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The map label for this gene is czcD [H]

Identifier: 28199682

GI number: 28199682

Start: 2115202

End: 2116125

Strand: Reverse

Name: czcD [H]

Synonym: PD1811

Alternate gene names: 28199682

Gene position: 2116125-2115202 (Counterclockwise)

Preceding gene: 28199683

Following gene: 28199679

Centisome position: 83.98

GC content: 54.87

Gene sequence:

>924_bases
TTGCAAATAGGGAGGTGTCACATGGGACACGACCACACGCATGTACCGAAGGGGATGCATCACGAGCGCCCCTTGTGGTG
GGCGCTTGGGCTTACGGCGAGTGTCCTAGTGGCCGAAATTATTGGTGCGGTGCTGACACGTAGTTTGGCGCTGTTGTCTG
ATGCGGTGCACATGGCTACCGACGTGTTTGCGTTAATGATTGCATTGGTCGCGGTGCGTCTGAGTCGGCGTCCGCCTGAT
GTGCGTCGTACCTATGGTTATGCACGGTTAGAGGCGTTTGGTGCGTTGGTTAACGGGGTATTGCTGTTTGGCGTCGGTGG
TTACATTTTGTGGGAGGCTGTGCAGCGCTTGCGCGCTCCGCAGGAGATTGTGTCCAGCGGTATGCTGGTCATTGCCGTCT
TGGGTTTGGTCATCAATCTGATCGTAATGCGTTTGTTGCATGCCGGTCGTGGTGAGAACCTCAGTATGAAGGGGGCTTAC
CTTGAGGTGTGGAGCGATATGCTCGGTTCGGTCGCTGTCATCGTTGCTGCGATGGTGATCTATGTGACCCGTTGGTATTG
GGTGGATTCGGTATTGGCTGCGTTGATTGGGCTATGGGTTTTGCCGCGAACCTGGCTGCTATTAAGTGAGGCTGTCAATG
TGTTGTTGGAAGGGGTGCCGAAGGGGTTTGCGTTGCCACCCATACGTGATGCACTTAGTGATCATCCTGGTGTGGCCAAT
GTCCATGATGTGCATCTGTGGGCATTAGGGTCCAGGCAGCCGTTGCTGACGGCGCATGTGGTGGCAATCCAAGGCACTGC
ACCGGATGCGTTGCGTCGCACATTGCAGGAGTTGCTGCATGAGCGCTTTAGTATTGAGCATGTGACGTTGCAAATTGAGA
TCGAGCATTGTGGGAGTGATGCTTGTGACGCGAAGCGTTCATAG

Upstream 100 bases:

>100_bases
ATGTGGCTTGTCGATCCGTGGGGGGGGATCAGAGCAGTGATGTGGTAGGGGCAGCATCGTGTTATACCTTTCAGCAGATG
TCGAAAGTAAGCTACACCTA

Downstream 100 bases:

>100_bases
TGTTTCAATGGGCGTTTGTGGTTTGCCCTGATGTGGGGCGCGAATGTCGTTACTGGCGTTGCTGTGCTGTTATTGAGACG
GAATTCCACTTTGGTCGAAG

Product: cobalt-zinc-cadmium resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MQIGRCHMGHDHTHVPKGMHHERPLWWALGLTASVLVAEIIGAVLTRSLALLSDAVHMATDVFALMIALVAVRLSRRPPD
VRRTYGYARLEAFGALVNGVLLFGVGGYILWEAVQRLRAPQEIVSSGMLVIAVLGLVINLIVMRLLHAGRGENLSMKGAY
LEVWSDMLGSVAVIVAAMVIYVTRWYWVDSVLAALIGLWVLPRTWLLLSEAVNVLLEGVPKGFALPPIRDALSDHPGVAN
VHDVHLWALGSRQPLLTAHVVAIQGTAPDALRRTLQELLHERFSIEHVTLQIEIEHCGSDACDAKRS

Sequences:

>Translated_307_residues
MQIGRCHMGHDHTHVPKGMHHERPLWWALGLTASVLVAEIIGAVLTRSLALLSDAVHMATDVFALMIALVAVRLSRRPPD
VRRTYGYARLEAFGALVNGVLLFGVGGYILWEAVQRLRAPQEIVSSGMLVIAVLGLVINLIVMRLLHAGRGENLSMKGAY
LEVWSDMLGSVAVIVAAMVIYVTRWYWVDSVLAALIGLWVLPRTWLLLSEAVNVLLEGVPKGFALPPIRDALSDHPGVAN
VHDVHLWALGSRQPLLTAHVVAIQGTAPDALRRTLQELLHERFSIEHVTLQIEIEHCGSDACDAKRS
>Mature_307_residues
MQIGRCHMGHDHTHVPKGMHHERPLWWALGLTASVLVAEIIGAVLTRSLALLSDAVHMATDVFALMIALVAVRLSRRPPD
VRRTYGYARLEAFGALVNGVLLFGVGGYILWEAVQRLRAPQEIVSSGMLVIAVLGLVINLIVMRLLHAGRGENLSMKGAY
LEVWSDMLGSVAVIVAAMVIYVTRWYWVDSVLAALIGLWVLPRTWLLLSEAVNVLLEGVPKGFALPPIRDALSDHPGVAN
VHDVHLWALGSRQPLLTAHVVAIQGTAPDALRRTLQELLHERFSIEHVTLQIEIEHCGSDACDAKRS

Specific function: Necessary for activation of the czc determinant [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=303, Percent_Identity=32.6732673267327, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI21361112, Length=306, Percent_Identity=31.3725490196078, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI289803013, Length=302, Percent_Identity=27.4834437086093, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI289803009, Length=302, Percent_Identity=27.4834437086093, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI289803007, Length=302, Percent_Identity=27.4834437086093, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI289803003, Length=302, Percent_Identity=27.4834437086093, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI64762489, Length=302, Percent_Identity=27.4834437086093, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI21359890, Length=322, Percent_Identity=26.7080745341615, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI14210520, Length=217, Percent_Identity=33.1797235023041, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI20070323, Length=317, Percent_Identity=25.5520504731861, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI52351208, Length=119, Percent_Identity=41.1764705882353, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI222080086, Length=120, Percent_Identity=32.5, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI40255009, Length=120, Percent_Identity=32.5, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI52352803, Length=129, Percent_Identity=40.3100775193798, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786966, Length=282, Percent_Identity=41.8439716312057, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI1790349, Length=234, Percent_Identity=23.5042735042735, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193210990, Length=325, Percent_Identity=29.5384615384615, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17555794, Length=320, Percent_Identity=29.0625, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17555796, Length=310, Percent_Identity=29.0322580645161, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI32564488, Length=301, Percent_Identity=26.9102990033223, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17550442, Length=122, Percent_Identity=36.0655737704918, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17550440, Length=122, Percent_Identity=36.0655737704918, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320411, Length=175, Percent_Identity=31.4285714285714, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323899, Length=128, Percent_Identity=38.28125, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=116, Percent_Identity=40.5172413793103, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24583858, Length=354, Percent_Identity=27.9661016949153, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24656728, Length=347, Percent_Identity=28.2420749279539, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24656724, Length=347, Percent_Identity=28.2420749279539, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24656720, Length=347, Percent_Identity=28.2420749279539, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24656715, Length=347, Percent_Identity=28.2420749279539, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357035, Length=347, Percent_Identity=28.2420749279539, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585900, Length=123, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585898, Length=123, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585896, Length=123, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921672, Length=123, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24584409, Length=137, Percent_Identity=32.1167883211679, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24645863, Length=108, Percent_Identity=34.2592592592593, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574430, Length=137, Percent_Identity=32.1167883211679, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33691; Mature: 33691

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCC
>Mature Secondary Structure
MQIGRCHMGHDHTHVPKGMHHERPLWWALGLTASVLVAEIIGAVLTRSLALLSDAVHMAT
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVFALMIALVAVRLSRRPPDVRRTYGYARLEAFGALVNGVLLFGVGGYILWEAVQRLRAP
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QEIVSSGMLVIAVLGLVINLIVMRLLHAGRGENLSMKGAYLEVWSDMLGSVAVIVAAMVI
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YVTRWYWVDSVLAALIGLWVLPRTWLLLSEAVNVLLEGVPKGFALPPIRDALSDHPGVAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCC
VHDVHLWALGSRQPLLTAHVVAIQGTAPDALRRTLQELLHERFSIEHVTLQIEIEHCGSD
CEEEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCEEEEEEEEEEEECCCC
ACDAKRS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8829543 [H]