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The map label for this gene is yogA [H]

Identifier: 28563928

GI number: 28563928

Start: 1425155

End: 1426135

Strand: Direct

Name: yogA [H]

Synonym: OB1376

Alternate gene names: 28563928

Gene position: 1425155-1426135 (Clockwise)

Preceding gene: 23098830

Following gene: 23098839

Centisome position: 39.25

GC content: 39.04

Gene sequence:

>981_bases
ATGAGAGGGTTAGTACACGAACGTAATCAAGTAACAATCAAAGATATGGACGAGCCAACACCAGCTTCAAATGAAGTTGT
TGTTAAATTAAAGGCAGCTGGCTTAAATCGAAGAGACTTGGCAATTCCGAAACGTAGAGGCGATGAACAAGAAGCTTTAA
TTCTTGGCTCTGATGGTGCTGGAGTGATCGATTCTATTGGAGATGAAGTAGAGAACGTACAAGTTGGTGATGAAGTGATA
ATTAATCCATCATTAAGATGGAAGCAAAATAGTGATGCACCTCCGAAAGGATTTGATATTTTAGGAATGCCTGATCACGG
AACTATAGCTGAGAAAATTGTAATTGCTTCAGACCAAGTAGAACCAAAGCCATCTTATTTGTCTTGGGAAGAGGCAGCAG
TGTTTTCGTTGGCAGCACTTACAGGTTATCGGGCAATCTTTACGAAAGGTAAGTTACAACCGGGGGAGACTGTATTTATT
CCAGGTGCGGGAAGTGGAGTTGCATCATTTCTAATTCATTTTGCTAAAAATCATGGTGCACGAGTAATTACTACATCTCG
TAGTAAGGATAAACAAGAAAAAGCAAAGGATTTAGGAGCAGACGTTGTATTGGATACTTCGGATGATTGGGAAGCAGCTT
TACAGGACGAGACGATAGATATGGTTATTGACAGTGTAGGAAAAGCCACTTTTCATCGCTCTTTAGCAGTACTGAAAAAA
GGGGGAAGATTTGTTACATTCGGGGCAACGACGGAAGATGTCATTGATTTTGACTTACGTTCATTCTTCTATGGACAATA
CCAATTAATCGGCACAACGATGGGATGTAAAGAAGAGTTAGAGGCTGCATTAAATCATTACATTAAATATGAAACACGTC
CTGTTGTAGATAAAGTATTTAACTTAGAAGAAAGCCTAGATGCTTTAGAGTATTTAAAAGAAGGGAAACAATTTGGGAAG
GTAGCGATACGTATTTCATAA

Upstream 100 bases:

>100_bases
AAGATCAAAATAAAGTTATAATCCCTTTATTTACTGAAGATATAACAAGTATGGAGCAATTGGAAAAAATGAATAGCTTT
TTATAGAAAGGAAGATTTTG

Downstream 100 bases:

>100_bases
GGTAATAAAATAGTTCTATACATCAGAGCAGTTGAAAATAGGGAGTAATCAAATCGGGTACTGAATGAATCGGAACTACT
TATTTTTGTTCGCAAAATAA

Product: alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MRGLVHERNQVTIKDMDEPTPASNEVVVKLKAAGLNRRDLAIPKRRGDEQEALILGSDGAGVIDSIGDEVENVQVGDEVI
INPSLRWKQNSDAPPKGFDILGMPDHGTIAEKIVIASDQVEPKPSYLSWEEAAVFSLAALTGYRAIFTKGKLQPGETVFI
PGAGSGVASFLIHFAKNHGARVITTSRSKDKQEKAKDLGADVVLDTSDDWEAALQDETIDMVIDSVGKATFHRSLAVLKK
GGRFVTFGATTEDVIDFDLRSFFYGQYQLIGTTMGCKEELEAALNHYIKYETRPVVDKVFNLEESLDALEYLKEGKQFGK
VAIRIS

Sequences:

