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The map label for this gene is fabF [H]

Identifier: 238925488

GI number: 238925488

Start: 2994991

End: 2996223

Strand: Reverse

Name: fabF [H]

Synonym: EUBREC_3144

Alternate gene names: 238925488

Gene position: 2996223-2994991 (Counterclockwise)

Preceding gene: 238925489

Following gene: 238925487

Centisome position: 86.85

GC content: 45.66

Gene sequence:

>1233_bases
ATGAGTAGAAGAGTAGTTGTAACAGGACTTGGAGCAGTAACACCAATCGGAAATAATGTGGACGATTTCTGGACATCGGT
AAAGGCCGGAAAAATCGGATTTGACCACATCACAAAATTTGACACAACAGATTATAAATGTCACATTGCAGCAGAGCTTA
AGGACTTTAACCCACAGGATTTTATGGACAGAAAGGCTGCAAAGAGAATGGAACCATTCTCACAGTACGCTGTAGCTGCT
GCAAAGCAGGCAATTGATGACAGCGGACTTGATATCGAAAAGGAAGATCCATACATGGTTGGATGTGCCATCGGTTCAGG
TATCGGAAGTCTTCAGGCTATGGAGCGCGAGACACAAAAGCTTTATGAAAAGGGACCAAACAGAGTCAATCCTCTGCTTG
TTCCGCTTATGATCTGTAACATGGCAGCAGGAAATGTTTCTATCCAGTTCGGTCTCAAGGGAAAGAGTATCAATGATGTA
ACAGCCTGCGCTACAGGAACAAACACAATCGGTGAGGCATACAGAAGCATCCAGTACGGTGAGGCTGACGTGATGGTAGC
CGGTGGTACAGAGGGCAGTGTATGTCCTATCGGAATCGCAGGATTTACAGCACTTACAGCGCTTTCTACAGTAGATGATC
CGACAAAGTGTTCACTTCCGTTTGACAAAAACAGAAGCGGCTTTGTAATGGGTGAGGGCGCAGGAGTTGTTATCCTTGAA
GAGCTTGAGCATGCAAAGGCAAGAGGTGCAAAGATTTATGCAGAGGTAGTCGGATACGGCTGCTCATCTGATGCATACCA
CATCACATCTCCGCAGGAGGATGGCGCAGGCGCAGCAAGAGCCATGACCAATGCCATGAGCGATGCAGGTGTCACACCGG
CAGATGTAAAATACATCAATGCTCACGGAACAGGCACACATCACAATGATCTCTTTGAGACAAGAGCGATCAAGCTTGCG
TTCGGTGATGAGGCTGCAAATCTTAAAATCAATTCAACAAAGTCTATGATAGGACATCTGCTCGGAGCAGCGGGAGCTGT
TGAGTTTATAACATGTGTGAAGGAAATTCAGGATGGATTTATACATAAGACTGTTGGCTATGAGACTCCTGATGAGGAGA
TTGACCTCAATTACTGCAAGAACAGCTATGAGGAGCCTGTTGAGTATGCACTTAGCAATTCACTGGGATTCGGTGGACAT
AATGCAAGTATTCTGCTCAAGGCGTATAAATAA

Upstream 100 bases:

>100_bases
GAAACACAAAGGATATCGCAAACGCAGTATTATTTTTAGCATCAGATGCAGCAGGCTACATCACAGGCCAGGTGCTGTCT
GTTGACGGAGGAATGGCAAT

Downstream 100 bases:

>100_bases
ATAGCTTCTGCTTTTTAAGGGGCTTCGCGCATTCAGGCTGTGAGGTCCGGTGGAGCACACAGTATATTCCTCATAAAAAA
TATGAAGTCAGTCACGGCAT

Product: FabF

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSRRVVVTGLGAVTPIGNNVDDFWTSVKAGKIGFDHITKFDTTDYKCHIAAELKDFNPQDFMDRKAAKRMEPFSQYAVAA
AKQAIDDSGLDIEKEDPYMVGCAIGSGIGSLQAMERETQKLYEKGPNRVNPLLVPLMICNMAAGNVSIQFGLKGKSINDV
TACATGTNTIGEAYRSIQYGEADVMVAGGTEGSVCPIGIAGFTALTALSTVDDPTKCSLPFDKNRSGFVMGEGAGVVILE
ELEHAKARGAKIYAEVVGYGCSSDAYHITSPQEDGAGAARAMTNAMSDAGVTPADVKYINAHGTGTHHNDLFETRAIKLA
FGDEAANLKINSTKSMIGHLLGAAGAVEFITCVKEIQDGFIHKTVGYETPDEEIDLNYCKNSYEEPVEYALSNSLGFGGH
NASILLKAYK

Sequences:

>Translated_410_residues
MSRRVVVTGLGAVTPIGNNVDDFWTSVKAGKIGFDHITKFDTTDYKCHIAAELKDFNPQDFMDRKAAKRMEPFSQYAVAA
AKQAIDDSGLDIEKEDPYMVGCAIGSGIGSLQAMERETQKLYEKGPNRVNPLLVPLMICNMAAGNVSIQFGLKGKSINDV
TACATGTNTIGEAYRSIQYGEADVMVAGGTEGSVCPIGIAGFTALTALSTVDDPTKCSLPFDKNRSGFVMGEGAGVVILE
ELEHAKARGAKIYAEVVGYGCSSDAYHITSPQEDGAGAARAMTNAMSDAGVTPADVKYINAHGTGTHHNDLFETRAIKLA
FGDEAANLKINSTKSMIGHLLGAAGAVEFITCVKEIQDGFIHKTVGYETPDEEIDLNYCKNSYEEPVEYALSNSLGFGGH
NASILLKAYK
>Mature_409_residues
SRRVVVTGLGAVTPIGNNVDDFWTSVKAGKIGFDHITKFDTTDYKCHIAAELKDFNPQDFMDRKAAKRMEPFSQYAVAAA
KQAIDDSGLDIEKEDPYMVGCAIGSGIGSLQAMERETQKLYEKGPNRVNPLLVPLMICNMAAGNVSIQFGLKGKSINDVT
ACATGTNTIGEAYRSIQYGEADVMVAGGTEGSVCPIGIAGFTALTALSTVDDPTKCSLPFDKNRSGFVMGEGAGVVILEE
LEHAKARGAKIYAEVVGYGCSSDAYHITSPQEDGAGAARAMTNAMSDAGVTPADVKYINAHGTGTHHNDLFETRAIKLAF
GDEAANLKINSTKSMIGHLLGAAGAVEFITCVKEIQDGFIHKTVGYETPDEEIDLNYCKNSYEEPVEYALSNSLGFGGHN
ASILLKAYK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=42.7207637231504, Blast_Score=311, Evalue=5e-85,
Organism=Homo sapiens, GI223972627, Length=199, Percent_Identity=34.6733668341709, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI41872631, Length=426, Percent_Identity=25.8215962441315, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1787337, Length=408, Percent_Identity=49.7549019607843, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1788663, Length=416, Percent_Identity=37.5, Blast_Score=229, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71983541, Length=414, Percent_Identity=35.9903381642512, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=42.0454545454545, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=424, Percent_Identity=26.4150943396226, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=380, Percent_Identity=23.6842105263158, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=38.8392857142857, Blast_Score=281, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=42.5837320574163, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI221330659, Length=371, Percent_Identity=27.4932614555256, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19920632, Length=371, Percent_Identity=27.2237196765499, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24581345, Length=424, Percent_Identity=25, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43688; Mature: 43557

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRVVVTGLGAVTPIGNNVDDFWTSVKAGKIGFDHITKFDTTDYKCHIAAELKDFNPQD
CCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEEEECCCCCCHH
FMDRKAAKRMEPFSQYAVAAAKQAIDDSGLDIEKEDPYMVGCAIGSGIGSLQAMERETQK
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
LYEKGPNRVNPLLVPLMICNMAAGNVSIQFGLKGKSINDVTACATGTNTIGEAYRSIQYG
HHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCHHHHHHHHHCCCC
EADVMVAGGTEGSVCPIGIAGFTALTALSTVDDPTKCSLPFDKNRSGFVMGEGAGVVILE
CCEEEEECCCCCCCCEECHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEECCCCEEEEE
ELEHAKARGAKIYAEVVGYGCSSDAYHITSPQEDGAGAARAMTNAMSDAGVTPADVKYIN
HHHHHHHCCCEEEEHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEE
AHGTGTHHNDLFETRAIKLAFGDEAANLKINSTKSMIGHLLGAAGAVEFITCVKEIQDGF
CCCCCCCCCHHHHHEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IHKTVGYETPDEEIDLNYCKNSYEEPVEYALSNSLGFGGHNASILLKAYK
EEEECCCCCCCCCEEHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
SRRVVVTGLGAVTPIGNNVDDFWTSVKAGKIGFDHITKFDTTDYKCHIAAELKDFNPQD
CCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEEEECCCCCCHH
FMDRKAAKRMEPFSQYAVAAAKQAIDDSGLDIEKEDPYMVGCAIGSGIGSLQAMERETQK
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
LYEKGPNRVNPLLVPLMICNMAAGNVSIQFGLKGKSINDVTACATGTNTIGEAYRSIQYG
HHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCHHHHHHHHHCCCC
EADVMVAGGTEGSVCPIGIAGFTALTALSTVDDPTKCSLPFDKNRSGFVMGEGAGVVILE
CCEEEEECCCCCCCCEECHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEECCCCEEEEE
ELEHAKARGAKIYAEVVGYGCSSDAYHITSPQEDGAGAARAMTNAMSDAGVTPADVKYIN
HHHHHHHCCCEEEEHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEE
AHGTGTHHNDLFETRAIKLAFGDEAANLKINSTKSMIGHLLGAAGAVEFITCVKEIQDGF
CCCCCCCCCHHHHHEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IHKTVGYETPDEEIDLNYCKNSYEEPVEYALSNSLGFGGHNASILLKAYK
EEEECCCCCCCCCEEHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]