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The map label for this gene is pgm2

Identifier: 28377477

GI number: 28377477

Start: 570711

End: 571388

Strand: Direct

Name: pgm2

Synonym: lp_0597

Alternate gene names: 28377477

Gene position: 570711-571388 (Clockwise)

Preceding gene: 28377476

Following gene: 28377478

Centisome position: 17.25

GC content: 48.82

Gene sequence:

>678_bases
ATGACAGAACTAGTATTGGTTCGCCATGGTGAGAGTACGGCCAATCGGGATAATACGTATACCGGTTGGAGTGACGTCCC
GCTAACAGCAGTGGGTATTGCACAGGCTCATCAAGCTGGCAAGCGATTACGAGCTACGGGACTGCAGTTTGGCGCTGTAC
ATACCTCAGTCCTAAAACGGGCTATCGTTACCGCGAATATTATGTTAAGTGAAATTGATCAGTTATGGCTGCCTGAGTAT
AAGACGTGGCGGTTAAATGAACGACATTACGGTGCCTTACGTGGTCAAAATAAGGATGTGACTCGTCAAGAGTACGGTAA
GGCGCAAGTTCAACAGTGGCGGCGGAGCTTTTATACGGTGCCGCCGTTGTTGACACCAGCTGAACTAGACCATGATCGAC
GTTACACCAAGTACGGTGCCGCCGTCGAACCGCGGGGAGAAAGCTTGAAGATGGCTTACGACCGCATCATGCCTTATTGG
ATCGATGAGATTGCACCGCGGTTGTTAGACGGCCAAAACCAACTCGTGGTGGCGCATGGTAGTACGTTGCGTGCGATGAT
CAAATATTTAGAGCATATTAGTGATACTGGGATTGATGGTGTCGAAGTTGCTAACGGAGTGCCAATTTGTTATCACCTTG
ATCGGCAACTGCACGTTATCGGTAAAGAAGAGTATTAA

Upstream 100 bases:

>100_bases
TGGCAAGCGCGTTATCGCACGTAACAGCTGGTTGTGACTTTGAAAAATGAACCAAATCGATTATCATAGGAAGTATTGAA
GATAGTAGGTGGGAAAGAGA

Downstream 100 bases:

>100_bases
ATTTAGTAATAGTTCTCCTAAGCGGTACTTTTATTTAAAGTAAGTGCTAATCTGGACTGCTTTTTTAGACCATTATCAGA
TTAATCGAGCCTGAGTTAAG

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: BPG-dependent PGAM 1; PGAM 1; Phosphoglyceromutase 1; dPGM 1

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MTELVLVRHGESTANRDNTYTGWSDVPLTAVGIAQAHQAGKRLRATGLQFGAVHTSVLKRAIVTANIMLSEIDQLWLPEY
KTWRLNERHYGALRGQNKDVTRQEYGKAQVQQWRRSFYTVPPLLTPAELDHDRRYTKYGAAVEPRGESLKMAYDRIMPYW
IDEIAPRLLDGQNQLVVAHGSTLRAMIKYLEHISDTGIDGVEVANGVPICYHLDRQLHVIGKEEY

Sequences:

>Translated_225_residues
MTELVLVRHGESTANRDNTYTGWSDVPLTAVGIAQAHQAGKRLRATGLQFGAVHTSVLKRAIVTANIMLSEIDQLWLPEY
KTWRLNERHYGALRGQNKDVTRQEYGKAQVQQWRRSFYTVPPLLTPAELDHDRRYTKYGAAVEPRGESLKMAYDRIMPYW
IDEIAPRLLDGQNQLVVAHGSTLRAMIKYLEHISDTGIDGVEVANGVPICYHLDRQLHVIGKEEY
>Mature_224_residues
TELVLVRHGESTANRDNTYTGWSDVPLTAVGIAQAHQAGKRLRATGLQFGAVHTSVLKRAIVTANIMLSEIDQLWLPEYK
TWRLNERHYGALRGQNKDVTRQEYGKAQVQQWRRSFYTVPPLLTPAELDHDRRYTKYGAAVEPRGESLKMAYDRIMPYWI
DEIAPRLLDGQNQLVVAHGSTLRAMIKYLEHISDTGIDGVEVANGVPICYHLDRQLHVIGKEEY

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI4502445, Length=230, Percent_Identity=40.8695652173913, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI40353764, Length=230, Percent_Identity=40.8695652173913, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI50593010, Length=219, Percent_Identity=42.0091324200913, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI4505753, Length=228, Percent_Identity=42.5438596491228, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI71274132, Length=228, Percent_Identity=40.7894736842105, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=45.3416149068323, Blast_Score=127, Evalue=5e-30,
Organism=Escherichia coli, GI1786970, Length=220, Percent_Identity=47.2727272727273, Blast_Score=213, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6322697, Length=220, Percent_Identity=43.1818181818182, Blast_Score=192, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6324516, Length=264, Percent_Identity=29.1666666666667, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6320183, Length=270, Percent_Identity=30.3703703703704, Blast_Score=111, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24646216, Length=227, Percent_Identity=41.8502202643172, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI85725270, Length=234, Percent_Identity=41.8803418803419, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI85725272, Length=234, Percent_Identity=41.8803418803419, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24650981, Length=234, Percent_Identity=41.8803418803419, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI28571815, Length=220, Percent_Identity=38.1818181818182, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28571817, Length=220, Percent_Identity=38.1818181818182, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24648979, Length=220, Percent_Identity=38.1818181818182, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA1_LACPL (Q88YY8)

Other databases:

- EMBL:   AL935253
- RefSeq:   NP_784369.1
- ProteinModelPortal:   Q88YY8
- SMR:   Q88YY8
- GeneID:   1061573
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0597
- NMPDR:   fig|220668.1.peg.503
- HOGENOM:   HBG658938
- OMA:   YTGWSDV
- ProtClustDB:   CLSK581144
- BioCyc:   LPLA220668:LP_0597-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 25625; Mature: 25494

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELVLVRHGESTANRDNTYTGWSDVPLTAVGIAQAHQAGKRLRATGLQFGAVHTSVLKR
CCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AIVTANIMLSEIDQLWLPEYKTWRLNERHYGALRGQNKDVTRQEYGKAQVQQWRRSFYTV
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
PPLLTPAELDHDRRYTKYGAAVEPRGESLKMAYDRIMPYWIDEIAPRLLDGQNQLVVAHG
CCCCCCCCCCCCCHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
STLRAMIKYLEHISDTGIDGVEVANGVPICYHLDRQLHVIGKEEY
HHHHHHHHHHHHHHCCCCCCEECCCCCEEEEECCCEEEEECCCCC
>Mature Secondary Structure 
TELVLVRHGESTANRDNTYTGWSDVPLTAVGIAQAHQAGKRLRATGLQFGAVHTSVLKR
CEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AIVTANIMLSEIDQLWLPEYKTWRLNERHYGALRGQNKDVTRQEYGKAQVQQWRRSFYTV
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
PPLLTPAELDHDRRYTKYGAAVEPRGESLKMAYDRIMPYWIDEIAPRLLDGQNQLVVAHG
CCCCCCCCCCCCCHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
STLRAMIKYLEHISDTGIDGVEVANGVPICYHLDRQLHVIGKEEY
HHHHHHHHHHHHHHCCCCCCEECCCCCEEEEECCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566