| Definition | Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome. |
|---|---|
| Accession | NC_004631 |
| Length | 4,791,961 |
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The map label for this gene is mrcB [H]
Identifier: 29140739
GI number: 29140739
Start: 225323
End: 227845
Strand: Direct
Name: mrcB [H]
Synonym: t0198
Alternate gene names: 29140739
Gene position: 225323-227845 (Clockwise)
Preceding gene: 161486817
Following gene: 29140740
Centisome position: 4.7
GC content: 56.44
Gene sequence:
>2523_bases ATGGCGGGGAATGACCGCGAGCCGATTGGACGTAAGGGGAAACCGTCACGTCCTGTGAAACAAAAGGTGAGCCGTCGTCG GCAGCATGACGACGATTATGATGATGACTATGAGGATGAAGAACCGATGCCGCGTAAAGGTAAGGGCAAAGGGCGTAAGC CTCGTGGCAAGCGCGGCTGGCTGTGGCTATTGCTAAAACTGTTTATCGTTTTTGTGGTGCTGTTCGCCATTTACGGCGTC TATCTGGATCAAAAAATCCGCAGCCGTATTGATGGCAAGGTCTGGCAGCTTCCGGCGGCGGTATATGGCCGGATGGTGAA CCTTGAGCCAGACATGCCTGTCAGCAAAAACGAGATGGTGAAATTGCTGGAAGCGACGCAGTATCGTCTGGTGACGAAGA TGACCCGTCCCGGCGAATTTACCGTGCAGGCCAATAGCATTGAGATGATCCGTCGTCCGTTTGACTTCCCGGACAGCAAA GAAGGGCAGGTGCGCGCGCGGCTGACGTTCAGTGACGGGCGTCTGGAAACCATCGTCAATCTGGATAACAACCGCCAGTT TGGCTTCTTCCGCCTCGATCCGCGGCTTATCACCATGCTTTCTTCGCCAAATGGCGAGCAGCGTTTATTCGTCCCGCGCA GCGGTTTCCCGGATCTGCTGGTCGATACGCTGTTGGCGACGGAAGACCGTCGTTTCTATGAGCATGATGGCATTAGTCTT TACTCTATCGGGCGTGCGGTGCTGGCCAACCTGACGGCGGGACGCACGGTGCAGGGGGCCAGTACGCTGACCCAGCAGCT GGTGAAGAACCTGTTCCTCTCCAGCGAAAGATCATACTGGCGTAAAGCGAATGAAGCCTACATGGCGCTGATCATGGATG CCCGTTACAGTAAAGATCGTATTCTTGAGCTGTACATGAACGAGGTCTACCTCGGTCAAAGCGGGGATAATGAAATTCGC GGTTTTCCGCTGGCGAGCCTGTATTACTTTGGTCGTCCGGTAGAGGAACTGAGCCTCGATCAGCAGGCGTTACTGGTGGG GATGGTAAAAGGGGCGTCGATTTATAACCCGTGGCGTAACCCGAAACTGGCGCTGGAGCGTCGTAACCTAGTGTTACGCC TGTTACAGCAGCAGAAAATCATCGATCAGGAACTCTATGACATGCTGAGCGCGCGTCCGCTTGGCGTACAGCCGCGCGGC GGCGTTATTTCACCGCAGCCAGCGTTTATGCAGATGGTTCGTCAGGAACTGCAGGCGAAGCTGGGGGATAAAATTAAAGA TCTCTCCGGCGTGAAGATCTTCACCACCTTTGACTCCGTGGCGCAGGATGCCGCAGAAAAAGCCGTTGTCGAAGGCATTC CGGCGTTGAAGAAGCAGCGTAAATTGAGCGATCTGGAAACTGCGATGGTGGTAGTGGATCGCTTTAGCGGCGAGGTACGC GCGATGGTTGGCGGGGCGGAGCCGCAGTATGCTGGCTATAACCGTGCCATGCAGGCACGCCGTTCCATCGGGTCGCTGGC GAAACCGGCGACCTATCTGACCGCGTTAAGTCAGCCGAACTTATACCGTCTGAACACCTGGATTGCCGATGCGCCGATTT CTCTGCGCCAGCCGAATGGTCAGGTCTGGTCGCCGGAGAACGACGATCGTCGCTACAGCGAAAGCGGGAAAGTGATGCTG GTGGATGCGTTAACTCGTTCAATGAACGTACCGACGGTCAATCTGGGGATGGCGTTAGGTTTACCGGCGGTAACCGATAC CTGGACGAAGCTCGGCGTGCCGAAAGATCAGCTCAATCCGGTTCCGGCGATGCTGTTAGGGGCGCTGAACCTGACGCCGA TCGAAGTGGCGCAAGCGTTCCAGACTATCGCCAGCGGCGGAAATCGCGCGCCGTTATCAGCGCTGCGTTCGGTTATTGCG GAAGATGGTAAAGTGCTGTACCAAAGTTATCCGCAAGCTGAACGCGCCGTACCGGCACAGGCGGCTTACCTGACGCTCTG GACAATGCAGCAGGTCGTCCAGCGTGGTACGGGGCGTCAGCTTGGCGCGAAATATCCGGGTCTGCATCTGGTGGGTAAAA CCGGGACGACAAACAACAATGTCGATACCTGGTTTGCCGGTATCGACGGCAGCCAGGTGACTATCACCTGGGTAGGCCGT GATAACAACCAGCCAACGAAATTGTACGGTGCCAGCGGCGCGATGGCGATTTACCAGCGCTATCTGGCGAACCAGACGCC GACGCCTTTAGTTCTGACGCCGCCGGAAGATGTGGTGGATATGGGCGTTGATTACGACGGTAATTTTGTCTGTAACGGCG GTATGCGCACTCTGCCGGTCTGGACGGACGATCCAAATACGCTGTGCCAGCAGGGCGAGATGATGCAGCAGCAACAGCAG CCGTCAGGCAATCCGTTCGATCAGTCGTCTCAGCCGCAGCAGCCTGCGCAGCAACAGCCGCCGAAAGAAGAGAAGAGCGA CGGCGTTGCCGGCTGGATTAAGGAGATGTTTGGCGGCAATTAA
Upstream 100 bases:
>100_bases GCCATCCGGCAAAAAGGTAAATTGAGAGATTTCTTCTTCTGTCGTCTGGCGGAAGAATAGAGAATCGGGCCTTTGCGCCT GTATGTTGCGGAGAAAAAGC
Downstream 100 bases:
>100_bases TCACGGTAATAGTGCCGGGTGGCGCTGTGCTTACTCGGTCCACACCGTTACGACCCCATTATGTGCGACGTAGGCCGAAT AAGACGCTTACATCGCCATC
Product: penicillin-binding protein 1b
Products: NA
Alternate protein names: PBP-1b; PBP1b; Murein polymerase; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Peptidoglycan glycosyltransferase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 840; Mature: 839
Protein sequence:
>840_residues MAGNDREPIGRKGKPSRPVKQKVSRRRQHDDDYDDDYEDEEPMPRKGKGKGRKPRGKRGWLWLLLKLFIVFVVLFAIYGV YLDQKIRSRIDGKVWQLPAAVYGRMVNLEPDMPVSKNEMVKLLEATQYRLVTKMTRPGEFTVQANSIEMIRRPFDFPDSK EGQVRARLTFSDGRLETIVNLDNNRQFGFFRLDPRLITMLSSPNGEQRLFVPRSGFPDLLVDTLLATEDRRFYEHDGISL YSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIMDARYSKDRILELYMNEVYLGQSGDNEIR GFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRLLQQQKIIDQELYDMLSARPLGVQPRG GVISPQPAFMQMVRQELQAKLGDKIKDLSGVKIFTTFDSVAQDAAEKAVVEGIPALKKQRKLSDLETAMVVVDRFSGEVR AMVGGAEPQYAGYNRAMQARRSIGSLAKPATYLTALSQPNLYRLNTWIADAPISLRQPNGQVWSPENDDRRYSESGKVML VDALTRSMNVPTVNLGMALGLPAVTDTWTKLGVPKDQLNPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIA EDGKVLYQSYPQAERAVPAQAAYLTLWTMQQVVQRGTGRQLGAKYPGLHLVGKTGTTNNNVDTWFAGIDGSQVTITWVGR DNNQPTKLYGASGAMAIYQRYLANQTPTPLVLTPPEDVVDMGVDYDGNFVCNGGMRTLPVWTDDPNTLCQQGEMMQQQQQ PSGNPFDQSSQPQQPAQQQPPKEEKSDGVAGWIKEMFGGN
Sequences:
>Translated_840_residues MAGNDREPIGRKGKPSRPVKQKVSRRRQHDDDYDDDYEDEEPMPRKGKGKGRKPRGKRGWLWLLLKLFIVFVVLFAIYGV YLDQKIRSRIDGKVWQLPAAVYGRMVNLEPDMPVSKNEMVKLLEATQYRLVTKMTRPGEFTVQANSIEMIRRPFDFPDSK EGQVRARLTFSDGRLETIVNLDNNRQFGFFRLDPRLITMLSSPNGEQRLFVPRSGFPDLLVDTLLATEDRRFYEHDGISL YSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIMDARYSKDRILELYMNEVYLGQSGDNEIR GFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRLLQQQKIIDQELYDMLSARPLGVQPRG GVISPQPAFMQMVRQELQAKLGDKIKDLSGVKIFTTFDSVAQDAAEKAVVEGIPALKKQRKLSDLETAMVVVDRFSGEVR AMVGGAEPQYAGYNRAMQARRSIGSLAKPATYLTALSQPNLYRLNTWIADAPISLRQPNGQVWSPENDDRRYSESGKVML VDALTRSMNVPTVNLGMALGLPAVTDTWTKLGVPKDQLNPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIA EDGKVLYQSYPQAERAVPAQAAYLTLWTMQQVVQRGTGRQLGAKYPGLHLVGKTGTTNNNVDTWFAGIDGSQVTITWVGR DNNQPTKLYGASGAMAIYQRYLANQTPTPLVLTPPEDVVDMGVDYDGNFVCNGGMRTLPVWTDDPNTLCQQGEMMQQQQQ PSGNPFDQSSQPQQPAQQQPPKEEKSDGVAGWIKEMFGGN >Mature_839_residues AGNDREPIGRKGKPSRPVKQKVSRRRQHDDDYDDDYEDEEPMPRKGKGKGRKPRGKRGWLWLLLKLFIVFVVLFAIYGVY