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The map label for this gene is mutT [H]

Identifier: 29140682

GI number: 29140682

Start: 162959

End: 163354

Strand: Direct

Name: mutT [H]

Synonym: t0141

Alternate gene names: 29140682

Gene position: 162959-163354 (Clockwise)

Preceding gene: 29140681

Following gene: 29140684

Centisome position: 3.4

GC content: 52.02

Gene sequence:

>396_bases
ATGAAAAAACTGCAAATCGCGGTTGGGATTATCCGCAACCCGAACGACGAAATTTTTATTACCCGACGCGCCGCTGATGC
GCATATGGCGAACAAGCTGGAATTTCCCGGCGGAAAAATTGAAGCCGGCGAAACACCAGAGCAGGCGTTGATCCGGGAGC
TACAGGAAGAGGTGGGGATTACGCCAACACAGGTGACATTATTCGACACTCTGGAATATCAATTCCCGGATAGACACATT
ACGCTGTGGTTTTGGCTGGTTGAACGCTGGGAGGGCGAACCGTGGGGGAAAGAAGGACAGCCGGGACGGTGGATCGCGCA
AAACGCGTTGAATACGGACGATTTTCCGCCGGCCAATGAACCGATTATTCGTAAATTACGCCAATTTGCGCCTTAG

Upstream 100 bases:

>100_bases
TGCTGGCATTATTGCCGAAGGGCGCTACGCTTATTCGGCCTAGCATTGAACACAGATAAAAAGGCGCAGGCGACTGCGCC
TTTTTTATGGATGCACCAAG

Downstream 100 bases:

>100_bases
TGGGGGATCGCAACACGATCCCCATCGATCTTATTAGCGATTTAATGTCGACATAATTTCCGGCCAGTAGCGGGGGCCGG
CTGCGGCGTCGTGAGGAAAA

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 131; Mature: 131

Protein sequence:

>131_residues
MKKLQIAVGIIRNPNDEIFITRRAADAHMANKLEFPGGKIEAGETPEQALIRELQEEVGITPTQVTLFDTLEYQFPDRHI
TLWFWLVERWEGEPWGKEGQPGRWIAQNALNTDDFPPANEPIIRKLRQFAP

Sequences:

>Translated_131_residues
MKKLQIAVGIIRNPNDEIFITRRAADAHMANKLEFPGGKIEAGETPEQALIRELQEEVGITPTQVTLFDTLEYQFPDRHI
TLWFWLVERWEGEPWGKEGQPGRWIAQNALNTDDFPPANEPIIRKLRQFAP
>Mature_131_residues
MKKLQIAVGIIRNPNDEIFITRRAADAHMANKLEFPGGKIEAGETPEQALIRELQEEVGITPTQVTLFDTLEYQFPDRHI
TLWFWLVERWEGEPWGKEGQPGRWIAQNALNTDDFPPANEPIIRKLRQFAP

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=129, Percent_Identity=81.3953488372093, Blast_Score=223, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 15120; Mature: 15120

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLQIAVGIIRNPNDEIFITRRAADAHMANKLEFPGGKIEAGETPEQALIRELQEEVGI
CCCEEEEEEEEECCCCCEEEEECCCCHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHCC
TPTQVTLFDTLEYQFPDRHITLWFWLVERWEGEPWGKEGQPGRWIAQNALNTDDFPPANE
CCCEEEEEEEEEEECCCCEEEEEEEEEHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCC
PIIRKLRQFAP
HHHHHHHHHCC
>Mature Secondary Structure
MKKLQIAVGIIRNPNDEIFITRRAADAHMANKLEFPGGKIEAGETPEQALIRELQEEVGI
CCCEEEEEEEEECCCCCEEEEECCCCHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHCC
TPTQVTLFDTLEYQFPDRHITLWFWLVERWEGEPWGKEGQPGRWIAQNALNTDDFPPANE
CCCEEEEEEEEEEECCCCEEEEEEEEEHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCC
PIIRKLRQFAP
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3033442; 1630901; 9278503; 2841285; 8202364; 3288626; 1851162; 1309939; 7578113; 9063868 [H]