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The map label for this gene is alr

Identifier: 28199693

GI number: 28199693

Start: 2127646

End: 2128743

Strand: Reverse

Name: alr

Synonym: PD1823

Alternate gene names: 28199693

Gene position: 2128743-2127646 (Counterclockwise)

Preceding gene: 28199694

Following gene: 28199692

Centisome position: 84.48

GC content: 54.46

Gene sequence:

>1098_bases
GTGTGCTCCGTGCGTCCCGCCCACGCCGTAATTGATCTGGATGCGTTACGTCACAATTATCGATTTGCTCGCCGTCTTGG
CGGTGGCAAGGCGTTAGCTGTGGTGAAAGCCGATGCGTATGGTCACGGTGCGGTGCGTTGTGCGCAGGCTTTGGAGGCTG
AAGTTGATGGTTTTGCGGTGGCGTGTATCGAAGAGGCGTTGGAGTTACGCCAAGCCGGTATCCAGGCACCGATCCTGTTG
CTGGAAGGATTTTTCGAGGTTGAAGAGCTGGAATTGATTGCTAAGCACAATTTATGGACTGTGATTGCTTCGTCCTGGCA
GGTGCGGGCGTTGGCTGCGTTCCACAGTCCATCTCCAATTGGGGTGTGGCTTAAGTTGGATAGTGGCATGCATCGGCTTG
GTTTGGAGCCAAAGGAGTTTCGTGATGCTTGGATGTCTCTGCATAGTCTGCCGCAGGTGGGCGAGGTCGTCTTGATGACG
CATTTGGCCCGTGCTGATGAGTTGGATAATCCTCGTACCAATGAGCAGGCATCGGTTTTTGCACATGCTTCGCAGGGAAT
GGTGGCGCCAGCAAGTGTGTGTAACTCTTCAGGTTTGCTTGGTTGGGCAGGGTTGTACAGTGATTGGGGTCGGCCCGGGT
TAATGTTGTACGGTGTCAATCCTATTTCGCAGGAGAGCACGTCACTTAGTGGGCCATTGCGTCCTGTGATGATGGTGTAT
TCCAAGCTGATTGCGGTACGCGAGTTGCCTGCCGGCGAGCCAGTTGGCTATGGGGCATCCTTTGTCACTGAGCGGCCAAC
CCGGGTTGGTGTGGTAGCGATGGGCTATGCAGACGGTTACCCGTATTTTGCGGTCAATGGTACGCCGCTCTTGGTTGATG
GGCGTGTTTGTCCGTTGATCGGCCGGGTTTCTATGGACATGTTGACGGTTGATCTGACAGACCATCCGCAGGCGGATGTT
GGCAGTCAAGTGCAATTGTGGGGTGTGCAACCGGGTGTGGCTGAACTTGCGGCACATTGTAATTTGAGCGCTTATCAGTT
GTTGTGCGGTCTTAAGCGTGTACGTCGATACTATTTGGGTGAGATGGGCGCAGTGTGA

Upstream 100 bases:

>100_bases
GTTATTTAGCCGATTTGATATGTTGTCGCCCTTGTGAAATCTCCAGTGAAGGGTTGGATATGTTCCGTTACTTGGTGTCG
ACGATACCTTGCCCGCAAGA

Downstream 100 bases:

>100_bases
GGGCTGGGGTGCTGCTAGTGGAGCAGTTTTGTGTTTTTCTAACGTTCACTACGGTCGTGTTTCTACGGTGTTCAAGCTGT
TTGGCGTCAAATGGGTTATA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MCSVRPAHAVIDLDALRHNYRFARRLGGGKALAVVKADAYGHGAVRCAQALEAEVDGFAVACIEEALELRQAGIQAPILL
LEGFFEVEELELIAKHNLWTVIASSWQVRALAAFHSPSPIGVWLKLDSGMHRLGLEPKEFRDAWMSLHSLPQVGEVVLMT
HLARADELDNPRTNEQASVFAHASQGMVAPASVCNSSGLLGWAGLYSDWGRPGLMLYGVNPISQESTSLSGPLRPVMMVY
SKLIAVRELPAGEPVGYGASFVTERPTRVGVVAMGYADGYPYFAVNGTPLLVDGRVCPLIGRVSMDMLTVDLTDHPQADV
GSQVQLWGVQPGVAELAAHCNLSAYQLLCGLKRVRRYYLGEMGAV

Sequences:

>Translated_365_residues
MCSVRPAHAVIDLDALRHNYRFARRLGGGKALAVVKADAYGHGAVRCAQALEAEVDGFAVACIEEALELRQAGIQAPILL
LEGFFEVEELELIAKHNLWTVIASSWQVRALAAFHSPSPIGVWLKLDSGMHRLGLEPKEFRDAWMSLHSLPQVGEVVLMT
HLARADELDNPRTNEQASVFAHASQGMVAPASVCNSSGLLGWAGLYSDWGRPGLMLYGVNPISQESTSLSGPLRPVMMVY
SKLIAVRELPAGEPVGYGASFVTERPTRVGVVAMGYADGYPYFAVNGTPLLVDGRVCPLIGRVSMDMLTVDLTDHPQADV
GSQVQLWGVQPGVAELAAHCNLSAYQLLCGLKRVRRYYLGEMGAV
>Mature_365_residues
MCSVRPAHAVIDLDALRHNYRFARRLGGGKALAVVKADAYGHGAVRCAQALEAEVDGFAVACIEEALELRQAGIQAPILL
LEGFFEVEELELIAKHNLWTVIASSWQVRALAAFHSPSPIGVWLKLDSGMHRLGLEPKEFRDAWMSLHSLPQVGEVVLMT
HLARADELDNPRTNEQASVFAHASQGMVAPASVCNSSGLLGWAGLYSDWGRPGLMLYGVNPISQESTSLSGPLRPVMMVY
SKLIAVRELPAGEPVGYGASFVTERPTRVGVVAMGYADGYPYFAVNGTPLLVDGRVCPLIGRVSMDMLTVDLTDHPQADV
GSQVQLWGVQPGVAELAAHCNLSAYQLLCGLKRVRRYYLGEMGAV

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=356, Percent_Identity=44.9438202247191, Blast_Score=282, Evalue=2e-77,
Organism=Escherichia coli, GI1787439, Length=349, Percent_Identity=41.8338108882521, Blast_Score=274, Evalue=8e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_XYLFT (Q87AK1)

Other databases:

- EMBL:   AE009442
- RefSeq:   NP_780007.1
- ProteinModelPortal:   Q87AK1
- SMR:   Q87AK1
- STRING:   Q87AK1
- GeneID:   1143165
- GenomeReviews:   AE009442_GR
- KEGG:   xft:PD1823
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   EGTPVWV
- ProtClustDB:   PRK00053
- BioCyc:   XFAS183190:PD_1823-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 39446; Mature: 39446

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 36-36 ACT_SITE 257-257

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSVRPAHAVIDLDALRHNYRFARRLGGGKALAVVKADAYGHGAVRCAQALEAEVDGFAV
CCCCCCCHHEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHH
ACIEEALELRQAGIQAPILLLEGFFEVEELELIAKHNLWTVIASSWQVRALAAFHSPSPI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEECCCCCE
GVWLKLDSGMHRLGLEPKEFRDAWMSLHSLPQVGEVVLMTHLARADELDNPRTNEQASVF
EEEEEECCCHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
AHASQGMVAPASVCNSSGLLGWAGLYSDWGRPGLMLYGVNPISQESTSLSGPLRPVMMVY
EECCCCCCCHHHHCCCCCCEEEHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
SKLIAVRELPAGEPVGYGASFVTERPTRVGVVAMGYADGYPYFAVNGTPLLVDGRVCPLI
HHHHHHHCCCCCCCCCCCCHHHCCCCCEEEEEEEECCCCCCEEEECCEEEEECCCCCCHH
GRVSMDMLTVDLTDHPQADVGSQVQLWGVQPGVAELAAHCNLSAYQLLCGLKRVRRYYLG
HCCEEEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
EMGAV
HCCCC
>Mature Secondary Structure
MCSVRPAHAVIDLDALRHNYRFARRLGGGKALAVVKADAYGHGAVRCAQALEAEVDGFAV
CCCCCCCHHEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHH
ACIEEALELRQAGIQAPILLLEGFFEVEELELIAKHNLWTVIASSWQVRALAAFHSPSPI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEECCCCCE
GVWLKLDSGMHRLGLEPKEFRDAWMSLHSLPQVGEVVLMTHLARADELDNPRTNEQASVF
EEEEEECCCHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
AHASQGMVAPASVCNSSGLLGWAGLYSDWGRPGLMLYGVNPISQESTSLSGPLRPVMMVY
EECCCCCCCHHHHCCCCCCEEEHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
SKLIAVRELPAGEPVGYGASFVTERPTRVGVVAMGYADGYPYFAVNGTPLLVDGRVCPLI
HHHHHHHCCCCCCCCCCCCHHHCCCCCEEEEEEEECCCCCCEEEECCEEEEECCCCCCHH
GRVSMDMLTVDLTDHPQADVGSQVQLWGVQPGVAELAAHCNLSAYQLLCGLKRVRRYYLG
HCCEEEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
EMGAV
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12533478