LDQKIRSRIDGKVWQLPAAVYGRMVNLEPDMPVSKNEMVKLLEATQYRLVTKMTRPGEFTVQANSIEMIRRPFDFPDSKE GQVRARLTFSDGRLETIVNLDNNRQFGFFRLDPRLITMLSSPNGEQRLFVPRSGFPDLLVDTLLATEDRRFYEHDGISLY SIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIMDARYSKDRILELYMNEVYLGQSGDNEIRG FPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRLLQQQKIIDQELYDMLSARPLGVQPRGG VISPQPAFMQMVRQELQAKLGDKIKDLSGVKIFTTFDSVAQDAAEKAVVEGIPALKKQRKLSDLETAMVVVDRFSGEVRA MVGGAEPQYAGYNRAMQARRSIGSLAKPATYLTALSQPNLYRLNTWIADAPISLRQPNGQVWSPENDDRRYSESGKVMLV DALTRSMNVPTVNLGMALGLPAVTDTWTKLGVPKDQLNPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAE DGKVLYQSYPQAERAVPAQAAYLTLWTMQQVVQRGTGRQLGAKYPGLHLVGKTGTTNNNVDTWFAGIDGSQVTITWVGRD NNQPTKLYGASGAMAIYQRYLANQTPTPLVLTPPEDVVDMGVDYDGNFVCNGGMRTLPVWTDDPNTLCQQGEMMQQQQQP SGNPFDQSSQPQQPAQQQPPKEEKSDGVAGWIKEMFGGN
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG0744
COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1786343, Length=847, Percent_Identity=89.8465171192444, Blast_Score=1457, Evalue=0.0, Organism=Escherichia coli, GI87082258, Length=245, Percent_Identity=36.3265306122449, Blast_Score=156, Evalue=6e-39, Organism=Escherichia coli, GI1788867, Length=515, Percent_Identity=26.9902912621359, Blast_Score=124, Evalue=2e-29, Organism=Escherichia coli, GI1789601, Length=127, Percent_Identity=37.007874015748, Blast_Score=79, Evalue=9e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011813 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: =2.4.1.129 [H]
Molecular weight: Translated: 93944; Mature: 93813
Theoretical pI: Translated: 9.63; Mature: 9.63
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 3.5 %Met (Translated Protein) 3.7 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 3.3 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAGNDREPIGRKGKPSRPVKQKVSRRRQHDDDYDDDYEDEEPMPRKGKGKGRKPRGKRGW CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH LWLLLKLFIVFVVLFAIYGVYLDQKIRSRIDGKVWQLPAAVYGRMVNLEPDMPVSKNEMV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECHHHHCEEEECCCCCCCCHHHHH KLLEATQYRLVTKMTRPGEFTVQANSIEMIRRPFDFPDSKEGQVRARLTFSDGRLETIVN HHHHHHHHHHHHHCCCCCCEEEECCCHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEE LDNNRQFGFFRLDPRLITMLSSPNGEQRLFVPRSGFPDLLVDTLLATEDRRFYEHDGISL CCCCCEEEEEEECHHHEEEECCCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHCCCEEH YSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIMDARYSKDR HHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCCHHH ILELYMNEVYLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRN HHHHHHHHEEECCCCCCCCCCCCHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCCCCC PKLALERRNLVLRLLQQQKIIDQELYDMLSARPLGVQPRGGVISPQPAFMQMVRQELQAK CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH LGDKIKDLSGVKIFTTFDSVAQDAAEKAVVEGIPALKKQRKLSDLETAMVVVDRFSGEVR HCHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEE AMVGGAEPQYAGYNRAMQARRSIGSLAKPATYLTALSQPNLYRLNTWIADAPISLRQPNG EEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEEEEECCCCEEECCCC QVWSPENDDRRYSESGKVMLVDALTRSMNVPTVNLGMALGLPAVTDTWTKLGVPKDQLNP CCCCCCCCCCHHCCCCCEEEEEHHHHCCCCCEEECHHHHCCCCHHHHHHHCCCCHHHCCC VPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGKVLYQSYPQAERAVPAQ HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHCCCCH AAYLTLWTMQQVVQRGTGRQLGAKYPGLHLVGKTGTTNNNVDTWFAGIDGSQVTITWVGR HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCEEEEEEEEC DNNQPTKLYGASGAMAIYQRYLANQTPTPLVLTPPEDVVDMGVDYDGNFVCNGGMRTLPV CCCCCCEEECCCCHHHHHHHHHCCCCCCCEEECCCHHHHHCCCCCCCCEEECCCCEEEEE WTDDPNTLCQQGEMMQQQQQPSGNPFDQSSQPQQPAQQQPPKEEKSDGVAGWIKEMFGGN EECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCHHHCCCHHHHHHHHHCCC >Mature Secondary Structure AGNDREPIGRKGKPSRPVKQKVSRRRQHDDDYDDDYEDEEPMPRKGKGKGRKPRGKRGW CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH LWLLLKLFIVFVVLFAIYGVYLDQKIRSRIDGKVWQLPAAVYGRMVNLEPDMPVSKNEMV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECHHHHCEEEECCCCCCCCHHHHH KLLEATQYRLVTKMTRPGEFTVQANSIEMIRRPFDFPDSKEGQVRARLTFSDGRLETIVN HHHHHHHHHHHHHCCCCCCEEEECCCHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEE LDNNRQFGFFRLDPRLITMLSSPNGEQRLFVPRSGFPDLLVDTLLATEDRRFYEHDGISL CCCCCEEEEEEECHHHEEEECCCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHCCCEEH YSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIMDARYSKDR HHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCCHHH ILELYMNEVYLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRN HHHHHHHHEEECCCCCCCCCCCCHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCCCCC PKLALERRNLVLRLLQQQKIIDQELYDMLSARPLGVQPRGGVISPQPAFMQMVRQELQAK CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH LGDKIKDLSGVKIFTTFDSVAQDAAEKAVVEGIPALKKQRKLSDLETAMVVVDRFSGEVR HCHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEE AMVGGAEPQYAGYNRAMQARRSIGSLAKPATYLTALSQPNLYRLNTWIADAPISLRQPNG EEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEEEEECCCCEEECCCC QVWSPENDDRRYSESGKVMLVDALTRSMNVPTVNLGMALGLPAVTDTWTKLGVPKDQLNP CCCCCCCCCCHHCCCCCEEEEEHHHHCCCCCEEECHHHHCCCCHHHHHHHCCCCHHHCCC VPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGKVLYQSYPQAERAVPAQ HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHCCCCH AAYLTLWTMQQVVQRGTGRQLGAKYPGLHLVGKTGTTNNNVDTWFAGIDGSQVTITWVGR HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCEEEEEEEEC DNNQPTKLYGASGAMAIYQRYLANQTPTPLVLTPPEDVVDMGVDYDGNFVCNGGMRTLPV CCCCCCEEECCCCHHHHHHHHHCCCCCCCEEECCCHHHHHCCCCCCCCEEECCCCEEEEE WTDDPNTLCQQGEMMQQQQQPSGNPFDQSSQPQQPAQQQPPKEEKSDGVAGWIKEMFGGN EECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCHHHCCCHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 3882429; 8202364; 9278503; 3920658; 8645198; 9244263; 3330753; 1885547; 10037771; 10564478; 9841666 [H]