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The map label for this gene is dacC [H]

Identifier: 28199163

GI number: 28199163

Start: 1488625

End: 1489815

Strand: Reverse

Name: dacC [H]

Synonym: PD1277

Alternate gene names: 28199163

Gene position: 1489815-1488625 (Counterclockwise)

Preceding gene: 77747685

Following gene: 28199162

Centisome position: 59.12

GC content: 53.15

Gene sequence:

>1191_bases
GTGAAATTCCTGTTTGCGACTGTTGCTACTTTCATGTGTGCGGTGAGTTCGGCTGTTGCGCAGGTTCCGCAGCCTGTCCC
TGCTCCAGCTCCTGCAATACCCATTCCCAAGGCGCCAGCGCCTGCTTCAGCCAAAGCATGGGTTGTGATGGACTATGCGT
CCGGTCAGGTGCTTGCAGGGGAGAACATCCATACGCATCTTGCTCCGGCCAGCCTGACCAAGGTGATGACTTCCTATGTG
ATTGCCGCTGAGATCAAGAACGGCAAAGTGCATCGTGATGATCAGGTGATGATGACCGAAAATGCTTGGCGCAAGGGAGG
CGCTGGCACCGATGGCAGTTATAGTGGCTTTCCTGTCAACAAGACTGCGCGCTTGGAGGATATGGAGCAGGGCATGATTG
TGCAGTCGGGGAATGATGCTGCGATCGCGCTGGCTCAGCATGTGGCTGGTAGCGAGGAGGCATTTGCTTCGTTGATGAAT
AGCTACGCTCAGCGCATTGGAATGAAGAACTCGCACTTTGTCGATGCGACAGGCTTGAGTGCTGAGGGGCATTACTCCAG
TGCGTATGACATGGCACTGCTTGGTCGCGCGTTGATTCGAGATTTCCCAGAAACCTACGCCTATAACAAAGTGAAGGAGT
TGGTGGTTAATGGAATCAAGCAGTCCAACCGCAATTTGCTCCTGTGGCGAGATCCCTCTGTGGATGGTATTAAAACAGGC
CATACTTCCGAGGCAGGCTATTGCATTATTAATTCGGCCAAGCGTGGTGATCAGCGCATCCTGACCGTTGTGATGGGCGA
TGTTTCCGAGAAAAAGCGTGCTGAGGATAGCCTGGCCTTGTTGAACTGGGGCTTTCGCTTTTTCGAGACTCACACCCTCT
ATGAGCCTGGCAAGGTGGTGACCAAACATAAGATATGGAAGGGGCAAGTTTCCGAAGTGCAGTTAGGGGTGCCTCGTCCG
CTATTTGTCACTGTACAGCGTGGTCGCTATAACGACCTTAAACCCAGTATCGAAGTGCCACGTAACCTTGAAGCACCGAT
TAAACCTGGACAGTCGGTGGGTAAGGTGAAAGTCACACTGGATGGTAAGGTCGTCGCACAGGCACCGTTGACAGCAATGG
CTGGTGCCGAGAAGGGAGGATTCTTTAAGCGGCTATGGGACGCCTTCTGGATGTGGTGGGAGCTTAAGTGA

Upstream 100 bases:

>100_bases
AGAAGAATGAATCTTCCTTCAATAAACGCCTCAGAAATTAAGTGAAGTCTATTACAATTTTACAGTTACCACGGTTAGGT
GTCTCAGGGGGAATATCTCG

Downstream 100 bases:

>100_bases
CCTGCGCGGTGAGAAACACCGACATCAACAGACCTGGCGATCAAAATAATGTCATCGCTTTTCCCTGTCACACCATCAGC
GGCTTATGGTGTGTGTGACA

Product: penicillin-binding protein 6 precursor

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKFLFATVATFMCAVSSAVAQVPQPVPAPAPAIPIPKAPAPASAKAWVVMDYASGQVLAGENIHTHLAPASLTKVMTSYV
IAAEIKNGKVHRDDQVMMTENAWRKGGAGTDGSYSGFPVNKTARLEDMEQGMIVQSGNDAAIALAQHVAGSEEAFASLMN
SYAQRIGMKNSHFVDATGLSAEGHYSSAYDMALLGRALIRDFPETYAYNKVKELVVNGIKQSNRNLLLWRDPSVDGIKTG
HTSEAGYCIINSAKRGDQRILTVVMGDVSEKKRAEDSLALLNWGFRFFETHTLYEPGKVVTKHKIWKGQVSEVQLGVPRP
LFVTVQRGRYNDLKPSIEVPRNLEAPIKPGQSVGKVKVTLDGKVVAQAPLTAMAGAEKGGFFKRLWDAFWMWWELK

Sequences:

