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The map label for this gene is slyA

Identifier: 29141771

GI number: 29141771

Start: 1374291

End: 1374725

Strand: Direct

Name: slyA

Synonym: t1312

Alternate gene names: 29141771

Gene position: 1374291-1374725 (Clockwise)

Preceding gene: 29141767

Following gene: 29141773

Centisome position: 28.68

GC content: 49.2

Gene sequence:

>435_bases
TTGGAATCGCCACTAGGTTCTGATCTGGCACGGTTGGTGCGCATTTGGCGTGCTCTGATTGACCATCGCCTCAAGCCTCT
GGAATTGACGCAGACACATTGGGTCACGTTGCACAATATTCATCAATTGCCGCCTGACCAGTCGCAGATTCAATTGGCTA
AAGCGATAGGCATTGAGCAGCCATCGCTGGTACGCACGTTGGATCAACTTGAAGATAAGGGGCTAATTTCGCGGCAAACC
TGCGCCAGCGATCGTCGCGCTAAGCGGATTAAACTGACCGAAAAAGCGGAGCCGCTGATCGCTGAGATGGAAGAGGTCAT
TCATAAAACGCGCGGTGAAATTTTGGCTGGGATTTCTTCAGAGGAGATTGAGCTTCTGATTAAACTTGTCGCTAAACTTG
AACACAACATTATGGAATTGCACTCTCACGATTGA

Upstream 100 bases:

>100_bases
TAAGCAAATTTAGCAATACATTTGTTTTGAGAATACAAATACTGCACACTATTCTAAAATCAGCATAATAACTTAGCAAG
CTAATTATAAGGAGGTGAAA

Downstream 100 bases:

>100_bases
GGTGCAGGGGCATACGTGTGGCCATGTGACCACACGTAAAGCCTGGTTTAGCGTGGAGAGACAGTAACCTGGCTGCCGTT
GCTGGCCAGCACGACACGCT

Product: transcriptional regulator SlyA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEDKGLISRQT
CASDRRAKRIKLTEKAEPLIAEMEEVIHKTRGEILAGISSEEIELLIKLVAKLEHNIMELHSHD

Sequences:

>Translated_144_residues
MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEDKGLISRQT
CASDRRAKRIKLTEKAEPLIAEMEEVIHKTRGEILAGISSEEIELLIKLVAKLEHNIMELHSHD
>Mature_144_residues
MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEDKGLISRQT
CASDRRAKRIKLTEKAEPLIAEMEEVIHKTRGEILAGISSEEIELLIKLVAKLEHNIMELHSHD

Specific function: Transcription regulator that either activates or represses expression of target genes. Required to activate expression of virulent genes

COG id: COG1846

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH marR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI87081950, Length=142, Percent_Identity=90.1408450704225, Blast_Score=255, Evalue=8e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SLYA_SALCH (P61090)

Other databases:

- EMBL:   AB010776
- EMBL:   AF242419
- EMBL:   AE017220
- RefSeq:   YP_216449.1
- ProteinModelPortal:   P61090
- SMR:   P61090
- GeneID:   3333918
- GenomeReviews:   AE017220_GR
- KEGG:   sec:SC1462
- HOGENOM:   HBG728159
- OMA:   DEHRFGM
- ProtClustDB:   PRK03573
- BioCyc:   SENT321314:SCH_1462-MONOMER
- GO:   GO:0005622
- GO:   GO:0009405
- HAMAP:   MF_01819
- InterPro:   IPR000835
- InterPro:   IPR023071
- InterPro:   IPR023187
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00598
- SMART:   SM00347

Pfam domain/function: PF01047 MarR

EC number: NA

Molecular weight: Translated: 16448; Mature: 16448

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS01117 HTH_MARR_1; PS50995 HTH_MARR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQ
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
PSLVRTLDQLEDKGLISRQTCASDRRAKRIKLTEKAEPLIAEMEEVIHKTRGEILAGISS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHCCCH
EEIELLIKLVAKLEHNIMELHSHD
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQ
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
PSLVRTLDQLEDKGLISRQTCASDRRAKRIKLTEKAEPLIAEMEEVIHKTRGEILAGISS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHCCCH
EEIELLIKLVAKLEHNIMELHSHD
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10385201; 11939575