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The map label for this gene is qor [C]

Identifier: 28378586

GI number: 28378586

Start: 1757912

End: 1758856

Strand: Direct

Name: qor [C]

Synonym: lp_1939

Alternate gene names: 28378586

Gene position: 1757912-1758856 (Clockwise)

Preceding gene: 28378585

Following gene: 28378593

Centisome position: 53.14

GC content: 52.28

Gene sequence:

>945_bases
ATGAAAGCAGTCATTATTAATCAGTACGGTGGGCCCGAAGAACTCCAGATGGCCACTATCGAACGTCCCAGCATTGATCA
GGACGAGGTCTTAGTCGCCGTTCAGGCAACGAGTATCAACCCCATCGATTGGAAAGCTCGTCAAGGGTTGCTTAAAGGCA
TGTTTGACTGGCAAATGCCAGTTGTCCTTGGTTGGGACGTCGCTGGGACCATTGTTGAGGCTGGCGCGGCCGTGACCAAC
TTTAAGGTTGGTGATGAAGTCTTTGCCCGCCCAGACATTTATGCGGATGGCCGGCGCGGGACCTACGCTGAATATGCCGC
AGTCAAAGAAGACAAGTTAGCTCTAAAACCAGCCAGTCTTTCTTTTGAACAAGCCGCCGCTTTGCCGTTAGCGGGGCTAA
CTGCTTACCAAGTCATTCATGACCAATTAAAGATTCAAGCTGGCGAGAAAGTCTTAATTCAAGCCGGTGCTGGCGGGGTT
GGTTTAAATGCCATCCAGATTGCTAAGTACCTCGGTGCCGAAGTTGCGACTACTGCGAGCGCCAATCACCATACGCTGTT
GAGGCAAATCGGCGCTGACCACGTCATTGATTACCACACGACGGCTATTCAAGATGTCCTTACAGACTACGATGCCGTCT
TTGATACCATTGACGCCATTGATGAGGCCTTGGCAATCTTAAAGCCAACTGGCCGACTCGTGACGATTGATGGGCAACCA
ACGGCGGCTCAAAAATCCCAAGGCCCCACTGTCTCCAGCTGGTGGTTGCAACCCAACGGCCGGGAGTTAGCCATCTTGGG
GCAGCTCGCCGTTGAAGGACACTTACAAGTCATCATCGACCAAGTCTTTCCGTTTAGCACGGCTGGTCTCCAAGCCGCCC
ACCGGTATAGCGAAAACAGCCATAGTGCTGGCAAGCTCATCATCAACGTCGGTACTGAAGCTTAA

Upstream 100 bases:

>100_bases
GACGCGCATCTAATTCACGCTAGTCCGAACTAAATAATTGAATTGAGCACAATTAAAATGCTAAGCTAGGTTATTCAGTT
TCAGGGAGGAATTATTTAAA

Downstream 100 bases:

>100_bases
TACGGCATCGGCTCCAGCCTCAGCCAATTGACCAATCGCCACATTGACTGTCAAACGACGCATTAAAGCCTTAAAAGGGC
GCTTCAAGAATCCACTACGA

Product: oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKAVIINQYGGPEELQMATIERPSIDQDEVLVAVQATSINPIDWKARQGLLKGMFDWQMPVVLGWDVAGTIVEAGAAVTN
FKVGDEVFARPDIYADGRRGTYAEYAAVKEDKLALKPASLSFEQAAALPLAGLTAYQVIHDQLKIQAGEKVLIQAGAGGV
GLNAIQIAKYLGAEVATTASANHHTLLRQIGADHVIDYHTTAIQDVLTDYDAVFDTIDAIDEALAILKPTGRLVTIDGQP
TAAQKSQGPTVSSWWLQPNGRELAILGQLAVEGHLQVIIDQVFPFSTAGLQAAHRYSENSHSAGKLIINVGTEA

Sequences:

>Translated_314_residues
MKAVIINQYGGPEELQMATIERPSIDQDEVLVAVQATSINPIDWKARQGLLKGMFDWQMPVVLGWDVAGTIVEAGAAVTN
FKVGDEVFARPDIYADGRRGTYAEYAAVKEDKLALKPASLSFEQAAALPLAGLTAYQVIHDQLKIQAGEKVLIQAGAGGV
GLNAIQIAKYLGAEVATTASANHHTLLRQIGADHVIDYHTTAIQDVLTDYDAVFDTIDAIDEALAILKPTGRLVTIDGQP
TAAQKSQGPTVSSWWLQPNGRELAILGQLAVEGHLQVIIDQVFPFSTAGLQAAHRYSENSHSAGKLIINVGTEA
>Mature_314_residues
MKAVIINQYGGPEELQMATIERPSIDQDEVLVAVQATSINPIDWKARQGLLKGMFDWQMPVVLGWDVAGTIVEAGAAVTN
FKVGDEVFARPDIYADGRRGTYAEYAAVKEDKLALKPASLSFEQAAALPLAGLTAYQVIHDQLKIQAGEKVLIQAGAGGV
GLNAIQIAKYLGAEVATTASANHHTLLRQIGADHVIDYHTTAIQDVLTDYDAVFDTIDAIDEALAILKPTGRLVTIDGQP
TAAQKSQGPTVSSWWLQPNGRELAILGQLAVEGHLQVIIDQVFPFSTAGLQAAHRYSENSHSAGKLIINVGTEA

