGCATTATTACGCCACCACCTGAAGGTTCAGCTCCAGGATTCAGGTCACCA
GGTCGATGCCGCAGAAGATGCCAGGGAAGCTGATTACTACCTTAATGAACACCTTCCGGATATCGCTATTGTCGATTTAG
GTCTGCCGGATGAAGACGGCCTTTCCTTAATACGCCGCTGGCGCAGCAGTGATGTTTCACTGCCGGTTCTGGTGTTAACC
GCGCGCGAAGGCTGGCAGGATAAAGTCGAGGTTCTCAGCTCCGGGGCCGATGACTACGTGACGAAGCCATTCCACATCGA
AGAGGTAATGGCGCGTATGCAGGCGTTAATGCGCCGTAATAGCGGTCTGGCCTCCCAGGTGATCAACATCTCGCCTTTCC
AGGTGGATCTCTCACGCCGGGAATTATCCGTCAATGAAGAGGTCATCAAACTCACGGCGTTCGAATACACCATTATGGAA
ACGCTTATCCGTAACAACGGTAAAGTGGTCAGCAAAGATTCTCTGATGCTTCAGCTGTATCCGGATGCGGAACTGCGGGA
AAGTCATACCATTGATGTTCTCATGGGGCGTCTGCGGAAAAAAATACAGGCCCAGTATCCGCACGATGTCATTACCACCG
TACGCGGACAAGGATATCTTTTTGAATTGCGCTAA

Upstream 100 bases:

>100_bases
CAGAAAGAGGGTGACTATTTGTCTGGTTTATTAACTGTTTATCCCCAAAGCACCATAATCAACGCTAGACTGTTCTTATT
GTTAACACAAGGGAGAAGAG

Downstream 100 bases:

>100_bases
TGAATAAATTTGCTCGCCATTTTCTGCCGCTGTCGCTGCGGGTTCGTTTTTTGCTGGCGACAGCCGGCGTCGTGCTGGTG
CTTTCTCTGGCATATGGCAT

Product: DNA-binding transcriptional regulator PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MMRVLVVEDNALLRHHLKVQLQDSGHQVDAAEDAREADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSSDVSLPVLVLT
AREGWQDKVEVLSSGADDYVTKPFHIEEVMARMQALMRRNSGLASQVINISPFQVDLSRRELSVNEEVIKLTAFEYTIME
TLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPHDVITTVRGQGYLFELR

Sequences:

>Translated_224_residues
MMRVLVVEDNALLRHHLKVQLQDSGHQVDAAEDAREADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSSDVSLPVLVLT
AREGWQDKVEVLSSGADDYVTKPFHIEEVMARMQALMRRNSGLASQVINISPFQVDLSRRELSVNEEVIKLTAFEYTIME
TLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPHDVITTVRGQGYLFELR
>Mature_224_residues
MMRVLVVEDNALLRHHLKVQLQDSGHQVDAAEDAREADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSSDVSLPVLVLT
AREGWQDKVEVLSSGADDYVTKPFHIEEVMARMQALMRRNSGLASQVINISPFQVDLSRRELSVNEEVIKLTAFEYTIME
TLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPHDVITTVRGQGYLFELR

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=92.8251121076233, Blast_Score=429, Evalue=1e-122,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=36.5638766519824, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=37.1559633027523, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35.4545454545455, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=34.2222222222222, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=33.0357142857143, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.3612334801762, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=35.6164383561644, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=30.9090909090909, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=32.4444444444444, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=29.8245614035088, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.5154185022026, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=29.1304347826087, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=31.7757009345794, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=25.1063829787234, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=33.9622641509434, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=32.4074074074074, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25624; Mature: 25624

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRVLVVEDNALLRHHLKVQLQDSGHQVDAAEDAREADYYLNEHLPDIAIVDLGLPDEDG
CEEEEEECCCHHEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHH
LSLIRRWRSSDVSLPVLVLTAREGWQDKVEVLSSGADDYVTKPFHIEEVMARMQALMRRN
HHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHC
SGLASQVINISPFQVDLSRRELSVNEEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLY
CCCHHHEEECCCEEEECCHHHCCCCHHHEEEHHHHHHHHHHHHHCCCCEEECCCEEEEEC
PDAELRESHTIDVLMGRLRKKIQAQYPHDVITTVRGQGYLFELR
CCCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHEECCCCEEEEEC
>Mature Secondary Structure
MMRVLVVEDNALLRHHLKVQLQDSGHQVDAAEDAREADYYLNEHLPDIAIVDLGLPDEDG
CEEEEEECCCHHEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHH
LSLIRRWRSSDVSLPVLVLTAREGWQDKVEVLSSGADDYVTKPFHIEEVMARMQALMRRN
HHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHC
SGLASQVINISPFQVDLSRRELSVNEEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLY
CCCHHHEEECCCEEEECCHHHCCCCHHHEEEHHHHHHHHHHHHHCCCCEEECCCEEEEEC
PDAELRESHTIDVLMGRLRKKIQAQYPHDVITTVRGQGYLFELR
CCCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA