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The map label for this gene is tpx

Identifier: 29142026

GI number: 29142026

Start: 1646262

End: 1646768

Strand: Direct

Name: tpx

Synonym: t1586

Alternate gene names: 29142026

Gene position: 1646262-1646768 (Clockwise)

Preceding gene: 29142024

Following gene: 29142027

Centisome position: 34.35

GC content: 49.7

Gene sequence:

>507_bases
ATGTCACAGACTGTACATTTCCAGGATAACCCGGTCACCGTTGCCAACGTTATTCCGCAGGCTGGTAGCAAAGCACAGGC
TTTTACTCTTGTCGCAAAAGATTTGTCTGACGTTTCCCTCAGCCAATATGCAGGCAAACGCAAAGTGCTGAATATTTTCC
CAAGCATTGATACTGGCGTATGCGCCGCATCAGTTCGTAAGTTTAATCAACTGGCCACAGAAGTGGAGAATACCGTCGTA
TTGTGCGTTTCTGCTGACCTGCCTTTTGCACAGTCGCGTTTTTGCGGCGCGGAAGGCCTGAGCAACGTTATTACGCTTTC
CACTCTGCGTAATAACGAGTTTCTAAAAAACTACGGCGTCGAAATCGTTGACGGCCCGCTGAAAGGTTTGGCGGCGCGCG
CAGTCATCGTGCTTGACGAAAACGACAACGTTATTTTCAGCCAGTTGGTGGATGAAATCACCCACGAGCCGGATTACGAC
GCCGCGCTTAATGTCCTGAAGGCATAA

Upstream 100 bases:

>100_bases
AGCGCCGGACGCGGCTTGCTACAAATAGTATTTGCCGTGTTAATGAATAATGACTTAAACTGGATTTCGACGTTAACTAT
AAGTAAATAGGAACATAATT

Downstream 100 bases:

>100_bases
GCCAGCGCCTGCTGGCGCTACGTTTGTCAGTGCTACAGGCGGTGCTCTTTTGTCACAAGAAGGCCTCTATCCGGAGGCCT
TCTTTTTTTTGTCTATGGAA

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MSQTVHFQDNPVTVANVIPQAGSKAQAFTLVAKDLSDVSLSQYAGKRKVLNIFPSIDTGVCAASVRKFNQLATEVENTVV
LCVSADLPFAQSRFCGAEGLSNVITLSTLRNNEFLKNYGVEIVDGPLKGLAARAVIVLDENDNVIFSQLVDEITHEPDYD
AALNVLKA

Sequences:

>Translated_168_residues
MSQTVHFQDNPVTVANVIPQAGSKAQAFTLVAKDLSDVSLSQYAGKRKVLNIFPSIDTGVCAASVRKFNQLATEVENTVV
LCVSADLPFAQSRFCGAEGLSNVITLSTLRNNEFLKNYGVEIVDGPLKGLAARAVIVLDENDNVIFSQLVDEITHEPDYD
AALNVLKA
>Mature_167_residues
SQTVHFQDNPVTVANVIPQAGSKAQAFTLVAKDLSDVSLSQYAGKRKVLNIFPSIDTGVCAASVRKFNQLATEVENTVVL
CVSADLPFAQSRFCGAEGLSNVITLSTLRNNEFLKNYGVEIVDGPLKGLAARAVIVLDENDNVIFSQLVDEITHEPDYDA
ALNVLKA

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2)

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Escherichia coli, GI1787584, Length=168, Percent_Identity=87.5, Blast_Score=304, Evalue=2e-84,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TPX_SALTI (Q8Z7A8)

Other databases:

- EMBL:   AL627270
- EMBL:   AE014613
- RefSeq:   NP_455822.1
- RefSeq:   NP_805368.1
- ProteinModelPortal:   Q8Z7A8
- SMR:   Q8Z7A8
- GeneID:   1071081
- GeneID:   1247777
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t1586
- KEGG:   sty:STY1381
- HOGENOM:   HBG493509
- OMA:   VRKFNAQ
- ProtClustDB:   PRK00522
- BioCyc:   SENT209261:T1586-MONOMER
- BioCyc:   SENT220341:STY1381-MONOMER
- HAMAP:   MF_00269
- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10681:SF3

Pfam domain/function: PF08534 Redoxin; SSF52833 Thiordxn-like_fd

EC number: 1.11.1.- [C]

Molecular weight: Translated: 18084; Mature: 17952

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS51352 THIOREDOXIN_2; PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTVHFQDNPVTVANVIPQAGSKAQAFTLVAKDLSDVSLSQYAGKRKVLNIFPSIDTGV
CCCEEECCCCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCCCHH
CAASVRKFNQLATEVENTVVLCVSADLPFAQSRFCGAEGLSNVITLSTLRNNEFLKNYGV
HHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHCCCCCCCCCEEEEEECCCCHHHHHCCC
EIVDGPLKGLAARAVIVLDENDNVIFSQLVDEITHEPDYDAALNVLKA
EEEECCHHCCEEEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SQTVHFQDNPVTVANVIPQAGSKAQAFTLVAKDLSDVSLSQYAGKRKVLNIFPSIDTGV
CCEEECCCCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCCCHH
CAASVRKFNQLATEVENTVVLCVSADLPFAQSRFCGAEGLSNVITLSTLRNNEFLKNYGV
HHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHCCCCCCCCCEEEEEECCCCHHHHHCCC
EIVDGPLKGLAARAVIVLDENDNVIFSQLVDEITHEPDYDAALNVLKA
EEEECCHHCCEEEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504