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The map label for this gene is dxr [H]

Identifier: 29140760

GI number: 29140760

Start: 254722

End: 255918

Strand: Direct

Name: dxr [H]

Synonym: t0221

Alternate gene names: 29140760

Gene position: 254722-255918 (Clockwise)

Preceding gene: 29140759

Following gene: 29140761

Centisome position: 5.32

GC content: 55.64

Gene sequence:

>1197_bases
ATGAAGCAATTAACCATTCTGGGCTCGACCGGCTCTATTGGTTGCAGCACACTGGACGTGGTGCACCATAATCCTGATAG
CTTTCGCGTTATCGCGCTGGTGGCGGGTAAAAATGTCGCCCGCATGGCGGAGCAGTGCCTGGAGTTCTCGCCGCGTTATG
CCGTGATGGACGATACGTCGAGCGCAGAACAGCTCAAAATAATGCTTCAGCAGCATGGCAGCCGCACCGAGGTTCTGAGC
GGTCAGCAGGCTGCCTGTGAGATGGCGGCGCTTGATGAGGTTGGGCATGTGATGGCGGCCATTGTGGGCGCGGCTGGTTT
ACTGCCGACCTTGGCGGCGATCCGCGCAGGGAAGACGATTCTGCTGGCGAATAAAGAATCGCTGGTGACCTGCGGGCGGC
TGTTTATGGACGAAGTGAAACGCAGCAACGCCCGGCTTTTACCCGTCGATAGCGAACATAACGCGATTTTTCAGAGTTTG
CCGCAATCTATTCAGCATAATCTGGGATACGCTGACCTTGAGCAAAATGGCGTAACGTCGATTTTGCTTACCGGGTCTGG
TGGCCCGTTTCGTGAAACGCCCATGTGCGATCTGGCAGCGATGACGCCGGATCAGGCATGTCGTCATCCGAACTGGTCGA
TGGGGCGAAAAATCTCCGTCGACTCCGCCACCATGATGAATAAAGGTCTGGAATACATTGAAGCGCGTTGGTTATTTAAT
GCCAGCGCACGTCAGATGGAAGTGTTGATCCATCCGCAATCGGTCATTCATTCGATGGTGCGTTATCAGGACGGCAGCGT
CCTGGCGCAGCTTGGAGAACCTGACATGCGTACGCCTATTGCGCATACGATGGCATGGCCGAATCGCGTCACGTCCGGCG
CGCAGCCGCTCGATTTTTGCAAACTCAGCGCGCTGACGTTTAGCGCGCCAGATTATCAGCGTTATCCTTGCCTGAAGCTG
GCGATGGAGGCGTTTGAGCAAGGTCAGGCGGCAACGACGGCGCTCAATGCGGCAAACGAAATCACCGTTGCCGCGTTTCT
GGCGCAACAGATTCGTTTTACCGATATCGCCGGGCTCAATTTAGCGGTGCTGGAGAGGATGGATTTACACGAACCGGCAA
GCGTTGATGACGTATTGCAGGTTGACGCCATCGCGCGTGAAGTAGCCAGAAAACAAGTGATACGGCTCTCACGCTGA

Upstream 100 bases:

>100_bases
TGGCGGATGAGTGGTGTACAAAGCGCCGCGCAGAAGACATTATCAGGTCTCCTGTGCGGCGTTTTGCTTTTTATTCCGTT
TCAACACTTCTGGACGTTTC

Downstream 100 bases:

>100_bases
CGATTATCCCGCGACAGAAGATCGTGCTATTTGTTAGCGTTGGGCTTCGGTGATATAGTCTGCGCCACCTGATCGCAGGT
TTTTGGCTTTTTTCGGTCAG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKQLTILGSTGSIGCSTLDVVHHNPDSFRVIALVAGKNVARMAEQCLEFSPRYAVMDDTSSAEQLKIMLQQHGSRTEVLS
GQQAACEMAALDEVGHVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDEVKRSNARLLPVDSEHNAIFQSL
PQSIQHNLGYADLEQNGVTSILLTGSGGPFRETPMCDLAAMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASARQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVTSGAQPLDFCKLSALTFSAPDYQRYPCLKL
AMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAGLNLAVLERMDLHEPASVDDVLQVDAIAREVARKQVIRLSR

Sequences:

>Translated_398_residues
MKQLTILGSTGSIGCSTLDVVHHNPDSFRVIALVAGKNVARMAEQCLEFSPRYAVMDDTSSAEQLKIMLQQHGSRTEVLS
GQQAACEMAALDEVGHVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDEVKRSNARLLPVDSEHNAIFQSL
PQSIQHNLGYADLEQNGVTSILLTGSGGPFRETPMCDLAAMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASARQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVTSGAQPLDFCKLSALTFSAPDYQRYPCLKL
AMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAGLNLAVLERMDLHEPASVDDVLQVDAIAREVARKQVIRLSR
>Mature_398_residues
MKQLTILGSTGSIGCSTLDVVHHNPDSFRVIALVAGKNVARMAEQCLEFSPRYAVMDDTSSAEQLKIMLQQHGSRTEVLS
GQQAACEMAALDEVGHVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDEVKRSNARLLPVDSEHNAIFQSL
PQSIQHNLGYADLEQNGVTSILLTGSGGPFRETPMCDLAAMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASARQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVTSGAQPLDFCKLSALTFSAPDYQRYPCLKL
AMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAGLNLAVLERMDLHEPASVDDVLQVDAIAREVARKQVIRLSR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=397, Percent_Identity=88.9168765743073, Blast_Score=715, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 43329; Mature: 43329

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLTILGSTGSIGCSTLDVVHHNPDSFRVIALVAGKNVARMAEQCLEFSPRYAVMDDTS
CCEEEEEECCCCCCCEEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCC
SAEQLKIMLQQHGSRTEVLSGQQAACEMAALDEVGHVMAAIVGAAGLLPTLAAIRAGKTI
CHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKESLVTCGRLFMDEVKRSNARLLPVDSEHNAIFQSLPQSIQHNLGYADLEQNGVTS
EEECCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
ILLTGSGGPFRETPMCDLAAMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCCCCCCCCHHCCCCCHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHEEC
ASARQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVTSGAQPLDFC
CCCCEEEEEECCHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHCCCHHHCCCCCCHHHH
KLSALTFSAPDYQRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAGLN
HHHHEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCH
LAVLERMDLHEPASVDDVLQVDAIAREVARKQVIRLSR
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQLTILGSTGSIGCSTLDVVHHNPDSFRVIALVAGKNVARMAEQCLEFSPRYAVMDDTS
CCEEEEEECCCCCCCEEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCC
SAEQLKIMLQQHGSRTEVLSGQQAACEMAALDEVGHVMAAIVGAAGLLPTLAAIRAGKTI
CHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKESLVTCGRLFMDEVKRSNARLLPVDSEHNAIFQSLPQSIQHNLGYADLEQNGVTS
EEECCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
ILLTGSGGPFRETPMCDLAAMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCCCCCCCCHHCCCCCHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHEEC
ASARQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVTSGAQPLDFC
CCCCEEEEEECCHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHCCCHHHCCCCCCHHHH
KLSALTFSAPDYQRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAGLN
HHHHEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCH
LAVLERMDLHEPASVDDVLQVDAIAREVARKQVIRLSR
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA