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The map label for this gene is accC1 [H]

Identifier: 28377471

GI number: 28377471

Start: 563682

End: 565004

Strand: Direct

Name: accC1 [H]

Synonym: lp_0590

Alternate gene names: 28377471

Gene position: 563682-565004 (Clockwise)

Preceding gene: 28377470

Following gene: 28377472

Centisome position: 17.04

GC content: 49.28

Gene sequence:

>1323_bases
ATGTTTCGCAAGCTGTTAATCGCGAATCGCGGTGAAATTGCCGTACGGATTATCAAAGCCTGTCAACAATTGAATATTCA
GACGGTCGCCGTTTGCTCAACTGCTGATCGGCATGCGGGTTACACACAATTAGCGGATGAAGTGGTCTGTATCGGACCTG
CAGCTGCCAGTGGATCGTATTTAAATGCCGAAGCGATTCTAATGGCTGCAATTAATACGCACGCCGATGCGATTCACCCG
GGATATGGTTTTTTAGCTGAAAATGCGGATTTTGCCGCCATGTGTGCGGAATGTGGCATTGCCTGGATTGGCCCGCAGAC
TGAGCAAATTAAGTTGATGGGTGATAAGGCCCGCGCTAAGGATTTTGCACGGCAACAAGCCGTTCCGGTACTAGCAGGTC
AATCATTACAGGGCTTAGCATGGCCGGATATTAAACACGCGGCCGCCAAGATCGGTTTTCCACTAGTTTTGAAAGCCAGT
TATGGTGGCGGTGGCAAGGGTATTCGAGTGCTTACCAACGTTCATGAACTCCATCAACAATTGCGGGCTGCGCGTCAAGA
AGCTGCTGCGTCCTTTTTGAACGATGCGATGTATTTAGAGCAATTTCTGACAACTGCCCGCCACATTGAAGTTCAAGTCC
TCGGTACGGGGACGAAATTATTCATTCTTGGTGATCGTGACTGTAGCCTCCAATTGCACAAGCAAAAGGTTCTCGAAGAA
AGTTCGGCAAGTATTTTGACTGAGACACAACGCCGGACCTTATACGATCTGTCCCGGCAGTTATTAGCGGGTACACATTA
TCAAAGCTTGGGCACAATTGAATACTTATTTGCGGATGGTCAGTTCTATTTCATGGAAATGAATACGCGTTTACAGGTTG
AACACGGGGTGACAGAATTAACCACCGGAATTGATATTGTGGCTGAACAAATCAAACAGGCGGCTGGCGTTACGGTTGAT
TTTCCAGAACATGTTGGCTTGCAGCCCAAGTGTACGGCGATTGAAGCTCGGTTGACCGCGACCTTACCGGTTAAGCAGAC
GCGGATTGAAACGCTGAGCTGGCCAGCCGATGTACGAGTGGATACGGATTATCATCAGGGCGATCGGCTAGTAACCATGT
ATGATGGTTTGATTGCCAAGTTGATGGTCACCGGTGCGAACCGTCAGCAAGCCGTGCGCAACTTACAACGGGCCTTAGCG
CAAGTAACATTGACGGGACCCACGACGAACTTAACTTTTCTACAGCAAACGGTGGCCCGGCCGGCCTACATTCATGATCA
GTACACGATTCACAGTCTAGCACGTTGGGAGGCGTCGAAATGA

Upstream 100 bases:

>100_bases
TTAGTCCGACCGATGGGACGTTAACAGCAGTACTAGTTGCTGACGACGCCACTGTTGAGTACGAACAACCGTTATTTACA
ATGCGAAAGGATCGGTAGCT

Downstream 100 bases:

>100_bases
GTCATTATCCAGCTTCTGGGACCTGGCAAGCCTGCCCTAAGTGCGGTCGGCACGTCCACCAACGCCAATGGGGCACTTAT
CAGCAATGTCCTTATTGTCA

Product: acetyl-CoA carboxylase, biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MFRKLLIANRGEIAVRIIKACQQLNIQTVAVCSTADRHAGYTQLADEVVCIGPAAASGSYLNAEAILMAAINTHADAIHP
GYGFLAENADFAAMCAECGIAWIGPQTEQIKLMGDKARAKDFARQQAVPVLAGQSLQGLAWPDIKHAAAKIGFPLVLKAS
YGGGGKGIRVLTNVHELHQQLRAARQEAAASFLNDAMYLEQFLTTARHIEVQVLGTGTKLFILGDRDCSLQLHKQKVLEE
SSASILTETQRRTLYDLSRQLLAGTHYQSLGTIEYLFADGQFYFMEMNTRLQVEHGVTELTTGIDIVAEQIKQAAGVTVD
FPEHVGLQPKCTAIEARLTATLPVKQTRIETLSWPADVRVDTDYHQGDRLVTMYDGLIAKLMVTGANRQQAVRNLQRALA
QVTLTGPTTNLTFLQQTVARPAYIHDQYTIHSLARWEASK

Sequences:

>Translated_440_residues
MFRKLLIANRGEIAVRIIKACQQLNIQTVAVCSTADRHAGYTQLADEVVCIGPAAASGSYLNAEAILMAAINTHADAIHP
GYGFLAENADFAAMCAECGIAWIGPQTEQIKLMGDKARAKDFARQQAVPVLAGQSLQGLAWPDIKHAAAKIGFPLVLKAS
YGGGGKGIRVLTNVHELHQQLRAARQEAAASFLNDAMYLEQFLTTARHIEVQVLGTGTKLFILGDRDCSLQLHKQKVLEE
SSASILTETQRRTLYDLSRQLLAGTHYQSLGTIEYLFADGQFYFMEMNTRLQVEHGVTELTTGIDIVAEQIKQAAGVTVD
FPEHVGLQPKCTAIEARLTATLPVKQTRIETLSWPADVRVDTDYHQGDRLVTMYDGLIAKLMVTGANRQQAVRNLQRALA
QVTLTGPTTNLTFLQQTVARPAYIHDQYTIHSLARWEASK
>Mature_440_residues
MFRKLLIANRGEIAVRIIKACQQLNIQTVAVCSTADRHAGYTQLADEVVCIGPAAASGSYLNAEAILMAAINTHADAIHP
GYGFLAENADFAAMCAECGIAWIGPQTEQIKLMGDKARAKDFARQQAVPVLAGQSLQGLAWPDIKHAAAKIGFPLVLKAS
YGGGGKGIRVLTNVHELHQQLRAARQEAAASFLNDAMYLEQFLTTARHIEVQVLGTGTKLFILGDRDCSLQLHKQKVLEE
SSASILTETQRRTLYDLSRQLLAGTHYQSLGTIEYLFADGQFYFMEMNTRLQVEHGVTELTTGIDIVAEQIKQAAGVTVD
FPEHVGLQPKCTAIEARLTATLPVKQTRIETLSWPADVRVDTDYHQGDRLVTMYDGLIAKLMVTGANRQQAVRNLQRALA
QVTLTGPTTNLTFLQQTVARPAYIHDQYTIHSLARWEASK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=432, Percent_Identity=40.7407407407407, Blast_Score=312, Evalue=3e-85,
Organism=Homo sapiens, GI189095269, Length=439, Percent_Identity=39.4077448747153, Blast_Score=292, Evalue=5e-79,
Organism=Homo sapiens, GI295821183, Length=439, Percent_Identity=39.4077448747153, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI65506442, Length=439, Percent_Identity=39.4077448747153, Blast_Score=291, Evalue=8e-79,
Organism=Homo sapiens, GI106049528, Length=432, Percent_Identity=37.962962962963, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI106049295, Length=432, Percent_Identity=37.962962962963, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI106049292, Length=432, Percent_Identity=37.962962962963, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI38679971, Length=476, Percent_Identity=27.3109243697479, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI38679977, Length=476, Percent_Identity=27.3109243697479, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI38679967, Length=476, Percent_Identity=27.3109243697479, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI38679960, Length=476, Percent_Identity=27.3109243697479, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI38679974, Length=476, Percent_Identity=27.3109243697479, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI134142062, Length=362, Percent_Identity=31.4917127071823, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=41.0313901345291, Blast_Score=308, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI71987519, Length=429, Percent_Identity=39.6270396270396, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17567343, Length=432, Percent_Identity=41.4351851851852, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=36.1607142857143, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=26.2230919765166, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=26.2230919765166, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI133931226, Length=497, Percent_Identity=26.7605633802817, Blast_Score=147, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6319685, Length=426, Percent_Identity=37.3239436619718, Blast_Score=285, Evalue=8e-78,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=34.7533632286996, Blast_Score=223, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6321376, Length=445, Percent_Identity=35.9550561797753, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323863, Length=440, Percent_Identity=28.4090909090909, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6324343, Length=357, Percent_Identity=30.2521008403361, Blast_Score=153, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24651757, Length=432, Percent_Identity=39.8148148148148, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24651759, Length=395, Percent_Identity=38.9873417721519, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=35.6502242152466, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=35.6502242152466, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=35.6502242152466, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=35.6502242152466, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=35.6502242152466, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=35.6502242152466, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=35.6502242152466, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=35.6502242152466, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=35.6502242152466, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=35.6502242152466, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI161076409, Length=479, Percent_Identity=27.348643006263, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI161076407, Length=479, Percent_Identity=27.348643006263, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24586460, Length=479, Percent_Identity=27.348643006263, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24586458, Length=479, Percent_Identity=27.348643006263, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48254; Mature: 48254

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRKLLIANRGEIAVRIIKACQQLNIQTVAVCSTADRHAGYTQLADEVVCIGPAAASGSY
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHCCCEEEEECCCCCCCC
LNAEAILMAAINTHADAIHPGYGFLAENADFAAMCAECGIAWIGPQTEQIKLMGDKARAK
CCHHEEEEEEHHCCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCCCEEEEECCHHHHH
DFARQQAVPVLAGQSLQGLAWPDIKHAAAKIGFPLVLKASYGGGGKGIRVLTNVHELHQQ
HHHHHHCCCEECCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
LRAARQEAAASFLNDAMYLEQFLTTARHIEVQVLGTGTKLFILGDRDCSLQLHKQKVLEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEEEEEECCCCCCHHHHHHHHHH
SSASILTETQRRTLYDLSRQLLAGTHYQSLGTIEYLFADGQFYFMEMNTRLQVEHGVTEL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEECCEEEEEEECCEEEEECCHHHH
TTGIDIVAEQIKQAAGVTVDFPEHVGLQPKCTAIEARLTATLPVKQTRIETLSWPADVRV
HHHHHHHHHHHHHHCCCEEECHHHCCCCCCCEEEEEEEEEECCCHHHHHHHCCCCCCEEE
DTDYHQGDRLVTMYDGLIAKLMVTGANRQQAVRNLQRALAQVTLTGPTTNLTFLQQTVAR
ECCCCCCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHCC
PAYIHDQYTIHSLARWEASK
CCEECCCHHHHHHHHCCCCC
>Mature Secondary Structure
MFRKLLIANRGEIAVRIIKACQQLNIQTVAVCSTADRHAGYTQLADEVVCIGPAAASGSY
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHCCCEEEEECCCCCCCC
LNAEAILMAAINTHADAIHPGYGFLAENADFAAMCAECGIAWIGPQTEQIKLMGDKARAK
CCHHEEEEEEHHCCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCCCEEEEECCHHHHH
DFARQQAVPVLAGQSLQGLAWPDIKHAAAKIGFPLVLKASYGGGGKGIRVLTNVHELHQQ
HHHHHHCCCEECCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
LRAARQEAAASFLNDAMYLEQFLTTARHIEVQVLGTGTKLFILGDRDCSLQLHKQKVLEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEEEEEECCCCCCHHHHHHHHHH
SSASILTETQRRTLYDLSRQLLAGTHYQSLGTIEYLFADGQFYFMEMNTRLQVEHGVTEL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEECCEEEEEEECCEEEEECCHHHH
TTGIDIVAEQIKQAAGVTVDFPEHVGLQPKCTAIEARLTATLPVKQTRIETLSWPADVRV
HHHHHHHHHHHHHHCCCEEECHHHCCCCCCCEEEEEEEEEECCCHHHHHHHCCCCCCEEE
DTDYHQGDRLVTMYDGLIAKLMVTGANRQQAVRNLQRALAQVTLTGPTTNLTFLQQTVAR
ECCCCCCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHCC
PAYIHDQYTIHSLARWEASK
CCEECCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]