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=365, Percent_Identity=30.4109589041096, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI18379349, Length=353, Percent_Identity=28.6118980169972, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI194239674, Length=251, Percent_Identity=30.6772908366534, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI13236495, Length=251, Percent_Identity=30.6772908366534, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI194239676, Length=200, Percent_Identity=34.5, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI22538446, Length=346, Percent_Identity=28.0346820809249, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI22538444, Length=346, Percent_Identity=28.0346820809249, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI24308257, Length=264, Percent_Identity=26.8939393939394, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI67078404, Length=263, Percent_Identity=26.9961977186312, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI90669511, Length=186, Percent_Identity=29.5698924731183, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790485, Length=240, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17507255, Length=244, Percent_Identity=29.0983606557377, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71987554, Length=358, Percent_Identity=27.3743016759777, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=219, Percent_Identity=25.5707762557078, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17536829, Length=193, Percent_Identity=31.0880829015544, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17556000, Length=202, Percent_Identity=28.7128712871287, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319520, Length=249, Percent_Identity=30.9236947791165, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324195, Length=262, Percent_Identity=27.8625954198473, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319945, Length=234, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323493, Length=256, Percent_Identity=27.34375, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=220, Percent_Identity=27.2727272727273, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24581341, Length=364, Percent_Identity=26.0989010989011, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581339, Length=364, Percent_Identity=26.0989010989011, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 33587; Mature: 33587

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVIINQYGGPEELQMATIERPSIDQDEVLVAVQATSINPIDWKARQGLLKGMFDWQMP
CCEEEEECCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
VVLGWDVAGTIVEAGAAVTNFKVGDEVFARPDIYADGRRGTYAEYAAVKEDKLALKPASL
EEEECCHHHHHHHCCCCEEEEECCCHHHCCCCCEECCCCCCHHHHHHCCCCCEEECCCCC
SFEQAAALPLAGLTAYQVIHDQLKIQAGEKVLIQAGAGGVGLNAIQIAKYLGAEVATTAS
CHHHHHCCCCCCHHHHHHHHHHHHEECCCEEEEEECCCCCCCHHHHHHHHHCCHHEECCC
ANHHTLLRQIGADHVIDYHTTAIQDVLTDYDAVFDTIDAIDEALAILKPTGRLVTIDGQP
CCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
TAAQKSQGPTVSSWWLQPNGRELAILGQLAVEGHLQVIIDQVFPFSTAGLQAAHRYSENS
CCCCCCCCCCEEEEEECCCCCEEEEEEEEHHCCHHHHEEHHHCCCCHHHHHHHHHHCCCC
HSAGKLIINVGTEA
CCCCEEEEEECCCC
>Mature Secondary Structure
MKAVIINQYGGPEELQMATIERPSIDQDEVLVAVQATSINPIDWKARQGLLKGMFDWQMP
CCEEEEECCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
VVLGWDVAGTIVEAGAAVTNFKVGDEVFARPDIYADGRRGTYAEYAAVKEDKLALKPASL
EEEECCHHHHHHHCCCCEEEEECCCHHHCCCCCEECCCCCCHHHHHHCCCCCEEECCCCC
SFEQAAALPLAGLTAYQVIHDQLKIQAGEKVLIQAGAGGVGLNAIQIAKYLGAEVATTAS
CHHHHHCCCCCCHHHHHHHHHHHHEECCCEEEEEECCCCCCCHHHHHHHHHCCHHEECCC
ANHHTLLRQIGADHVIDYHTTAIQDVLTDYDAVFDTIDAIDEALAILKPTGRLVTIDGQP
CCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
TAAQKSQGPTVSSWWLQPNGRELAILGQLAVEGHLQVIIDQVFPFSTAGLQAAHRYSENS
CCCCCCCCCCEEEEEECCCCCEEEEEEEEHHCCHHHHEEHHHCCCCHHHHHHHHHHCCCC
HSAGKLIINVGTEA
CCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]