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The map label for this gene is yugH [H]

Identifier: 239617865

GI number: 239617865

Start: 1591758

End: 1592948

Strand: Reverse

Name: yugH [H]

Synonym: Kole_1492

Alternate gene names: 239617865

Gene position: 1592948-1591758 (Counterclockwise)

Preceding gene: 239617866

Following gene: 239617858

Centisome position: 69.19

GC content: 44.33

Gene sequence:

>1191_bases
ATGAAAATCTCTTCTCGCGGTGTGAACATGCCAGCATCGCCCATAAGGAAGCTTGTGCCTTATGCCGAAATCGCAAAAAA
GCGAGGAATAAAGGTTTACCATCTCAACATCGGGCAACCGGACATTCCAACCCCAGAAGTTTTCTTCAATGCTATTCGCA
ATCACTCTGAAGAGGTTGTCGCCTATTCACATTCAGCTGGCATCTACAACCTCAGAGAAGCTTTCTCAAAATACTACCGT
TCCTGGGGAATCGACGTCAGCCCGGATGAGATTATAGTCACCAATGGCGGAAGCGAAGCAATTATATTTGCTATAGGAAG
TATAGCTGATCCAGGTGATGAGCTGATTGTCATAGAGCCTTTCTACGCCAATTACAAAGGTTTTGCCAGTATGCTCAATG
TAAAACTTGTTCCCGTAAGTGCCAACGTAACCGACGGTTACAGATTACCACCTATAGAGCTCTTCGAAAAAGCTCTGAGT
AATAAAACCCGGGGAATAATATTTTCCAACCCTTCCAACCCCACAGGTGTGGTTTACACCAGAGAAGAGCTAGAAGCTCT
GCTTGACTTTGCCAGAGCTCACGATCTTTTTGTTATAACAGATGAGGTGTACAGGGAATTCGTTTTTGATGGGAAAAACA
CCGTTCCTGTTTTGTCGCTGGATGAGAGCGAAAGAATCATCATTGTGGACAGCATTTCGAAAAGATACAGTGCCTGCGGT
GCACGTGTAGGAACTTTTCTTACCAAAAACAAAGAACTGTACAATACCGTCATGAAATTCGCTCAGGCAAGGCTTTCACC
CCCGACAATGGCACAGGTGGGGACAATAGGACTTCTCAACCTCGGTAAAGATTACACCGACAACATAAGGGAAGAATACC
AGAAACGAAGGGATATTGTTTTTGAAGAACTCTCGAAGATAGATGGAGTGATAATGCAAAAACCAGAAGGAGCTTTTTAT
ATCTCCGTAAAACTACCCGTGAAAAACTCGGAAGATTTCGTGCGCTGGATGTTAACCGATTTTGATGTTGGTGGAGAAAC
CACTATGGTCGCTCCTTTACAAGGCTTTTACGCGACTCCGGGAATGGGAGCATCTGAAATAAGAATCGCTTACGTCCTCT
CCGCAGAAAACCTTCGAAAAGCCTGTGAGATAATCAGGTTAGGCCTTGAAAAATACCTGGGCAGTTTGTAA

Upstream 100 bases:

>100_bases
AGAAAACAACGATCCCGAAGGTACTGGAAGTGACTGGATGGATGTGTACGAAATGTCGGTAAAATAATTAAATAATTAAA
TATTGAATGGAGGGAAAGTA

Downstream 100 bases:

>100_bases
AGATTCACCAGATAAAAGAGAGACAAAAAAAAGAAAGGCGCCGAAACAGGCGCCTTATTTTATGATTTTTGTTTCATTCT
ATGACTCTAACCTTTGCGGC

Product: aspartate aminotransferase

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKISSRGVNMPASPIRKLVPYAEIAKKRGIKVYHLNIGQPDIPTPEVFFNAIRNHSEEVVAYSHSAGIYNLREAFSKYYR
SWGIDVSPDEIIVTNGGSEAIIFAIGSIADPGDELIVIEPFYANYKGFASMLNVKLVPVSANVTDGYRLPPIELFEKALS
NKTRGIIFSNPSNPTGVVYTREELEALLDFARAHDLFVITDEVYREFVFDGKNTVPVLSLDESERIIIVDSISKRYSACG
ARVGTFLTKNKELYNTVMKFAQARLSPPTMAQVGTIGLLNLGKDYTDNIREEYQKRRDIVFEELSKIDGVIMQKPEGAFY
ISVKLPVKNSEDFVRWMLTDFDVGGETTMVAPLQGFYATPGMGASEIRIAYVLSAENLRKACEIIRLGLEKYLGSL

Sequences:

>Translated_396_residues
MKISSRGVNMPASPIRKLVPYAEIAKKRGIKVYHLNIGQPDIPTPEVFFNAIRNHSEEVVAYSHSAGIYNLREAFSKYYR
SWGIDVSPDEIIVTNGGSEAIIFAIGSIADPGDELIVIEPFYANYKGFASMLNVKLVPVSANVTDGYRLPPIELFEKALS
NKTRGIIFSNPSNPTGVVYTREELEALLDFARAHDLFVITDEVYREFVFDGKNTVPVLSLDESERIIIVDSISKRYSACG
ARVGTFLTKNKELYNTVMKFAQARLSPPTMAQVGTIGLLNLGKDYTDNIREEYQKRRDIVFEELSKIDGVIMQKPEGAFY
ISVKLPVKNSEDFVRWMLTDFDVGGETTMVAPLQGFYATPGMGASEIRIAYVLSAENLRKACEIIRLGLEKYLGSL
>Mature_396_residues
MKISSRGVNMPASPIRKLVPYAEIAKKRGIKVYHLNIGQPDIPTPEVFFNAIRNHSEEVVAYSHSAGIYNLREAFSKYYR
SWGIDVSPDEIIVTNGGSEAIIFAIGSIADPGDELIVIEPFYANYKGFASMLNVKLVPVSANVTDGYRLPPIELFEKALS
NKTRGIIFSNPSNPTGVVYTREELEALLDFARAHDLFVITDEVYREFVFDGKNTVPVLSLDESERIIIVDSISKRYSACG
ARVGTFLTKNKELYNTVMKFAQARLSPPTMAQVGTIGLLNLGKDYTDNIREEYQKRRDIVFEELSKIDGVIMQKPEGAFY
ISVKLPVKNSEDFVRWMLTDFDVGGETTMVAPLQGFYATPGMGASEIRIAYVLSAENLRKACEIIRLGLEKYLGSL

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=407, Percent_Identity=25.7985257985258, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI169881279, Length=407, Percent_Identity=25.7985257985258, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI4507369, Length=339, Percent_Identity=24.4837758112094, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI56713254, Length=391, Percent_Identity=26.5984654731458, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI56713256, Length=391, Percent_Identity=26.5984654731458, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI169881281, Length=306, Percent_Identity=25.8169934640523, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI149944424, Length=207, Percent_Identity=31.8840579710145, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI187936925, Length=224, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI14211921, Length=224, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4885351, Length=283, Percent_Identity=27.9151943462898, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI7705897, Length=275, Percent_Identity=26.5454545454545, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI33469970, Length=275, Percent_Identity=26.5454545454545, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI215599424, Length=292, Percent_Identity=23.972602739726, Blast_Score=65, Evalue=1e-10,
Organism=Homo sapiens, GI19263340, Length=292, Percent_Identity=23.972602739726, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1788627, Length=335, Percent_Identity=28.955223880597, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788722, Length=395, Percent_Identity=26.0759493670886, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786816, Length=360, Percent_Identity=27.7777777777778, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790797, Length=303, Percent_Identity=24.4224422442244, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787710, Length=215, Percent_Identity=28.3720930232558, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788332, Length=182, Percent_Identity=28.021978021978, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17567663, Length=393, Percent_Identity=25.9541984732824, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71994476, Length=392, Percent_Identity=26.530612244898, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71994472, Length=392, Percent_Identity=26.530612244898, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17567369, Length=227, Percent_Identity=30.3964757709251, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71981209, Length=293, Percent_Identity=25.2559726962457, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322401, Length=378, Percent_Identity=28.5714285714286, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320317, Length=301, Percent_Identity=24.2524916943522, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323118, Length=367, Percent_Identity=25.3405994550409, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI28573069, Length=390, Percent_Identity=28.2051282051282, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646114, Length=390, Percent_Identity=28.2051282051282, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28573067, Length=390, Percent_Identity=28.2051282051282, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28573065, Length=390, Percent_Identity=28.2051282051282, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI18859735, Length=397, Percent_Identity=23.4256926952141, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45551451, Length=314, Percent_Identity=28.0254777070064, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24641770, Length=314, Percent_Identity=28.0254777070064, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24641760, Length=314, Percent_Identity=28.0254777070064, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24641768, Length=314, Percent_Identity=28.0254777070064, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24641766, Length=314, Percent_Identity=28.0254777070064, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24641764, Length=314, Percent_Identity=28.0254777070064, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 44201; Mature: 44201

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISSRGVNMPASPIRKLVPYAEIAKKRGIKVYHLNIGQPDIPTPEVFFNAIRNHSEEVV
CCCCCCCCCCCHHHHHHHCCHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCEE
AYSHSAGIYNLREAFSKYYRSWGIDVSPDEIIVTNGGSEAIIFAIGSIADPGDELIVIEP
EEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCEEEECC
FYANYKGFASMLNVKLVPVSANVTDGYRLPPIELFEKALSNKTRGIIFSNPSNPTGVVYT
HHCCHHHHHHHHEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEEE
REELEALLDFARAHDLFVITDEVYREFVFDGKNTVPVLSLDESERIIIVDSISKRYSACG
HHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCHHHHHHHH
ARVGTFLTKNKELYNTVMKFAQARLSPPTMAQVGTIGLLNLGKDYTDNIREEYQKRRDIV
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHCCEEEEECCCCHHHHHHHHHHHHHHHH
FEELSKIDGVIMQKPEGAFYISVKLPVKNSEDFVRWMLTDFDVGGETTMVAPLQGFYATP
HHHHHHHCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCEECCC
GMGASEIRIAYVLSAENLRKACEIIRLGLEKYLGSL
CCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKISSRGVNMPASPIRKLVPYAEIAKKRGIKVYHLNIGQPDIPTPEVFFNAIRNHSEEVV
CCCCCCCCCCCHHHHHHHCCHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCEE
AYSHSAGIYNLREAFSKYYRSWGIDVSPDEIIVTNGGSEAIIFAIGSIADPGDELIVIEP
EEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCEEEECC
FYANYKGFASMLNVKLVPVSANVTDGYRLPPIELFEKALSNKTRGIIFSNPSNPTGVVYT
HHCCHHHHHHHHEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEEE
REELEALLDFARAHDLFVITDEVYREFVFDGKNTVPVLSLDESERIIIVDSISKRYSACG
HHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCHHHHHHHH
ARVGTFLTKNKELYNTVMKFAQARLSPPTMAQVGTIGLLNLGKDYTDNIREEYQKRRDIV
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHCCEEEEECCCCHHHHHHHHHHHHHHHH
FEELSKIDGVIMQKPEGAFYISVKLPVKNSEDFVRWMLTDFDVGGETTMVAPLQGFYATP
HHHHHHHCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCEECCC
GMGASEIRIAYVLSAENLRKACEIIRLGLEKYLGSL
CCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]