>Translated_326_residues
MRGLVHERNQVTIKDMDEPTPASNEVVVKLKAAGLNRRDLAIPKRRGDEQEALILGSDGAGVIDSIGDEVENVQVGDEVI
INPSLRWKQNSDAPPKGFDILGMPDHGTIAEKIVIASDQVEPKPSYLSWEEAAVFSLAALTGYRAIFTKGKLQPGETVFI
PGAGSGVASFLIHFAKNHGARVITTSRSKDKQEKAKDLGADVVLDTSDDWEAALQDETIDMVIDSVGKATFHRSLAVLKK
GGRFVTFGATTEDVIDFDLRSFFYGQYQLIGTTMGCKEELEAALNHYIKYETRPVVDKVFNLEESLDALEYLKEGKQFGK
VAIRIS
>Mature_326_residues
MRGLVHERNQVTIKDMDEPTPASNEVVVKLKAAGLNRRDLAIPKRRGDEQEALILGSDGAGVIDSIGDEVENVQVGDEVI
INPSLRWKQNSDAPPKGFDILGMPDHGTIAEKIVIASDQVEPKPSYLSWEEAAVFSLAALTGYRAIFTKGKLQPGETVFI
PGAGSGVASFLIHFAKNHGARVITTSRSKDKQEKAKDLGADVVLDTSDDWEAALQDETIDMVIDSVGKATFHRSLAVLKK
GGRFVTFGATTEDVIDFDLRSFFYGQYQLIGTTMGCKEELEAALNHYIKYETRPVVDKVFNLEESLDALEYLKEGKQFGK
VAIRIS

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=316, Percent_Identity=24.6835443037975, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI13236495, Length=316, Percent_Identity=24.6835443037975, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI47519420, Length=354, Percent_Identity=29.3785310734463, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI22538446, Length=338, Percent_Identity=23.0769230769231, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI22538444, Length=338, Percent_Identity=23.0769230769231, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI18379349, Length=330, Percent_Identity=25.1515151515152, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI24308257, Length=346, Percent_Identity=21.9653179190751, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI156627571, Length=343, Percent_Identity=23.6151603498542, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4501933, Length=242, Percent_Identity=26.4462809917355, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI194239676, Length=195, Percent_Identity=25.6410256410256, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790485, Length=247, Percent_Identity=29.5546558704453, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI87081918, Length=311, Percent_Identity=22.8295819935691, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787863, Length=267, Percent_Identity=26.5917602996255, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536829, Length=295, Percent_Identity=26.1016949152542, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=339, Percent_Identity=23.3038348082596, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=252, Percent_Identity=25.3968253968254, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=334, Percent_Identity=25.4491017964072, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=298, Percent_Identity=24.1610738255034, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319520, Length=254, Percent_Identity=26.7716535433071, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=336, Percent_Identity=22.3214285714286, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=343, Percent_Identity=21.865889212828, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=342, Percent_Identity=22.5146198830409, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24581345, Length=253, Percent_Identity=25.296442687747, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330659, Length=259, Percent_Identity=24.7104247104247, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19920632, Length=259, Percent_Identity=24.7104247104247, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 35743; Mature: 35743

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGLVHERNQVTIKDMDEPTPASNEVVVKLKAAGLNRRDLAIPKRRGDEQEALILGSDGA
CCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCC
GVIDSIGDEVENVQVGDEVIINPSLRWKQNSDAPPKGFDILGMPDHGTIAEKIVIASDQV
CHHHHHCCHHHCEECCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHEEEEECCCC
EPKPSYLSWEEAAVFSLAALTGYRAIFTKGKLQPGETVFIPGAGSGVASFLIHFAKNHGA
CCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCCCC
RVITTSRSKDKQEKAKDLGADVVLDTSDDWEAALQDETIDMVIDSVGKATFHRSLAVLKK
EEEEECCCCHHHHHHHHCCCCEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
GGRFVTFGATTEDVIDFDLRSFFYGQYQLIGTTMGCKEELEAALNHYIKYETRPVVDKVF
CCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHH
NLEESLDALEYLKEGKQFGKVAIRIS
CHHHHHHHHHHHHCCHHHCEEEEEEC
>Mature Secondary Structure
MRGLVHERNQVTIKDMDEPTPASNEVVVKLKAAGLNRRDLAIPKRRGDEQEALILGSDGA
CCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCC
GVIDSIGDEVENVQVGDEVIINPSLRWKQNSDAPPKGFDILGMPDHGTIAEKIVIASDQV
CHHHHHCCHHHCEECCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHEEEEECCCC
EPKPSYLSWEEAAVFSLAALTGYRAIFTKGKLQPGETVFIPGAGSGVASFLIHFAKNHGA
CCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCCCC
RVITTSRSKDKQEKAKDLGADVVLDTSDDWEAALQDETIDMVIDSVGKATFHRSLAVLKK
EEEEECCCCHHHHHHHHCCCCEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
GGRFVTFGATTEDVIDFDLRSFFYGQYQLIGTTMGCKEELEAALNHYIKYETRPVVDKVF
CCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHH
NLEESLDALEYLKEGKQFGKVAIRIS
CHHHHHHHHHHHHCCHHHCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]