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The map label for this gene is tyrP [H]

Identifier: 29141424

GI number: 29141424

Start: 1030643

End: 1031854

Strand: Reverse

Name: tyrP [H]

Synonym: t0941

Alternate gene names: 29141424

Gene position: 1031854-1030643 (Counterclockwise)

Preceding gene: 29141426

Following gene: 29141414

Centisome position: 21.53

GC content: 55.78

Gene sequence:

>1212_bases
GTGAAAAACAGAACTCTGGGCAGTATTTTTATCGTGGCAGGCACCACTATCGGCGCCGGGATGCTGGCAATGCCGCTGGC
AGCGGCTGGCGTTGGTTTCAGCGTCACGCTGGGATTGTTGATTGGTCTGTGGGCGCTGATGTGTTATACCGCGCTACTAT
TACTGGAAGTATATCAACATGTTCCGGCGGATACCGGGCTGGGCTCGTTGGCAAAACGCTATCTTGGACGTTACGGACAG
TGGCTTACGGGATTCAGCATGATGTTCTTAATGTATGCGCTCACCGCCGCCTACATTTCCGGAGCCGGAGAATTACTGGC
ATCCAGTATTAATAACTGGCTTGGCGCCACGCTCTCGCCCGCTGCCGGGGTGCTGCTGTTCACCTTTGTTGCCGGTGGGG
TGGTGTGTGTGGGCACCTCGCTGGTCGACCTTTTTAACCGCTTCCTGTTTAGCGCGAAGATCATTTTTCTGGTCATCATG
CTTGCGTTGCTCACGCCACATATTCATAAAGTAAATCTTCTTACGCTTCCTTTACAGCAGGGGCTGGCATTGTCCGCCAT
ACCGGTCATTTTCACCTCGTTTGGTTTTCACGGAAGCGTACCGAGTATTGTGAGTTATATGAACGGCAACATTCGCCGGC
TGCGTTGGGTCTTTATGACGGGTAGCGCCATTCCGCTAGTGGCCTATATTTTTTGGCAGCTCGCCACGCTGGGAAGTATC
GACTCGCCGACATTCAGAGGGCTACTGGCCAGCCATGCCGGGTTAAATGGCCTGCTGCAGGCGCTCAGAGAAGTGGTCGC
TTCGCCACATGTCGAACTGGCGGTCCACCTGTTCGCCGATCTGGCGCTGGCGACCTCTTTTCTGGGCGTAGCGCTAGGAT
TATTTGATTACCTGGCCGATCTATTCCAGCGCCGCAGTACGGTGTCCGGACGCCTGCAAACCGGGCTGATTACCTTTCTG
CCGCCGCTGGCGTTTGCGCTTTTCTACCCACGTGGATTTGTGATGGCATTAGGCTATGCCGGCGTAGCGCTGGCAGTGCT
GGCACTACTCATCCCTGCCATGCTGGTCTGGCAATGCCGTAAACAGAGCCCTCAGGCGGGATATCGTGTGGCAGGCGGCA
CGCCAGCGCTGGCGCTGGTGTTTATCTGCGGCATTGTCGTGATTGGCGTCCAGTTTTCGATCGCACTGGGGTTCCTGCCC
GATCCAGGTTAA

Upstream 100 bases:

>100_bases
TCCAGTACACCTATTGTAACGACCATTTGACGAAAATAGCGTAATGCCTTACCCTGCGCCGCGGATATCACCGTTCTTTG
TTACCGGGGTAGTAGAAAGC

Downstream 100 bases:

>100_bases
CGCCAGGCAAAGATTACCGGGCCCGGACGCCGTCCAGGCTCGATAATCATCACGCTATGGCCGTTTACGAGCCATTAATG
CAGGCAGCACTGCTTAAATT

Product: tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFSVTLGLLIGLWALMCYTALLLLEVYQHVPADTGLGSLAKRYLGRYGQ
WLTGFSMMFLMYALTAAYISGAGELLASSINNWLGATLSPAAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVIM
LALLTPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMNGNIRRLRWVFMTGSAIPLVAYIFWQLATLGSI
DSPTFRGLLASHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVALGLFDYLADLFQRRSTVSGRLQTGLITFL
PPLAFALFYPRGFVMALGYAGVALAVLALLIPAMLVWQCRKQSPQAGYRVAGGTPALALVFICGIVVIGVQFSIALGFLP
DPG

Sequences:

>Translated_403_residues
MKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFSVTLGLLIGLWALMCYTALLLLEVYQHVPADTGLGSLAKRYLGRYGQ
WLTGFSMMFLMYALTAAYISGAGELLASSINNWLGATLSPAAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVIM
LALLTPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMNGNIRRLRWVFMTGSAIPLVAYIFWQLATLGSI
DSPTFRGLLASHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVALGLFDYLADLFQRRSTVSGRLQTGLITFL
PPLAFALFYPRGFVMALGYAGVALAVLALLIPAMLVWQCRKQSPQAGYRVAGGTPALALVFICGIVVIGVQFSIALGFLP
DPG
>Mature_403_residues
MKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFSVTLGLLIGLWALMCYTALLLLEVYQHVPADTGLGSLAKRYLGRYGQ
WLTGFSMMFLMYALTAAYISGAGELLASSINNWLGATLSPAAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVIM
LALLTPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMNGNIRRLRWVFMTGSAIPLVAYIFWQLATLGSI
DSPTFRGLLASHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVALGLFDYLADLFQRRSTVSGRLQTGLITFL
PPLAFALFYPRGFVMALGYAGVALAVLALLIPAMLVWQCRKQSPQAGYRVAGGTPALALVFICGIVVIGVQFSIALGFLP
DPG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=88.833746898263, Blast_Score=695, Evalue=0.0,
Organism=Escherichia coli, GI1790145, Length=410, Percent_Identity=32.4390243902439, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1789552, Length=369, Percent_Identity=33.0623306233062, Blast_Score=197, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42765; Mature: 42765

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFSVTLGLLIGLWALMCYTALLLLEVYQH
CCCCCEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPADTGLGSLAKRYLGRYGQWLTGFSMMFLMYALTAAYISGAGELLASSINNWLGATLSP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVIMLALLTPHIHKVNLLTLPLQQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHC
GLALSAIPVIFTSFGFHGSVPSIVSYMNGNIRRLRWVFMTGSAIPLVAYIFWQLATLGSI
CCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCC
DSPTFRGLLASHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVALGLFDYLAD
CCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFQRRSTVSGRLQTGLITFLPPLAFALFYPRGFVMALGYAGVALAVLALLIPAMLVWQCR
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQSPQAGYRVAGGTPALALVFICGIVVIGVQFSIALGFLPDPG
CCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFSVTLGLLIGLWALMCYTALLLLEVYQH
CCCCCEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPADTGLGSLAKRYLGRYGQWLTGFSMMFLMYALTAAYISGAGELLASSINNWLGATLSP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVIMLALLTPHIHKVNLLTLPLQQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHC
GLALSAIPVIFTSFGFHGSVPSIVSYMNGNIRRLRWVFMTGSAIPLVAYIFWQLATLGSI
CCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCC
DSPTFRGLLASHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVALGLFDYLAD
CCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFQRRSTVSGRLQTGLITFLPPLAFALFYPRGFVMALGYAGVALAVLALLIPAMLVWQCR
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQSPQAGYRVAGGTPALALVFICGIVVIGVQFSIALGFLPDPG
CCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]