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The map label for this gene is maeB [H]

Identifier: 29140914

GI number: 29140914

Start: 462248

End: 464527

Strand: Direct

Name: maeB [H]

Synonym: t0387

Alternate gene names: 29140914

Gene position: 462248-464527 (Clockwise)

Preceding gene: 29140911

Following gene: 29140915

Centisome position: 9.65

GC content: 56.32

Gene sequence:

>2280_bases
ATGGATGAGCAGTTAAAACAAAGCGCCCTTGATTTCCACGAATTTCCGGTACCCGGTAAAATTCAGGTTTCTCCGACTAA
GCCCCTTGCCACCCAACGCGATCTGGCGTTGGCTTACTCGCCAGGCGTGGCGGCGCCCTGCCTGGAAATCGAAAAAGATC
CGCTGGCAGCCTACAAATACACCGCGCGCGGCAACCTTGTCGCGGTCATTTCCAACGGTACAGCGGTGCTGGGGTTAGGC
AACATCGGCGCGCTGGCCGGCAAGCCGGTCATGGAAGGCAAAGGCGTTCTGTTTAAAAAATTCGCCGGCATCGATGTGTT
TGACATTGAAGTCGATGAGCTTGATCCGGACAAATTTATCAATGTGGTCGCAGCGCTGGAGCCGACCTTTGGCGGCATTA
ACCTCGAAGACATTAAAGCGCCGGAATGTTTCTATATTGAGCAGAAACTGCGCGAGCGCATGAACATCCCGGTTTTCCAT
GACGATCAGCACGGAACGGCGATCATCAGTACGGCCGCCATTCTTAATGGCCTGCGAGTCGTAGAGAAAAATATTTCCGA
CGTGCGGATGGTCGTCTCCGGCGCAGGGGCGGCGGCAATCGCTTGTATGAACCTGCTGGTCGCGTTGGGGATGCAGAAGC
ACAACATCGTGGTGTGCGACTCTAAGGGCGTTATTTACAAAGGCCGTGAGCCGAATATGGCGGAGACCAAAGCGGCCTAT
GCGGTAGACGACAGCGGCAAGCGCACGCTGGATGAGGTCATTGACGGCGCGGATATTTTCCTCGGCTGTTCAGGCCCGAA
AGTGCTGACTCAGGAGATGGTGAAGAAAATGGCCCGCGCGCCAATGATTCTGGCGCTGGCTAACCCGGAACCGGAAATTC
TGCCGCCGCTGGCGAAAGAAGTGCGTCCGGACGCCATCATCTGTACCGGTCGTTCCGACTATCCGAACCAGGTGAACAAC
GTATTGTGCTTCCCGTTTATCTTCCGCGGCGCACTGGACGTCGGCGCGACGGCGATCAACGAAGAGATGAAACTGGCGGC
GGTCCGTGCGATTGCCGAGCTGGCGCACGCCGAACAGAGCGAAGTGGTGGCCTCGGCCTATGGCGATCAGGACCTGAGCT
TTGGGCCGGAATACATTATTCCGAAACCGTTTGACCCGCGTCTGATTGTCAAAATCGCTCCGGCGGTCGCGAAAGCGGCA
ATGGATTCCGGCGTGGCGACGCGCCCGATTGCTGACTTTGATGCCTATATCGATAAACTGACCGAGTTTGTCTACAAAAC
TAACCTGTTCATGAAGCCGATCTTCTCGCAGGCACGCAAAGATCCGAAGCGCGTAGTGCTGCCGGAAGGGGAAGAGGCGC
GCGTGCTGCACGCAACCCAGGAGTTGATAACCCTGGGGCTGGCGAAGCCCATCCTGATCGGGCGTCCGAGCGTGATCGAA
ATGCGTATCCAGAAACTGGGGTTACAGATCAAAGCGGGCGTTGATTTCGAGATCGTGAATAATGAATCCGATCCGCGCTT
CAAAGAGTACTGGAGCGAGTATTACCAGATCATGAAGCGTCGCGGGGTAACTCAGGAACAGGCGCAGCGTGCGATGATCG
GCAACCATACGGCCATTGGCGCGATCATGGTGCAGCGTGGAGAAGCGGATGCGATGATCTGCGGCACCATCGGCGACTAC
CATGAGCATTTCAGCGTCGTGAAAGCCGTCTTTGGCTACCGTGACGGCGTGCATACGGCAGGGGCGATGAACGCCTTACT
GCTGCCAAGCGGCAACACTTTTATCGCCGATACTTATGTTAACGAAGATCCCACGCCGGAACAGTTGGCGGAGATCGCCG
TAATGGCGGCGGAAACCGTTCGCCGCTTTGGTATTGAGCCGAAAGTCGCGCTGTTGTCGCACTCTAACTTTGGTTCCTCA
AATTCGCTGTCCGCCAGCAAAATGCGCGAAACCCTTGAGCGGGTACGCGAACGAGCGCCCGATCTGATGATTGACGGTGA
GATGCACGGTGATGCGGCGTTGGTGGAAAGTATTCGTAATGACCGGATGCCGGATAGTCCGCTGAAGGGAGCCGCCAATA
TTCTGGTGATGCCGAATATGGAAGCCGCCCGCATTAGTTACAACTTACTCCGCGTCTCCAGTTCCGAAGGCGTCACGGTC
GGCCCGGTCCTGATGGGCGTGTCTAAACCGGTACATGTATTAACGCCGATCGCCTCTGTACGCCGTATCGTGAATATGGT
GGCGTTAGCGGTAGTTGAAGCGCAAACCACGCCGCTTTAA

Upstream 100 bases:

>100_bases
AGTTTGCAGACCTTCAAAGTTTGTGTTGCGCAGTACGGTGATAATGTGCGGCGCACCAGGCCGCGTCACTTTTTGAACGA
TACGTGAAAGGAACAACAAA

Downstream 100 bases:

>100_bases
TAACGCATTACTCTCTCTTCTGGCGCAGGTTCTCCTGCGCTTTTTTGTCTATGGAAAACCCCCAGCTAGGCTGGGGGTTC
CGGAAAGCTTTCAGCTTTAA

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MDEQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLAAYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFINVVAALEPTFGGINLEDIKAPECFYIEQKLRERMNIPVFH
DDQHGTAIISTAAILNGLRVVEKNISDVRMVVSGAGAAAIACMNLLVALGMQKHNIVVCDSKGVIYKGREPNMAETKAAY
AVDDSGKRTLDEVIDGADIFLGCSGPKVLTQEMVKKMARAPMILALANPEPEILPPLAKEVRPDAIICTGRSDYPNQVNN
VLCFPFIFRGALDVGATAINEEMKLAAVRAIAELAHAEQSEVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAA
MDSGVATRPIADFDAYIDKLTEFVYKTNLFMKPIFSQARKDPKRVVLPEGEEARVLHATQELITLGLAKPILIGRPSVIE
MRIQKLGLQIKAGVDFEIVNNESDPRFKEYWSEYYQIMKRRGVTQEQAQRAMIGNHTAIGAIMVQRGEADAMICGTIGDY
HEHFSVVKAVFGYRDGVHTAGAMNALLLPSGNTFIADTYVNEDPTPEQLAEIAVMAAETVRRFGIEPKVALLSHSNFGSS
NSLSASKMRETLERVRERAPDLMIDGEMHGDAALVESIRNDRMPDSPLKGAANILVMPNMEAARISYNLLRVSSSEGVTV
GPVLMGVSKPVHVLTPIASVRRIVNMVALAVVEAQTTPL

Sequences:

>Translated_759_residues
MDEQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLAAYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFINVVAALEPTFGGINLEDIKAPECFYIEQKLRERMNIPVFH
DDQHGTAIISTAAILNGLRVVEKNISDVRMVVSGAGAAAIACMNLLVALGMQKHNIVVCDSKGVIYKGREPNMAETKAAY
AVDDSGKRTLDEVIDGADIFLGCSGPKVLTQEMVKKMARAPMILALANPEPEILPPLAKEVRPDAIICTGRSDYPNQVNN
VLCFPFIFRGALDVGATAINEEMKLAAVRAIAELAHAEQSEVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAA
MDSGVATRPIADFDAYIDKLTEFVYKTNLFMKPIFSQARKDPKRVVLPEGEEARVLHATQELITLGLAKPILIGRPSVIE
MRIQKLGLQIKAGVDFEIVNNESDPRFKEYWSEYYQIMKRRGVTQEQAQRAMIGNHTAIGAIMVQRGEADAMICGTIGDY
HEHFSVVKAVFGYRDGVHTAGAMNALLLPSGNTFIADTYVNEDPTPEQLAEIAVMAAETVRRFGIEPKVALLSHSNFGSS
NSLSASKMRETLERVRERAPDLMIDGEMHGDAALVESIRNDRMPDSPLKGAANILVMPNMEAARISYNLLRVSSSEGVTV
GPVLMGVSKPVHVLTPIASVRRIVNMVALAVVEAQTTPL
>Mature_759_residues
MDEQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLAAYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFINVVAALEPTFGGINLEDIKAPECFYIEQKLRERMNIPVFH
DDQHGTAIISTAAILNGLRVVEKNISDVRMVVSGAGAAAIACMNLLVALGMQKHNIVVCDSKGVIYKGREPNMAETKAAY
AVDDSGKRTLDEVIDGADIFLGCSGPKVLTQEMVKKMARAPMILALANPEPEILPPLAKEVRPDAIICTGRSDYPNQVNN
VLCFPFIFRGALDVGATAINEEMKLAAVRAIAELAHAEQSEVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAA
MDSGVATRPIADFDAYIDKLTEFVYKTNLFMKPIFSQARKDPKRVVLPEGEEARVLHATQELITLGLAKPILIGRPSVIE
MRIQKLGLQIKAGVDFEIVNNESDPRFKEYWSEYYQIMKRRGVTQEQAQRAMIGNHTAIGAIMVQRGEADAMICGTIGDY
HEHFSVVKAVFGYRDGVHTAGAMNALLLPSGNTFIADTYVNEDPTPEQLAEIAVMAAETVRRFGIEPKVALLSHSNFGSS
NSLSASKMRETLERVRERAPDLMIDGEMHGDAALVESIRNDRMPDSPLKGAANILVMPNMEAARISYNLLRVSSSEGVTV
GPVLMGVSKPVHVLTPIASVRRIVNMVALAVVEAQTTPL

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=402, Percent_Identity=25.6218905472637, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI62420882, Length=345, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI62420880, Length=345, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI239049447, Length=345, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788806, Length=759, Percent_Identity=94.33465085639, Blast_Score=1469, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=346, Percent_Identity=30.9248554913295, Blast_Score=169, Evalue=7e-43,
Organism=Escherichia coli, GI1788800, Length=325, Percent_Identity=33.5384615384615, Blast_Score=151, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17537199, Length=398, Percent_Identity=26.3819095477387, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=28.7313432835821, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21356279, Length=449, Percent_Identity=25.1670378619154, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI281362674, Length=449, Percent_Identity=25.1670378619154, Blast_Score=83, Evalue=8e-16,
Organism=Drosophila melanogaster, GI281362672, Length=449, Percent_Identity=25.1670378619154, Blast_Score=83, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82309; Mature: 82309

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLAAYKY
CCHHHHHHHCCHHCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEE
TARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFI
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEECCCCHHHHH
NVVAALEPTFGGINLEDIKAPECFYIEQKLRERMNIPVFHDDQHGTAIISTAAILNGLRV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
VEKNISDVRMVVSGAGAAAIACMNLLVALGMQKHNIVVCDSKGVIYKGREPNMAETKAAY
HHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCHHHCEEE
AVDDSGKRTLDEVIDGADIFLGCSGPKVLTQEMVKKMARAPMILALANPEPEILPPLAKE
EECCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHH
VRPDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATAINEEMKLAAVRAIAELAHAEQS
CCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHH
EVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMDSGVATRPIADFDAYIDKL
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
TEFVYKTNLFMKPIFSQARKDPKRVVLPEGEEARVLHATQELITLGLAKPILIGRPSVIE
HHHHHHHCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHH
MRIQKLGLQIKAGVDFEIVNNESDPRFKEYWSEYYQIMKRRGVTQEQAQRAMIGNHTAIG
HHHHHCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEE
AIMVQRGEADAMICGTIGDYHEHFSVVKAVFGYRDGVHTAGAMNALLLPSGNTFIADTYV
EEEEECCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECC
NEDPTPEQLAEIAVMAAETVRRFGIEPKVALLSHSNFGSSNSLSASKMRETLERVRERAP
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
DLMIDGEMHGDAALVESIRNDRMPDSPLKGAANILVMPNMEAARISYNLLRVSSSEGVTV
CEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHEEEEEEEEECCCCCEE
GPVLMGVSKPVHVLTPIASVRRIVNMVALAVVEAQTTPL
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDEQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLAAYKY
CCHHHHHHHCCHHCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEE
TARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFI
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEECCCCHHHHH
NVVAALEPTFGGINLEDIKAPECFYIEQKLRERMNIPVFHDDQHGTAIISTAAILNGLRV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
VEKNISDVRMVVSGAGAAAIACMNLLVALGMQKHNIVVCDSKGVIYKGREPNMAETKAAY
HHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCHHHCEEE
AVDDSGKRTLDEVIDGADIFLGCSGPKVLTQEMVKKMARAPMILALANPEPEILPPLAKE
EECCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHH
VRPDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATAINEEMKLAAVRAIAELAHAEQS
CCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHH
EVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMDSGVATRPIADFDAYIDKL
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
TEFVYKTNLFMKPIFSQARKDPKRVVLPEGEEARVLHATQELITLGLAKPILIGRPSVIE
HHHHHHHCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHH
MRIQKLGLQIKAGVDFEIVNNESDPRFKEYWSEYYQIMKRRGVTQEQAQRAMIGNHTAIG
HHHHHCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEE
AIMVQRGEADAMICGTIGDYHEHFSVVKAVFGYRDGVHTAGAMNALLLPSGNTFIADTYV
EEEEECCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECC
NEDPTPEQLAEIAVMAAETVRRFGIEPKVALLSHSNFGSSNSLSASKMRETLERVRERAP
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
DLMIDGEMHGDAALVESIRNDRMPDSPLKGAANILVMPNMEAARISYNLLRVSSSEGVTV
CEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHEEEEEEEEECCCCCEE
GPVLMGVSKPVHVLTPIASVRRIVNMVALAVVEAQTTPL
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]