>Translated_396_residues
MKFLFATVATFMCAVSSAVAQVPQPVPAPAPAIPIPKAPAPASAKAWVVMDYASGQVLAGENIHTHLAPASLTKVMTSYV
IAAEIKNGKVHRDDQVMMTENAWRKGGAGTDGSYSGFPVNKTARLEDMEQGMIVQSGNDAAIALAQHVAGSEEAFASLMN
SYAQRIGMKNSHFVDATGLSAEGHYSSAYDMALLGRALIRDFPETYAYNKVKELVVNGIKQSNRNLLLWRDPSVDGIKTG
HTSEAGYCIINSAKRGDQRILTVVMGDVSEKKRAEDSLALLNWGFRFFETHTLYEPGKVVTKHKIWKGQVSEVQLGVPRP
LFVTVQRGRYNDLKPSIEVPRNLEAPIKPGQSVGKVKVTLDGKVVAQAPLTAMAGAEKGGFFKRLWDAFWMWWELK
>Mature_396_residues
MKFLFATVATFMCAVSSAVAQVPQPVPAPAPAIPIPKAPAPASAKAWVVMDYASGQVLAGENIHTHLAPASLTKVMTSYV
IAAEIKNGKVHRDDQVMMTENAWRKGGAGTDGSYSGFPVNKTARLEDMEQGMIVQSGNDAAIALAQHVAGSEEAFASLMN
SYAQRIGMKNSHFVDATGLSAEGHYSSAYDMALLGRALIRDFPETYAYNKVKELVVNGIKQSNRNLLLWRDPSVDGIKTG
HTSEAGYCIINSAKRGDQRILTVVMGDVSEKKRAEDSLALLNWGFRFFETHTLYEPGKVVTKHKIWKGQVSEVQLGVPRP
LFVTVQRGRYNDLKPSIEVPRNLEAPIKPGQSVGKVKVTLDGKVVAQAPLTAMAGAEKGGFFKRLWDAFWMWWELK

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=369, Percent_Identity=45.7994579945799, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1786851, Length=396, Percent_Identity=41.9191919191919, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI87082022, Length=389, Percent_Identity=38.0462724935733, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI87082054, Length=256, Percent_Identity=27.34375, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 43208; Mature: 43208

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLFATVATFMCAVSSAVAQVPQPVPAPAPAIPIPKAPAPASAKAWVVMDYASGQVLAG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEC
ENIHTHLAPASLTKVMTSYVIAAEIKNGKVHRDDQVMMTENAWRKGGAGTDGSYSGFPVN
CCCEECCCHHHHHHHHHHHHEEEEECCCCCCCCCCEEEECCCHHCCCCCCCCCCCCCCCC
KTARLEDMEQGMIVQSGNDAAIALAQHVAGSEEAFASLMNSYAQRIGMKNSHFVDATGLS
CCHHHHHHHCCEEEECCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCC
AEGHYSSAYDMALLGRALIRDFPETYAYNKVKELVVNGIKQSNRNLLLWRDPSVDGIKTG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
HTSEAGYCIINSAKRGDQRILTVVMGDVSEKKRAEDSLALLNWGFRFFETHTLYEPGKVV
CCCCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCHHHHEECCCCCCCCEE
TKHKIWKGQVSEVQLGVPRPLFVTVQRGRYNDLKPSIEVPRNLEAPIKPGQSVGKVKVTL
EEEEECCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
DGKVVAQAPLTAMAGAEKGGFFKRLWDAFWMWWELK
CCEEEECCCHHHHCCCCCCCHHHHHHHHHHEEEECC
>Mature Secondary Structure
MKFLFATVATFMCAVSSAVAQVPQPVPAPAPAIPIPKAPAPASAKAWVVMDYASGQVLAG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEC
ENIHTHLAPASLTKVMTSYVIAAEIKNGKVHRDDQVMMTENAWRKGGAGTDGSYSGFPVN
CCCEECCCHHHHHHHHHHHHEEEEECCCCCCCCCCEEEECCCHHCCCCCCCCCCCCCCCC
KTARLEDMEQGMIVQSGNDAAIALAQHVAGSEEAFASLMNSYAQRIGMKNSHFVDATGLS
CCHHHHHHHCCEEEECCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCC
AEGHYSSAYDMALLGRALIRDFPETYAYNKVKELVVNGIKQSNRNLLLWRDPSVDGIKTG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
HTSEAGYCIINSAKRGDQRILTVVMGDVSEKKRAEDSLALLNWGFRFFETHTLYEPGKVV
CCCCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCHHHHEECCCCCCCCEE
TKHKIWKGQVSEVQLGVPRPLFVTVQRGRYNDLKPSIEVPRNLEAPIKPGQSVGKVKVTL
EEEEECCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
DGKVVAQAPLTAMAGAEKGGFFKRLWDAFWMWWELK
CCEEEECCCHHHHCCCCCCCHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]