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The map label for this gene is hisI [H]

Identifier: 28199147

GI number: 28199147

Start: 1470917

End: 1471537

Strand: Reverse

Name: hisI [H]

Synonym: PD1261

Alternate gene names: 28199147

Gene position: 1471537-1470917 (Counterclockwise)

Preceding gene: 28199148

Following gene: 28199140

Centisome position: 58.4

GC content: 57.81

Gene sequence:

>621_bases
ATGTGTAATGAGCCTGCGACGAGCGATGTTGCATTGCCTGATCTGGATTGGGCCAAGGGTGATGGCTTGTTGCCCGTGAT
CGTGCAGGACGCCGATACGCTGCGTGTGCTGATGCTTGGCTATATGAACAGCCAGGCATTAGAGGTCACGCAGCGCAGCC
GCTTGGTGACGTTTTACAGCCGCAGTAAGCAGCGTTTATGGACCAAGGGGGAGCGTTCTGGGCATGTGCTGCATCTGGTG
GCCATTGATGCCGATTGCGATGCCGATACGTTATTAGTGCAGGCCCGACCCCGTGGACCCACGTGTCATCTGGGCAGGAC
CAGTTGTTTTCCTGCAGCCCCTGGACAGTTTCTTGGTGCGCTGGATGCGCTGGTGGCGGAGCGCGAACGTGAGCGGCCAC
AAGACAGTTACACCACCGCATTGTTTGAGCAGGGCGTCCGCCGCATCGCGCAGAAGGTCGGTGAGGAAGGGGTGGAGACC
GCATTGGCTGGCGTGGTCCAGGCTGATGATGCACTCCTTGATGAATCAGCAGACCTGCTTTACCACCTGATTGTGTTGTT
GCGTGCCCGTGGTTTATCGCTTGCCGATGCCGTTACCGTATTAGAGGCACGGCATCGTTAA

Upstream 100 bases:

>100_bases
GATGTTGATGGTGCATTGGCGGCCAGCGTATTCCATAGCGGCGCGATTTCGATTCCGGGTTTAAAACAGTTTCTGCGTGA
GCAGCAAATTGAGGTCCGCG

Downstream 100 bases:

>100_bases
TGCCGATGGCGTGTTGCCCGCAGCGCGGAGTGTTGCCGTGGCTGAGTGCTTGATGTGTCATCTCACTGATGGGTGCCAGC
GTTGTTTGGTGAGGGGGGCA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MCNEPATSDVALPDLDWAKGDGLLPVIVQDADTLRVLMLGYMNSQALEVTQRSRLVTFYSRSKQRLWTKGERSGHVLHLV
AIDADCDADTLLVQARPRGPTCHLGRTSCFPAAPGQFLGALDALVAERERERPQDSYTTALFEQGVRRIAQKVGEEGVET
ALAGVVQADDALLDESADLLYHLIVLLRARGLSLADAVTVLEARHR

Sequences:

>Translated_206_residues
MCNEPATSDVALPDLDWAKGDGLLPVIVQDADTLRVLMLGYMNSQALEVTQRSRLVTFYSRSKQRLWTKGERSGHVLHLV
AIDADCDADTLLVQARPRGPTCHLGRTSCFPAAPGQFLGALDALVAERERERPQDSYTTALFEQGVRRIAQKVGEEGVET
ALAGVVQADDALLDESADLLYHLIVLLRARGLSLADAVTVLEARHR
>Mature_206_residues
MCNEPATSDVALPDLDWAKGDGLLPVIVQDADTLRVLMLGYMNSQALEVTQRSRLVTFYSRSKQRLWTKGERSGHVLHLV
AIDADCDADTLLVQARPRGPTCHLGRTSCFPAAPGQFLGALDALVAERERERPQDSYTTALFEQGVRRIAQKVGEEGVET
ALAGVVQADDALLDESADLLYHLIVLLRARGLSLADAVTVLEARHR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=195, Percent_Identity=56.4102564102564, Blast_Score=216, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6319819, Length=190, Percent_Identity=33.6842105263158, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 22532; Mature: 22532

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCNEPATSDVALPDLDWAKGDGLLPVIVQDADTLRVLMLGYMNSQALEVTQRSRLVTFYS
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RSKQRLWTKGERSGHVLHLVAIDADCDADTLLVQARPRGPTCHLGRTSCFPAAPGQFLGA
HHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCEEECCCCCCCCCCCHHHHHH
LDALVAERERERPQDSYTTALFEQGVRRIAQKVGEEGVETALAGVVQADDALLDESADLL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHH
YHLIVLLRARGLSLADAVTVLEARHR
HHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MCNEPATSDVALPDLDWAKGDGLLPVIVQDADTLRVLMLGYMNSQALEVTQRSRLVTFYS
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RSKQRLWTKGERSGHVLHLVAIDADCDADTLLVQARPRGPTCHLGRTSCFPAAPGQFLGA
HHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCEEECCCCCCCCCCCHHHHHH
LDALVAERERERPQDSYTTALFEQGVRRIAQKVGEEGVETALAGVVQADDALLDESADLL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHH
YHLIVLLRARGLSLADAVTVLEARHR
HHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]