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The map label for this gene is hemC

Identifier: 28199044

GI number: 28199044

Start: 1349775

End: 1350692

Strand: Reverse

Name: hemC

Synonym: PD1152

Alternate gene names: 28199044

Gene position: 1350692-1349775 (Counterclockwise)

Preceding gene: 28199045

Following gene: 28199041

Centisome position: 53.6

GC content: 55.45

Gene sequence:

>918_bases
ATGCCTTTACTTCGTATTGCTACTCGCAAAAGTTTACTTGCTATGTGGCAAAGCGAGTATGTCGCTGCGCGTTTACGTAT
GCTGTGCCCTGATTTAGATGTGGTGTTGGTGCCGATGAGCACTCGTGGCGATGAGATCCTGGATCGCTCCCTGGCTGCAA
TTGGTGGTAAAGGGCTGTTTCTCAAGGAGCTGGAACTGGCGATGTTACGTGGTGATGCTGATTGCGCGGTGCATTCGCTG
AAAGATGTGCCTATGGATTTGGAGCCCCCATTTATGCTTGCGGCTGTTTTGAGTCGTGATGACCCGGCCGATGCGCTGAT
TTCTAATGTCTACCTTTCGCTAGAGTCACTCCCAATTGGGGCGCGTGTGGCGACTTCTTCGCTGCGCCGACAAGCCCAGT
TACGCTTTTATCGGCCTGACCTGCGGTTGTTTGACTTGCGGGGTAACGTTAACACGCGCTTGGCGAAGCTTGATAACGGA
GATTACGATGCGATCGTGCTGGCTTGTGCGGGGTTACGTCGGCTAGGATTGGAGCAACGCATGACGGCTCGGCTAGCACC
GCCAGAATGGTTACCTGCGCCAGGTCAGGGGGCGATTGCGGTGGAGTCACTGACCGAGGATGCTCGGATCGGTACGTTGT
TGGCTGGTCTTGACGATCTGCCAACGCGCAAATGCGTGATTGCTGAGCGTACGATGAATCGTGCTCTTCATGGTAGCTGC
CATGTGCCAGTGGGGGCTTATGCATCCTACGAAGTTGGTGGTATGCGATTACAGGGCTTGGTGGGTTGTGTTGCCGATGG
TCGTCTCGTGCGTGCGGAGCTGTGTTCGGCAAAGGATGAGGGCGATATGCTCGGCAGGGCAGTCGCACAGTGCTTGTTGG
ATGCTGGTGCGGCTGAGTTGCTAGCCGCCACTGCATAG

Upstream 100 bases:

>100_bases
AATGTTGTTACACCGTTAGCCGTGAGTCGGCGTTGTGTCCCTTTGCTGTGTGATCAGTTGCGTCTGTCGGCTGTTTTGAC
AGGTCGCTGGTAATACCACG

Downstream 100 bases:

>100_bases
GATCCTTTGAGACTAAACATGCTGTGTAGATACCACCCACAGCAAGATGATGATTATTTGAAACTGTAGACCAAGTTCAC
TGTGGTCAATGTGTTTGTTT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MPLLRIATRKSLLAMWQSEYVAARLRMLCPDLDVVLVPMSTRGDEILDRSLAAIGGKGLFLKELELAMLRGDADCAVHSL
KDVPMDLEPPFMLAAVLSRDDPADALISNVYLSLESLPIGARVATSSLRRQAQLRFYRPDLRLFDLRGNVNTRLAKLDNG
DYDAIVLACAGLRRLGLEQRMTARLAPPEWLPAPGQGAIAVESLTEDARIGTLLAGLDDLPTRKCVIAERTMNRALHGSC
HVPVGAYASYEVGGMRLQGLVGCVADGRLVRAELCSAKDEGDMLGRAVAQCLLDAGAAELLAATA

Sequences:

>Translated_305_residues
MPLLRIATRKSLLAMWQSEYVAARLRMLCPDLDVVLVPMSTRGDEILDRSLAAIGGKGLFLKELELAMLRGDADCAVHSL
KDVPMDLEPPFMLAAVLSRDDPADALISNVYLSLESLPIGARVATSSLRRQAQLRFYRPDLRLFDLRGNVNTRLAKLDNG
DYDAIVLACAGLRRLGLEQRMTARLAPPEWLPAPGQGAIAVESLTEDARIGTLLAGLDDLPTRKCVIAERTMNRALHGSC
HVPVGAYASYEVGGMRLQGLVGCVADGRLVRAELCSAKDEGDMLGRAVAQCLLDAGAAELLAATA
>Mature_304_residues
PLLRIATRKSLLAMWQSEYVAARLRMLCPDLDVVLVPMSTRGDEILDRSLAAIGGKGLFLKELELAMLRGDADCAVHSLK
DVPMDLEPPFMLAAVLSRDDPADALISNVYLSLESLPIGARVATSSLRRQAQLRFYRPDLRLFDLRGNVNTRLAKLDNGD
YDAIVLACAGLRRLGLEQRMTARLAPPEWLPAPGQGAIAVESLTEDARIGTLLAGLDDLPTRKCVIAERTMNRALHGSCH
VPVGAYASYEVGGMRLQGLVGCVADGRLVRAELCSAKDEGDMLGRAVAQCLLDAGAAELLAATA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=265, Percent_Identity=44.1509433962264, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI66933009, Length=265, Percent_Identity=44.1509433962264, Blast_Score=196, Evalue=2e-50,
Organism=Escherichia coli, GI48994974, Length=300, Percent_Identity=52.3333333333333, Blast_Score=284, Evalue=5e-78,
Organism=Saccharomyces cerevisiae, GI6319996, Length=313, Percent_Identity=37.0607028753994, Blast_Score=178, Evalue=7e-46,
Organism=Drosophila melanogaster, GI20130425, Length=298, Percent_Identity=39.9328859060403, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_XYLF2 (B2I5K8)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001829927.1
- ProteinModelPortal:   B2I5K8
- SMR:   B2I5K8
- GeneID:   6203280
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1225
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 32861; Mature: 32730

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLRIATRKSLLAMWQSEYVAARLRMLCPDLDVVLVPMSTRGDEILDRSLAAIGGKGLF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCH
LKELELAMLRGDADCAVHSLKDVPMDLEPPFMLAAVLSRDDPADALISNVYLSLESLPIG
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
ARVATSSLRRQAQLRFYRPDLRLFDLRGNVNTRLAKLDNGDYDAIVLACAGLRRLGLEQR
HHHHHHHHHHHHHHEEECCCCEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHCHHHH
MTARLAPPEWLPAPGQGAIAVESLTEDARIGTLLAGLDDLPTRKCVIAERTMNRALHGSC
HHHHCCCCCCCCCCCCCCEEEHHHCCCHHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCCC
HVPVGAYASYEVGGMRLQGLVGCVADGRLVRAELCSAKDEGDMLGRAVAQCLLDAGAAEL
CCCCCCCCCCCCCCEEHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHH
LAATA
HHCCC
>Mature Secondary Structure 
PLLRIATRKSLLAMWQSEYVAARLRMLCPDLDVVLVPMSTRGDEILDRSLAAIGGKGLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCH
LKELELAMLRGDADCAVHSLKDVPMDLEPPFMLAAVLSRDDPADALISNVYLSLESLPIG
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
ARVATSSLRRQAQLRFYRPDLRLFDLRGNVNTRLAKLDNGDYDAIVLACAGLRRLGLEQR
HHHHHHHHHHHHHHEEECCCCEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHCHHHH
MTARLAPPEWLPAPGQGAIAVESLTEDARIGTLLAGLDDLPTRKCVIAERTMNRALHGSC
HHHHCCCCCCCCCCCCCCEEEHHHCCCHHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCCC
HVPVGAYASYEVGGMRLQGLVGCVADGRLVRAELCSAKDEGDMLGRAVAQCLLDAGAAEL
CCCCCCCCCCCCCCEEHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHH
LAATA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA