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The map label for this gene is gcvT [H]

Identifier: 239617994

GI number: 239617994

Start: 1741213

End: 1742319

Strand: Reverse

Name: gcvT [H]

Synonym: Kole_1622

Alternate gene names: 239617994

Gene position: 1742319-1741213 (Counterclockwise)

Preceding gene: 239617995

Following gene: 239617993

Centisome position: 75.68

GC content: 44.72

Gene sequence:

>1107_bases
ATGGAAAAACTTAAAAGAACTCCTCTTTATCAAGAACATCTGCGACTGGACGCGCAAATGGTGGATTTTGCGGGCTGGGA
AATGCCTGTGCAATATACCTCTATACTTGATGAGCATAACACGGTGAGGAACATAGCCGGGCTGTTCGATGTTTCTCACA
TGGGGGAGATTGAGATCACCGGACCAAACGCACTTATTTTTGCAGATTATCTTGTAACGAATTCCGTTTCCGGTTTAAAA
AATGGCGAGATTTGTTACACACCCATGTGTAACGAAAACGGCGGCGTTGTAGACGACCTCCTTGTGTACAGGTTCTCTGA
GGACAAGATCCTTTTCGTGGTTAATGCGGCAAATACAGACAAAGATTTTGAGTGGGTAAAAAAACACTCTGCCAGATTCA
ATGTCGAAGTCAAAAACATCTCTTCTGAAACAGCTCAGCTGGCCTTCCAAGGCCCCCGGGCGGAAGAATTTTTGCAGGAA
ATAGCACAGGTAAAACTCAGCGAAATTCCTTTCTATCATTTCACAGAAGGAAAGGTTGTTGGAATCGATTGTATCATCTC
CAGAACAGGCTATACCGGAGAGGATGGGTTTGAGCTCTACACATCTCCTGAAGGGGCTGTTCCCCTCTGGCGAAAGATCC
TTGAGATAGGTGCCCCCTATGGCGTTAAACCCATCGGGCTTGGAGCAAGAGATACATTGAGATTTGAAGCCTGTTATATG
TTGTACGGTAATGAGCTCAACGACGAGATAACTCCTCTAGAGGCAGGCCTTAAATGGACAGTGAAGTTGGACAAAGATTT
CATCGGAAAGGACAAACTTCTGAAGCAGTTGGAAAACGGCTTGGAATACAAGCTTCGCGGAATAGAGCTCGTTGAAAAAG
GTATCCCGAGGCACGGTTACGAGGTGTACGCTGATGGAGAAAAAATTGGTTGGGTAAGCAGTGGAATGCTTTCGCCGACA
TTGAAAAAGCCAGTGGCCCTGGCCTATCTCAAGAAAGGATACTGGAAAAGAGGAACAGAAGTTGAGATTAAGATAAGGAG
CAAGATGGTAAAAGCGGTTGTAACCAAAACACCATTTTATAGAGGTTCAGTAAAATCAAAAGGTTAA

Upstream 100 bases:

>100_bases
CTTTGGGGAAGGTTCAATCACGGATGTACTTGTACCCGATGAAATGTTGGAAAAAGCAAAGAATATTCTCAAAGAATATA
GAGGAAAGGAGCAATAACCG

Downstream 100 bases:

>100_bases
TAAAAGGAGGTTATCTGTCATGAAAAAGTTTGCAAAGTCTCATGAATGGATTTCCATCGAAGGTGAAATTGGAACAGTAG
GCATAACGAATTACGCCCAG

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MEKLKRTPLYQEHLRLDAQMVDFAGWEMPVQYTSILDEHNTVRNIAGLFDVSHMGEIEITGPNALIFADYLVTNSVSGLK
NGEICYTPMCNENGGVVDDLLVYRFSEDKILFVVNAANTDKDFEWVKKHSARFNVEVKNISSETAQLAFQGPRAEEFLQE
IAQVKLSEIPFYHFTEGKVVGIDCIISRTGYTGEDGFELYTSPEGAVPLWRKILEIGAPYGVKPIGLGARDTLRFEACYM
LYGNELNDEITPLEAGLKWTVKLDKDFIGKDKLLKQLENGLEYKLRGIELVEKGIPRHGYEVYADGEKIGWVSSGMLSPT
LKKPVALAYLKKGYWKRGTEVEIKIRSKMVKAVVTKTPFYRGSVKSKG

Sequences:

>Translated_368_residues
MEKLKRTPLYQEHLRLDAQMVDFAGWEMPVQYTSILDEHNTVRNIAGLFDVSHMGEIEITGPNALIFADYLVTNSVSGLK
NGEICYTPMCNENGGVVDDLLVYRFSEDKILFVVNAANTDKDFEWVKKHSARFNVEVKNISSETAQLAFQGPRAEEFLQE
IAQVKLSEIPFYHFTEGKVVGIDCIISRTGYTGEDGFELYTSPEGAVPLWRKILEIGAPYGVKPIGLGARDTLRFEACYM
LYGNELNDEITPLEAGLKWTVKLDKDFIGKDKLLKQLENGLEYKLRGIELVEKGIPRHGYEVYADGEKIGWVSSGMLSPT
LKKPVALAYLKKGYWKRGTEVEIKIRSKMVKAVVTKTPFYRGSVKSKG
>Mature_368_residues
MEKLKRTPLYQEHLRLDAQMVDFAGWEMPVQYTSILDEHNTVRNIAGLFDVSHMGEIEITGPNALIFADYLVTNSVSGLK
NGEICYTPMCNENGGVVDDLLVYRFSEDKILFVVNAANTDKDFEWVKKHSARFNVEVKNISSETAQLAFQGPRAEEFLQE
IAQVKLSEIPFYHFTEGKVVGIDCIISRTGYTGEDGFELYTSPEGAVPLWRKILEIGAPYGVKPIGLGARDTLRFEACYM
LYGNELNDEITPLEAGLKWTVKLDKDFIGKDKLLKQLENGLEYKLRGIELVEKGIPRHGYEVYADGEKIGWVSSGMLSPT
LKKPVALAYLKKGYWKRGTEVEIKIRSKMVKAVVTKTPFYRGSVKSKG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=369, Percent_Identity=37.1273712737127, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI257796258, Length=357, Percent_Identity=36.4145658263305, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI257796254, Length=366, Percent_Identity=34.9726775956284, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI257796256, Length=315, Percent_Identity=34.2857142857143, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI24797151, Length=377, Percent_Identity=29.7082228116711, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI194306651, Length=368, Percent_Identity=27.445652173913, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI197927446, Length=336, Percent_Identity=27.3809523809524, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI21361378, Length=336, Percent_Identity=27.3809523809524, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1789272, Length=370, Percent_Identity=40.5405405405405, Blast_Score=258, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17560118, Length=369, Percent_Identity=36.8563685636856, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI32563613, Length=318, Percent_Identity=27.3584905660377, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71994045, Length=375, Percent_Identity=24.5333333333333, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71994052, Length=375, Percent_Identity=24.5333333333333, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320222, Length=391, Percent_Identity=35.2941176470588, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI20129441, Length=376, Percent_Identity=33.7765957446808, Blast_Score=217, Evalue=8e-57,
Organism=Drosophila melanogaster, GI28571104, Length=324, Percent_Identity=27.7777777777778, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20130091, Length=428, Percent_Identity=23.3644859813084, Blast_Score=95, Evalue=9e-20,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41473; Mature: 41473

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLKRTPLYQEHLRLDAQMVDFAGWEMPVQYTSILDEHNTVRNIAGLFDVSHMGEIEIT
CCCCCCCCCHHHHHHCCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
GPNALIFADYLVTNSVSGLKNGEICYTPMCNENGGVVDDLLVYRFSEDKILFVVNAANTD
CCCEEEEEEHHHHCCCCCCCCCCEEEEECCCCCCCCHHHEEEEEECCCCEEEEEECCCCC
KDFEWVKKHSARFNVEVKNISSETAQLAFQGPRAEEFLQEIAQVKLSEIPFYHFTEGKVV
CHHHHHHHCCCEEEEEEECCCCCHHEEEECCCCHHHHHHHHHHHHHHHCCEEEECCCCEE
GIDCIISRTGYTGEDGFELYTSPEGAVPLWRKILEIGAPYGVKPIGLGARDTLRFEACYM
EEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCEECCCCCCCEEEEEEEE
LYGNELNDEITPLEAGLKWTVKLDKDFIGKDKLLKQLENGLEYKLRGIELVEKGIPRHGY
EECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCC
EVYADGEKIGWVSSGMLSPTLKKPVALAYLKKGYWKRGTEVEIKIRSKMVKAVVTKTPFY
EEEECCCEECEEECCCCCCHHHCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCC
RGSVKSKG
CCCCCCCC
>Mature Secondary Structure
MEKLKRTPLYQEHLRLDAQMVDFAGWEMPVQYTSILDEHNTVRNIAGLFDVSHMGEIEIT
CCCCCCCCCHHHHHHCCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
GPNALIFADYLVTNSVSGLKNGEICYTPMCNENGGVVDDLLVYRFSEDKILFVVNAANTD
CCCEEEEEEHHHHCCCCCCCCCCEEEEECCCCCCCCHHHEEEEEECCCCEEEEEECCCCC
KDFEWVKKHSARFNVEVKNISSETAQLAFQGPRAEEFLQEIAQVKLSEIPFYHFTEGKVV
CHHHHHHHCCCEEEEEEECCCCCHHEEEECCCCHHHHHHHHHHHHHHHCCEEEECCCCEE
GIDCIISRTGYTGEDGFELYTSPEGAVPLWRKILEIGAPYGVKPIGLGARDTLRFEACYM
EEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCEECCCCCCCEEEEEEEE
LYGNELNDEITPLEAGLKWTVKLDKDFIGKDKLLKQLENGLEYKLRGIELVEKGIPRHGY
EECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCC
EVYADGEKIGWVSSGMLSPTLKKPVALAYLKKGYWKRGTEVEIKIRSKMVKAVVTKTPFY
EEEECCCEECEEECCCCCCHHHCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCC
RGSVKSKG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA