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The map label for this gene is hflK [H]

Identifier: 28199507

GI number: 28199507

Start: 1887361

End: 1888500

Strand: Reverse

Name: hflK [H]

Synonym: PD1630

Alternate gene names: 28199507

Gene position: 1888500-1887361 (Counterclockwise)

Preceding gene: 28199510

Following gene: 28199506

Centisome position: 74.95

GC content: 54.21

Gene sequence:

>1140_bases
ATGGCTTGGAACATACCTGGAAGCAAGGGTAAACATGCTTCAGAGTCGCAACATCGTGGTTCAGGTCCGTTACGTGGTGG
CGGTAATGGCGGTGGTTTCTGGAAGGTGCCAGGGCCACTTAAGGATTTATTTGATGCGGGTATCCTGAGTTGGGTGCTGA
TTGGGGTGCTTTTGATCGTGGTCTTCTCTAGTGTCCAGTTAATTGGCGAGCAGCAGCGTGGTGTGGTGCTGCGCTTTGGG
CAGTTTGTGAGGGTGTTGCAGCCGGGGTTGAGCCTCAAGCTGCCGTGGCCCGTGGAGTCGGTGTATAAGGTCAACGCCAC
CGAGATTAAGACTTTCGGTAAGCAGGTCCCTGTGTTGACCCGTGACGAGAACATAGTGAATGTCACGCTCAATGTGCAGT
ACCAGATTAATGACCCGCACCTATACTTGTATGGCTCGCGTAATGCGAATGAAGTGCTGGTTCAGGCTGCCCAAAGTGCG
GTCCGTGAACAAGTGGGTCGATCCGATCTCAACTCGGTACTCAATAACCGTGGTCCCTTGTCGACAGCCTCTAAAGAGCG
TTTACAGGCATCGTTGGATGCTTACCGTACTGGTCTGTTGGTCACTGGTTTGACTTTGCCTGACGCACGCCCCCCAGAGG
AAGTGAAGTCGGCTTTTGATGAGGTGAATGGTGCTCAGCAGGTACGTGAGCGCCTTATTGATGAGGCTCAGGCTTATGCC
GCCAAGGTTGTTCCTGAGGCACGTGGCCGTGCGGCTAGTAACCGTACGGCGGCTGAGGGATATAAGCAGGCGGTGATTGC
ACGTGCACAGGGAGATGCTGACCGTTTTACTCTTCTGCAGGCCCAATACAAGAACGCTCCGGAGGTTACGCGTAAGCGTT
TGTGGTTGGAGACAATACAGCAGGTCCTGGAACAGAATCGTAAGGTGATCGGTGCCGATGGCCGTCAATTGATTTATGTG
CCGATAGCATCGGACGTGCCACGTCTACCGGCTACTACCATCCAGGGAGGGGTGGGCAATGCGCCTCCGGTGTCACAGGA
TCTATTGATCCCCGAATCGCTTAGCAAGCCATCTAATGAGAATATCCGTAATCCGCAGCGCGTTGTCCGTCCTGCAGGCC
GTGAAGGAGCTCCTCTATGA

Upstream 100 bases:

>100_bases
TATCTACCCCATACCCATAAGTTTGTACAATTCTCGGATTCATTCATCATGGCGGCAATGCGGGATTACCCCCGCTCCGC
CTTTCCATCATGGAGTATGC

Downstream 100 bases:

>100_bases
AAAATTATTTGTGGATTGTTGTTACGGCTGTGCTTTTTCTTAGTTTGTTCAGCTCGATCTTTGTAGTGCGCGAGGATCAG
ACTGCGATGGTCATCAATCT

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MAWNIPGSKGKHASESQHRGSGPLRGGGNGGGFWKVPGPLKDLFDAGILSWVLIGVLLIVVFSSVQLIGEQQRGVVLRFG
QFVRVLQPGLSLKLPWPVESVYKVNATEIKTFGKQVPVLTRDENIVNVTLNVQYQINDPHLYLYGSRNANEVLVQAAQSA
VREQVGRSDLNSVLNNRGPLSTASKERLQASLDAYRTGLLVTGLTLPDARPPEEVKSAFDEVNGAQQVRERLIDEAQAYA
AKVVPEARGRAASNRTAAEGYKQAVIARAQGDADRFTLLQAQYKNAPEVTRKRLWLETIQQVLEQNRKVIGADGRQLIYV
PIASDVPRLPATTIQGGVGNAPPVSQDLLIPESLSKPSNENIRNPQRVVRPAGREGAPL

