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The map label for this gene is dxs

Identifier: 28199179

GI number: 28199179

Start: 1510984

End: 1512891

Strand: Reverse

Name: dxs

Synonym: PD1293

Alternate gene names: 28199179

Gene position: 1512891-1510984 (Counterclockwise)

Preceding gene: 28199180

Following gene: 28199168

Centisome position: 60.04

GC content: 52.57

Gene sequence:

>1908_bases
ATGATTGATTTCACTTGTTATCCACGTTTGTCGCGTATCCAAACTCCAGAGGATCTCCGCGCTTTTCAGGAGTCGGAGTT
GCGTGCGGTTGCCGATGAGTTGCGGAATTATCTGATCGAATCAGTAGGCCTCAGTGGTGGTCACTTTGCTGCTGGGTTGG
GTGTGGTCGAATTGACGATCGCTTTGCATTATTTGTACTGCACTCCTATTGATCAGCTTGTCTGGGACGTGGGTCATCAA
ACGTATCCGCATAAGATATTGACCGGTCGCCGTGACAAGATTAGTACGGTTAAGCATCAAGGTGGTTTGGCACCGTTTCC
TAAGCGTGAGGAGAGTATCTATGACACGTTCGGTGTCGGTCATTCTTCTACTTCTATTTCAGCTGCGCTTGGGATGGCGA
TTGTGGCGCAGCGTAATGGGGATGAGCGTAAGGTGGTGGCCATCATCGGCGATGGTGCGATGACAGCGGGGATGGCTTAT
GAGGCGCTTAATCATGCTGGCGGGATGAGTCCTGCACCGAATCTTCTTGTGATTCTTAACGACAATCGTATGTCGATTTC
CGAAGCGGTCGGTGGGCTTACCAAGATGCTTGGTCGTGCGACTGGCAGCAAAGCATTGAATGCGATCCGTGAGGGTGGCA
AGAGAATTTTTGGGGATAAGAAAACCAATGCAACTGCGCGTTTTTTACGTCGTTGGGAGGAGCATTGGAAGGGGATGTTT
GTGCCGTCGACGTTGTTCGAAGAGATGGGGTTCCATTATACCGGCCCGATTGATGGCCATGATTTGCCGGCCCTTCTTGG
TGCGTTGAAGACGTTGCGTACGTTGAAGGGTCCACAGTTGTTGCATGTGATCACAACCAAAGGGAAGGGGTATGAGCTGG
CTGAGGGAGACCAGATTGGTTACCACGCCGTCGCCCCGTTTGATCCGCAAAAGGGTCTGATTAAGGCGGGAGCAAAGAAG
CAAACATATACGGACGTGTTTAGTGAGTGGTTGTGTGATATGGCAGCGGTGGAACCACGTTTGCTGGCTATTACACCGGC
GATGCGTGAGGGATCGGGGTTGGTGCGTTTTAGTCAGGAGTATCCGCAGCGTTATTTTGATGTGGCCATTGCTGAGCAGC
ACGCGATAACGTTGGCGGCTGGTATGGCGACTCAAGGTGCTAAGCCTGTGGTGGCGATTTACTCGACCTTTTTGCAGCGT
GGTTACGATCAATTGGTTCACGATGTTGCGTTGCAGAAGTTGGATGTGCTTTTTGCAGTAGATCGCGGTGGTGTGGTTGG
TCCAGATGGTGCGACGCATGCGGGTAATTTGGATCTCAGTTTCCTGCGTTGCGTGCCAAACATGATGTTGATGGCTCCTG
CCGATGAGGCAGAGTGCCGGAAGATGTTGAGTACCGGTTTCCACTATTCTGGGCCAGTAGCGGTGCGTTATCCGCGTGGG
ACGGGTCCTGGGGTGGTTCCGTCCGCTGAGTTGGATGTGTTGCCGGTTGGTGTGGCGCAGTTACGTCATTCTGGTACACG
GATCGCTCTACTTGGTTTTGGGGTGTGCGTTGCTCCTGCTGAACAGGTGGGGCGTAGGCTTGGTTTGACTGTGGTCAATA
TGCGTTTTATCAAACCGTTGGATCGAACGTTGCTGTTGGAGTTGGCGCGTACTCACGAAGTGTTTGTCACGATTGAAGAT
AATGTAGTTGCTGGCGGAGCTGGCTCAGGGGTTGCGGAATTACTTAACGCTGAAGGCATCGTTTTGCCGATTGTGCATCT
TGGTCTTCCAGATGCGTTCCAGCAGCACGCTTCCCGTGAGGATTTACTGGCTGAGGCGGGTATTGATGCGGCTGGTGTGT
ACGCTGCGCTGTTAAGTCGTTGGCCTGATTTGGCGGTGCAGAACCATCCGCTGAGTGCGGTGAGTTGA

Upstream 100 bases:

>100_bases
CAGTAGGTAAGTCATCAATGTCATCTTTATGCTTCACTAGATTGCTTGCTCGGGTCCATTATGGGGAGGACAATGGTGGT
TCCGTTGGAATGCCAAGACG

Downstream 100 bases:

>100_bases
GCTCAGTACTGTTTCTGTTTCATCTTCTGTAATTGAGCTGTACGACGATCATTAATATCTGGTCATGCAGGCGTGTCCCG
CAGGGTGGTTGTGTGAGTGC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MIDFTCYPRLSRIQTPEDLRAFQESELRAVADELRNYLIESVGLSGGHFAAGLGVVELTIALHYLYCTPIDQLVWDVGHQ
TYPHKILTGRRDKISTVKHQGGLAPFPKREESIYDTFGVGHSSTSISAALGMAIVAQRNGDERKVVAIIGDGAMTAGMAY
EALNHAGGMSPAPNLLVILNDNRMSISEAVGGLTKMLGRATGSKALNAIREGGKRIFGDKKTNATARFLRRWEEHWKGMF
VPSTLFEEMGFHYTGPIDGHDLPALLGALKTLRTLKGPQLLHVITTKGKGYELAEGDQIGYHAVAPFDPQKGLIKAGAKK
QTYTDVFSEWLCDMAAVEPRLLAITPAMREGSGLVRFSQEYPQRYFDVAIAEQHAITLAAGMATQGAKPVVAIYSTFLQR
GYDQLVHDVALQKLDVLFAVDRGGVVGPDGATHAGNLDLSFLRCVPNMMLMAPADEAECRKMLSTGFHYSGPVAVRYPRG
TGPGVVPSAELDVLPVGVAQLRHSGTRIALLGFGVCVAPAEQVGRRLGLTVVNMRFIKPLDRTLLLELARTHEVFVTIED
NVVAGGAGSGVAELLNAEGIVLPIVHLGLPDAFQQHASREDLLAEAGIDAAGVYAALLSRWPDLAVQNHPLSAVS

Sequences:

>Translated_635_residues
MIDFTCYPRLSRIQTPEDLRAFQESELRAVADELRNYLIESVGLSGGHFAAGLGVVELTIALHYLYCTPIDQLVWDVGHQ
TYPHKILTGRRDKISTVKHQGGLAPFPKREESIYDTFGVGHSSTSISAALGMAIVAQRNGDERKVVAIIGDGAMTAGMAY
EALNHAGGMSPAPNLLVILNDNRMSISEAVGGLTKMLGRATGSKALNAIREGGKRIFGDKKTNATARFLRRWEEHWKGMF
VPSTLFEEMGFHYTGPIDGHDLPALLGALKTLRTLKGPQLLHVITTKGKGYELAEGDQIGYHAVAPFDPQKGLIKAGAKK
QTYTDVFSEWLCDMAAVEPRLLAITPAMREGSGLVRFSQEYPQRYFDVAIAEQHAITLAAGMATQGAKPVVAIYSTFLQR
GYDQLVHDVALQKLDVLFAVDRGGVVGPDGATHAGNLDLSFLRCVPNMMLMAPADEAECRKMLSTGFHYSGPVAVRYPRG
TGPGVVPSAELDVLPVGVAQLRHSGTRIALLGFGVCVAPAEQVGRRLGLTVVNMRFIKPLDRTLLLELARTHEVFVTIED
NVVAGGAGSGVAELLNAEGIVLPIVHLGLPDAFQQHASREDLLAEAGIDAAGVYAALLSRWPDLAVQNHPLSAVS
>Mature_635_residues
MIDFTCYPRLSRIQTPEDLRAFQESELRAVADELRNYLIESVGLSGGHFAAGLGVVELTIALHYLYCTPIDQLVWDVGHQ
TYPHKILTGRRDKISTVKHQGGLAPFPKREESIYDTFGVGHSSTSISAALGMAIVAQRNGDERKVVAIIGDGAMTAGMAY
EALNHAGGMSPAPNLLVILNDNRMSISEAVGGLTKMLGRATGSKALNAIREGGKRIFGDKKTNATARFLRRWEEHWKGMF
VPSTLFEEMGFHYTGPIDGHDLPALLGALKTLRTLKGPQLLHVITTKGKGYELAEGDQIGYHAVAPFDPQKGLIKAGAKK
QTYTDVFSEWLCDMAAVEPRLLAITPAMREGSGLVRFSQEYPQRYFDVAIAEQHAITLAAGMATQGAKPVVAIYSTFLQR
GYDQLVHDVALQKLDVLFAVDRGGVVGPDGATHAGNLDLSFLRCVPNMMLMAPADEAECRKMLSTGFHYSGPVAVRYPRG
TGPGVVPSAELDVLPVGVAQLRHSGTRIALLGFGVCVAPAEQVGRRLGLTVVNMRFIKPLDRTLLLELARTHEVFVTIED
NVVAGGAGSGVAELLNAEGIVLPIVHLGLPDAFQQHASREDLLAEAGIDAAGVYAALLSRWPDLAVQNHPLSAVS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=553, Percent_Identity=23.1464737793852, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4507521, Length=553, Percent_Identity=23.1464737793852, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI225637463, Length=271, Percent_Identity=25.0922509225092, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI225637461, Length=271, Percent_Identity=25.0922509225092, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI225637459, Length=271, Percent_Identity=25.0922509225092, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI133778974, Length=270, Percent_Identity=25.5555555555556, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1786622, Length=618, Percent_Identity=55.5016181229773, Blast_Score=716, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=483, Percent_Identity=22.5672877846791, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45551847, Length=259, Percent_Identity=24.7104247104247, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45550715, Length=259, Percent_Identity=24.7104247104247, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24645119, Length=259, Percent_Identity=24.7104247104247, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666278, Length=504, Percent_Identity=24.0079365079365, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_XYLF2 (B2I607)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830070.1
- ProteinModelPortal:   B2I607
- SMR:   B2I607
- GeneID:   6202307
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1378
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68438; Mature: 68438

