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The map label for this gene is sirA [H]

Identifier: 29141415

GI number: 29141415

Start: 1023352

End: 1024008

Strand: Direct

Name: sirA [H]

Synonym: t0929

Alternate gene names: 29141415

Gene position: 1023352-1024008 (Clockwise)

Preceding gene: 29141412

Following gene: 29141416

Centisome position: 21.36

GC content: 51.29

Gene sequence:

>657_bases
TTGATCAACGTTCTTCTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTTGAAGATATAAAGGGCAT
TAAAGTTGTCGGTGAAGCGTGCTGCGGAGAGGATGCGGTAAAATGGTGCCGTACTAACGCCGTTGACGTCGTGCTGATGG
ATATGAACATGCCCGGTATTGGCGGCCTTGAGGCGACGCGTAAAATTGCCCGATCGACAGCGGATATCAAAGTGATCATG
CTGACCGTCCATACGGAGAACCCGTTGCCCGCCAAAGTGATGCAGGCTGGCGCAGCTGGCTATCTCAGCAAAGGCGCTGC
GCCTCAGGAGGTGGTGAGCGCTATTCGTTCGGTGTATTCCGGACAACGTTATATCGCCTCCGATATCGCTCAACAGATGG
CGCTCAGTCAGATTGAGCCTGCAAAAACGGAAACGCCGTTCGCCAGTTTGTCTGAACGCGAGTTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATTTCAGAACAGCTGAATCTCAGTCCTAAAACGGTGAACAGCTATCGCTATCG
TATGTTCAGTAAATTAAACATTCATGGTGATGTTGAGCTGACTCACCTGGCAATCCGCCATGGCCTGTGTAATGCGGAGA
CGTTAACAAGCCAGTGA

Upstream 100 bases:

>100_bases
AATACCCGGTGTTTTTTTACGTTTCAAAGTTGAGATAAAACCAGCTAATATAAGGGCGATTAACTATCAGTAGCGTTATC
CCTATTCTGGAGATATTCCT

Downstream 100 bases:

>100_bases
GTGAAATATTTGACGCAAAGGCGTTCCTGAAAACCGTTACCAGCCAACCCGGTGTCTATCGTATGTATGACGCCGGCGGT
ACGGTTATCTATGTTGGTAA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKIARSTADIKVIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPAKTETPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLTSQ

Sequences:

>Translated_218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKIARSTADIKVIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPAKTETPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLTSQ
>Mature_218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKIARSTADIKVIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPAKTETPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLTSQ

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=218, Percent_Identity=96.7889908256881, Blast_Score=440, Evalue=1e-125,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=36, Blast_Score=123, Evalue=7e-30,
Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=32.5242718446602, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=27.8048780487805, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788712, Length=207, Percent_Identity=27.0531400966184, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1787473, Length=184, Percent_Identity=29.3478260869565, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=25.9803921568627, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23906; Mature: 23906

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEECCCCCC
GGLEATRKIARSTADIKVIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYS
CCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHC
GQRYIASDIAQQMALSQIEPAKTETPFASLSERELQIMLMITKGQKVNEISEQLNLSPKT
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCCH
VNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLTSQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEECCCCCC
GGLEATRKIARSTADIKVIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYS
CCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHC
GQRYIASDIAQQMALSQIEPAKTETPFASLSERELQIMLMITKGQKVNEISEQLNLSPKT
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCCH
VNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLTSQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]