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The map label for this gene is gabP

Identifier: 255767156

GI number: 255767156

Start: 685155

End: 686564

Strand: Reverse

Name: gabP

Synonym: BSU06310

Alternate gene names: 255767156

Gene position: 686564-685155 (Counterclockwise)

Preceding gene: 255767157

Following gene: 16077697

Centisome position: 16.29

GC content: 46.88

Gene sequence:

>1410_bases
ATGAACCAGTCTCAATCAGGATTAAAAAAGGAATTAAAGACCCGCCATATGACAATGATTTCGATTGCCGGTGTAATCGG
AGCCGGCCTATTTGTAGGCAGCGGTTCAGTGATTCACTCGACCGGTCCGGGTGCCGTTGTTTCTTACGCGTTAGCCGGAT
TATTGGTGATTTTTATTATGAGAATGCTCGGTGAGATGTCTGCCGTAAACCCGACGAGCGGATCGTTTTCTCAATACGCT
CACGACGCCATCGGACCGTGGGCAGGATTTACAATCGGCTGGCTGTACTGGTTTTTCTGGGTGATCGTCATAGCGATCGA
AGCCATTGCCGGTGCTGGCATTATTCAATACTGGTTCCATGATATTCCGCTGTGGCTGACAAGTTTGATCTTGACCATTG
TGCTCACCCTGACAAACGTCTACTCCGTTAAGTCTTTCGGTGAGTTTGAATATTGGTTCTCCCTCATTAAAGTTGTGACT
ATCATTGCTTTTCTAATCGTTGGTTTTGCCTTTATTTTTGGCTTTGCACCGGGCAGTGAGCCAGTCGGTTTTTCGAATCT
TACAGGCAAAGGCGGATTTTTCCCGGAGGGCATCAGCTCCGTATTGCTCGGCATTGTCGTTGTCATCTTCTCTTTTATGG
GAACTGAAATCGTTGCCATTGCAGCAGGGGAAACATCCAACCCGATCGAATCTGTGACAAAAGCCACCAGATCCGTTGTA
TGGCGCATCATCGTCTTTTACGTGGGCTCAATCGCCATTGTCGTGGCGCTGTTGCCATGGAATTCAGCAAATATTTTAGA
AAGCCCTTTCGTCGCTGTACTTGAGCATATAGGAGTGCCCGCAGCCGCACAGATTATGAACTTTATCGTCCTCACAGCCG
TACTCTCTTGCCTGAATTCAGGTTTGTATACCACATCCAGAATGCTGTATTCACTTGCAGAAAGAAATGAAGCGCCGCGC
CGTTTTATGAAATTGAGCAAAAAAGGCGTTCCCGTACAAGCCATTGTGGCCGGGACATTTTTCTCTTATATCGCGGTCGT
AATGAACTATTTTTCACCGGATACCGTCTTTTTATTCTTAGTCAACTCATCAGGCGCAATCGCTTTACTCGTCTATCTTG
TCATCGCCGTTTCCCAGCTGAAAATGCGGAAAAAACTCGAAAAAACAAACCCAGAAGCATTGAAGATCAAAATGTGGCTC
TTCCCTTTCCTAACCTACTTGACCATCATCGCCATTTGCGGAATTTTAGTGTCCATGGCGTTTATTGATTCCATGAGAGA
CGAGCTGCTGCTGACAGGCGTCATCACGGGAATCGTTCTGATTTCTTACCTTGTGTTCAGAAAACGCAAGGTGAGCGAGA
AAGCGGCTGCCAACCCAGTCACACAGCAGCAACCCGATATCCTGCCTTAA

Upstream 100 bases:

>100_bases
TATATTTTCTTACACGAATTTTCGACAAACTGTATATTTATGATAGAGTTTCAATTATCATAATATTCAGTAATGATTGC
ATTTTAAAAGGAGGTAACTT

Downstream 100 bases:

>100_bases
TGCTGATCAAATCCTAAACGGCCTGCCGTTTAGGATTTTGTTATTTTCTTCTTCGGGCGGGCTGCAGCACGAAGATTTTT
TGTAACCATCACGTCCTTAT

Product: gamma-aminobutyrate (GABA) permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPGAVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYA
HDAIGPWAGFTIGWLYWFFWVIVIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT
IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIVAIAAGETSNPIESVTKATRSVV
WRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEHIGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPR
RFMKLSKKGVPVQAIVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPEALKIKMWL
FPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRKVSEKAAANPVTQQQPDILP

Sequences:

>Translated_469_residues
MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPGAVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYA
HDAIGPWAGFTIGWLYWFFWVIVIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT
IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIVAIAAGETSNPIESVTKATRSVV
WRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEHIGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPR
RFMKLSKKGVPVQAIVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPEALKIKMWL
FPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRKVSEKAAANPVTQQQPDILP
>Mature_469_residues
MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPGAVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYA
HDAIGPWAGFTIGWLYWFFWVIVIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT
IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIVAIAAGETSNPIESVTKATRSVV
WRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEHIGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPR
RFMKLSKKGVPVQAIVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPEALKIKMWL
FPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRKVSEKAAANPVTQQQPDILP

Specific function: Transporter for GABA

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family

Homologues:

Organism=Homo sapiens, GI4507047, Length=435, Percent_Identity=22.0689655172414, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI110347453, Length=357, Percent_Identity=22.6890756302521, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI258645169, Length=432, Percent_Identity=22.9166666666667, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI181337167, Length=333, Percent_Identity=23.7237237237237, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI258614003, Length=347, Percent_Identity=23.342939481268, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI258614005, Length=347, Percent_Identity=23.342939481268, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1789017, Length=455, Percent_Identity=49.010989010989, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1788480, Length=439, Percent_Identity=40.7744874715262, Blast_Score=328, Evalue=4e-91,
Organism=Escherichia coli, GI1786302, Length=454, Percent_Identity=35.9030837004405, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI87081708, Length=462, Percent_Identity=37.2294372294372, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI48994972, Length=435, Percent_Identity=38.1609195402299, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI1786789, Length=448, Percent_Identity=35.7142857142857, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1790653, Length=454, Percent_Identity=34.5814977973568, Blast_Score=296, Evalue=3e-81,
Organism=Escherichia coli, GI87081915, Length=473, Percent_Identity=38.4778012684989, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1786602, Length=397, Percent_Identity=38.5390428211587, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI2367353, Length=331, Percent_Identity=26.2839879154079, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081869, Length=324, Percent_Identity=24.3827160493827, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=404, Percent_Identity=24.7524752475248, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320772, Length=435, Percent_Identity=34.2528735632184, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6324061, Length=422, Percent_Identity=32.4644549763033, Blast_Score=226, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6324059, Length=423, Percent_Identity=32.6241134751773, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=434, Percent_Identity=29.9539170506912, Blast_Score=199, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6324990, Length=409, Percent_Identity=32.7628361858191, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324553, Length=387, Percent_Identity=33.8501291989664, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6320717, Length=401, Percent_Identity=28.1795511221945, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322892, Length=403, Percent_Identity=31.7617866004963, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6321629, Length=400, Percent_Identity=29.25, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321053, Length=418, Percent_Identity=28.2296650717703, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6319542, Length=398, Percent_Identity=29.3969849246231, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319824, Length=402, Percent_Identity=26.865671641791, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319543, Length=398, Percent_Identity=26.8844221105528, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6320251, Length=404, Percent_Identity=27.7227722772277, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322967, Length=391, Percent_Identity=28.3887468030691, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=435, Percent_Identity=22.9885057471264, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6324981, Length=400, Percent_Identity=29.5, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6320364, Length=495, Percent_Identity=26.2626262626263, Blast_Score=106, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24668806, Length=416, Percent_Identity=24.5192307692308, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356285, Length=416, Percent_Identity=24.5192307692308, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24668802, Length=416, Percent_Identity=24.5192307692308, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666159, Length=412, Percent_Identity=22.3300970873786, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221512776, Length=412, Percent_Identity=22.3300970873786, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667468, Length=413, Percent_Identity=23.0024213075061, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281366235, Length=426, Percent_Identity=24.4131455399061, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007820, Length=426, Percent_Identity=24.4131455399061, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GABP_BACSU (P46349)

Other databases:

- EMBL:   U31756
- EMBL:   U51115
- EMBL:   AL009126
- PIR:   C69628
- RefSeq:   NP_388512.2
- ProteinModelPortal:   P46349
- EnsemblBacteria:   EBBACT00000000834
- GeneID:   939485
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU06310
- NMPDR:   fig|224308.1.peg.631
- GenoList:   BSU06310
- GeneTree:   EBGT00070000031860
- HOGENOM:   HBG492579
- ProtClustDB:   CLSK2793845
- BioCyc:   BSUB:BSU06310-MONOMER
- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060
- TIGRFAMs:   TIGR01773

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 51085; Mature: 51085

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xcf97a8c)-; HASH(0xc55beac)-; HASH(0xd690de4)-; HASH(0xc7688fc)-; HASH(0xd3f7100)-; HASH(0xd5355b4)-; HASH(0xd590814)-; HASH(0xd68ae74)-; HASH(0xd01bcdc)-; HASH(0xd6bda9c)-; HASH(0xc424974)-; HASH(0xd5f5310)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377