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The map label for this gene is rnc [H]

Identifier: 29140810

GI number: 29140810

Start: 315255

End: 315935

Strand: Direct

Name: rnc [H]

Synonym: t0277

Alternate gene names: 29140810

Gene position: 315255-315935 (Clockwise)

Preceding gene: 29140809

Following gene: 29140811

Centisome position: 6.58

GC content: 53.01

Gene sequence:

>681_bases
ATGAACCCCATCGTAATTAATCGGCTTCAACGGAAGCTGGGCTACACTTTTAATCATCAGGAGCTGTTGCAGCAGGCATT
AACTCACCGCAGCGCCAGCAGTAAACATAACGAACGCCTGGAGTTTTTAGGCGATTCAATCCTGAGCTTCGTTATCGCTA
ACGCGCTTTATCACCGTTTTCCACGGGTGGATGAGGGAGATATGAGCCGTATGCGCGCCACGTTGGTACGTGGTAATACG
CTGGCGGAATTAGCCCGTGAATTTGATTTAGGCGAGTGCCTGCGTTTAGGGCCGGGCGAATTAAAAAGCGGCGGATTTCG
TCGGGAGTCCATTCTGGCGGACACCGTGGAAGCGTTAATCGGCGGAGTATTTCTCGATAGCAATATCCAGACCGTCGAGC
AGTTAATCCTTAACTGGTATAAAACCCGTCTGGATGAGATAAGTCCGGGCGATAAACAAAAAGATCCTAAAACGCGCTTG
CAGGAGTATTTGCAGGGTCGCCATCTGCCGCTGCCATCTTACCTGGTTGTGCAGGTACGCGGCGAGGCGCACGATCAGGA
ATTTACTATCCACTGCCAGGTCAGCGGCCTGAGCGAACCGGTGGTTGGCACGGGTTCCAGCCGTCGTAAGGCGGAGCAGG
CTGCCGCCGAACAGGCGCTGAAAAAACTGGAGTTGGAATGA

Upstream 100 bases:

>100_bases
GACAACCTTCTTTCCGCTGCAGCGATGCGGCAGGACAGATGACGTGTATCAGGTCTGTTTCGTGTGCTGGATTGTTGACG
CATTCATTTATTGGTATCGC

Downstream 100 bases:

>100_bases
GCACCGACAAAACTTACTGCGGATTTATTGCCATCGTCGGACGTCCGAACGTTGGCAAATCCACCTTGCTGAACAAACTG
CTCGGGCAGAAGATTTCGAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNT
LAELAREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSNIQTVEQLILNWYKTRLDEISPGDKQKDPKTRL
QEYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE

Sequences:

>Translated_226_residues
MNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNT
LAELAREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSNIQTVEQLILNWYKTRLDEISPGDKQKDPKTRL
QEYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE
>Mature_226_residues
MNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNT
LAELAREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSNIQTVEQLILNWYKTRLDEISPGDKQKDPKTRL
QEYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=230, Percent_Identity=29.1304347826087, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI155030234, Length=230, Percent_Identity=29.1304347826087, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI1788920, Length=226, Percent_Identity=97.3451327433628, Blast_Score=436, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=31.2775330396476, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=31.2775330396476, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323895, Length=204, Percent_Identity=28.921568627451, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=28.3842794759825, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25505; Mature: 25505

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRF
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PRVDEGDMSRMRATLVRGNTLAELAREFDLGECLRLGPGELKSGGFRRESILADTVEALI
CCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GGVFLDSNIQTVEQLILNWYKTRLDEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVR
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
GEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRF
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PRVDEGDMSRMRATLVRGNTLAELAREFDLGECLRLGPGELKSGGFRRESILADTVEALI
CCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GGVFLDSNIQTVEQLILNWYKTRLDEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVR
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
GEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA