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The map label for this gene is rnb [H]

Identifier: 29142051

GI number: 29142051

Start: 1669819

End: 1671753

Strand: Direct

Name: rnb [H]

Synonym: t1615

Alternate gene names: 29142051

Gene position: 1669819-1671753 (Clockwise)

Preceding gene: 29142050

Following gene: 29142052

Centisome position: 34.85

GC content: 55.71

Gene sequence:

>1935_bases
ATGTTTCAGGACAACCCGCTGCTAGCGCAGCTTAAACAGCAACTGCATTCCCAGACGCCGCGCGCTGAAGGGGTCGTAAA
AGCCACGGAAAAAGGCTTTGGCTTCCTTGAGGTTGACGCGCAAAAAAGCTACTTCATTCCTCCGCCGCAGATGAAAAAAG
TGATGCATGGCGATCGTATCGTCGCGGTCATCCACACGGAAAAAGAACGTGAGTCTGCCGAGCCGGAAGAACTGATCGAA
CCGTTCCTGACGCGCTTTGTGGGAAAAGTTCAGGGTAAAAATGACCGCCTGTCCATCGTGCCAGATCATCCGTTGCTGAA
AGACGCGATTCCCTGCCGCGCCGCGCGCGGCGTTCAGCATGAGTTCAAAGAAGGTGACTGGGCGGTTGCCGAAATGCGCC
GCCATCCGCTTAAAGGCGACCGTTCGTTTTACGCCGATTTAACGCAGTACATCACCTTTGCCGACGATCACTTTGTTCCC
TGGTGGGTTACGCTTGCCCGCCATAACCTGGAAAAAGAAGCGCCGAACGGCGTAGCGACGGAGATGCTGGACGAAGGGCT
GGAGCGCCAGGATCTTACCGCGCTGAATTTCGTCACTATCGATAGCGCCAGCACTGAAGATATGGATGACGCGCTTTATG
CTGAGGAATTAGCGGACGGCAGACTCCAGCTTACGGTGGCTATCGCCGATCCTACCGCCTGGATTGCCGAAGGCAGTAAG
CTGGATAACGCCGCGAAAATTCGCGCCTTCACCAACTACCTGCCGGGCTTCAATATTCCTATGCTGCCACGTGAGCTGTC
TGACGATCTGTGTTCGCTGCGCGCCAACGAAGTGCGTCCGGCGCTCGCCTGTCGCATGATCATCGCCGCGGACGGCACCA
TTGACGATGATATTGCCTTTTTTGCGGCCACCATCGAATCGAAGGCCAAGCTGGTGTACGACAATGTCTCCGACTGGCTG
GAAAATAACAGCACCTGGCAGCCGGAGAACGAAGGCATTGCCCAGCAGATTCGTCTGTTGCACCGTATTTGTCTAAGCCG
CAGTGAGTGGCGTCATCATCATGCGTTAGTCTTTAAAGACCGCCCGGATTACCGCTTTGTGCTTGGCGAAAAAGGCGAAG
TACTGGATATTGTGGCGGAACCGCGCCGTATCGCTAACCGTATCGTAGAAGAGTCGATGATCGCCGCTAACCTTTGCGCC
GCGCGCGTACTGCGCGATAAGCTCGGTTTCGGTATTTACAACGTACATACGGGCTTCGATCCCGCGAATGCCGACGCGCT
GGCCGCGCTGCTGAAAACGCATGGTCTGCATGTCGATGCCGAAGAGGTGCTGACGCTGGAAGGCTTCTGTAAACTGCGTC
GCGAACTGGATGCGCAGCCCTCCGGTTTCCTTGACAGCCGCATTCGTCGCTTCCAGTCTTTTGCGGAAATCAGCACCGAG
CCGGGGCCGCATTTCGGTCTTGGTCTTGAGGCTTATGCCACCTGGACCTCTCCCATCCGTAAGTATGGCGATATGATTAA
CCATCGCCTGCTGAAAGCGGTCATCAAGGGGGAAGCTATTGCGCGTCCGCAGGAAGATATCACCCAGCAAATGGCGGAAC
GCCGTCGCCTGAACCGCATGGCGGAGCGCGATGTCGGCGACTGGTTATATGCACGCTTCCTTAACGATAAGGCGGGGACA
AATACCCGTTTCGCGGCAGAAATTATTGACGTCAGCCGCGGTGGTATGCGTGTGCGACTGGTCGATAACGGCGCTATCGC
CTTTATCCCTGCCCCGTTCCTGCACGCCGTTCGCGATGAACTGGTATGCAGCCAGGAAAACGGTACGGTACAGATTAAAG
GTGAGACGGTTTATAAAGTGACGGATGTCATTGATGTCACTATTGCGGAAGTTCGCATGGAAACCCGCAGCATTATTGCC
CGACCGGCAGCGTAA

