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The map label for this gene is yleA [C]

Identifier: 239616755

GI number: 239616755

Start: 366047

End: 367324

Strand: Direct

Name: yleA [C]

Synonym: Kole_0348

Alternate gene names: 239616755

Gene position: 366047-367324 (Clockwise)

Preceding gene: 239616754

Following gene: 239616756

Centisome position: 15.9

GC content: 39.83

Gene sequence:

>1278_bases
ATGAAAGAAATCGTTTCCTTTTTTACCTTCGGTTGCAAACTCAATCAATATGAAACCGAAGGGATGGCGGAGTTATTGCA
AAACGATTTTAGGGTTACATTCGACTCGGAGATCGCCGATATTTTCGTTATCAATTCCTGTACGGTAACCGCAGAAGCTG
AAAGGAAACTCCGGCAGCTATATAGAAGGCTTAAAGCAAAGAATCCAGGTAGCAAATTTGTGATTGTGGGTTGTTACTCA
GAACTTTCAGCGGGAGAGCTGAAAGATCTTGGTTTTGACCTGATTCTGGGGATCAAAGATAAATTGAAAATTAAAGAATT
CCTTAAAGAAAATACTGAGAACACCTGCATAAAGGATTATTTTCAGGTTACAAAGGGTCCTTATGGAAGAACCCGTGCAT
ATATTGGCATACAGGATGGATGTTTGAACAATTGTTCATACTGTCGAATAAGATTGGCCAGAGGAAACAAAATCATCAGC
AAACCCCCTGAAGTTGTTGCCGAAGAATTAAAAACACTCGTTGAGCATGGGTTTCAGGAAATAGTGTTGACAGGGATAAA
CATAGGTTTTTACGGATTTGGAGAAGGTTATTCCCTGATTTCTTTATTGAAACAACTGGTAAAGATCGAGGGAGAATGGA
GATTAAGATTAAGCTCTCTCGATCCGAGGCTCGTTTCAAACGAATTAATCACGTTTATGACCGATAACCCAAAAATAGCT
CAGCATGTTCATCTTTCTCTTCAAAGCGGTTCAGATAAAGTTTTGAAATCGATGAATCGTAATTACACCACTAACGACGT
CGAACAGATTGTAGCACTCTTCAGATCCAGGAACAATCGTTTTTCTTTTACCACGGATGTCATAGTGGGATTTCCCGGTG
AAACCGACACGGATTTTGTAGAAACACTCGAATTTGTTAAACGTATCAGATTTTTGAAAGTTCATATATTCAGATTTTCT
CCACGTCCCGGCACCAAAGCTGCCCGCATGAGCAATCAAATCTCCGGGAATATTAAAAAAGAGCGAGCTACTGTCCTGAA
AAAGGTCGCATTAGAAGCATCAAAAGACTATCTTAATGAACATGTTGGCAAGGAAAGCACTGTTCTTATTGAAAAGAACG
ATGGAATTTTTAGCTACGGTTACGACGAATTCTATATCCCTCACAGGGTTACCGGAAGCATAGAAAATGGTTTTGTCAAG
GTACAAATTGGTGGCATAGAAGAACTGGAGGCTTTTTCGGATGTTGAATTATCTTGCAGGTCAGTGGCTGTCCGATGA

Upstream 100 bases:

>100_bases
GATTAAAAACCCTACCTGTCGTGGATGATGACCATAAACTCGTAGGGATCATAACCCGCTTGAATCTCATTTATTCGGCC
CTTCAGGGGCGGGTACTTGA

Downstream 100 bases:

>100_bases
GGAAGCCACCATAAATGTCAAAAATACTGGTATTTTAACAGGAATCTCCGTATACGAGGTTCTAAGAACCTACAACGGTC
TTCCTTTTGCTGCAAAAAAA

Product: MiaB-like tRNA modifying enzyme

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKEIVSFFTFGCKLNQYETEGMAELLQNDFRVTFDSEIADIFVINSCTVTAEAERKLRQLYRRLKAKNPGSKFVIVGCYS
ELSAGELKDLGFDLILGIKDKLKIKEFLKENTENTCIKDYFQVTKGPYGRTRAYIGIQDGCLNNCSYCRIRLARGNKIIS
KPPEVVAEELKTLVEHGFQEIVLTGINIGFYGFGEGYSLISLLKQLVKIEGEWRLRLSSLDPRLVSNELITFMTDNPKIA
QHVHLSLQSGSDKVLKSMNRNYTTNDVEQIVALFRSRNNRFSFTTDVIVGFPGETDTDFVETLEFVKRIRFLKVHIFRFS
PRPGTKAARMSNQISGNIKKERATVLKKVALEASKDYLNEHVGKESTVLIEKNDGIFSYGYDEFYIPHRVTGSIENGFVK
VQIGGIEELEAFSDVELSCRSVAVR

Sequences:

>Translated_425_residues
MKEIVSFFTFGCKLNQYETEGMAELLQNDFRVTFDSEIADIFVINSCTVTAEAERKLRQLYRRLKAKNPGSKFVIVGCYS
ELSAGELKDLGFDLILGIKDKLKIKEFLKENTENTCIKDYFQVTKGPYGRTRAYIGIQDGCLNNCSYCRIRLARGNKIIS
KPPEVVAEELKTLVEHGFQEIVLTGINIGFYGFGEGYSLISLLKQLVKIEGEWRLRLSSLDPRLVSNELITFMTDNPKIA
QHVHLSLQSGSDKVLKSMNRNYTTNDVEQIVALFRSRNNRFSFTTDVIVGFPGETDTDFVETLEFVKRIRFLKVHIFRFS
PRPGTKAARMSNQISGNIKKERATVLKKVALEASKDYLNEHVGKESTVLIEKNDGIFSYGYDEFYIPHRVTGSIENGFVK
VQIGGIEELEAFSDVELSCRSVAVR
>Mature_425_residues
MKEIVSFFTFGCKLNQYETEGMAELLQNDFRVTFDSEIADIFVINSCTVTAEAERKLRQLYRRLKAKNPGSKFVIVGCYS
ELSAGELKDLGFDLILGIKDKLKIKEFLKENTENTCIKDYFQVTKGPYGRTRAYIGIQDGCLNNCSYCRIRLARGNKIIS
KPPEVVAEELKTLVEHGFQEIVLTGINIGFYGFGEGYSLISLLKQLVKIEGEWRLRLSSLDPRLVSNELITFMTDNPKIA
QHVHLSLQSGSDKVLKSMNRNYTTNDVEQIVALFRSRNNRFSFTTDVIVGFPGETDTDFVETLEFVKRIRFLKVHIFRFS
PRPGTKAARMSNQISGNIKKERATVLKKVALEASKDYLNEHVGKESTVLIEKNDGIFSYGYDEFYIPHRVTGSIENGFVK
VQIGGIEELEAFSDVELSCRSVAVR

Specific function: Unknown

COG id: COG0621

COG function: function code J; 2-methylthioadenine synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MTTase N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI93277076, Length=402, Percent_Identity=30.8457711442786, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI28872784, Length=426, Percent_Identity=26.2910798122066, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI28872782, Length=427, Percent_Identity=26.2295081967213, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1786882, Length=384, Percent_Identity=27.8645833333333, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1787057, Length=439, Percent_Identity=27.1070615034169, Blast_Score=131, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17553146, Length=429, Percent_Identity=25.4079254079254, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71996771, Length=327, Percent_Identity=28.4403669724771, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI19922432, Length=399, Percent_Identity=32.0802005012531, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21356207, Length=415, Percent_Identity=26.0240963855422, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR005839
- InterPro:   IPR020612
- InterPro:   IPR013848
- InterPro:   IPR006467
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM; PF00919 UPF0004 [H]

EC number: NA

Molecular weight: Translated: 48231; Mature: 48231

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS01278 UPF0004

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIVSFFTFGCKLNQYETEGMAELLQNDFRVTFDSEIADIFVINSCTVTAEAERKLRQL
CHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEECCCCEEEEEEECEEEEHHHHHHHHHH
YRRLKAKNPGSKFVIVGCYSELSAGELKDLGFDLILGIKDKLKIKEFLKENTENTCIKDY
HHHHHCCCCCCCEEEEEECCCCCCCHHHHCCCEEEECCCHHHHHHHHHHCCCCCHHHHHH
FQVTKGPYGRTRAYIGIQDGCLNNCSYCRIRLARGNKIISKPPEVVAEELKTLVEHGFQE
HHHHCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHH
IVLTGINIGFYGFGEGYSLISLLKQLVKIEGEWRLRLSSLDPRLVSNELITFMTDNPKIA
EEHEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHCCCEEEEEECCCCEE
QHVHLSLQSGSDKVLKSMNRNYTTNDVEQIVALFRSRNNRFSFTTDVIVGFPGETDTDFV
EEEEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCHHHH
ETLEFVKRIRFLKVHIFRFSPRPGTKAARMSNQISGNIKKERATVLKKVALEASKDYLNE
HHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
HVGKESTVLIEKNDGIFSYGYDEFYIPHRVTGSIENGFVKVQIGGIEELEAFSDVELSCR
HCCCCCEEEEECCCCEEEECCCCEECCCEECCCCCCCEEEEEECCHHHHHHHCCCHHHHH
SVAVR
HCCCC
>Mature Secondary Structure
MKEIVSFFTFGCKLNQYETEGMAELLQNDFRVTFDSEIADIFVINSCTVTAEAERKLRQL
CHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEECCCCEEEEEEECEEEEHHHHHHHHHH
YRRLKAKNPGSKFVIVGCYSELSAGELKDLGFDLILGIKDKLKIKEFLKENTENTCIKDY
HHHHHCCCCCCCEEEEEECCCCCCCHHHHCCCEEEECCCHHHHHHHHHHCCCCCHHHHHH
FQVTKGPYGRTRAYIGIQDGCLNNCSYCRIRLARGNKIISKPPEVVAEELKTLVEHGFQE
HHHHCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHH
IVLTGINIGFYGFGEGYSLISLLKQLVKIEGEWRLRLSSLDPRLVSNELITFMTDNPKIA
EEHEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHCCCEEEEEECCCCEE
QHVHLSLQSGSDKVLKSMNRNYTTNDVEQIVALFRSRNNRFSFTTDVIVGFPGETDTDFV
EEEEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCHHHH
ETLEFVKRIRFLKVHIFRFSPRPGTKAARMSNQISGNIKKERATVLKKVALEASKDYLNE
HHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
HVGKESTVLIEKNDGIFSYGYDEFYIPHRVTGSIENGFVKVQIGGIEELEAFSDVELSCR
HCCCCCEEEEECCCCEEEECCCCEECCCEECCCCCCCEEEEEECCHHHHHHHCCCHHHHH
SVAVR
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]