Click here to switch to the map view.

The map label for this gene is murC [H]

Identifier: 29140674

GI number: 29140674

Start: 152549

End: 154024

Strand: Direct

Name: murC [H]

Synonym: t0133

Alternate gene names: 29140674

Gene position: 152549-154024 (Clockwise)

Preceding gene: 29140673

Following gene: 29140675

Centisome position: 3.18

GC content: 56.5

Gene sequence:

>1476_bases
ATGAATACACAACAACTGGCAAAACTGCGTTCCATCGTGCCCGAAATGCGTCGCGTTCGGCACATTCACTTTGTCGGCAT
CGGTGGTGCTGGTATGGGCGGTATTGCCGAAGTTCTGGCCAATGAAGGGTATCAGATCAGTGGTTCCGATTTAGCGCCGA
ATCCGGTGACCCAGCAGTTGACGAGCCTGGGGGCGACGATTTTCTTTAACCATCGTCCGGAAAATGTGCGTGATGCCAGC
GTGGTCGTCGTTTCCAGCGCAATTTCCGCGGATAACCCGGAAATTGTCGCGGCGCATGAAGCGCGTATTCCGGTTATTCG
CCGTGCGGAAATGCTGGCGGAACTGATGCGTTTTCGCCACGGCATCGCCATTGCCGGGACGCACGGAAAAACCACAACGA
CCGCGATGGTGTCCAGTATTTATGCCGAAGCGGGGCTGGACCCGACTTTCGTGAATGGCGGATTGGTGAAAGCCGCAGGC
GTTCATGCGCGTCTGGGCCATAGTCGTTACCTGATTGCCGAGGCAGATGAGAGCGACGCATCCTTCCTGCATTTGCAGCC
GATGGTTGCGATCGTCACCAACATCGAAGCCGACCATATGGATACCTATCATGGCGACTTTGAAAATTTAAAGCAGACGT
TTATTAACTTCCTGCATAACCTGCCGTTCTACGGTCGCGCGGTAATGTGCGTCGACGATCCGGTCATCCGCGAGTTGCTG
CCGCGGGTGGGGCGTCAGACCACGACGTATGGCTTTAGCGAGGATGCTGACGTCCGCGTAGAAGATTATCAGCAGATAGG
GCCGCAGGGGCACTTTACGCTGTTGCGCCAGGGAATGCCGGATCTGCATGTCACGTTGAATGCGCCGGGTCGCCACAATG
CCCTGAATGCCGCCGCGGCAGTGGCGGTAGCGACCGAAGAAGGCATCGACGATGACGCTATCCTGCGCGCGCTGGAAAGC
TTCCAGGGGACCGGGCGTCGTTTTGACTTCCTCGGCGAGTTCCCGCTTGAGCCGGTGAATGGTAAAGCCGGGACGGCGAT
GCTGGTGGATGACTATGGACATCATCCGACCGAAGTGGACGCCACCATTAAAGCTGCGCGAGCAGGGTGGCCGGATAAAA
ACCTGGTGATGCTGTTTCAGCCGCATCGTTACACGCGCACGCGCGATCTGTATGACGATTTCGCCAATGTGCTGACCCAG
GTCGATGCGCTGCTGATGCTGGACGTTTACCCGGCGGGCGAAGCGCCGATTCCGGGCGCGGATAGCCGTTCTTTATGTCG
CACGATTCGTAATCGGGGAAAAATTGACCCGATTCTGGTTTCCGATCCGGCTCAGGTTGCGACAATGTTAGCGCCGGTGC
TGACGGGTAACGACTTGATATTAGTGCAAGGCGCAGGAAATGTTGGCAAAATTGCGCGTTACTTATCTGAAATCAAGCTG
AAGCCGCAAATCCAGGAGGAAGAGCAACATGGCTGA

Upstream 100 bases:

>100_bases
GCATCGCAGGGTTTTTCTACCCTCAATAATTTGGGTTGCAGGCAAGCCAACGCATCTGCAATTTGAAGTATGGCGGGTAT
TGGAGTTAATGGCGTAAAGA

Downstream 100 bases:

>100_bases
TAAAATCGCGGTCCTGTTGGGCGGAACCTCTGCGGAGCGGGACGTTTCGTTAAATTCCGGCGCGGCAGTGTTGGCCGGGT
TACGTGAAGGCGGTATTGAT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLTSLGATIFFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAAVAVATEEGIDDDAILRALES
FQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRYTRTRDLYDDFANVLTQ
VDALLMLDVYPAGEAPIPGADSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKL
KPQIQEEEQHG

Sequences:

>Translated_491_residues
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLTSLGATIFFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAAVAVATEEGIDDDAILRALES
FQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRYTRTRDLYDDFANVLTQ
VDALLMLDVYPAGEAPIPGADSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKL
KPQIQEEEQHG
>Mature_491_residues
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLTSLGATIFFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAAVAVATEEGIDDDAILRALES
FQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRYTRTRDLYDDFANVLTQ
VDALLMLDVYPAGEAPIPGADSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKL
KPQIQEEEQHG

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=490, Percent_Identity=94.8979591836735, Blast_Score=877, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=480, Percent_Identity=27.7083333333333, Blast_Score=143, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53482; Mature: 53482

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHH
TSLGATIFFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
HHCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCEECCCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
CEEEHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAA
HHCCCCCEECCCCCCCCCCHHHHHHCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHH
VAVATEEGIDDDAILRALESFQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVD
EEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCHH
ATIKAARAGWPDKNLVMLFQPHRYTRTRDLYDDFANVLTQVDALLMLDVYPAGEAPIPGA
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
DSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKL
CHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCC
KPQIQEEEQHG
CCCCCCCCCCC
>Mature Secondary Structure
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHH
TSLGATIFFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
HHCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCEECCCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
CEEEHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAA
HHCCCCCEECCCCCCCCCCHHHHHHCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHH
VAVATEEGIDDDAILRALESFQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVD
EEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCHH
ATIKAARAGWPDKNLVMLFQPHRYTRTRDLYDDFANVLTQVDALLMLDVYPAGEAPIPGA
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
DSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKL
CHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCC
KPQIQEEEQHG
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA