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The map label for this gene is supH [H]

Identifier: 28377673

GI number: 28377673

Start: 764446

End: 765261

Strand: Direct

Name: supH [H]

Synonym: lp_0824

Alternate gene names: 28377673

Gene position: 764446-765261 (Clockwise)

Preceding gene: 28377672

Following gene: 28377676

Centisome position: 23.11

GC content: 44.73

Gene sequence:

>816_bases
GTGGCAATCAATTTAATTGCAACTGACTTGAATGGAACATTATTGCATCAAGATCAGCGTTTTGACAAAGAACGGTTTAA
ACGGGTTTTGGCGCAGTTACGGGCGATAAACGTTTCCCTAGTACTTTCGTCCGGTAACCAATATGCCCATCTTAGACAGT
TATTTAAAGATGTTATGGCGGATAATCTTATCGTTGTTGCTGAAAATGGGGCGTCGATTTATGCCCAAGACCGCTTGATC
TTTGATGGTAGTCTTTCAGCAGACCAGCAACGAAAGTTTGTGACTGTTGATCGTCACCAGCCACTATTCAAAGACGCATA
CGTAATCTTAGTTGGTAGCCATGGGTCGTATACTGAGTTAGGAGCACCTGATAAGTTAGTAGCGATGGCCCGTCAGTTTT
ATGATCATTTACACTTGGTTGCGGATCTGGCCACTGTTGATGATACCGTTAAAAAAATCAGTATCTCAACGTCACCGGAC
CAGGCTGCTGATCTGGTGGCACGAGCTAATGATTATTTTGATGGCGAGTTACGTGCGCATGATAGTGGGTATGGCGTCGT
AGATTTGGTTGATCAGCGGGTCGGAAAATTACCAGCAATTCAATTCTTGGCGACTAAACTTGGGTTAACTGCAGCTAATG
TGATGGCCTTCGGTGATGGGGCGAATGATGTCCCATTATTGCGATATGCAGCGCACAGTTATGCGATGTGCAACGCACCG
GCGGACATTCAAGCCGCAGCAAAACACGTGACGGCCCTGGATAATGAACATGATGGGGTATTAGCAACCATTGAACAAGA
GTTGTTAAATAATTAA

Upstream 100 bases:

>100_bases
GCAATGTAACTGAGTGTCATGTTGATGTTTAATCGGCTGAATCACATGACGAGACGAGGCCGATTTTGTTAGTAAATGAT
AAAAGATGGGGTGGCTACTT

Downstream 100 bases:

>100_bases
AAGCCTATAACTAGTCAGTAAAAAGCTGAGCTATCGAATGAACATCGTTATTCGATAGCTCAGCTTTTTGGGTCCTATTA
AAGTGATTGATTAGGGTAGA

Product: HAD superfamily hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MAINLIATDLNGTLLHQDQRFDKERFKRVLAQLRAINVSLVLSSGNQYAHLRQLFKDVMADNLIVVAENGASIYAQDRLI
FDGSLSADQQRKFVTVDRHQPLFKDAYVILVGSHGSYTELGAPDKLVAMARQFYDHLHLVADLATVDDTVKKISISTSPD
QAADLVARANDYFDGELRAHDSGYGVVDLVDQRVGKLPAIQFLATKLGLTAANVMAFGDGANDVPLLRYAAHSYAMCNAP
ADIQAAAKHVTALDNEHDGVLATIEQELLNN

Sequences:

>Translated_271_residues
MAINLIATDLNGTLLHQDQRFDKERFKRVLAQLRAINVSLVLSSGNQYAHLRQLFKDVMADNLIVVAENGASIYAQDRLI
FDGSLSADQQRKFVTVDRHQPLFKDAYVILVGSHGSYTELGAPDKLVAMARQFYDHLHLVADLATVDDTVKKISISTSPD
QAADLVARANDYFDGELRAHDSGYGVVDLVDQRVGKLPAIQFLATKLGLTAANVMAFGDGANDVPLLRYAAHSYAMCNAP
ADIQAAAKHVTALDNEHDGVLATIEQELLNN
>Mature_270_residues
AINLIATDLNGTLLHQDQRFDKERFKRVLAQLRAINVSLVLSSGNQYAHLRQLFKDVMADNLIVVAENGASIYAQDRLIF
DGSLSADQQRKFVTVDRHQPLFKDAYVILVGSHGSYTELGAPDKLVAMARQFYDHLHLVADLATVDDTVKKISISTSPDQ
AADLVARANDYFDGELRAHDSGYGVVDLVDQRVGKLPAIQFLATKLGLTAANVMAFGDGANDVPLLRYAAHSYAMCNAPA
DIQAAAKHVTALDNEHDGVLATIEQELLNN

Specific function: Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of fructose-1-P most efficiently, but it remains uncertain if this is the real substrate in vivo [H]

COG id: COG0561

COG function: function code R; Predicted hydrolases of the HAD superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. Cof family. SupH subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787043, Length=273, Percent_Identity=31.5018315018315, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI87081790, Length=268, Percent_Identity=30.9701492537313, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI2367265, Length=288, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006379
- InterPro:   IPR000150 [H]

Pfam domain/function: PF08282 Hydrolase_3 [H]

EC number: =3.1.3.23 [H]

Molecular weight: Translated: 29631; Mature: 29500

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAINLIATDLNGTLLHQDQRFDKERFKRVLAQLRAINVSLVLSSGNQYAHLRQLFKDVMA
CEEEEEEECCCCEEEECHHHCCHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHH
DNLIVVAENGASIYAQDRLIFDGSLSADQQRKFVTVDRHQPLFKDAYVILVGSHGSYTEL
CCEEEEEECCCEEEEECEEEECCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCC
GAPDKLVAMARQFYDHLHLVADLATVDDTVKKISISTSPDQAADLVARANDYFDGELRAH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCCEEEEC
DSGYGVVDLVDQRVGKLPAIQFLATKLGLTAANVMAFGDGANDVPLLRYAAHSYAMCNAP
CCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHEEEECCCCCCCHHHHHHHHHHEECCCC
ADIQAAAKHVTALDNEHDGVLATIEQELLNN
CCHHHHHHHHHHCCCCCCCCHHEEHHHHHCC
>Mature Secondary Structure 
AINLIATDLNGTLLHQDQRFDKERFKRVLAQLRAINVSLVLSSGNQYAHLRQLFKDVMA
EEEEEEECCCCEEEECHHHCCHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHH
DNLIVVAENGASIYAQDRLIFDGSLSADQQRKFVTVDRHQPLFKDAYVILVGSHGSYTEL
CCEEEEEECCCEEEEECEEEECCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCC
GAPDKLVAMARQFYDHLHLVADLATVDDTVKKISISTSPDQAADLVARANDYFDGELRAH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCCEEEEC
DSGYGVVDLVDQRVGKLPAIQFLATKLGLTAANVMAFGDGANDVPLLRYAAHSYAMCNAP
CCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHEEEECCCCCCCHHHHHHHHHHEECCCC
ADIQAAAKHVTALDNEHDGVLATIEQELLNN
CCHHHHHHHHHHCCCCCCCCHHEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]