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The map label for this gene is natA [H]

Identifier: 238925436

GI number: 238925436

Start: 2954063

End: 2954713

Strand: Reverse

Name: natA [H]

Synonym: EUBREC_3091

Alternate gene names: 238925436

Gene position: 2954713-2954063 (Counterclockwise)

Preceding gene: 238925437

Following gene: 238925435

Centisome position: 85.65

GC content: 39.78

Gene sequence:

>651_bases
ATGGATGAGACAATTATAAAAATAGAAAATGCCGCTTTAAAATTAAAAAAATTTATGATTAAGCCCGCAAATTTAGAAAT
ACCAAAGGGCTACATTGTAGGTGTACAGGGAGAAAACGGTGCGGGAAAGACCACACTGCTTCATATGATGCTTGGAATGT
ATGACAAAATGAAGGGAAAAATATACATAGACGGTCTTGATGTTGTAAAAAATAAGACCAAGGTAAAAGAGCTTGTAGGA
ATAGTGTCGCAGGACAGGATATTTTACCTGTCGCAGGATGCCAATGGAAACGAAAAAATATACAGTCCATTTTATAAGAA
TTGGGATAGTGAGGAGTATCACAGGATGCTTGCACATTTGGAGCTTTCTCCAAGACGCAGATTGTGCTCGTTTTCTACAG
GAGAAATGATAAAGTATCAGTTTGCATTTGCGGCAGCATACAGACCCAAAGTGCTTCTGATGGATGAGCCGACTGCCAAT
CTCGACCCGGTGTTCAGGGATGATTTCTTAAAATTACTGCAGGAATTTGTGGCAGAGTATGAGATGACAATACTTCTTGC
CACGCATCTGGACGAGGATTTGTCGAGGGTGGCAGACTATGTTATAGATATAAAGAACGGAGAATATTCAATGCGTGAGA
TACTTGAGTAG

Upstream 100 bases:

>100_bases
ATCTTGAGAACAGGATGTCAGAACTGCTTGCAGATTGTGAGAATGCCGGAATGACCTTGAAGGATATAATAGATATGGTT
CGTGTATTGGGAGAAAAATA

Downstream 100 bases:

>100_bases
CTTATAATTGCTGCCGGTAATACCGGGGGTGAATGGTATAATTTTATAGCTTGCATTAGGTGTACAACACGCAATAGAAA
ACAGATGGAGATGTGAAATG

Product: putative ABC transporter

Products: NA

Alternate protein names: Na(+) ABC transporter [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MDETIIKIENAALKLKKFMIKPANLEIPKGYIVGVQGENGAGKTTLLHMMLGMYDKMKGKIYIDGLDVVKNKTKVKELVG
IVSQDRIFYLSQDANGNEKIYSPFYKNWDSEEYHRMLAHLELSPRRRLCSFSTGEMIKYQFAFAAAYRPKVLLMDEPTAN
LDPVFRDDFLKLLQEFVAEYEMTILLATHLDEDLSRVADYVIDIKNGEYSMREILE

Sequences:

>Translated_216_residues
MDETIIKIENAALKLKKFMIKPANLEIPKGYIVGVQGENGAGKTTLLHMMLGMYDKMKGKIYIDGLDVVKNKTKVKELVG
IVSQDRIFYLSQDANGNEKIYSPFYKNWDSEEYHRMLAHLELSPRRRLCSFSTGEMIKYQFAFAAAYRPKVLLMDEPTAN
LDPVFRDDFLKLLQEFVAEYEMTILLATHLDEDLSRVADYVIDIKNGEYSMREILE
>Mature_216_residues
MDETIIKIENAALKLKKFMIKPANLEIPKGYIVGVQGENGAGKTTLLHMMLGMYDKMKGKIYIDGLDVVKNKTKVKELVG
IVSQDRIFYLSQDANGNEKIYSPFYKNWDSEEYHRMLAHLELSPRRRLCSFSTGEMIKYQFAFAAAYRPKVLLMDEPTAN
LDPVFRDDFLKLLQEFVAEYEMTILLATHLDEDLSRVADYVIDIKNGEYSMREILE

Specific function: Involved in ATP-dependent electrogenic sodium extrusion [H]

COG id: COG1131

COG function: function code V; ABC-type multidrug transport system, ATPase component

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI116734710, Length=200, Percent_Identity=28.5, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI47078218, Length=201, Percent_Identity=26.865671641791, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI27477115, Length=196, Percent_Identity=27.5510204081633, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI45446740, Length=199, Percent_Identity=27.1356783919598, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI27881501, Length=199, Percent_Identity=24.1206030150754, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI30795238, Length=199, Percent_Identity=24.1206030150754, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI21536376, Length=190, Percent_Identity=27.3684210526316, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI153792144, Length=191, Percent_Identity=26.7015706806283, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI42741659, Length=154, Percent_Identity=27.9220779220779, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI48994943, Length=203, Percent_Identity=27.0935960591133, Blast_Score=84, Evalue=5e-18,
Organism=Escherichia coli, GI87081782, Length=194, Percent_Identity=27.319587628866, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786398, Length=196, Percent_Identity=31.1224489795918, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787029, Length=198, Percent_Identity=30.8080808080808, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081709, Length=188, Percent_Identity=28.7234042553192, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1788540, Length=196, Percent_Identity=29.0816326530612, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1789873, Length=206, Percent_Identity=27.1844660194175, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786803, Length=221, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786703, Length=197, Percent_Identity=29.9492385786802, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790162, Length=232, Percent_Identity=26.2931034482759, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI87081791, Length=197, Percent_Identity=26.3959390862944, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1789672, Length=228, Percent_Identity=25, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1788472, Length=203, Percent_Identity=25.615763546798, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1786319, Length=205, Percent_Identity=26.8292682926829, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI87082268, Length=192, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787112, Length=198, Percent_Identity=26.7676767676768, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787164, Length=195, Percent_Identity=26.6666666666667, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787792, Length=210, Percent_Identity=26.6666666666667, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790190, Length=208, Percent_Identity=25.9615384615385, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788210, Length=190, Percent_Identity=26.3157894736842, Blast_Score=60, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17510237, Length=191, Percent_Identity=26.1780104712042, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI115533608, Length=176, Percent_Identity=30.6818181818182, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17565586, Length=188, Percent_Identity=26.063829787234, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17541710, Length=200, Percent_Identity=30.5, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24666092, Length=195, Percent_Identity=28.2051282051282, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24650855, Length=201, Percent_Identity=28.3582089552239, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650853, Length=201, Percent_Identity=28.3582089552239, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281362751, Length=201, Percent_Identity=28.3582089552239, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24643674, Length=197, Percent_Identity=26.3959390862944, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24582014, Length=198, Percent_Identity=26.7676767676768, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24582012, Length=198, Percent_Identity=26.7676767676768, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648314, Length=182, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI221512771, Length=195, Percent_Identity=25.1282051282051, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 24937; Mature: 24937

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDETIIKIENAALKLKKFMIKPANLEIPKGYIVGVQGENGAGKTTLLHMMLGMYDKMKGK
CCCEEEEEHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCE
IYIDGLDVVKNKTKVKELVGIVSQDRIFYLSQDANGNEKIYSPFYKNWDSEEYHRMLAHL
EEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHC
ELSPRRRLCSFSTGEMIKYQFAFAAAYRPKVLLMDEPTANLDPVFRDDFLKLLQEFVAEY
CCCCHHHHHCCCCCCCEEEHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
EMTILLATHLDEDLSRVADYVIDIKNGEYSMREILE
HHHEEEEHHCCHHHHHHHHHEEEECCCCCHHHHHCC
>Mature Secondary Structure
MDETIIKIENAALKLKKFMIKPANLEIPKGYIVGVQGENGAGKTTLLHMMLGMYDKMKGK
CCCEEEEEHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCE
IYIDGLDVVKNKTKVKELVGIVSQDRIFYLSQDANGNEKIYSPFYKNWDSEEYHRMLAHL
EEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHC
ELSPRRRLCSFSTGEMIKYQFAFAAAYRPKVLLMDEPTANLDPVFRDDFLKLLQEFVAEY
CCCCHHHHHCCCCCCCEEEHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
EMTILLATHLDEDLSRVADYVIDIKNGEYSMREILE
HHHEEEEHHCCHHHHHHHHHEEEECCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9106203; 9274031; 9384377 [H]