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The map label for this gene is mutSB [H]

Identifier: 239618218

GI number: 239618218

Start: 1985200

End: 1987518

Strand: Reverse

Name: mutSB [H]

Synonym: Kole_1854

Alternate gene names: 239618218

Gene position: 1987518-1985200 (Counterclockwise)

Preceding gene: 239618219

Following gene: 239618217

Centisome position: 86.33

GC content: 41.79

Gene sequence:

>2319_bases
ATGGTTTTTTCACTGCTAGATGAAACCCTCCGGCTTATCGAATTTGATCATGTCCTGGAGAAGATTTCCCTTCATTGTTT
CTCCACTTACGGCAAAAACGCTTTCAAAATTCTTTCCCCCGCTGAAAAACCTTACGAAAGGCTGGAAAGGGGAAAAGAAT
TCTTTGAACTTCTGCTCTACGAAGGTGAACCACCAACGTCTGGTATCCATGATTTGAGCATAGAGATAGAAAGAGCATCA
TCAGGGAGCATCTTAAGCGGACAGGATCTGAGAAAAATCTCCTCCACTCTTAAATCTCTTTGTAGAATTAAGGAATTCAT
CGAAGCTGTTAAAGAAAAATACCCGGAAGTCTGGAAAATAGCTGAAAATCTTTATTGTGAGCGCGGATTGGTTAATGAAA
TAGAAAAAGCCATAGATGAAAATGGAAATGTAAAAGACAACGCTTCTCCGGCATTAAAAGGAATAAGAAGGGAACTGACA
AGCTTAACAAAAACCCTCAGAACAAAACTCGATAACCTCATCTCGCAATATCAAGAAAACCTGACCAGCAGCAACCTTGT
TACCCGTGAAGGAAGATACGTCCTGCCACTGCTGGCTGCCAGAAAGAACCTTTATGAAGGAATCATACATGGTGCGTCCG
CAAGTGGTGCTACCGTCTATTTTGAACCAAAGGAGCTGGTATCTCTAAACGATAGGCTCAAAATCCTTTACTCAATGGAA
GAAGAAGAAATACACAGGATACTTAGAAACCTTACCCAAAAATTCTTCCTTTCGCTGGAACGCTTGAAAAAAAACATTGC
AGCTATCTCAGAATTGGATGTTCTCTACGCAGCTGCAATCTATGCGAAGAAAAATCGAGCGATCTTTATCTTCCCCAATA
CCGAATTTGAATTTGATCTGATAAATCTAAGACATCCTTTGATCCCTTCTGACAAAGTTGTACCAATAGATTTTCAGCTT
CCTCCTGACAAAAGTGCCGTCATAATAACAGGCCCAAATACTGGCGGAAAAACCGTAGCATTGAAAAATATTGGTCTTGC
AGTTGCATTAACGATGTGCGGCCTTCCAGTTCAAGCAGCTAATGGATCAAAAATTCCATACTTCGATAAACTTTTCGCCG
ATATAGGAGATGAACAATCAATTGAACAAAGCCTCAGTACGTTTTCTTCTCATATGAGCAGGATCGTGAAAATACTCGAA
AATGCTGATAGAAATACCCTGGTTCTCCTCGACGAGCTGGGCGCTGGAACCGACCCTGTGGAAGGCGCGGGACTTTCCAT
GGCTATAATAGATAAACTTCTGGAAAAGAAATGCAAAAGCGTAATAACCACTCACCTATCCCCTCTGAAAATGTACGCCA
TGGAGAAAGAAAAAGTCCTCAACGCGAGTGTCGAATTCGATGTAGAAAGTCTGAAGCCTACCTATCATTTGATTATAGGT
GTCCCCGGGAGCTCGAACGCAATCCAGATTTCCAGAAAGCTCGGGCTTTCACAGGAGGTGGTTAAAAAAGCCCAAAGTTA
CCTTACCTCAGAAACTGTGGATTTTGAAAAACTCATTTCCAAACTGCATAGGGAAAGATCTACGGTAGAAAAACTCAAGC
GGGAACTGTTAAATGAAAAACAAAATCTCAAAGAACTGAAAAAAACCTATGAGAAAAAACTCGAGCTACTGAAGAAAAAG
CGATACGCCGAGGTTAGCGAAGAGTTGAAGGAACTTGAAGAGAAAGTTACCAGACTCATGAGTGAAATCGAAAATGCAAT
AAACCTCTCGCGTTCCAGCAGAGAAAAAGATAAGGTCGAAGCTGTGAAAAAACTCCAGAAAGTTCGTAAGGAAATGGACG
CCGGGAAGTTAATAAGTCGAGAAAAAACCTTCAAAAAATTCAAAACAGGTGAAACGGTGAAAATAATCGAAACAGGTTTA
ACAGGAGAAATAATTGATATAGATGAGAACCGGGCAATTGTAAAATCCGGCCGATTGACTCTGGATCTCCCTCTAGAAAA
ACTTGAACACGCTGATACCCCCACAAATCTGACCGACATAAGTAGCGATTCTTACACCCCTTCAGGATCCCGTGGATTCA
CCGCAAAGGAGATTGACATTCGCGGTATGGTCACTGAAGATGTTCCATTCGTCCTCGATAAATTCATCAATGAGTTACTT
AACGAAGAGCTCAGAACAGGGTATATAATCCACGGGAAGGGCACGGGAAAACTAGCTGAAGCCGTCTGGCGTTATCTAAG
AAAATCAAAGAAAATTAAAACCTTCAGAGTGGGAACCCCTTCTGAGGGTGGCCACGGTGTAACGGTGATAGAGGTGTGA

Upstream 100 bases:

>100_bases
CTGCTGGCTGTTGCTGGAGTTTATCTGTTATTATCGATCTATGACAAAAAAAACAGAGAAAAACTCATGCCACGTATACT
CAGGAAGGTGGGTAAAAGCA

Downstream 100 bases:

>100_bases
TGATGTTCAGCGTTGGGACAGATATAGTAGCCATCTCGAGAATTTCCGAAGAATTGGCGGAAAGAATTCTGAGTGAAGAA
GAAAAAAAGATCTACAACAG

Product: MutS2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 772; Mature: 772

Protein sequence:

>772_residues
MVFSLLDETLRLIEFDHVLEKISLHCFSTYGKNAFKILSPAEKPYERLERGKEFFELLLYEGEPPTSGIHDLSIEIERAS
SGSILSGQDLRKISSTLKSLCRIKEFIEAVKEKYPEVWKIAENLYCERGLVNEIEKAIDENGNVKDNASPALKGIRRELT
SLTKTLRTKLDNLISQYQENLTSSNLVTREGRYVLPLLAARKNLYEGIIHGASASGATVYFEPKELVSLNDRLKILYSME
EEEIHRILRNLTQKFFLSLERLKKNIAAISELDVLYAAAIYAKKNRAIFIFPNTEFEFDLINLRHPLIPSDKVVPIDFQL
PPDKSAVIITGPNTGGKTVALKNIGLAVALTMCGLPVQAANGSKIPYFDKLFADIGDEQSIEQSLSTFSSHMSRIVKILE
NADRNTLVLLDELGAGTDPVEGAGLSMAIIDKLLEKKCKSVITTHLSPLKMYAMEKEKVLNASVEFDVESLKPTYHLIIG
VPGSSNAIQISRKLGLSQEVVKKAQSYLTSETVDFEKLISKLHRERSTVEKLKRELLNEKQNLKELKKTYEKKLELLKKK
RYAEVSEELKELEEKVTRLMSEIENAINLSRSSREKDKVEAVKKLQKVRKEMDAGKLISREKTFKKFKTGETVKIIETGL
TGEIIDIDENRAIVKSGRLTLDLPLEKLEHADTPTNLTDISSDSYTPSGSRGFTAKEIDIRGMVTEDVPFVLDKFINELL
NEELRTGYIIHGKGTGKLAEAVWRYLRKSKKIKTFRVGTPSEGGHGVTVIEV

Sequences:

>Translated_772_residues
MVFSLLDETLRLIEFDHVLEKISLHCFSTYGKNAFKILSPAEKPYERLERGKEFFELLLYEGEPPTSGIHDLSIEIERAS
SGSILSGQDLRKISSTLKSLCRIKEFIEAVKEKYPEVWKIAENLYCERGLVNEIEKAIDENGNVKDNASPALKGIRRELT
SLTKTLRTKLDNLISQYQENLTSSNLVTREGRYVLPLLAARKNLYEGIIHGASASGATVYFEPKELVSLNDRLKILYSME
EEEIHRILRNLTQKFFLSLERLKKNIAAISELDVLYAAAIYAKKNRAIFIFPNTEFEFDLINLRHPLIPSDKVVPIDFQL
PPDKSAVIITGPNTGGKTVALKNIGLAVALTMCGLPVQAANGSKIPYFDKLFADIGDEQSIEQSLSTFSSHMSRIVKILE
NADRNTLVLLDELGAGTDPVEGAGLSMAIIDKLLEKKCKSVITTHLSPLKMYAMEKEKVLNASVEFDVESLKPTYHLIIG
VPGSSNAIQISRKLGLSQEVVKKAQSYLTSETVDFEKLISKLHRERSTVEKLKRELLNEKQNLKELKKTYEKKLELLKKK
RYAEVSEELKELEEKVTRLMSEIENAINLSRSSREKDKVEAVKKLQKVRKEMDAGKLISREKTFKKFKTGETVKIIETGL
TGEIIDIDENRAIVKSGRLTLDLPLEKLEHADTPTNLTDISSDSYTPSGSRGFTAKEIDIRGMVTEDVPFVLDKFINELL
NEELRTGYIIHGKGTGKLAEAVWRYLRKSKKIKTFRVGTPSEGGHGVTVIEV
>Mature_772_residues
MVFSLLDETLRLIEFDHVLEKISLHCFSTYGKNAFKILSPAEKPYERLERGKEFFELLLYEGEPPTSGIHDLSIEIERAS
SGSILSGQDLRKISSTLKSLCRIKEFIEAVKEKYPEVWKIAENLYCERGLVNEIEKAIDENGNVKDNASPALKGIRRELT
SLTKTLRTKLDNLISQYQENLTSSNLVTREGRYVLPLLAARKNLYEGIIHGASASGATVYFEPKELVSLNDRLKILYSME
EEEIHRILRNLTQKFFLSLERLKKNIAAISELDVLYAAAIYAKKNRAIFIFPNTEFEFDLINLRHPLIPSDKVVPIDFQL
PPDKSAVIITGPNTGGKTVALKNIGLAVALTMCGLPVQAANGSKIPYFDKLFADIGDEQSIEQSLSTFSSHMSRIVKILE
NADRNTLVLLDELGAGTDPVEGAGLSMAIIDKLLEKKCKSVITTHLSPLKMYAMEKEKVLNASVEFDVESLKPTYHLIIG
VPGSSNAIQISRKLGLSQEVVKKAQSYLTSETVDFEKLISKLHRERSTVEKLKRELLNEKQNLKELKKTYEKKLELLKKK
RYAEVSEELKELEEKVTRLMSEIENAINLSRSSREKDKVEAVKKLQKVRKEMDAGKLISREKTFKKFKTGETVKIIETGL
TGEIIDIDENRAIVKSGRLTLDLPLEKLEHADTPTNLTDISSDSYTPSGSRGFTAKEIDIRGMVTEDVPFVLDKFINELL
NEELRTGYIIHGKGTGKLAEAVWRYLRKSKKIKTFRVGTPSEGGHGVTVIEV

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI4504191, Length=324, Percent_Identity=26.8518518518519, Blast_Score=97, Evalue=8e-20,
Organism=Homo sapiens, GI284813531, Length=284, Percent_Identity=26.4084507042254, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI26638666, Length=214, Percent_Identity=30.3738317757009, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI4505253, Length=214, Percent_Identity=30.3738317757009, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI36949366, Length=261, Percent_Identity=28.3524904214559, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI26638664, Length=215, Percent_Identity=30.2325581395349, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI4557761, Length=260, Percent_Identity=27.3076923076923, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI262231786, Length=139, Percent_Identity=35.9712230215827, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1789089, Length=259, Percent_Identity=28.1853281853282, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17508445, Length=309, Percent_Identity=28.4789644012945, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17534743, Length=234, Percent_Identity=29.9145299145299, Blast_Score=100, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17508447, Length=306, Percent_Identity=25.4901960784314, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539736, Length=352, Percent_Identity=23.5795454545455, Blast_Score=67, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324482, Length=319, Percent_Identity=26.9592476489028, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321912, Length=330, Percent_Identity=25.1515151515152, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319935, Length=282, Percent_Identity=29.7872340425532, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321109, Length=186, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320047, Length=428, Percent_Identity=24.7663551401869, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320302, Length=384, Percent_Identity=22.65625, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24664545, Length=323, Percent_Identity=27.2445820433437, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24584320, Length=249, Percent_Identity=29.3172690763052, Blast_Score=98, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 86940; Mature: 86940

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFSLLDETLRLIEFDHVLEKISLHCFSTYGKNAFKILSPAEKPYERLERGKEFFELLLY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHC
EGEPPTSGIHDLSIEIERASSGSILSGQDLRKISSTLKSLCRIKEFIEAVKEKYPEVWKI
CCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
AENLYCERGLVNEIEKAIDENGNVKDNASPALKGIRRELTSLTKTLRTKLDNLISQYQEN
HHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LTSSNLVTREGRYVLPLLAARKNLYEGIIHGASASGATVYFEPKELVSLNDRLKILYSME
CCCCCCEECCCCEEHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHCCCCHHHHEECCC
EEEIHRILRNLTQKFFLSLERLKKNIAAISELDVLYAAAIYAKKNRAIFIFPNTEFEFDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEE
INLRHPLIPSDKVVPIDFQLPPDKSAVIITGPNTGGKTVALKNIGLAVALTMCGLPVQAA
EECCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHHCCCEECC
NGSKIPYFDKLFADIGDEQSIEQSLSTFSSHMSRIVKILENADRNTLVLLDELGAGTDPV
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
EGAGLSMAIIDKLLEKKCKSVITTHLSPLKMYAMEKEKVLNASVEFDVESLKPTYHLIIG
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEECHHHCCCEEEEEEE
VPGSSNAIQISRKLGLSQEVVKKAQSYLTSETVDFEKLISKLHRERSTVEKLKRELLNEK
CCCCCCCEEEHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QNLKELKKTYEKKLELLKKKRYAEVSEELKELEEKVTRLMSEIENAINLSRSSREKDKVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AVKKLQKVRKEMDAGKLISREKTFKKFKTGETVKIIETGLTGEIIDIDENRAIVKSGRLT
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCEEEECCCEE
LDLPLEKLEHADTPTNLTDISSDSYTPSGSRGFTAKEIDIRGMVTEDVPFVLDKFINELL
EECCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECEEECCCHHHHHHHHHHHHH
NEELRTGYIIHGKGTGKLAEAVWRYLRKSKKIKTFRVGTPSEGGHGVTVIEV
HHHHHCCEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEC
>Mature Secondary Structure
MVFSLLDETLRLIEFDHVLEKISLHCFSTYGKNAFKILSPAEKPYERLERGKEFFELLLY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHC
EGEPPTSGIHDLSIEIERASSGSILSGQDLRKISSTLKSLCRIKEFIEAVKEKYPEVWKI
CCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
AENLYCERGLVNEIEKAIDENGNVKDNASPALKGIRRELTSLTKTLRTKLDNLISQYQEN
HHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LTSSNLVTREGRYVLPLLAARKNLYEGIIHGASASGATVYFEPKELVSLNDRLKILYSME
CCCCCCEECCCCEEHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHCCCCHHHHEECCC
EEEIHRILRNLTQKFFLSLERLKKNIAAISELDVLYAAAIYAKKNRAIFIFPNTEFEFDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEE
INLRHPLIPSDKVVPIDFQLPPDKSAVIITGPNTGGKTVALKNIGLAVALTMCGLPVQAA
EECCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHHCCCEECC
NGSKIPYFDKLFADIGDEQSIEQSLSTFSSHMSRIVKILENADRNTLVLLDELGAGTDPV
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
EGAGLSMAIIDKLLEKKCKSVITTHLSPLKMYAMEKEKVLNASVEFDVESLKPTYHLIIG
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEECHHHCCCEEEEEEE
VPGSSNAIQISRKLGLSQEVVKKAQSYLTSETVDFEKLISKLHRERSTVEKLKRELLNEK
CCCCCCCEEEHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QNLKELKKTYEKKLELLKKKRYAEVSEELKELEEKVTRLMSEIENAINLSRSSREKDKVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AVKKLQKVRKEMDAGKLISREKTFKKFKTGETVKIIETGLTGEIIDIDENRAIVKSGRLT
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCEEEECCCEE
LDLPLEKLEHADTPTNLTDISSDSYTPSGSRGFTAKEIDIRGMVTEDVPFVLDKFINELL
EECCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECEEECCCHHHHHHHHHHHHH
NEELRTGYIIHGKGTGKLAEAVWRYLRKSKKIKTFRVGTPSEGGHGVTVIEV
HHHHHCCEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]