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The map label for this gene is pdxK

Identifier: 29140949

GI number: 29140949

Start: 495473

End: 496339

Strand: Direct

Name: pdxK

Synonym: t0423

Alternate gene names: 29140949

Gene position: 495473-496339 (Clockwise)

Preceding gene: 29140945

Following gene: 29140950

Centisome position: 10.34

GC content: 56.75

Gene sequence:

>867_bases
ATGGGACAAGAGAGTGATATTCAGTCAGTGCTCTTCGACGACAACCATCGGGCGTTACAGACCGATATCGTCGCCGTCCA
GTCACAGGTTGTGTACGGCAGCGTAGGCAACAGTATCGCTGTTCCGGCCATTAAAGCGCAGGGATTACGCGTGACGGCGG
TCCCGACGGTGTTGTTCAGCAATACGCCGCACTATAAAACGTTTTATGGCGGCATTATTCCCGCCGAGTGGTTTGCAGGC
TACCTTACGGCGTTGAATGAGCGCGATGCGCTACGTGAATTAAAAGCGATTACCACCGGTTACATGGGCAGCGCAGACCA
AATTGTCTTGCTTTCGAAGTGGCTAATGGCGATCCGGGCTTCGCATCCGGAGGTGTGTATTCTTGTTGATCCCGTCATTG
GCGATACCGACAGTGGAATGTATGTGCAGGCGGAAATTCCGCAGGCTTATCGCACACATTTGTTGCCGCAGGCGCAGGGG
CTAACGCCGAACGTATTTGAGCTGGAGATGCTGAGTGGTAAACCGTGTCGCACGCTGGAAGAGGCGGTGGCGGCGGCGCA
ATCGCTGCTTTCCGATACGCTGAAATGGGTGGTTATCACCAGCGCGCCGGGCGAATCTCTGGAGACCATAACGGTTGCCG
TCGTTACCGCGCAGGTCGTGGAGGTCTTTGCCCATCCGCGGGTGGCGACGGAGTTAAAAGGGACGGGAGATCTCTTCTGC
GCCGAGCTGGTCAGCGGTATTGTGCAGGGAAAAAAACTGACGACCGCGGCAAAAGATGCGGCGCAGCGCGTGCTGGAGGT
GATGACCTGGACACAGCAGTGTGGCTGTGATGAGTTAATTCTGCCGCCGGCAGGGGAGGCGCGATGA

Upstream 100 bases:

>100_bases
GGTTTTTCCGTCGATCATTATTGACCTATGACAAAATGAATTTTAGCATATGACAATGATAATGAGGCGGTAGCCTGCTG
TCCAGCGAGAGGAAAATTTT

Downstream 100 bases:

>100_bases
AGAGTTATCGGCTGGTGGTTCGCCAGCAGGGGCGTATCGTGGGGCATTTTGAAACGAGCGGGCTGGACGCGCTGGAAGAT
ATCTGCGTGGCGCGAGCGAT

Product: pyridoxal kinase

Products: NA

Alternate protein names: PN/PL/PM kinase; Pyridoxal kinase; Pyridoxamine kinase; Vitamin B6 kinase

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MGQESDIQSVLFDDNHRALQTDIVAVQSQVVYGSVGNSIAVPAIKAQGLRVTAVPTVLFSNTPHYKTFYGGIIPAEWFAG
YLTALNERDALRELKAITTGYMGSADQIVLLSKWLMAIRASHPEVCILVDPVIGDTDSGMYVQAEIPQAYRTHLLPQAQG
LTPNVFELEMLSGKPCRTLEEAVAAAQSLLSDTLKWVVITSAPGESLETITVAVVTAQVVEVFAHPRVATELKGTGDLFC
AELVSGIVQGKKLTTAAKDAAQRVLEVMTWTQQCGCDELILPPAGEAR

Sequences:

>Translated_288_residues
MGQESDIQSVLFDDNHRALQTDIVAVQSQVVYGSVGNSIAVPAIKAQGLRVTAVPTVLFSNTPHYKTFYGGIIPAEWFAG
YLTALNERDALRELKAITTGYMGSADQIVLLSKWLMAIRASHPEVCILVDPVIGDTDSGMYVQAEIPQAYRTHLLPQAQG
LTPNVFELEMLSGKPCRTLEEAVAAAQSLLSDTLKWVVITSAPGESLETITVAVVTAQVVEVFAHPRVATELKGTGDLFC
AELVSGIVQGKKLTTAAKDAAQRVLEVMTWTQQCGCDELILPPAGEAR
>Mature_287_residues
GQESDIQSVLFDDNHRALQTDIVAVQSQVVYGSVGNSIAVPAIKAQGLRVTAVPTVLFSNTPHYKTFYGGIIPAEWFAGY
LTALNERDALRELKAITTGYMGSADQIVLLSKWLMAIRASHPEVCILVDPVIGDTDSGMYVQAEIPQAYRTHLLPQAQGL
TPNVFELEMLSGKPCRTLEEAVAAAQSLLSDTLKWVVITSAPGESLETITVAVVTAQVVEVFAHPRVATELKGTGDLFCA
ELVSGIVQGKKLTTAAKDAAQRVLEVMTWTQQCGCDELILPPAGEAR

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family

Homologues:

Organism=Homo sapiens, GI4505701, Length=270, Percent_Identity=26.2962962962963, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1788758, Length=279, Percent_Identity=67.741935483871, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1787924, Length=259, Percent_Identity=28.957528957529, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17507759, Length=257, Percent_Identity=29.1828793774319, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17507757, Length=272, Percent_Identity=30.1470588235294, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320806, Length=258, Percent_Identity=27.906976744186, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324354, Length=252, Percent_Identity=26.984126984127, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45553007, Length=233, Percent_Identity=30.4721030042918, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXK_SALCH (Q57LS3)

Other databases:

- EMBL:   AE017220
- RefSeq:   YP_217420.1
- HSSP:   P82197
- ProteinModelPortal:   Q57LS3
- SMR:   Q57LS3
- PRIDE:   Q57LS3
- GeneID:   3334925
- GenomeReviews:   AE017220_GR
- KEGG:   sec:SC2433
- HOGENOM:   HBG661459
- OMA:   RARMLVS
- ProtClustDB:   PRK08176
- BioCyc:   SENT321314:SCH_2433-MONOMER
- BRENDA:   2.7.1.35
- HAMAP:   MF_01638
- InterPro:   IPR013749
- InterPro:   IPR004625
- TIGRFAMs:   TIGR00687

Pfam domain/function: PF08543 Phos_pyr_kin

EC number: =2.7.1.35

Molecular weight: Translated: 30968; Mature: 30837

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: BINDING 28-28 BINDING 141-141 BINDING 237-237

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQESDIQSVLFDDNHRALQTDIVAVQSQVVYGSVGNSIAVPAIKAQGLRVTAVPTVLFS
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCCEECCEEECCCEEEEEEEEEEEC
NTPHYKTFYGGIIPAEWFAGYLTALNERDALRELKAITTGYMGSADQIVLLSKWLMAIRA
CCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
SHPEVCILVDPVIGDTDSGMYVQAEIPQAYRTHLLPQAQGLTPNVFELEMLSGKPCRTLE
CCCCEEEEECCCCCCCCCCEEEEEECCHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHH
EAVAAAQSLLSDTLKWVVITSAPGESLETITVAVVTAQVVEVFAHPRVATELKGTGDLFC
HHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHH
AELVSGIVQGKKLTTAAKDAAQRVLEVMTWTQQCGCDELILPPAGEAR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCC
>Mature Secondary Structure 
GQESDIQSVLFDDNHRALQTDIVAVQSQVVYGSVGNSIAVPAIKAQGLRVTAVPTVLFS
CCHHHHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCCEECCEEECCCEEEEEEEEEEEC
NTPHYKTFYGGIIPAEWFAGYLTALNERDALRELKAITTGYMGSADQIVLLSKWLMAIRA
CCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
SHPEVCILVDPVIGDTDSGMYVQAEIPQAYRTHLLPQAQGLTPNVFELEMLSGKPCRTLE
CCCCEEEEECCCCCCCCCCEEEEEECCHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHH
EAVAAAQSLLSDTLKWVVITSAPGESLETITVAVVTAQVVEVFAHPRVATELKGTGDLFC
HHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHH
AELVSGIVQGKKLTTAAKDAAQRVLEVMTWTQQCGCDELILPPAGEAR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA