Click here to switch to the map view.

The map label for this gene is gluP [H]

Identifier: 239617958

GI number: 239617958

Start: 1700536

End: 1701393

Strand: Reverse

Name: gluP [H]

Synonym: Kole_1586

Alternate gene names: 239617958

Gene position: 1701393-1700536 (Counterclockwise)

Preceding gene: 239617959

Following gene: 239617957

Centisome position: 73.91

GC content: 42.77

Gene sequence:

>858_bases
ATGCGAATCTCAAAGCGTACAAATGCTACAATAATACTTATAATCATTAACCTGGCTGTTTATTTTTTCGTCTTTATTCT
ATCCCACTCCAGAAGAACTATTGATCTGTACAATCTGATCCTGATCTACGGTGGTATAAGCCGCGGTGCATTGTTAAGAG
GTCTTTTTTATACCCCTTTGACCGCGCTCTTTTTGCACGGAAACATGCTCCACATTCTTTTCAACATGTATGCCTTGTTT
CAGCTTGGATATCTTGTTGAGGGAATTTACGGCATGCGGAAATTTCTCATTTTCTATTTCGTCTCTGGAATAATTGGAAA
CCTGACGGCGGCCACAATGACCCCTTACATAACCATCGGATCCAGCAGCGCCATCTTCGGATTGGTCGGGGTGCTTTTTG
CCCTCGGCTTTAAAAAGGATACACCTGTTGTGTTGAAATCTGTTACAGGACTTTCTCTGCTGCCTATTATTCTCTTAAAC
CTCATGTTTGGTCTTATGATACCCAATATCAGCAACTCCGCTCACGTTGGTGGGCTTATCGCAGGAAGCCTGCTTGGGTG
GTTTGTTCTGCCACAGTATGCCATTGTGAGGAAACCTCGTGTAAGCCGTGTGAAACAAAAATCGCCAGAGGAAATCGCCA
GAGATATACTGCTGAAGTATGTCCCTATACTCAATGCCCTTAAAAACTCTCGGCAGGATAATAGGGAGATTGATGAAAGA
ACCGTGCAAATTGCCCAACTTAGGAAAGAACTCAGTGAACTGGCAGATTATGAACTGGCTTATAAGGTCCTTGGGGATCT
TTACAGGCGTAATCTGATAACGGATGATGAATTTGAAAAGCTCAGAAAATTCATTTAG

Upstream 100 bases:

>100_bases
GATGCCATTCGAATCATCTCCGAGATGCTCAAAAAAGATATAATTGATGAGAAGGAATACAAAAAACTTATAAGATTACT
CAGATAAGGTGGATAAAAAG

Downstream 100 bases:

>100_bases
GAGGAAAGCATGCTAAGAAACTTTCTCCTGACTTTTTTATTGAGTGTTATGCTTTTTGGTTTCGCTTTTGGAGAAAAGAA
ATACATTCCCTACAACCCAT

Product: Rhomboid family protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MRISKRTNATIILIIINLAVYFFVFILSHSRRTIDLYNLILIYGGISRGALLRGLFYTPLTALFLHGNMLHILFNMYALF
QLGYLVEGIYGMRKFLIFYFVSGIIGNLTAATMTPYITIGSSSAIFGLVGVLFALGFKKDTPVVLKSVTGLSLLPIILLN
LMFGLMIPNISNSAHVGGLIAGSLLGWFVLPQYAIVRKPRVSRVKQKSPEEIARDILLKYVPILNALKNSRQDNREIDER
TVQIAQLRKELSELADYELAYKVLGDLYRRNLITDDEFEKLRKFI

Sequences:

>Translated_285_residues
MRISKRTNATIILIIINLAVYFFVFILSHSRRTIDLYNLILIYGGISRGALLRGLFYTPLTALFLHGNMLHILFNMYALF
QLGYLVEGIYGMRKFLIFYFVSGIIGNLTAATMTPYITIGSSSAIFGLVGVLFALGFKKDTPVVLKSVTGLSLLPIILLN
LMFGLMIPNISNSAHVGGLIAGSLLGWFVLPQYAIVRKPRVSRVKQKSPEEIARDILLKYVPILNALKNSRQDNREIDER
TVQIAQLRKELSELADYELAYKVLGDLYRRNLITDDEFEKLRKFI
>Mature_285_residues
MRISKRTNATIILIIINLAVYFFVFILSHSRRTIDLYNLILIYGGISRGALLRGLFYTPLTALFLHGNMLHILFNMYALF
QLGYLVEGIYGMRKFLIFYFVSGIIGNLTAATMTPYITIGSSSAIFGLVGVLFALGFKKDTPVVLKSVTGLSLLPIILLN
LMFGLMIPNISNSAHVGGLIAGSLLGWFVLPQYAIVRKPRVSRVKQKSPEEIARDILLKYVPILNALKNSRQDNREIDER
TVQIAQLRKELSELADYELAYKVLGDLYRRNLITDDEFEKLRKFI

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI190341097, Length=139, Percent_Identity=33.8129496402878, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI301069362, Length=139, Percent_Identity=33.0935251798561, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 32230; Mature: 32230

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISKRTNATIILIIINLAVYFFVFILSHSRRTIDLYNLILIYGGISRGALLRGLFYTPL
CCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TALFLHGNMLHILFNMYALFQLGYLVEGIYGMRKFLIFYFVSGIIGNLTAATMTPYITIG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
SSSAIFGLVGVLFALGFKKDTPVVLKSVTGLSLLPIILLNLMFGLMIPNISNSAHVGGLI
CCHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AGSLLGWFVLPQYAIVRKPRVSRVKQKSPEEIARDILLKYVPILNALKNSRQDNREIDER
HHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
TVQIAQLRKELSELADYELAYKVLGDLYRRNLITDDEFEKLRKFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure
MRISKRTNATIILIIINLAVYFFVFILSHSRRTIDLYNLILIYGGISRGALLRGLFYTPL
CCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TALFLHGNMLHILFNMYALFQLGYLVEGIYGMRKFLIFYFVSGIIGNLTAATMTPYITIG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
SSSAIFGLVGVLFALGFKKDTPVVLKSVTGLSLLPIILLNLMFGLMIPNISNSAHVGGLI
CCHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AGSLLGWFVLPQYAIVRKPRVSRVKQKSPEEIARDILLKYVPILNALKNSRQDNREIDER
HHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
TVQIAQLRKELSELADYELAYKVLGDLYRRNLITDDEFEKLRKFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]