Sequences:

>Translated_379_residues
MAWNIPGSKGKHASESQHRGSGPLRGGGNGGGFWKVPGPLKDLFDAGILSWVLIGVLLIVVFSSVQLIGEQQRGVVLRFG
QFVRVLQPGLSLKLPWPVESVYKVNATEIKTFGKQVPVLTRDENIVNVTLNVQYQINDPHLYLYGSRNANEVLVQAAQSA
VREQVGRSDLNSVLNNRGPLSTASKERLQASLDAYRTGLLVTGLTLPDARPPEEVKSAFDEVNGAQQVRERLIDEAQAYA
AKVVPEARGRAASNRTAAEGYKQAVIARAQGDADRFTLLQAQYKNAPEVTRKRLWLETIQQVLEQNRKVIGADGRQLIYV
PIASDVPRLPATTIQGGVGNAPPVSQDLLIPESLSKPSNENIRNPQRVVRPAGREGAPL
>Mature_378_residues
AWNIPGSKGKHASESQHRGSGPLRGGGNGGGFWKVPGPLKDLFDAGILSWVLIGVLLIVVFSSVQLIGEQQRGVVLRFGQ
FVRVLQPGLSLKLPWPVESVYKVNATEIKTFGKQVPVLTRDENIVNVTLNVQYQINDPHLYLYGSRNANEVLVQAAQSAV
REQVGRSDLNSVLNNRGPLSTASKERLQASLDAYRTGLLVTGLTLPDARPPEEVKSAFDEVNGAQQVRERLIDEAQAYAA
KVVPEARGRAASNRTAAEGYKQAVIARAQGDADRFTLLQAQYKNAPEVTRKRLWLETIQQVLEQNRKVIGADGRQLIYVP
IASDVPRLPATTIQGGVGNAPPVSQDLLIPESLSKPSNENIRNPQRVVRPAGREGAPL

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=381, Percent_Identity=32.0209973753281, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1786697, Length=222, Percent_Identity=25.6756756756757, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550506, Length=213, Percent_Identity=25.3521126760563, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 41260; Mature: 41128

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNIPGSKGKHASESQHRGSGPLRGGGNGGGFWKVPGPLKDLFDAGILSWVLIGVLLIV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
VFSSVQLIGEQQRGVVLRFGQFVRVLQPGLSLKLPWPVESVYKVNATEIKTFGKQVPVLT
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHCCCHHHHHHHHCCCCEEE
RDENIVNVTLNVQYQINDPHLYLYGSRNANEVLVQAAQSAVREQVGRSDLNSVLNNRGPL
CCCCEEEEEEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCC
STASKERLQASLDAYRTGLLVTGLTLPDARPPEEVKSAFDEVNGAQQVRERLIDEAQAYA
CHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AKVVPEARGRAASNRTAAEGYKQAVIARAQGDADRFTLLQAQYKNAPEVTRKRLWLETIQ
HHHCHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
QVLEQNRKVIGADGRQLIYVPIASDVPRLPATTIQGGVGNAPPVSQDLLIPESLSKPSNE
HHHHHCCEEECCCCCEEEEEECCCCCCCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC
NIRNPQRVVRPAGREGAPL
CCCCHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AWNIPGSKGKHASESQHRGSGPLRGGGNGGGFWKVPGPLKDLFDAGILSWVLIGVLLIV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
VFSSVQLIGEQQRGVVLRFGQFVRVLQPGLSLKLPWPVESVYKVNATEIKTFGKQVPVLT
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHCCCHHHHHHHHCCCCEEE
RDENIVNVTLNVQYQINDPHLYLYGSRNANEVLVQAAQSAVREQVGRSDLNSVLNNRGPL
CCCCEEEEEEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCC
STASKERLQASLDAYRTGLLVTGLTLPDARPPEEVKSAFDEVNGAQQVRERLIDEAQAYA
CHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AKVVPEARGRAASNRTAAEGYKQAVIARAQGDADRFTLLQAQYKNAPEVTRKRLWLETIQ
HHHCHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
QVLEQNRKVIGADGRQLIYVPIASDVPRLPATTIQGGVGNAPPVSQDLLIPESLSKPSNE
HHHHHCCEEECCCCCEEEEEECCCCCCCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC
NIRNPQRVVRPAGREGAPL
CCCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]