Upstream 100 bases:

>100_bases
GAAACCTATTAACTCATCCATTACTGAAAGAGCGCTTGCTGCGCCAGGCAGAATCGCGTAAAACTGTCAGCCGCTCTTTT
GGCTACGAAAATAGACGAAT

Downstream 100 bases:

>100_bases
CCACGCTTAGCTCGCTCAACGGCCTTTGCTGAGAAGGCAAAGGCCGTTTCTTTTCTTCTTCTCCCTTCCGTCATGCTCTA
AGTTTAATCTTATTCAAGCG

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHTEKERESAEPEELIE
PFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQHEFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVP
WWVTLARHNLEKEAPNGVATEMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSK
LDNAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAFFAATIESKAKLVYDNVSDWL
ENNSTWQPENEGIAQQIRLLHRICLSRSEWRHHHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCA
ARVLRDKLGFGIYNVHTGFDPANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTE
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRMAERDVGDWLYARFLNDKAGT
NTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIA
RPAA

Sequences:

>Translated_644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHTEKERESAEPEELIE
PFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQHEFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVP
WWVTLARHNLEKEAPNGVATEMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSK
LDNAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAFFAATIESKAKLVYDNVSDWL
ENNSTWQPENEGIAQQIRLLHRICLSRSEWRHHHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCA
ARVLRDKLGFGIYNVHTGFDPANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTE
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRMAERDVGDWLYARFLNDKAGT
NTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIA
RPAA
>Mature_644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHTEKERESAEPEELIE
PFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQHEFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVP
WWVTLARHNLEKEAPNGVATEMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSK
LDNAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAFFAATIESKAKLVYDNVSDWL
ENNSTWQPENEGIAQQIRLLHRICLSRSEWRHHHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCA
ARVLRDKLGFGIYNVHTGFDPANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTE
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRMAERDVGDWLYARFLNDKAGT
NTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIA
RPAA

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=487, Percent_Identity=24.8459958932238, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI190014625, Length=457, Percent_Identity=25.164113785558, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI134288890, Length=409, Percent_Identity=27.8728606356968, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI219521928, Length=454, Percent_Identity=24.6696035242291, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI19115966, Length=454, Percent_Identity=24.6696035242291, Blast_Score=94, Evalue=5e-19,
Organism=Escherichia coli, GI1787542, Length=644, Percent_Identity=90.9937888198758, Blast_Score=1206, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=654, Percent_Identity=25.9938837920489, Blast_Score=175, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17553506, Length=414, Percent_Identity=26.5700483091787, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI212645896, Length=469, Percent_Identity=26.226012793177, Blast_Score=116, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6324552, Length=421, Percent_Identity=23.0403800475059, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24649634, Length=374, Percent_Identity=28.3422459893048, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24654592, Length=432, Percent_Identity=28.0092592592593, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19922976, Length=432, Percent_Identity=28.0092592592593, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24654597, Length=432, Percent_Identity=28.0092592592593, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 72482; Mature: 72482

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
VAVIHTEKERESAEPEELIEPFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQH
EEEEECCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHCCCHHHHHCCHH
EFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVPWWVTLARHNLEKEAPNGVAT
HHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHCCCCCHHH
EMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSK
HHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEEECCCHHHHCCCC
LDNAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAF
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHEEEEEECCCCCHHHHH
FAATIESKAKLVYDNVSDWLENNSTWQPENEGIAQQIRLLHRICLSRSEWRHHHALVFKD
HHHHHHHCHHEEHHCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCHHHCCCCEEEEEEC
RPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCAARVLRDKLGFGIYNVHTGFD
CCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTE
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AERDVGDWLYARFLNDKAGTNTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDE
HHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHH
LVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPAA
HHEECCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
VAVIHTEKERESAEPEELIEPFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQH
EEEEECCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHCCCHHHHHCCHH
EFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVPWWVTLARHNLEKEAPNGVAT
HHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHCCCCCHHH
EMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSK
HHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEEECCCHHHHCCCC
LDNAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAF
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHEEEEEECCCCCHHHHH
FAATIESKAKLVYDNVSDWLENNSTWQPENEGIAQQIRLLHRICLSRSEWRHHHALVFKD
HHHHHHHCHHEEHHCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCHHHCCCCEEEEEEC
RPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCAARVLRDKLGFGIYNVHTGFD
CCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTE
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AERDVGDWLYARFLNDKAGTNTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDE
HHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHH
LVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPAA
HHEECCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA