Definition Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome.
Accession NC_004631
Length 4,791,961

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The map label for this gene is pbpC [H]

Identifier: 29140858

GI number: 29140858

Start: 372866

End: 375181

Strand: Direct

Name: pbpC [H]

Synonym: t0325

Alternate gene names: 29140858

Gene position: 372866-375181 (Clockwise)

Preceding gene: 29140857

Following gene: 29140859

Centisome position: 7.78

GC content: 61.05

Gene sequence:

>2316_bases
ATGAACGGTTGGCGTGGTAAACGTGGCCGCTGGCTGTGGCTGGCGGGCGCGCCGCTTTTTATTTTCCTGGCGTTATGGGC
AGCGGATAAACTCTGGCCGCTGCCGCTCAATGAGGTCCATCCTGCGCGGGTCGTGGTCGCCCATGACGGTACGCCGCTGT
GGCGCTTTGCCGACGCCGGGGGGATCTGGCGTTATCCGGTGACGATTGAAGAGGTCTCTCCCCGTTACCTGGAGGCCTTA
ATCAATTACGAAGATCGCTGGTTCTGGCAGCACCCTGGCGTTAACCCTTTTTCCGTCGCGCGCGCGGCATGGCAGGATCT
TACCGCCGGGCGCGTTATTTCCGGCGGCAGTACGCTGACTATGCAGGTGGCGAGACTTCTGGACCCGCATTCGCGCACGT
TCGGCGGTAAAATCCGCCAGCTTTGGCGCGCCCTCCAGCTTGAATGGCATTTGTCCAAGCGCGATATCCTGACGTTGTAC
CTGAACCGCGCGCCGTTCGGCGGCACGCTACAGGGTATTGGCGCTGCAAGCTGGGCCTACTTCGGCAAGCCGCCCGCGCG
CCTGAGCTACGCTGACGCGGCGCTGCTGGCCGTATTGCCGCAGGCGCCGAGCCGGTTACGCCCCGACCGATGGCCTACGA
GAGCCGAAGCGGCACGGAATAAAGTGCTGGATCGGATGGCGGAGCAGGGCGTCTGGCCTGCCGAAACGGTACGCGAGTCG
CGTGAAGAGCCGGTCTGGCTGGCGCCGCGTCAAATGCCGCAACTGGCGCCGCTTTTTGCCCGAATGATGTTGAGTAAAAG
CCGGAGCGACAAAATTGTGACCACGCTGGACGCCGGGTTGCAGCGGCAACTGGAAGATCTGGCGCGGGCATGGAAAGGGC
GGCTGCCTGCACGCAGTTCATTGGCGATGATCGTCGTCGATCATACCGATATGAGCGTGCGCGGCTGGGTAGGATCGGTA
GACCTTAATGACGACAGCCGTTTTGGTCATGTCGACATGGTAACGGCGATCCGATCGCCGGGATCGGTACTCAAACCCTT
TGTGTATGGTCTGGCGCTGGATGACGGCTTGATCCATCCCGCATCACTATTACAGGACGTTCCGCGCCGCACCGGAGATT
ACCGCCCGGGAAACTTCGATAGCGGATTTCACGGCCCGGTTAGCATGAGCGACGCGCTGGTACGCTCGCTGAATCTGCCT
GCCGTTCAGGTGCTTGAAGCCTATGGGCCGAAACGATTTGCGGCAAAACTGCGTAACGTCGGCCTGCCGCTATATTTGCC
TGCTGGCGCGGCGCCCAATCTTTCGCTGATTCTGGGCGGCGCGGGCGCGCGGCTTGACGAGATGGCGGCGGCATACAGCG
CGTTCGCTCGTCATGGGAAAGCGGCGAAACTACGGTTACAGCCGGACGATCCGCTGTCGGAAAGACCATTAATGTCGCCG
GGAGCGGCGTGGATCATTCGACGGATTATGGCGGATGAAGCGCAACCCTTGCCGGATAACGCGCTGCCGCGCATTGTGCC
GTTGGCGTGGAAAACCGGCACCAGCTACGGCTATCGCGATGCGTGGGCTATTGGCGTTAACGCGCGCTATATCATCGGCA
TCTGGACAGGCAGACCCGACGGCACGCCTGTGGTGGGGCAATTTGGTTTTGCCAGCGCGGTGCCATTGCTTAACCAGGTC
AATAATCTGTTACTGGCGCATACGGGACGCCTGCCGGAAGATCCGCGTCCGCAGACGGTAAGCCGCGGCGTCATTTGCTG
GCCGGGCGGACAGACTCTGCCTGCCGGGAACAGCAACTGTCGCCGCCGACTGGCGACATGGCTGCTTGACGACAGCCAGC
CGCCCACGCTGCTGTTACCTGAGCAGGAAGACATCAACGGTATTCGTTTCCCGGTCTGGCTGGATGATACGGGGCGGCGT
GTCGCTGCCGACTGTCCGCAGGCGCGTGCGCATACGTTTATCGTCTGGCCGCGGCCGCTGGAGCCGTGGCTGCCGCCTGC
GGAAAGACGTAGCGCCCGCTTGCCCGCGGCGTCCGACCACTGTCCGCCGCTACAGGGCAATGATGCCGCGCCGTTAATGC
TGTCAGGAGTGAGGGATGGCGCGGTGATCAGGCAATTGCCAGGCCAGGAAAACGTCACGCTGCCCGTCTCGACTACCGGC
GGCAAAGGGCGTCGCTGGTGGTTTTTAAATGGCGAACCTGTTAATGGCGAAAATAATCGCCTTTCTTTATTACTCAATAT
CGCTGGACGTTATCAACTTGTCGTAATGGATGAGTCCGGTCAGGTTGCAGCGGTTAATTTTGAATTAATACGTTAA

Upstream 100 bases:

>100_bases
GGGGACGTACCAGCTTGCGCAACCGCAGGTGGAATCGATGTACGCGCCTCAGTGGCGGGCAACCGGCGCGAGCGAGGGAC
TGCTGATTGTGACGCCTTAA

Downstream 100 bases:

>100_bases
CCATTCTCCAAAATAGATTATCAATTCCTTTTAATTTAAGCTTAATGATAATTGTTAATTATTACTGGATCATACATAAC
CGGAGAGCTTGATAAATATC

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 771; Mature: 771

Protein sequence:

>771_residues
MNGWRGKRGRWLWLAGAPLFIFLALWAADKLWPLPLNEVHPARVVVAHDGTPLWRFADAGGIWRYPVTIEEVSPRYLEAL
INYEDRWFWQHPGVNPFSVARAAWQDLTAGRVISGGSTLTMQVARLLDPHSRTFGGKIRQLWRALQLEWHLSKRDILTLY
LNRAPFGGTLQGIGAASWAYFGKPPARLSYADAALLAVLPQAPSRLRPDRWPTRAEAARNKVLDRMAEQGVWPAETVRES
REEPVWLAPRQMPQLAPLFARMMLSKSRSDKIVTTLDAGLQRQLEDLARAWKGRLPARSSLAMIVVDHTDMSVRGWVGSV
DLNDDSRFGHVDMVTAIRSPGSVLKPFVYGLALDDGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPVSMSDALVRSLNLP
AVQVLEAYGPKRFAAKLRNVGLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAAKLRLQPDDPLSERPLMSP
GAAWIIRRIMADEAQPLPDNALPRIVPLAWKTGTSYGYRDAWAIGVNARYIIGIWTGRPDGTPVVGQFGFASAVPLLNQV
NNLLLAHTGRLPEDPRPQTVSRGVICWPGGQTLPAGNSNCRRRLATWLLDDSQPPTLLLPEQEDINGIRFPVWLDDTGRR
VAADCPQARAHTFIVWPRPLEPWLPPAERRSARLPAASDHCPPLQGNDAAPLMLSGVRDGAVIRQLPGQENVTLPVSTTG
GKGRRWWFLNGEPVNGENNRLSLLLNIAGRYQLVVMDESGQVAAVNFELIR

Sequences:

>Translated_771_residues
MNGWRGKRGRWLWLAGAPLFIFLALWAADKLWPLPLNEVHPARVVVAHDGTPLWRFADAGGIWRYPVTIEEVSPRYLEAL
INYEDRWFWQHPGVNPFSVARAAWQDLTAGRVISGGSTLTMQVARLLDPHSRTFGGKIRQLWRALQLEWHLSKRDILTLY
LNRAPFGGTLQGIGAASWAYFGKPPARLSYADAALLAVLPQAPSRLRPDRWPTRAEAARNKVLDRMAEQGVWPAETVRES
REEPVWLAPRQMPQLAPLFARMMLSKSRSDKIVTTLDAGLQRQLEDLARAWKGRLPARSSLAMIVVDHTDMSVRGWVGSV
DLNDDSRFGHVDMVTAIRSPGSVLKPFVYGLALDDGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPVSMSDALVRSLNLP
AVQVLEAYGPKRFAAKLRNVGLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAAKLRLQPDDPLSERPLMSP
GAAWIIRRIMADEAQPLPDNALPRIVPLAWKTGTSYGYRDAWAIGVNARYIIGIWTGRPDGTPVVGQFGFASAVPLLNQV
NNLLLAHTGRLPEDPRPQTVSRGVICWPGGQTLPAGNSNCRRRLATWLLDDSQPPTLLLPEQEDINGIRFPVWLDDTGRR
VAADCPQARAHTFIVWPRPLEPWLPPAERRSARLPAASDHCPPLQGNDAAPLMLSGVRDGAVIRQLPGQENVTLPVSTTG
GKGRRWWFLNGEPVNGENNRLSLLLNIAGRYQLVVMDESGQVAAVNFELIR
>Mature_771_residues
MNGWRGKRGRWLWLAGAPLFIFLALWAADKLWPLPLNEVHPARVVVAHDGTPLWRFADAGGIWRYPVTIEEVSPRYLEAL
INYEDRWFWQHPGVNPFSVARAAWQDLTAGRVISGGSTLTMQVARLLDPHSRTFGGKIRQLWRALQLEWHLSKRDILTLY
LNRAPFGGTLQGIGAASWAYFGKPPARLSYADAALLAVLPQAPSRLRPDRWPTRAEAARNKVLDRMAEQGVWPAETVRES
REEPVWLAPRQMPQLAPLFARMMLSKSRSDKIVTTLDAGLQRQLEDLARAWKGRLPARSSLAMIVVDHTDMSVRGWVGSV
DLNDDSRFGHVDMVTAIRSPGSVLKPFVYGLALDDGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPVSMSDALVRSLNLP
AVQVLEAYGPKRFAAKLRNVGLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAAKLRLQPDDPLSERPLMSP
GAAWIIRRIMADEAQPLPDNALPRIVPLAWKTGTSYGYRDAWAIGVNARYIIGIWTGRPDGTPVVGQFGFASAVPLLNQV
NNLLLAHTGRLPEDPRPQTVSRGVICWPGGQTLPAGNSNCRRRLATWLLDDSQPPTLLLPEQEDINGIRFPVWLDDTGRR
VAADCPQARAHTFIVWPRPLEPWLPPAERRSARLPAASDHCPPLQGNDAAPLMLSGVRDGAVIRQLPGQENVTLPVSTTG
GKGRRWWFLNGEPVNGENNRLSLLLNIAGRYQLVVMDESGQVAAVNFELIR

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=763, Percent_Identity=82.175622542595, Blast_Score=1284, Evalue=0.0,
Organism=Escherichia coli, GI87082258, Length=248, Percent_Identity=33.8709677419355, Blast_Score=129, Evalue=9e-31,
Organism=Escherichia coli, GI1786343, Length=513, Percent_Identity=28.6549707602339, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789601, Length=144, Percent_Identity=34.7222222222222, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 85196; Mature: 85196

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGWRGKRGRWLWLAGAPLFIFLALWAADKLWPLPLNEVHPARVVVAHDGTPLWRFADAG
CCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCC
GIWRYPVTIEEVSPRYLEALINYEDRWFWQHPGVNPFSVARAAWQDLTAGRVISGGSTLT
CEEECCEEHHHCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCCCHHH
MQVARLLDPHSRTFGGKIRQLWRALQLEWHLSKRDILTLYLNRAPFGGTLQGIGAASWAY
HHHHHHHCCCCCCCCHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCCCCCCCCCCHH
FGKPPARLSYADAALLAVLPQAPSRLRPDRWPTRAEAARNKVLDRMAEQGVWPAETVRES
CCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHC
REEPVWLAPRQMPQLAPLFARMMLSKSRSDKIVTTLDAGLQRQLEDLARAWKGRLPARSS
CCCCEEECCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCC
LAMIVVDHTDMSVRGWVGSVDLNDDSRFGHVDMVTAIRSPGSVLKPFVYGLALDDGLIHP
EEEEEEECCCCEEECEEEEEECCCCCCCCCEEEHHHHCCCCHHHHHHHHHEEECCCCCCH
ASLLQDVPRRTGDYRPGNFDSGFHGPVSMSDALVRSLNLPAVQVLEAYGPKRFAAKLRNV
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHC
GLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAAKLRLQPDDPLSERPLMSP
CCCEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCC
GAAWIIRRIMADEAQPLPDNALPRIVPLAWKTGTSYGYRDAWAIGVNARYIIGIWTGRPD
CHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCEEEEEEEECCCC
GTPVVGQFGFASAVPLLNQVNNLLLAHTGRLPEDPRPQTVSRGVICWPGGQTLPAGNSNC
CCCEEECCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHCCCEEECCCCCCCCCCCHHH
RRRLATWLLDDSQPPTLLLPEQEDINGIRFPVWLDDTGRRVAADCPQARAHTFIVWPRPL
HHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEEECCCCCEEECCCCCCCCCEEEEECCCC
EPWLPPAERRSARLPAASDHCPPLQGNDAAPLMLSGVRDGAVIRQLPGQENVTLPVSTTG
CCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHCCCCCCEEEEEECCC
GKGRRWWFLNGEPVNGENNRLSLLLNIAGRYQLVVMDESGQVAAVNFELIR
CCCCEEEEECCCCCCCCCCEEEEEEEECCCEEEEEECCCCCEEEEEEEEEC
>Mature Secondary Structure
MNGWRGKRGRWLWLAGAPLFIFLALWAADKLWPLPLNEVHPARVVVAHDGTPLWRFADAG
CCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCC
GIWRYPVTIEEVSPRYLEALINYEDRWFWQHPGVNPFSVARAAWQDLTAGRVISGGSTLT
CEEECCEEHHHCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCCCHHH
MQVARLLDPHSRTFGGKIRQLWRALQLEWHLSKRDILTLYLNRAPFGGTLQGIGAASWAY
HHHHHHHCCCCCCCCHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCCCCCCCCCCHH
FGKPPARLSYADAALLAVLPQAPSRLRPDRWPTRAEAARNKVLDRMAEQGVWPAETVRES
CCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHC
REEPVWLAPRQMPQLAPLFARMMLSKSRSDKIVTTLDAGLQRQLEDLARAWKGRLPARSS
CCCCEEECCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCC
LAMIVVDHTDMSVRGWVGSVDLNDDSRFGHVDMVTAIRSPGSVLKPFVYGLALDDGLIHP
EEEEEEECCCCEEECEEEEEECCCCCCCCCEEEHHHHCCCCHHHHHHHHHEEECCCCCCH
ASLLQDVPRRTGDYRPGNFDSGFHGPVSMSDALVRSLNLPAVQVLEAYGPKRFAAKLRNV
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHC
GLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAAKLRLQPDDPLSERPLMSP
CCCEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCC
GAAWIIRRIMADEAQPLPDNALPRIVPLAWKTGTSYGYRDAWAIGVNARYIIGIWTGRPD
CHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCEEEEEEEECCCC
GTPVVGQFGFASAVPLLNQVNNLLLAHTGRLPEDPRPQTVSRGVICWPGGQTLPAGNSNC
CCCEEECCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHCCCEEECCCCCCCCCCCHHH
RRRLATWLLDDSQPPTLLLPEQEDINGIRFPVWLDDTGRRVAADCPQARAHTFIVWPRPL
HHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEEECCCCCEEECCCCCCCCCEEEEECCCC
EPWLPPAERRSARLPAASDHCPPLQGNDAAPLMLSGVRDGAVIRQLPGQENVTLPVSTTG
CCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHCCCCCCEEEEEECCC
GKGRRWWFLNGEPVNGENNRLSLLLNIAGRYQLVVMDESGQVAAVNFELIR
CCCCEEEEECCCCCCCCCCEEEEEEEECCCEEEEEECCCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]