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The map label for this gene is pphA [H]

Identifier: 29141501

GI number: 29141501

Start: 1108195

End: 1108845

Strand: Direct

Name: pphA [H]

Synonym: t1025

Alternate gene names: 29141501

Gene position: 1108195-1108845 (Clockwise)

Preceding gene: 29141500

Following gene: 29141507

Centisome position: 23.13

GC content: 52.38

Gene sequence:

>651_bases
ATGATGCGGCCTGAAGAGATTTATCAGCGAATAGAGGCAAAGAATTGGCGGCATGTCTGGGTGGTCGGCGATATTCACGG
CTGTTTTTCAATGTTAATGAAAAGGTTACGTGAGTGTCAATTTGATCCGCAACAAGACTTGTTAGTTTCTGTGGGCGATC
TCATTGATAGAGGCCCGGACAGCCTGGGTTGCCTGGCTTTACTGCGTGAGTCCTGGATGACGGCGGTTCGCGGCAATCAT
GAACAAATGGCGCTGGATGCGCGGGCCTCATCGCAGTCGACGCTGTGGTTGATGAATGGTGGCGACTGGTTTACCCGCCT
GACGGCTGAACACGCTGCGCAAGCTGAAGCGCTTTTTATTCTTTGTCAGCGGCTGCCCTGGATACTGGAAGTTCGCTGCC
GCCATAGCACGCATGTGATCGCTCATGCAGATTATCCAGCGTCAACCTATCAATGGCAAAAAAAGGTCGACTTACATCAG
GTTCTCTGGAGCCGCGAACGGCTCATAAATAAGCGCGGCGGGATTAGCGGAGCCGATCATTTTTGGTTTGGCCATACGCC
GTTGCGTCGGCGCATGGATTTCGCCAACATACACTATATTGATACGGGCGCGGTATTTGGCGGGCAATTGACGTTAGCGC
GGATACAATAG

Upstream 100 bases:

>100_bases
ATGAAATTCGCTATTTACAACAGAGCACGTTTACTAAGCAAGAAAATCTGCACACGCTATCTTTTTATATCTATCTTGGA
TAATGAACGACAGGAAAAAC

Downstream 100 bases:

>100_bases
CGGCATCAGCGACTAGGGTTAAAAATCGCTATATTGCTGCGCAGGTCGCCAGAAGCCGTCGATAAAATCCTCTACCGGAA
AACAGCCGCCATGGCGAATC

Product: serine/threonine protein phosphatase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECQFDPQQDLLVSVGDLIDRGPDSLGCLALLRESWMTAVRGNH
EQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFILCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQ
VLWSRERLINKRGGISGADHFWFGHTPLRRRMDFANIHYIDTGAVFGGQLTLARIQ

Sequences:

>Translated_216_residues
MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECQFDPQQDLLVSVGDLIDRGPDSLGCLALLRESWMTAVRGNH
EQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFILCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQ
VLWSRERLINKRGGISGADHFWFGHTPLRRRMDFANIHYIDTGAVFGGQLTLARIQ
>Mature_216_residues
MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECQFDPQQDLLVSVGDLIDRGPDSLGCLALLRESWMTAVRGNH
EQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFILCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQ
VLWSRERLINKRGGISGADHFWFGHTPLRRRMDFANIHYIDTGAVFGGQLTLARIQ

Specific function: Can hydrolyze phosphorylated Ser-, Thr- or Tyr- substrates in vitro. The natural substrate is unknown [H]

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081988, Length=218, Percent_Identity=62.3853211009174, Blast_Score=288, Evalue=2e-79,
Organism=Escherichia coli, GI1789090, Length=217, Percent_Identity=43.778801843318, Blast_Score=192, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR006186 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 25023; Mature: 25023

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00125 SER_THR_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECQFDPQQDLLVSVGDLIDRGPD
CCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
SLGCLALLRESWMTAVRGNHEQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFI
HHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
LCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQVLWSRERLINKRGGISGADH
HHHHCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FWFGHTPLRRRMDFANIHYIDTGAVFGGQLTLARIQ
EEECCCHHHHCCCCCCEEEEECCCEECCEEEEEEEC
>Mature Secondary Structure
MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECQFDPQQDLLVSVGDLIDRGPD
CCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
SLGCLALLRESWMTAVRGNHEQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFI
HHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
LCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQVLWSRERLINKRGGISGADH
HHHHCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FWFGHTPLRRRMDFANIHYIDTGAVFGGQLTLARIQ
EEECCCHHHHCCCCCCEEEEECCCEECCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11717262; 11677609 [H]