Click here to switch to the map view.

The map label for this gene is eriC [H]

Identifier: 28377647

GI number: 28377647

Start: 730558

End: 732111

Strand: Direct

Name: eriC [H]

Synonym: lp_0794

Alternate gene names: 28377647

Gene position: 730558-732111 (Clockwise)

Preceding gene: 28377646

Following gene: 28377648

Centisome position: 22.08

GC content: 48.07

Gene sequence:

>1554_bases
ATGGTGGCACAGCGGCCGCACATTGCAAAACAACATTTTGACTTTACACGGTTCAGCTCGATTGGCCGGGCATTAATTGT
CGGTGTGATTGCTGGGATCGTGGTTAGTATTTTTCGTTTCAGCATCGAGCAGGGACTGAGGTTCGTTCAATGGGTGTACG
CACAAATTCATACAAATTGGCTACTGCTCTTTCCATGGATAGGCTTGTCTGTGGCTGTGGCGTTCTTTGTGGGTTGGTTA
GTTAAGAATGAACCGAATATTAAAGGGTCTGGCATTCCACAAGTTGAGGGTCAATTAGCTGGCGAGCTTGATTATAGTTG
GTGGTCAGTGCTCTGGCGCAAGTTTGTCGGTGGTATTCTGGGCATTGGTTCTGGACTGTTTCTCGGCCGCGAAGGCCCCT
CGATTCAATTGGGAGCTACGATTGGTCAGGGTGTCGCGTCGAAACTCAAACAGACGGGATCAGATCGACGCTCCTTGATT
GCCGGTGGTGCAGCAGCTGGCCTTTCAGCGGCCTTCAACGCACCGATTGCCAGTACGTTATTTGTTCTGGAAGAGGTTTA
TCATAATTTTTCACCAATCATTTGGACCACCGCATTAGTTAGTGCGATGGCCAGTAATTTTATTTCGCTCAATTTTTTTG
GCCTTGTACCAGTATTACACATTCCGTACGGCCATAACCTTCCGTTGAGTCAATATGGCAATCTGATTGGGCTCGGGATT
TTTCTCGGTATTTTCGGTTATCTATATCAAAACGTGACGCTGACGATGCCAAATTGGTATGCCAAGTTGCGGTTGCCCAG
TTGGTTGGATGGCTTGGTGCCATTTTTACTGGTGATTCCGATTGGATTAATTTGGCCGCAGCTATTAGGAGGCGGCAATG
CTGTTATTTTGAATTTGGCCGCAGTAACGCCAGCGTTACTCGCCTTGTTAGGAATTTTCGTGTTACGGTTTACCTTTTCT
ACCATTTCATATGGATCTGGTTTGCCGGGGGGCATCTTCTTGCCAATCTTGTCACTGGGCGCCATCTTAGGTGCAATCTA
TGCCCAGTTCATGGTTGCCGTTGGTTGGATGCCGACGAACTTGATTCCGAACTTTATTATTTTTGCAATGGCTGGATACT
TTGCCGGCATTGGTAAAGCACCGTTTACCGCAATTTTATTGATTACTGAAATGGTCGGGACACTACACCACTTGATGCCA
TTAGCAGTCGTTTCGATGACGGCCTACTTAGTCGTGGATCTCTTAGGCGGCGCTCCGATTTATGAGGCTTTGCTAGAGAA
GTTAATTCAGCCGCGGTTACCGGAACATAGCGGTATCCAGGATCGGTTAGAATTGCCGATCTTTGAAGGCTCTAAGTTAG
AGGGCCATCAAGTTCGTGATTTTAAATGGCCAGCAGAGTCATTATTGATCGCTATTCGCCGTGGGGAGCGTCAAGTGATC
CCGCATGGCGACACCTTGATGCGGGCTGGTGATACCTTAATTATCTTGACTGACCGGGATAACCGTGCGTGGGTGCGCCA
TCAAATCGCACATTTAACGGTCGCGACGCCCTGA

Upstream 100 bases:

>100_bases
CCACAGCAGATTCAGGCATTACATCCTGGAGCGCCCGTGACGTTAGCGGCCGTCCAGCAAGTGATTGCACAACGATTATC
ATGATTAAGAGGGGGAACTC

Downstream 100 bases:

>100_bases
GCACTAAACAAAGCAACGAATTGTTCAGGATACTGGAAAAATAAGGCAAAATATGTTAAATTGTTATAGACATAGCGGAG
GCTTTAGGAGGCACATTTCT

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MVAQRPHIAKQHFDFTRFSSIGRALIVGVIAGIVVSIFRFSIEQGLRFVQWVYAQIHTNWLLLFPWIGLSVAVAFFVGWL
VKNEPNIKGSGIPQVEGQLAGELDYSWWSVLWRKFVGGILGIGSGLFLGREGPSIQLGATIGQGVASKLKQTGSDRRSLI
AGGAAAGLSAAFNAPIASTLFVLEEVYHNFSPIIWTTALVSAMASNFISLNFFGLVPVLHIPYGHNLPLSQYGNLIGLGI
FLGIFGYLYQNVTLTMPNWYAKLRLPSWLDGLVPFLLVIPIGLIWPQLLGGGNAVILNLAAVTPALLALLGIFVLRFTFS
TISYGSGLPGGIFLPILSLGAILGAIYAQFMVAVGWMPTNLIPNFIIFAMAGYFAGIGKAPFTAILLITEMVGTLHHLMP
LAVVSMTAYLVVDLLGGAPIYEALLEKLIQPRLPEHSGIQDRLELPIFEGSKLEGHQVRDFKWPAESLLIAIRRGERQVI
PHGDTLMRAGDTLIILTDRDNRAWVRHQIAHLTVATP

Sequences:

>Translated_517_residues
MVAQRPHIAKQHFDFTRFSSIGRALIVGVIAGIVVSIFRFSIEQGLRFVQWVYAQIHTNWLLLFPWIGLSVAVAFFVGWL
VKNEPNIKGSGIPQVEGQLAGELDYSWWSVLWRKFVGGILGIGSGLFLGREGPSIQLGATIGQGVASKLKQTGSDRRSLI
AGGAAAGLSAAFNAPIASTLFVLEEVYHNFSPIIWTTALVSAMASNFISLNFFGLVPVLHIPYGHNLPLSQYGNLIGLGI
FLGIFGYLYQNVTLTMPNWYAKLRLPSWLDGLVPFLLVIPIGLIWPQLLGGGNAVILNLAAVTPALLALLGIFVLRFTFS
TISYGSGLPGGIFLPILSLGAILGAIYAQFMVAVGWMPTNLIPNFIIFAMAGYFAGIGKAPFTAILLITEMVGTLHHLMP
LAVVSMTAYLVVDLLGGAPIYEALLEKLIQPRLPEHSGIQDRLELPIFEGSKLEGHQVRDFKWPAESLLIAIRRGERQVI
PHGDTLMRAGDTLIILTDRDNRAWVRHQIAHLTVATP
>Mature_517_residues
MVAQRPHIAKQHFDFTRFSSIGRALIVGVIAGIVVSIFRFSIEQGLRFVQWVYAQIHTNWLLLFPWIGLSVAVAFFVGWL
VKNEPNIKGSGIPQVEGQLAGELDYSWWSVLWRKFVGGILGIGSGLFLGREGPSIQLGATIGQGVASKLKQTGSDRRSLI
AGGAAAGLSAAFNAPIASTLFVLEEVYHNFSPIIWTTALVSAMASNFISLNFFGLVPVLHIPYGHNLPLSQYGNLIGLGI
FLGIFGYLYQNVTLTMPNWYAKLRLPSWLDGLVPFLLVIPIGLIWPQLLGGGNAVILNLAAVTPALLALLGIFVLRFTFS
TISYGSGLPGGIFLPILSLGAILGAIYAQFMVAVGWMPTNLIPNFIIFAMAGYFAGIGKAPFTAILLITEMVGTLHHLMP
LAVVSMTAYLVVDLLGGAPIYEALLEKLIQPRLPEHSGIQDRLELPIFEGSKLEGHQVRDFKWPAESLLIAIRRGERQVI
PHGDTLMRAGDTLIILTDRDNRAWVRHQIAHLTVATP

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557473, Length=431, Percent_Identity=24.3619489559165, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI189217923, Length=431, Percent_Identity=24.3619489559165, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI189217921, Length=431, Percent_Identity=24.3619489559165, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI153252026, Length=430, Percent_Identity=25.1162790697674, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI55770838, Length=432, Percent_Identity=22.9166666666667, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI55770840, Length=427, Percent_Identity=22.9508196721311, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI119433677, Length=458, Percent_Identity=22.4890829694323, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1786350, Length=428, Percent_Identity=32.0093457943925, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI87081943, Length=425, Percent_Identity=26.5882352941176, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532615, Length=435, Percent_Identity=25.5172413793103, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322500, Length=410, Percent_Identity=25.8536585365854, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24665008, Length=424, Percent_Identity=25.4716981132075, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45551566, Length=410, Percent_Identity=26.3414634146341, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 56303; Mature: 56303

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCHHHHCCCEEEEEECCCCCHHHHHHHHHEEECCC
>Mature Secondary Structure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CCCCHHHHCCCEEEEEECCCCCHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA