| Definition | Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome. |
|---|---|
| Accession | NC_004631 |
| Length | 4,791,961 |
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The map label for this gene is ftsI [H]
Identifier: 29141517
GI number: 29141517
Start: 1124200
End: 1125945
Strand: Direct
Name: ftsI [H]
Synonym: t1042
Alternate gene names: 29141517
Gene position: 1124200-1125945 (Clockwise)
Preceding gene: 29141516
Following gene: 29141518
Centisome position: 23.46
GC content: 52.41
Gene sequence:
>1746_bases GTGAAAAAGAAAAGCGACGGCGATACCCGTAATTTTACACCCATACGTTTTGCACTACTTTGCACTGCCATTCTGCTCAG TATGGCATTGTTGTTAGGGCGGGTGGCATGGCTGCAAATTGTTACGCCGTCGAAACTGGTGAAACAAGAAGATATGCGCT CGCTTCGTGAAGTGACCACGGCCTCTCCACGCGGCATGATCACCGACAGAGAAGGGCGGCCCTTAGCGGTGAGCGTTCCG GTTAATGCTGTCTGGGCCGATCCGAAAACTATCATAAGCAAAGGCGGCGTTGGCTACAATGAGCGCTGGCAGGCGCTGGC CAGCGCCTTACATCTGTCTCTCAGTACGCTTGCGGAACGGGTAAACAGTAACCCGGCAGGTCGTTTTATCTACCTCGCGC GCCAGGTTTCACCCCAGCAAGCCGAATGGATAGATAAACTGAATCTACCGGGTATTAACCTGCGGGAAGAGTCGCGCCGT TTTTACCCTGCCGGACATGTAGCGGCCAATTTGATCGGCTTTACCAATATCGACGGGCAGGGAATAGAAGGTATTGAAAA GAGCTTTAACGCGCAACTGACGGGAAAACCGGGCTCCCGGCTGGTGCGTAAAGATAAATTTGGTCACGTTATTGAGAACA TTACGGAAGTGAATCCGGTTCCTGCTCATGAACTTCAGCTTAGCATTGATGAACGTCTGCAAACGGTTACCGAAGATGCG CTGGATAACGCCGTCATCTGGAACAAAGCGGAATCCGGCGCTGCCGTATTGATTAACATCCCAACGGGTGAAATTCTCTC GATGGCGAGCTACCCGGATTTCAACCCGAACAACCGTGAAGGCGCGCAGTTGGACGATTTTCGTAACCGCGCGATTAGCG ACACTTTCGAACCCGGTTCTACTGTGAAGCCATTGGTCATTATGACTGCGTTACAGCAGGGTATCGTGCAACCGGACAGC GTTATCGATACCCATCCTTTTACTCTCGATGGACACCGTATCCGCGACGTCGGCTACTATCCGGAACTGACATTAACCGG CATTTTGCAAAAATCCAGCGATACCGGCGTTTCTCACCTTTCTCTGGCGATGCCGGTGCAGAAATTAATGGATACTTATA AAAGCTTTGGTTTCGGCGTGCCTACCGGACTGGGTCTCACCGGAGAGAGCAGCGGGTTATTACCGAAACGCCGTTACTGG AGTGATTTAGATCGCGCTACCTTCGCTTTTGGCTATGGATTAATGGTGACGCCGCTGCAACTGGCGCATGTTTATGCCAC GATTGGCAGCTTTGGTATCTACCGTCCGTTATCGATCACCAAAGTTGATCCGCCCGTGATCGGCACGCGAGTAATGCCGG AAGAACTGGTGCACGAGGTGGAACATATGATGGAGAGCGTCGCGTTGCCTGGCGGCGGCGGAACAAAAGCCGCAGTAAGA GACTACCGTATTGCGGTCAAAACCGGGACGGCGAAAAAAATTGGCGATGATGGTAAATACGTTGATAAGTATGTGGCATA TACCGCAGGCGTCGCGCCGGCAAGTAACCCCAGATTTGCGCTGGTGGTGGTGATTAATAATCCACAAAATGGGGCTTATT ATGGCGGTGCGGTATCTGCGCCCGTATTCAGCCAGATCATGGGCGATGTACTGCGGCTGGAAAATGTTGAGCCAGACGGT ATGCCAGCCGATTCAGATCACCTTCTGGTGATGCATGGCAGCCACGTTGCGGTTCCGGGCTCGTAA
Upstream 100 bases:
>100_bases TTGTTGCAAAGGCGCGATGTTATTAGCATTGTTTTTTCTGGTTTTTCCGGCCGTTTCCCGTTAAATCAATCACCTGAAAA ATGATTCGGCTGGAGATCAG
Downstream 100 bases:
>100_bases AGGATTTTCCCGGGGCGCAATTCGCGTTACACTTGCGCCCTTTAGCGCCCCAGTCCGGAGTTGTCATGTCGTTTACCTGT CCGCTTTGCCATCAACCGCT
Product: penicillin-binding protein
Products: NA
Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]
Number of amino acids: Translated: 581; Mature: 581
Protein sequence:
>581_residues MKKKSDGDTRNFTPIRFALLCTAILLSMALLLGRVAWLQIVTPSKLVKQEDMRSLREVTTASPRGMITDREGRPLAVSVP VNAVWADPKTIISKGGVGYNERWQALASALHLSLSTLAERVNSNPAGRFIYLARQVSPQQAEWIDKLNLPGINLREESRR FYPAGHVAANLIGFTNIDGQGIEGIEKSFNAQLTGKPGSRLVRKDKFGHVIENITEVNPVPAHELQLSIDERLQTVTEDA LDNAVIWNKAESGAAVLINIPTGEILSMASYPDFNPNNREGAQLDDFRNRAISDTFEPGSTVKPLVIMTALQQGIVQPDS VIDTHPFTLDGHRIRDVGYYPELTLTGILQKSSDTGVSHLSLAMPVQKLMDTYKSFGFGVPTGLGLTGESSGLLPKRRYW SDLDRATFAFGYGLMVTPLQLAHVYATIGSFGIYRPLSITKVDPPVIGTRVMPEELVHEVEHMMESVALPGGGGTKAAVR DYRIAVKTGTAKKIGDDGKYVDKYVAYTAGVAPASNPRFALVVVINNPQNGAYYGGAVSAPVFSQIMGDVLRLENVEPDG MPADSDHLLVMHGSHVAVPGS
Sequences:
>Translated_581_residues MKKKSDGDTRNFTPIRFALLCTAILLSMALLLGRVAWLQIVTPSKLVKQEDMRSLREVTTASPRGMITDREGRPLAVSVP VNAVWADPKTIISKGGVGYNERWQALASALHLSLSTLAERVNSNPAGRFIYLARQVSPQQAEWIDKLNLPGINLREESRR FYPAGHVAANLIGFTNIDGQGIEGIEKSFNAQLTGKPGSRLVRKDKFGHVIENITEVNPVPAHELQLSIDERLQTVTEDA LDNAVIWNKAESGAAVLINIPTGEILSMASYPDFNPNNREGAQLDDFRNRAISDTFEPGSTVKPLVIMTALQQGIVQPDS VIDTHPFTLDGHRIRDVGYYPELTLTGILQKSSDTGVSHLSLAMPVQKLMDTYKSFGFGVPTGLGLTGESSGLLPKRRYW SDLDRATFAFGYGLMVTPLQLAHVYATIGSFGIYRPLSITKVDPPVIGTRVMPEELVHEVEHMMESVALPGGGGTKAAVR DYRIAVKTGTAKKIGDDGKYVDKYVAYTAGVAPASNPRFALVVVINNPQNGAYYGGAVSAPVFSQIMGDVLRLENVEPDG MPADSDHLLVMHGSHVAVPGS >Mature_581_residues MKKKSDGDTRNFTPIRFALLCTAILLSMALLLGRVAWLQIVTPSKLVKQEDMRSLREVTTASPRGMITDREGRPLAVSVP VNAVWADPKTIISKGGVGYNERWQALASALHLSLSTLAERVNSNPAGRFIYLARQVSPQQAEWIDKLNLPGINLREESRR FYPAGHVAANLIGFTNIDGQGIEGIEKSFNAQLTGKPGSRLVRKDKFGHVIENITEVNPVPAHELQLSIDERLQTVTEDA LDNAVIWNKAESGAAVLINIPTGEILSMASYPDFNPNNREGAQLDDFRNRAISDTFEPGSTVKPLVIMTALQQGIVQPDS VIDTHPFTLDGHRIRDVGYYPELTLTGILQKSSDTGVSHLSLAMPVQKLMDTYKSFGFGVPTGLGLTGESSGLLPKRRYW SDLDRATFAFGYGLMVTPLQLAHVYATIGSFGIYRPLSITKVDPPVIGTRVMPEELVHEVEHMMESVALPGGGGTKAAVR DYRIAVKTGTAKKIGDDGKYVDKYVAYTAGVAPASNPRFALVVVINNPQNGAYYGGAVSAPVFSQIMGDVLRLENVEPDG MPADSDHLLVMHGSHVAVPGS
Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]
COG id: COG0768
COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2
Gene ontology:
Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1786272, Length=573, Percent_Identity=63.6998254799302, Blast_Score=771, Evalue=0.0, Organism=Escherichia coli, GI1786854, Length=620, Percent_Identity=26.6129032258064, Blast_Score=137, Evalue=2e-33,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR005311 - InterPro: IPR001460 [H]
Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]
EC number: =2.4.1.129 [H]
Molecular weight: Translated: 63092; Mature: 63092
Theoretical pI: Translated: 7.02; Mature: 7.02
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKKSDGDTRNFTPIRFALLCTAILLSMALLLGRVAWLQIVTPSKLVKQEDMRSLREVTT CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHC ASPRGMITDREGRPLAVSVPVNAVWADPKTIISKGGVGYNERWQALASALHLSLSTLAER CCCCCCEECCCCCCEEEECCCCEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH VNSNPAGRFIYLARQVSPQQAEWIDKLNLPGINLREESRRFYPAGHVAANLIGFTNIDGQ HCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHEEECCCCC GIEGIEKSFNAQLTGKPGSRLVRKDKFGHVIENITEVNPVPAHELQLSIDERLQTVTEDA CCHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEHHHHHHHHHHHH LDNAVIWNKAESGAAVLINIPTGEILSMASYPDFNPNNREGAQLDDFRNRAISDTFEPGS HCCCEEEECCCCCCEEEEECCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC TVKPLVIMTALQQGIVQPDSVIDTHPFTLDGHRIRDVGYYPELTLTGILQKSSDTGVSHL CCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEECCCCCCEEEEEEEECCCCCCCHHH SLAMPVQKLMDTYKSFGFGVPTGLGLTGESSGLLPKRRYWSDLDRATFAFGYGLMVTPLQ HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH LAHVYATIGSFGIYRPLSITKVDPPVIGTRVMPEELVHEVEHMMESVALPGGGGTKAAVR HHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHE DYRIAVKTGTAKKIGDDGKYVDKYVAYTAGVAPASNPRFALVVVINNPQNGAYYGGAVSA EEEEEEECCCCHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCEECCCCCH PVFSQIMGDVLRLENVEPDGMPADSDHLLVMHGSHVAVPGS HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCEEECCCC >Mature Secondary Structure MKKKSDGDTRNFTPIRFALLCTAILLSMALLLGRVAWLQIVTPSKLVKQEDMRSLREVTT CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHC ASPRGMITDREGRPLAVSVPVNAVWADPKTIISKGGVGYNERWQALASALHLSLSTLAER CCCCCCEECCCCCCEEEECCCCEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH VNSNPAGRFIYLARQVSPQQAEWIDKLNLPGINLREESRRFYPAGHVAANLIGFTNIDGQ HCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHEEECCCCC GIEGIEKSFNAQLTGKPGSRLVRKDKFGHVIENITEVNPVPAHELQLSIDERLQTVTEDA CCHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEHHHHHHHHHHHH LDNAVIWNKAESGAAVLINIPTGEILSMASYPDFNPNNREGAQLDDFRNRAISDTFEPGS HCCCEEEECCCCCCEEEEECCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC TVKPLVIMTALQQGIVQPDSVIDTHPFTLDGHRIRDVGYYPELTLTGILQKSSDTGVSHL CCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEECCCCCCEEEEEEEECCCCCCCHHH SLAMPVQKLMDTYKSFGFGVPTGLGLTGESSGLLPKRRYWSDLDRATFAFGYGLMVTPLQ HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH LAHVYATIGSFGIYRPLSITKVDPPVIGTRVMPEELVHEVEHMMESVALPGGGGTKAAVR HHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHE DYRIAVKTGTAKKIGDDGKYVDKYVAYTAGVAPASNPRFALVVVINNPQNGAYYGGAVSA EEEEEEECCCCHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCEECCCCCH PVFSQIMGDVLRLENVEPDGMPADSDHLLVMHGSHVAVPGS HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCEEECCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]