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The map label for this gene is cutC

Identifier: 29141451

GI number: 29141451

Start: 1059750

End: 1060529

Strand: Direct

Name: cutC

Synonym: t0970

Alternate gene names: 29141451

Gene position: 1059750-1060529 (Clockwise)

Preceding gene: 29141450

Following gene: 29141457

Centisome position: 22.12

GC content: 53.72

Gene sequence:

>780_bases
ATGGCGTTACTTGAGATCTGTTGTTACAGCATGGAATGCGCGCTCACCGCGCAGCGAAACGGCGCGGATCGTATCGAACT
GTGCGCCGCGCCGAAAGAAGGGGGGCTTACGCCTTCTTTCGGCATCTTACGCAGCGTACGCGAGCATATTACGATTCCCG
TACATCCGATTATTCGTCCTCGCGGCGGAGATTTTTACTACACTGACGGCGAATTTGCCGCCATGCTGGAAGATATCCGT
CTCGTCAGAGAGTTGGGGTTTCCCGGGCTGGTTACTGGCGTGTTGACCGTTGATGGGGATGTCGATATGTCGCGAATGGA
AAAAATAATGGCGGCGGCCGGGCCGCTGGCGGTGACATTCCACCGCGCCTTCGATATGTGCGCTAATCCCTTCAATGCGC
TAAAGAATCTGGCTGACGCAGGCGTAGCAAGAGTACTGACTTCCGGGCAAAAAGCCGATGCGGCGCAAGGTTTATCAATA
ATTATGGAACTTATTGCCCAGGGGGATGCTCCAATCATTATGGCTGGTGCGGGGGTTCGTGCAAATAACCTGCAGAATTT
CCTCGATGCCGGAGTACGGGAAGTACACAGTTCCGCCGGAGTCTTACTGCCTTCGCCGATGCGCTATCGCAATCAGGGGT
TATCGATGTCTGCCGATATACAGGCGGACGAGTATTCTCGCTATAGGGTAGAGGGTGCGGCGGTCGCTGAGAATGAAAGG
AATCATTGTTCGCCATCAGGCCAAATGATTTTTACCGTTGCATCATGTCGCCCAATATGA

Upstream 100 bases:

>100_bases
GTGACCGATGGCCGCGTCACGGTAAAATTTCATCCATGGTCGATTGAAGCGATTGTCGCCAGCGAACAGGCGGCCCATTA
ACCTGCCGAGCGGAGTGAAT

Downstream 100 bases:

>100_bases
TGCTTGCTCGTACCAGGCCCCTGCCAATTCAACAGGGGCCTTTTTTTCTCCTTCATATTTCAAGCCGCAGCAGCGTTGGC
CGCCTCGCGCACCCCGGTCA

Product: copper homeostasis protein CutC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MALLEICCYSMECALTAQRNGADRIELCAAPKEGGLTPSFGILRSVREHITIPVHPIIRPRGGDFYYTDGEFAAMLEDIR
LVRELGFPGLVTGVLTVDGDVDMSRMEKIMAAAGPLAVTFHRAFDMCANPFNALKNLADAGVARVLTSGQKADAAQGLSI
IMELIAQGDAPIIMAGAGVRANNLQNFLDAGVREVHSSAGVLLPSPMRYRNQGLSMSADIQADEYSRYRVEGAAVAENER
NHCSPSGQMIFTVASCRPI

Sequences:

>Translated_259_residues
MALLEICCYSMECALTAQRNGADRIELCAAPKEGGLTPSFGILRSVREHITIPVHPIIRPRGGDFYYTDGEFAAMLEDIR
LVRELGFPGLVTGVLTVDGDVDMSRMEKIMAAAGPLAVTFHRAFDMCANPFNALKNLADAGVARVLTSGQKADAAQGLSI
IMELIAQGDAPIIMAGAGVRANNLQNFLDAGVREVHSSAGVLLPSPMRYRNQGLSMSADIQADEYSRYRVEGAAVAENER
NHCSPSGQMIFTVASCRPI
>Mature_258_residues
ALLEICCYSMECALTAQRNGADRIELCAAPKEGGLTPSFGILRSVREHITIPVHPIIRPRGGDFYYTDGEFAAMLEDIRL
VRELGFPGLVTGVLTVDGDVDMSRMEKIMAAAGPLAVTFHRAFDMCANPFNALKNLADAGVARVLTSGQKADAAQGLSII
MELIAQGDAPIIMAGAGVRANNLQNFLDAGVREVHSSAGVLLPSPMRYRNQGLSMSADIQADEYSRYRVEGAAVAENERN
HCSPSGQMIFTVASCRPI

Specific function: Involved in copper homeostasis

COG id: COG3142

COG function: function code P; Uncharacterized protein involved in copper resistance

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CutC family

Homologues:

Organism=Homo sapiens, GI148596990, Length=226, Percent_Identity=47.3451327433628, Blast_Score=199, Evalue=3e-51,
Organism=Escherichia coli, GI87081995, Length=237, Percent_Identity=82.7004219409283, Blast_Score=403, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17556905, Length=201, Percent_Identity=38.8059701492537, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21355415, Length=201, Percent_Identity=40.7960199004975, Blast_Score=146, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CUTC_SALTI (Q8Z5V9)

Other databases:

- EMBL:   AL627272
- EMBL:   AE014613
- RefSeq:   NP_456474.1
- RefSeq:   NP_804793.1
- ProteinModelPortal:   Q8Z5V9
- SMR:   Q8Z5V9
- GeneID:   1070276
- GeneID:   1248458
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t0970
- KEGG:   sty:STY2115
- HOGENOM:   HBG535337
- OMA:   PVYAMIR
- ProtClustDB:   PRK11572
- BioCyc:   SENT209261:T0970-MONOMER
- BioCyc:   SENT220341:STY2115-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00795
- InterPro:   IPR005627
- Gene3D:   G3DSA:3.20.20.380
- PANTHER:   PTHR12598

Pfam domain/function: PF03932 CutC; SSF110395 CutC

EC number: NA

Molecular weight: Translated: 27804; Mature: 27673

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLEICCYSMECALTAQRNGADRIELCAAPKEGGLTPSFGILRSVREHITIPVHPIIRP
CHHHHHHHHHHHHEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEEECC
RGGDFYYTDGEFAAMLEDIRLVRELGFPGLVTGVLTVDGDVDMSRMEKIMAAAGPLAVTF
CCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCHHHHH
HRAFDMCANPFNALKNLADAGVARVLTSGQKADAAQGLSIIMELIAQGDAPIIMAGAGVR
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCC
ANNLQNFLDAGVREVHSSAGVLLPSPMRYRNQGLSMSADIQADEYSRYRVEGAAVAENER
HHHHHHHHHHHHHHHHHCCCEECCCCHHHHHCCCCEEECCCCCCCHHEEECCCEECCCCC
NHCSPSGQMIFTVASCRPI
CCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
ALLEICCYSMECALTAQRNGADRIELCAAPKEGGLTPSFGILRSVREHITIPVHPIIRP
HHHHHHHHHHHHEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEEECC
RGGDFYYTDGEFAAMLEDIRLVRELGFPGLVTGVLTVDGDVDMSRMEKIMAAAGPLAVTF
CCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCHHHHH
HRAFDMCANPFNALKNLADAGVARVLTSGQKADAAQGLSIIMELIAQGDAPIIMAGAGVR
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCC
ANNLQNFLDAGVREVHSSAGVLLPSPMRYRNQGLSMSADIQADEYSRYRVEGAAVAENER
HHHHHHHHHHHHHHHHHCCCEECCCCHHHHHCCCCEEECCCCCCCHHEEECCCEECCCCC
NHCSPSGQMIFTVASCRPI
CCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504