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDFTCYPRLSRIQTPEDLRAFQESELRAVADELRNYLIESVGLSGGHFAAGLGVVELTI
CCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ALHYLYCTPIDQLVWDVGHQTYPHKILTGRRDKISTVKHQGGLAPFPKREESIYDTFGVG
HHHHHHHCCHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCC
HSSTSISAALGMAIVAQRNGDERKVVAIIGDGAMTAGMAYEALNHAGGMSPAPNLLVILN
CCCCHHHHHHHHHHEEECCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEEEC
DNRMSISEAVGGLTKMLGRATGSKALNAIREGGKRIFGDKKTNATARFLRRWEEHWKGMF
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHCCCC
VPSTLFEEMGFHYTGPIDGHDLPALLGALKTLRTLKGPQLLHVITTKGKGYELAEGDQIG
CHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCC
YHAVAPFDPQKGLIKAGAKKQTYTDVFSEWLCDMAAVEPRLLAITPAMREGSGLVRFSQE
EEEECCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHCCCCCEEECHH
YPQRYFDVAIAEQHAITLAAGMATQGAKPVVAIYSTFLQRGYDQLVHDVALQKLDVLFAV
CCHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
DRGGVVGPDGATHAGNLDLSFLRCVPNMMLMAPADEAECRKMLSTGFHYSGPVAVRYPRG
CCCCEECCCCCCCCCCCCHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCCEEEEECCC
TGPGVVPSAELDVLPVGVAQLRHSGTRIALLGFGVCVAPAEQVGRRLGLTVVNMRFIKPL
CCCCCCCCCCCCEEECCHHHHHCCCCEEEEEECCHHCCCHHHHHHHHCCEEEHHHHHHHH
DRTLLLELARTHEVFVTIEDNVVAGGAGSGVAELLNAEGIVLPIVHLGLPDAFQQHASRE
HHHHHHHHHCCCEEEEEEECCEEECCCCCCHHHHHCCCCEEEEHEECCCCHHHHHHCCHH
DLLAEAGIDAAGVYAALLSRWPDLAVQNHPLSAVS
HHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIDFTCYPRLSRIQTPEDLRAFQESELRAVADELRNYLIESVGLSGGHFAAGLGVVELTI
CCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ALHYLYCTPIDQLVWDVGHQTYPHKILTGRRDKISTVKHQGGLAPFPKREESIYDTFGVG
HHHHHHHCCHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCC
HSSTSISAALGMAIVAQRNGDERKVVAIIGDGAMTAGMAYEALNHAGGMSPAPNLLVILN
CCCCHHHHHHHHHHEEECCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEEEC
DNRMSISEAVGGLTKMLGRATGSKALNAIREGGKRIFGDKKTNATARFLRRWEEHWKGMF
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHCCCC
VPSTLFEEMGFHYTGPIDGHDLPALLGALKTLRTLKGPQLLHVITTKGKGYELAEGDQIG
CHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCC
YHAVAPFDPQKGLIKAGAKKQTYTDVFSEWLCDMAAVEPRLLAITPAMREGSGLVRFSQE
EEEECCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHCCCCCEEECHH
YPQRYFDVAIAEQHAITLAAGMATQGAKPVVAIYSTFLQRGYDQLVHDVALQKLDVLFAV
CCHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
DRGGVVGPDGATHAGNLDLSFLRCVPNMMLMAPADEAECRKMLSTGFHYSGPVAVRYPRG
CCCCEECCCCCCCCCCCCHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCCEEEEECCC
TGPGVVPSAELDVLPVGVAQLRHSGTRIALLGFGVCVAPAEQVGRRLGLTVVNMRFIKPL
CCCCCCCCCCCCEEECCHHHHHCCCCEEEEEECCHHCCCHHHHHHHHCCEEEHHHHHHHH
DRTLLLELARTHEVFVTIEDNVVAGGAGSGVAELLNAEGIVLPIVHLGLPDAFQQHASRE
HHHHHHHHHCCCEEEEEEECCEEECCCCCCHHHHHCCCCEEEEHEECCCCHHHHHHCCHH
DLLAEAGIDAAGVYAALLSRWPDLAVQNHPLSAVS
HHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA