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The map label for this gene is nuoH2 [H]

Identifier: 239616972

GI number: 239616972

Start: 620457

End: 621368

Strand: Reverse

Name: nuoH2 [H]

Synonym: Kole_0571

Alternate gene names: 239616972

Gene position: 621368-620457 (Counterclockwise)

Preceding gene: 239616973

Following gene: 239616971

Centisome position: 26.99

GC content: 42.87

Gene sequence:

>912_bases
TTGATTGTTTTTTATACCATTGTATTTCCGGGAATTCTCTTTACCGGTTTTGCAGGTTTAATAATATGGTGGCTGGAACG
CAAGCTTAGTGCTCTTTTCCAGCATAGGGTGGGGCCACCATGGTATCAGAATTTTCTGGATGTTTTCAAGTTGTTCGGGA
AAGAGAGCATTGTCCCTGAACTCTCAGCCTCTGTAGTGTATGTCCTTGCCCCGATTGTCTCATTTTCAACTGTTACAACC
CTTTCTACTGTTCTGGGATGTGCTGTCTTTCTTGGAATAAGAATCGCAGGGGATGTGATACTGATAATTTACCTGCTTAT
CCTTTGTTCTATGGCTACGTTTCTTGGAGCCGCTGCTTCGAGGAATGTTTACGCCGGTATAGGTGCTTCCAGAGAACTGA
AGATGCTTCTTGCTGATGAACTAGTTCTTATTATGGTCATTCTGGTGCCTGTTGTGAAATCGGGGTTTGATTTCAATCTG
TTAAGACTGATCTACGGTTCTCCGGCAATAACTTCTATCTCTGGAGTAATCGCATATATCCTGGGATTGGTCTGCATTCA
AGCTAAGTTAGCAATCCAACCCTTCGATTTACCTGAAGCAGAAACGGAACTTGCGGGTGGTGTAGAAATCGAGTATTCGG
GCGTGTTGCTTGGTTTATGGAAGCTTTCAAAAGGAATGAAGTTTTTGGTTGTTCCGTTGCTGTTGAGCGTTCTTTTTTTC
GGTGTTCCTCAGGAGATATCGATAGTCAGGTATCTGTGGATAGTAGCTTTCTATCTGATCACTTTCCTGATCGTTGTGGT
GGTTAAGAACATAAACCCAAGGGTAACAATTGAAAAAATGCTCGGTTTTTTCTGGAAGAAACTGGCACCTATGGCTTTTA
TAGCGCTTCTCATAGCACTTTTGGGGGGATGA

Upstream 100 bases:

>100_bases
TAGATGTTGAAAGAGAACAACCTGAGAATGGATTTTATTTTGCCGGAAAGTATCTTGCGATACGCGCGCCGAATTGGCGT
TATAAGGAGGGCAGAATAAT

Downstream 100 bases:

>100_bases
ATATGGGATTTTACACGAAGATTCTGAAAAGATCACTCTGGGTGTTTCATGTCAGCGCGTCACCATGTAATAACTGCGAT
ATAGAGATTCTCGATATGTT

Product: respiratory-chain NADH dehydrogenase subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H 2; NDH-1 subunit H 2 [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MIVFYTIVFPGILFTGFAGLIIWWLERKLSALFQHRVGPPWYQNFLDVFKLFGKESIVPELSASVVYVLAPIVSFSTVTT
LSTVLGCAVFLGIRIAGDVILIIYLLILCSMATFLGAAASRNVYAGIGASRELKMLLADELVLIMVILVPVVKSGFDFNL
LRLIYGSPAITSISGVIAYILGLVCIQAKLAIQPFDLPEAETELAGGVEIEYSGVLLGLWKLSKGMKFLVVPLLLSVLFF
GVPQEISIVRYLWIVAFYLITFLIVVVVKNINPRVTIEKMLGFFWKKLAPMAFIALLIALLGG

Sequences:

>Translated_303_residues
MIVFYTIVFPGILFTGFAGLIIWWLERKLSALFQHRVGPPWYQNFLDVFKLFGKESIVPELSASVVYVLAPIVSFSTVTT
LSTVLGCAVFLGIRIAGDVILIIYLLILCSMATFLGAAASRNVYAGIGASRELKMLLADELVLIMVILVPVVKSGFDFNL
LRLIYGSPAITSISGVIAYILGLVCIQAKLAIQPFDLPEAETELAGGVEIEYSGVLLGLWKLSKGMKFLVVPLLLSVLFF
GVPQEISIVRYLWIVAFYLITFLIVVVVKNINPRVTIEKMLGFFWKKLAPMAFIALLIALLGG
>Mature_303_residues
MIVFYTIVFPGILFTGFAGLIIWWLERKLSALFQHRVGPPWYQNFLDVFKLFGKESIVPELSASVVYVLAPIVSFSTVTT
LSTVLGCAVFLGIRIAGDVILIIYLLILCSMATFLGAAASRNVYAGIGASRELKMLLADELVLIMVILVPVVKSGFDFNL
LRLIYGSPAITSISGVIAYILGLVCIQAKLAIQPFDLPEAETELAGGVEIEYSGVLLGLWKLSKGMKFLVVPLLLSVLFF
GVPQEISIVRYLWIVAFYLITFLIVVVVKNINPRVTIEKMLGFFWKKLAPMAFIALLIALLGG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=283, Percent_Identity=26.1484098939929, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1788618, Length=289, Percent_Identity=28.719723183391, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI87082115, Length=248, Percent_Identity=33.0645161290323, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789077, Length=211, Percent_Identity=31.2796208530806, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 33289; Mature: 33289

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVFYTIVFPGILFTGFAGLIIWWLERKLSALFQHRVGPPWYQNFLDVFKLFGKESIVPE
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHH
LSASVVYVLAPIVSFSTVTTLSTVLGCAVFLGIRIAGDVILIIYLLILCSMATFLGAAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RNVYAGIGASRELKMLLADELVLIMVILVPVVKSGFDFNLLRLIYGSPAITSISGVIAYI
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHH
LGLVCIQAKLAIQPFDLPEAETELAGGVEIEYSGVLLGLWKLSKGMKFLVVPLLLSVLFF
HHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEECHHHHHHHHHHCCHHHHHHHHHHHHHHH
GVPQEISIVRYLWIVAFYLITFLIVVVVKNINPRVTIEKMLGFFWKKLAPMAFIALLIAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LGG
HCC
>Mature Secondary Structure
MIVFYTIVFPGILFTGFAGLIIWWLERKLSALFQHRVGPPWYQNFLDVFKLFGKESIVPE
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHH
LSASVVYVLAPIVSFSTVTTLSTVLGCAVFLGIRIAGDVILIIYLLILCSMATFLGAAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RNVYAGIGASRELKMLLADELVLIMVILVPVVKSGFDFNLLRLIYGSPAITSISGVIAYI
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHH
LGLVCIQAKLAIQPFDLPEAETELAGGVEIEYSGVLLGLWKLSKGMKFLVVPLLLSVLFF
HHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEECHHHHHHHHHHCCHHHHHHHHHHHHHHH
GVPQEISIVRYLWIVAFYLITFLIVVVVKNINPRVTIEKMLGFFWKKLAPMAFIALLIAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LGG
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA